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Protein

Ethanolamine-phosphate phospho-lyase

Gene

Etnppl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.By similarity

Caution

Does not seem to possess aminotransferase activity.By similarity

Catalytic activityi

Ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate.

Cofactori

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-MMU-1483213 Synthesis of PE

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine-phosphate phospho-lyase (EC:4.2.3.2)
Alternative name(s):
Alanine--glyoxylate aminotransferase 2-like 1
Gene namesi
Name:Etnppl
Synonyms:Agxt2l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1919010 Etnppl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876641 – 499Ethanolamine-phosphate phospho-lyaseAdd BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei278N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

MaxQBiQ8BWU8
PaxDbiQ8BWU8
PRIDEiQ8BWU8

PTM databases

iPTMnetiQ8BWU8
PhosphoSitePlusiQ8BWU8

Expressioni

Gene expression databases

BgeeiENSMUSG00000019232
CleanExiMM_AGXT2L1
ExpressionAtlasiQ8BWU8 baseline and differential
GenevisibleiQ8BWU8 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072121

Structurei

3D structure databases

ProteinModelPortaliQ8BWU8
SMRiQ8BWU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1403 Eukaryota
COG0160 LUCA
GeneTreeiENSGT00530000062907
HOGENOMiHOG000020206
HOVERGENiHBG004196
InParanoidiQ8BWU8
KOiK14286
OMAiRVGNYLT
OrthoDBiEOG091G08ZM
PhylomeDBiQ8BWU8
TreeFamiTF320468

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BWU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCELYSKQDT LALRERHIGP SCKIFFAADP IKIMRAQGQY MFDEKGERYL
60 70 80 90 100
DCINNVAHVG HCHPEVVKAA AKQMELLNTN SRFLHDNIIE FAKRLTATLP
110 120 130 140 150
QELSVCYFTN SGSEANDLAL RLARQFRGHQ DVITLDHAYH GHLSSLIEIS
160 170 180 190 200
PYKFQKGKDV KRETVHVAPA PDTYRGKYRE DHEDPSTAYA DEVKKIIEEA
210 220 230 240 250
HSSGRKIAAF IAESMQSCGG QIIPPAGYFQ KVAEHIHKAG GVFIADEVQV
260 270 280 290 300
GFGRVGRYFW SFQMYGEDFV PDIVTMGKPM GNGHPISCVV TTKEIAEAFS
310 320 330 340 350
SSGMEYFNTY GGNPVSCAVG LAVLDVIEKE NLQGNAVRVG TYLMELLSEQ
360 370 380 390 400
KAKHPLIGDI RGVGLFIGID LVKDREKRTP ATAEAQHIIY EMKGKGVLLS
410 420 430 440 450
ADGPHRNVLK IKPPMCFTED DAKFLVDHLD GILTVLEEAM DSKSGTVFSE
460 470 480 490
NTAYRTKMPK EIQVELPNLS ATEAREIPRG KRNGVCSDQQ ALLSKRLKT
Length:499
Mass (Da):55,496
Last modified:March 1, 2003 - v1
Checksum:i8CC1EDD075AAFDD1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12A → V in AAH43680 (PubMed:15489334).Curated1
Sequence conflicti282N → D in BAB23784 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005060 mRNA Translation: BAB23784.1
AK049937 mRNA Translation: BAC33993.1
BC043680 mRNA Translation: AAH43680.2
BC058592 mRNA Translation: AAH58592.1
CCDSiCCDS38638.1
RefSeqiNP_001157059.1, NM_001163587.1
NP_082183.2, NM_027907.3
UniGeneiMm.29125

Genome annotation databases

EnsembliENSMUST00000072271; ENSMUSP00000072121; ENSMUSG00000019232
ENSMUST00000166187; ENSMUSP00000131294; ENSMUSG00000019232
GeneIDi71760
KEGGimmu:71760
UCSCiuc008rjb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAT2L1_MOUSE
AccessioniPrimary (citable) accession number: Q8BWU8
Secondary accession number(s): Q811K4, Q9DBB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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