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Protein

Disco-interacting protein 2 homolog A

Gene

Dip2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May provide positional cues for axon pathfinding and patterning in the central nervous system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Disco-interacting protein 2 homolog A
Short name:
DIP2 homolog A
Gene namesi
Name:Dip2a
Synonyms:Dip2, Kiaa0184
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2385920. Dip2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799071 – 1523Disco-interacting protein 2 homolog AAdd BLAST1523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92PhosphothreonineCombined sources1
Modified residuei115PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BWT5.
PaxDbiQ8BWT5.
PeptideAtlasiQ8BWT5.
PRIDEiQ8BWT5.

PTM databases

iPTMnetiQ8BWT5.
PhosphoSitePlusiQ8BWT5.

Expressioni

Tissue specificityi

Developing nervous system.1 Publication

Developmental stagei

Expressed at all stages of development, including E7, E11, E15 and E17. Higher level of expression is seen at later stages of embryonic development. In E9.5 embryos, expression is diffusely distributed in the regions of the brain, optic vesicles, otic vesicles, cervical and upper thoracic segments of the spinal cord. The expression is more intense in the dorsal portions of the central nervous system (CNS). In the brain, expression is localized in prosencephalon, mesencephalon and rhombencephalon. In 10.5 embryos, expression area is more restricted, but still within the CNS and the sense organs. The spinal cord expression disappears.1 Publication

Gene expression databases

BgeeiENSMUSG00000020231.
ExpressionAtlasiQ8BWT5. baseline and differential.
GenevisibleiQ8BWT5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043710.

Structurei

3D structure databases

ProteinModelPortaliQ8BWT5.
SMRiQ8BWT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 51DMAP-interactionAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1066 – 1069Poly-Ala4
Compositional biasi1450 – 1453Poly-Val4

Sequence similaritiesi

Belongs to the DIP2 family.Curated
Contains 1 DMAP-interaction domain.Curated

Phylogenomic databases

eggNOGiKOG3628. Eukaryota.
COG0318. LUCA.
GeneTreeiENSGT00390000005268.
HOGENOMiHOG000045270.
HOVERGENiHBG026594.
InParanoidiQ8BWT5.

