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Protein

3-ketoacyl-CoA thiolase, mitochondrial

Gene

Acaa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Abolishes BNIP3-mediated apoptosis and mitochondrial damage.By similarity

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Acyl-thioester intermediateBy similarity1
Active sitei352Proton acceptorPROSITE-ProRule annotation1
Active sitei382Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation
UniPathwayiUPA00199

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolase, mitochondrial (EC:2.3.1.16)
Alternative name(s):
Acetyl-CoA acyltransferase
Beta-ketothiolase
Mitochondrial 3-oxoacyl-CoA thiolase
Gene namesi
Name:Acaa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1098623 Acaa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002233001 – 3973-ketoacyl-CoA thiolase, mitochondrialAdd BLAST397
Transit peptidei1 – 16Mitochondrion; not cleavedBy similarityAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25N6-acetyllysine; alternateCombined sources1
Modified residuei25N6-succinyllysine; alternateCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei45N6-succinyllysineCombined sources1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei127PhosphotyrosineBy similarity1
Modified residuei136PhosphothreonineCombined sources1
Modified residuei137N6-acetyllysine; alternateCombined sources1
Modified residuei137N6-succinyllysine; alternateCombined sources1
Modified residuei143N6-acetyllysine; alternateCombined sources1
Modified residuei143N6-succinyllysine; alternateCombined sources1
Modified residuei158N6-acetyllysine; alternateCombined sources1
Modified residuei158N6-succinyllysine; alternateCombined sources1
Modified residuei171N6-acetyllysine; alternateCombined sources1
Modified residuei171N6-succinyllysine; alternateCombined sources1
Modified residuei191N6-acetyllysine; alternateCombined sources1
Modified residuei191N6-succinyllysine; alternateCombined sources1
Modified residuei209N6-acetyllysine; alternateCombined sources1
Modified residuei209N6-succinyllysine; alternateCombined sources1
Modified residuei211N6-succinyllysineCombined sources1
Modified residuei212N6-succinyllysineCombined sources1
Modified residuei214N6-succinyllysineCombined sources1
Modified residuei234N6-acetyllysine; alternateCombined sources1
Modified residuei234N6-succinyllysine; alternateCombined sources1
Modified residuei240N6-succinyllysineCombined sources1
Modified residuei241N6-acetyllysineCombined sources1
Modified residuei269N6-acetyllysineCombined sources1
Modified residuei270N6-acetyllysineCombined sources1
Modified residuei305N6-acetyllysine; alternateCombined sources1
Modified residuei305N6-succinyllysine; alternateCombined sources1
Modified residuei310PhosphoserineCombined sources1
Modified residuei312N6-acetyllysine; alternateCombined sources1
Modified residuei312N6-succinyllysine; alternateCombined sources1
Modified residuei340N6-acetyllysineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei375N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BWT1
MaxQBiQ8BWT1
PaxDbiQ8BWT1
PeptideAtlasiQ8BWT1
PRIDEiQ8BWT1

2D gel databases

REPRODUCTION-2DPAGEiQ8BWT1

PTM databases

iPTMnetiQ8BWT1
PhosphoSitePlusiQ8BWT1
SwissPalmiQ8BWT1

Expressioni

Gene expression databases

BgeeiENSMUSG00000036880
GenevisibleiQ8BWT1 MM

Interactioni

Subunit structurei

Homotetramer. Interacts with BNIP3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi206649, 6 interactors
IntActiQ8BWT1, 9 interactors
MINTiQ8BWT1
STRINGi10090.ENSMUSP00000037348

Structurei

3D structure databases

ProteinModelPortaliQ8BWT1
SMRiQ8BWT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1391 Eukaryota
COG0183 LUCA
GeneTreeiENSGT00390000009412
HOGENOMiHOG000012238
HOVERGENiHBG003112
InParanoidiQ8BWT1
KOiK07508
OMAiCGGTESM
OrthoDBiEOG091G09C6
TreeFamiTF105696

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
InterProiView protein in InterPro
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BWT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLRGVFIV AAKRTPFGAY GGLLKDFSAT DLTEFAARAA LSAGKVPPET
60 70 80 90 100
IDSVIVGNVM QSSSDAAYLA RHVGLRVGVP TETGALTLNR LCGSGFQSIV
110 120 130 140 150
SGCQEICSKD AEVVLCGGTE SMSQSPYCVR NVRFGTKFGL DLKLEDTLWA
160 170 180 190 200
GLTDQHVKLP MGMTAENLAA KYNISREDCD RYALQSQQRW KAANEAGYFN
210 220 230 240 250
EEMAPIEVKT KKGKQTMQVD EHARPQTTLE QLQKLPSVFK KDGTVTAGNA
260 270 280 290 300
SGVSDGAGAV IIASEDAVKK HNFTPLARVV GYFVSGCDPT IMGIGPVPAI
310 320 330 340 350
NGALKKAGLS LKDMDLIDVN EAFAPQFLSV QKALDLDPSK TNVSGGAIAL
360 370 380 390
GHPLGGSGSR ITAHLVHELR RRGGKYAVGS ACIGGGQGIA LIIQNTA
Length:397
Mass (Da):41,830
Last modified:July 27, 2011 - v3
Checksum:i856840546F5CB8DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti397A → V in AAH28901 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050101 mRNA Translation: BAC34067.1
AK167567 mRNA Translation: BAE39630.1
AK167715 mRNA Translation: BAE39757.1
AK169359 mRNA Translation: BAE41108.1
CH466528 Genomic DNA Translation: EDL09521.1
BC028901 mRNA Translation: AAH28901.1
CCDSiCCDS29342.1
RefSeqiNP_803421.1, NM_177470.3
UniGeneiMm.245724

Genome annotation databases

EnsembliENSMUST00000041053; ENSMUSP00000037348; ENSMUSG00000036880
GeneIDi52538
KEGGimmu:52538
UCSCiuc008fpt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTHIM_MOUSE
AccessioniPrimary (citable) accession number: Q8BWT1
Secondary accession number(s): Q3TIT9, Q8JZR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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