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Protein

Rhophilin-2

Gene

Rhpn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5666185 RHO GTPases Activate Rhotekin and Rhophilins

Names & Taxonomyi

Protein namesi
Recommended name:
Rhophilin-2
Alternative name(s):
GTP-Rho-binding protein 2
Gene namesi
Name:Rhpn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1289234 Rhpn2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188991 – 686Rhophilin-2Add BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei655PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BWR8
PaxDbiQ8BWR8
PRIDEiQ8BWR8

PTM databases

iPTMnetiQ8BWR8
PhosphoSitePlusiQ8BWR8

Expressioni

Gene expression databases

BgeeiENSMUSG00000030494
CleanExiMM_RHPN2
GenevisibleiQ8BWR8 MM

Interactioni

Subunit structurei

Interacts with GTP-bound RhoA and RhoB. Interacts with both GTP- and GDP-bound RhoA. Interacts with KRT18 (By similarity).By similarity

Protein-protein interaction databases

BioGridi206579, 3 interactors
IntActiQ8BWR8, 1 interactor
MINTiQ8BWR8
STRINGi10090.ENSMUSP00000032705

Structurei

Secondary structure

1686
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi530 – 535Combined sources6
Helixi547 – 551Combined sources5
Beta strandi557 – 561Combined sources5
Helixi571 – 580Combined sources10
Turni581 – 583Combined sources3
Beta strandi584 – 586Combined sources3
Beta strandi588 – 591Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VAENMR-A506-603[»]
ProteinModelPortaliQ8BWR8
SMRiQ8BWR8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8BWR8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati38 – 110REMAdd BLAST73
Domaini111 – 502BRO1PROSITE-ProRule annotationAdd BLAST392
Domaini515 – 593PDZPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 66Interaction with RhoBy similarityAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi623 – 626Poly-Asp4

Sequence similaritiesi

Belongs to the RHPN family.Curated

Phylogenomic databases

eggNOGiKOG2220 Eukaryota
ENOG410XQX6 LUCA
GeneTreeiENSGT00780000121909
HOGENOMiHOG000046725
HOVERGENiHBG067197
InParanoidiQ8BWR8
OMAiIDHQLKP
OrthoDBiEOG091G04BO
PhylomeDBiQ8BWR8
TreeFamiTF323502

Family and domain databases

Gene3Di1.25.40.280, 1 hit
InterProiView protein in InterPro
IPR004328 BRO1_dom
IPR038499 BRO1_sf
IPR011072 HR1_rho-bd
IPR036274 HR1_rpt_sf
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF03097 BRO1, 1 hit
PF02185 HR1, 1 hit
SMARTiView protein in SMART
SM01041 BRO1, 1 hit
SM00742 Hr1, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46585 SSF46585, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51180 BRO1, 1 hit
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BWR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTLLPAAP QPLEKEGDDY FRKGCNPLAQ TGRSKLQNQR AALNQQILKA
60 70 80 90 100
VRMRTGAENL LKVATNQKVR EQVRLELSFV NSDLQMLKEE LEGLNISVGV
110 120 130 140 150
YQGTEEAFTI PLIPLGLKET KEVDFSIVFK DFILEHYSED SYLYEDDIAD
160 170 180 190 200
LMDLRQACRT PSRDEAGVEL LMSYFIQLGF VESRFFPPTR HMGLLFTWYD
210 220 230 240 250
SFTGVPVSQQ TLLLEKASVL FNIGALYTQI GTRCNRQTQA GLESAVDAFQ
260 270 280 290 300
RAAGVLNYLK ETFTHTPSYD MSPAMLSVLV KMMLAQAQES VFEKVCLPGI
310 320 330 340 350
QNEFFVLVKV AQEAAKVAEA YRQLHAAMSQ EPVKENIPYS WASVAYVKAY
360 370 380 390 400
HYGALAHYFA ATLLIDHQLK PGADEDHQEK CLSQLYDRMP EGMTPLATLK
410 420 430 440 450
NAGQRVLLGK GHLHRAIGFH EESLREANLC KKLRDIQVLR DVLSAAHQRT
460 470 480 490 500
QLKHTQHRED DDLLNLIDAP DVLPKTEREV KITFPDFSKV TVTDFFQKLG
510 520 530 540 550
PLSVFSASKR WSPPRGIHFT VEEGDLGFTL RGNTPVQVHF LDPHCSASLA
560 570 580 590 600
GAKEGDYIVS IQGVDCKWLT VSEVMKLLKS FGGEEVEMKV VSLLDSTSSM
610 620 630 640 650
HNKCATYSVG MQKTYSMICL SMDDDDKADK TKKISKKLSF LSWGTSKNRQ
660 670 680
KSASTLCLPE VGLARSQNKK KLPTPFSLLN SDSSLY
Length:686
Mass (Da):76,957
Last modified:February 1, 2005 - v2
Checksum:iBFEBEFB71D04F360
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55T → A in BAC34127 (PubMed:16141072).Curated1
Sequence conflicti518H → D in BAC34127 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004849 mRNA Translation: BAB23615.1
AK050214 mRNA Translation: BAC34127.1
CCDSiCCDS21148.1
RefSeqiNP_082173.3, NM_027897.4
UniGeneiMm.286600

Genome annotation databases

EnsembliENSMUST00000032705; ENSMUSP00000032705; ENSMUSG00000030494
ENSMUST00000085556; ENSMUSP00000082692; ENSMUSG00000030494
GeneIDi52428
KEGGimmu:52428
UCSCiuc009gjs.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRHPN2_MOUSE
AccessioniPrimary (citable) accession number: Q8BWR8
Secondary accession number(s): Q9DBN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health