Family and domain databases

InterProiIPR000873. AMP-dep_Synth/Lig.
IPR010506. DMAP1-bd.
[Graphical view]
PfamiPF00501. AMP-binding. 2 hits.
PF06464. DMAP_binding. 1 hit.
[Graphical view]
SMARTiSM01137. DMAP_binding. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BWT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRGCPLEA APLPAEVLES LAELELELSE GDITQKGYEK KRAKLLARYI
60 70 80 90 100
PLIQDVHTEA VQAALAKYKE RKMPMPSKRR SALVHSSVET YTPPDTSSAS
110 120 130 140 150
EDEGSLRRPG RLTSTLLQSH SGIEPWLDRV IQGSSTSSSA SSTSSHPGGR
160 170 180 190 200
PAAAPSASTA LAGLTAHAHI DLHSAPPDVT TGLVEHSSYE RPQMASVRGI
210 220 230 240 250
PRGHGRNVLE TADGVPVNSR VSSKIQQLLN TLKRPKRPPL KEFFVDDFEE
260 270 280 290 300
LLEVQQPDPN QPKPEGDQMA VLKGEPLSVG TNGPLSLLAA LQLWGTTQPK
310 320 330 340 350
APCLTALDTA GKATCTLTYG KLWSRSLKLA YTLLNKLTSK NEPLLNPGDR
360 370 380 390 400
VALVFPNSDP VMFMVAFYGC LLAELVPVPI EVPLTRKDAG SQQVGFLLGS
410 420 430 440 450
CGVTLALTTD ACQKGLPKAP TGEVATFKGW PPLAWLVIDG KHLTRPPKDW
460 470 480 490 500
YPLAQDTGSR TAYIEYKTSK EGSTVGVTVS HSSLLAQCQA LTQACGYTEA
510 520 530 540 550
ETLTNVLDFK RDAGLWHGVL TSVMNRMHVI TIPYALMKVN PLSWIQKVCS
560 570 580 590 600
YKARAALVKS RDMHWSLLAQ RGQRDVCLSS LRMLIVADGA NPWSISSCDA
610 620 630 640 650
FLNVFQSRGL RPEVICPCAS SPEALTVAIR RPPDLGGPPP RKAVLSMNGL
660 670 680 690 700
SYGVIRVDTE EKLSVLTVQD VGQVMPGASV CVVKVDGAPY LCKTDEIGEI
710 720 730 740 750
CVNSVATGTA YYGLLGITKN TFETVPVTAD GVPVSDRPFT RTGLLGFIGP
760 770 780 790 800
DNLVFVVGKL DGLMVVGVRR HNADDIVATA LAVEPMKFVY RGRIAVFSVT
810 820 830 840 850
VLHDDRIVLV AEQRPDASEE DSFQWMSRVL QAIDSIHQVG VYCLALVPAN
860 870 880 890 900
TLPKAPLGGI HISETKQRFL EGTLHPCNVL MCPHTCVTNL PKPRQKQPEV
910 920 930 940 950
GPASMIVGNL VAGKRIAQAS GRELAHLEDS DQARKFLFLA DVLQWRAHTT
960 970 980 990 1000
PDHPLFLLLN AKGTVTSTAT CIQLHKRAER VAAALMEKGR LDAGDHVALV
1010 1020 1030 1040 1050
YPPGVDLIAA FYGCLYCGCV PVTVRPPHPQ NLGTTLPTVK MIVEVSKSAC
1060 1070 1080 1090 1100
VLSTQAITRL LKSKEAAAAV DVRTWPTILD TDDIPKKKVA SIFRPPSPDV
1110 1120 1130 1140 1150
LAYLDFSVST TGILAGVKMS HAATSALCRS IKLQCELYPS RQIAICLDPY
1160 1170 1180 1190 1200
CGLGFALWCL CSVYSGHQSV LVPPLELESN VSLWLSAVSQ YKARVTFCSY
1210 1220 1230 1240 1250
SVMEMCTKGL GAQTGALRMK GVNLSCVRTC MVVAEERPRI SLTQSFSKLF
1260 1270 1280 1290 1300
KDLGLPARAV STTFGCRVNV AICLQGTTGP DPTTVYVDMR ALRHDRVRLV
1310 1320 1330 1340 1350
ERGSPHSLPL MESGKILPGV KVIIAHTETK GPLGDSHLGE IWVSSPHNAT
1360 1370 1380 1390 1400
GYYTVYGEET LHADHFSARL SFGDTQTIWA RTGYLGFLRR TELTDASGER
1410 1420 1430 1440 1450
HDALYVVGSL DETLELRGMR YHPIDIETSV IRAHRSIAEC AVFTWTNLLV
1460 1470 1480 1490 1500
VVVELDGLEQ DALDLVALVT NVVLEEHYLV VGVVVIVDPG VIPINSRGEK
1510 1520
QRMHLRDGFL ADQLDPIYVA YNM
Length:1,523
Mass (Da):165,255
Last modified:July 27, 2011 - v3
Checksum:iE5D54BF7E988D065
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42 – 54RAKLL…IPLIQ → SRATNSRDERFRS in BAC41397 (PubMed:12465718).CuratedAdd BLAST13
Sequence conflicti996H → R in BAC34043 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140851 Genomic DNA. No translation available.
AC141477 Genomic DNA. No translation available.
AK050040 mRNA. Translation: BAC34043.2.
AB093213 mRNA. Translation: BAC41397.2.
RefSeqiNP_001074888.2. NM_001081419.2.
UniGeneiMm.33183.

Genome annotation databases

EnsembliENSMUST00000160048; ENSMUSP00000125184; ENSMUSG00000020231.
GeneIDi64451.
KEGGimmu:64451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140851 Genomic DNA. No translation available.
AC141477 Genomic DNA. No translation available.
AK050040 mRNA. Translation: BAC34043.2.
AB093213 mRNA. Translation: BAC41397.2.
RefSeqiNP_001074888.2. NM_001081419.2.
UniGeneiMm.33183.

3D structure databases

ProteinModelPortaliQ8BWT5.
SMRiQ8BWT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043710.

PTM databases

iPTMnetiQ8BWT5.
PhosphoSitePlusiQ8BWT5.

Proteomic databases

MaxQBiQ8BWT5.
PaxDbiQ8BWT5.
PeptideAtlasiQ8BWT5.
PRIDEiQ8BWT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160048; ENSMUSP00000125184; ENSMUSG00000020231.
GeneIDi64451.
KEGGimmu:64451.

Organism-specific databases

CTDi23181.
MGIiMGI:2385920. Dip2a.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3628. Eukaryota.
COG0318. LUCA.
GeneTreeiENSGT00390000005268.
HOGENOMiHOG000045270.
HOVERGENiHBG026594.
InParanoidiQ8BWT5.

Miscellaneous databases

PROiQ8BWT5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020231.
ExpressionAtlasiQ8BWT5. baseline and differential.
GenevisibleiQ8BWT5. MM.

Family and domain databases

InterProiIPR000873. AMP-dep_Synth/Lig.
IPR010506. DMAP1-bd.
[Graphical view]
PfamiPF00501. AMP-binding. 2 hits.
PF06464. DMAP_binding. 1 hit.
[Graphical view]
SMARTiSM01137. DMAP_binding. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDIP2A_MOUSE
AccessioniPrimary (citable) accession number: Q8BWT5
Secondary accession number(s): E0CXM7, Q8CHI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.