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Protein

Ethanolamine-phosphate phospho-lyase

Gene

Etnppl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.By similarity

Catalytic activityi

Ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate.

Cofactori

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Lyase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-MMU-1483213. Synthesis of PE.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine-phosphate phospho-lyase (EC:4.2.3.2)
Alternative name(s):
Alanine--glyoxylate aminotransferase 2-like 1
Gene namesi
Name:Etnppl
Synonyms:Agxt2l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1919010. Etnppl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Ethanolamine-phosphate phospho-lyasePRO_0000287664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

EPDiQ8BWU8.
MaxQBiQ8BWU8.
PaxDbiQ8BWU8.
PRIDEiQ8BWU8.

PTM databases

iPTMnetiQ8BWU8.
PhosphoSiteiQ8BWU8.

Expressioni

Gene expression databases

BgeeiQ8BWU8.
CleanExiMM_AGXT2L1.
ExpressionAtlasiQ8BWU8. baseline and differential.
GenevisibleiQ8BWU8. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

MINTiMINT-1856086.
STRINGi10090.ENSMUSP00000072121.

Structurei

3D structure databases

ProteinModelPortaliQ8BWU8.
SMRiQ8BWU8. Positions 3-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1403. Eukaryota.
COG0160. LUCA.
GeneTreeiENSGT00530000062907.
HOGENOMiHOG000020206.
HOVERGENiHBG004196.
InParanoidiQ8BWU8.
KOiK14286.
OMAiPYKFNQL.
OrthoDBiEOG79KPF2.
PhylomeDBiQ8BWU8.
TreeFamiTF320468.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BWU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCELYSKQDT LALRERHIGP SCKIFFAADP IKIMRAQGQY MFDEKGERYL
60 70 80 90 100
DCINNVAHVG HCHPEVVKAA AKQMELLNTN SRFLHDNIIE FAKRLTATLP
110 120 130 140 150
QELSVCYFTN SGSEANDLAL RLARQFRGHQ DVITLDHAYH GHLSSLIEIS
160 170 180 190 200
PYKFQKGKDV KRETVHVAPA PDTYRGKYRE DHEDPSTAYA DEVKKIIEEA
210 220 230 240 250
HSSGRKIAAF IAESMQSCGG QIIPPAGYFQ KVAEHIHKAG GVFIADEVQV
260 270 280 290 300
GFGRVGRYFW SFQMYGEDFV PDIVTMGKPM GNGHPISCVV TTKEIAEAFS
310 320 330 340 350
SSGMEYFNTY GGNPVSCAVG LAVLDVIEKE NLQGNAVRVG TYLMELLSEQ
360 370 380 390 400
KAKHPLIGDI RGVGLFIGID LVKDREKRTP ATAEAQHIIY EMKGKGVLLS
410 420 430 440 450
ADGPHRNVLK IKPPMCFTED DAKFLVDHLD GILTVLEEAM DSKSGTVFSE
460 470 480 490
NTAYRTKMPK EIQVELPNLS ATEAREIPRG KRNGVCSDQQ ALLSKRLKT
Length:499
Mass (Da):55,496
Last modified:March 1, 2003 - v1
Checksum:i8CC1EDD075AAFDD1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121A → V in AAH43680 (PubMed:15489334).Curated
Sequence conflicti282 – 2821N → D in BAB23784 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005060 mRNA. Translation: BAB23784.1.
AK049937 mRNA. Translation: BAC33993.1.
BC043680 mRNA. Translation: AAH43680.2.
BC058592 mRNA. Translation: AAH58592.1.
CCDSiCCDS38638.1.
RefSeqiNP_001157059.1. NM_001163587.1.
NP_082183.2. NM_027907.3.
UniGeneiMm.29125.

Genome annotation databases

EnsembliENSMUST00000072271; ENSMUSP00000072121; ENSMUSG00000019232.
ENSMUST00000166187; ENSMUSP00000131294; ENSMUSG00000019232.
GeneIDi71760.
KEGGimmu:71760.
UCSCiuc008rjb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005060 mRNA. Translation: BAB23784.1.
AK049937 mRNA. Translation: BAC33993.1.
BC043680 mRNA. Translation: AAH43680.2.
BC058592 mRNA. Translation: AAH58592.1.
CCDSiCCDS38638.1.
RefSeqiNP_001157059.1. NM_001163587.1.
NP_082183.2. NM_027907.3.
UniGeneiMm.29125.

3D structure databases

ProteinModelPortaliQ8BWU8.
SMRiQ8BWU8. Positions 3-430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1856086.
STRINGi10090.ENSMUSP00000072121.

PTM databases

iPTMnetiQ8BWU8.
PhosphoSiteiQ8BWU8.

Proteomic databases

EPDiQ8BWU8.
MaxQBiQ8BWU8.
PaxDbiQ8BWU8.
PRIDEiQ8BWU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072271; ENSMUSP00000072121; ENSMUSG00000019232.
ENSMUST00000166187; ENSMUSP00000131294; ENSMUSG00000019232.
GeneIDi71760.
KEGGimmu:71760.
UCSCiuc008rjb.2. mouse.

Organism-specific databases

CTDi64850.
MGIiMGI:1919010. Etnppl.

Phylogenomic databases

eggNOGiKOG1403. Eukaryota.
COG0160. LUCA.
GeneTreeiENSGT00530000062907.
HOGENOMiHOG000020206.
HOVERGENiHBG004196.
InParanoidiQ8BWU8.
KOiK14286.
OMAiPYKFNQL.
OrthoDBiEOG79KPF2.
PhylomeDBiQ8BWU8.
TreeFamiTF320468.

Enzyme and pathway databases

ReactomeiR-MMU-1483213. Synthesis of PE.

Miscellaneous databases

NextBioi334425.
PROiQ8BWU8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BWU8.
CleanExiMM_AGXT2L1.
ExpressionAtlasiQ8BWU8. baseline and differential.
GenevisibleiQ8BWU8. MM.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus and Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Eye and Liver.

Entry informationi

Entry nameiAT2L1_MOUSE
AccessioniPrimary (citable) accession number: Q8BWU8
Secondary accession number(s): Q811K4, Q9DBB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.