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Protein

Serine/threonine-protein kinase DCLK3

Gene

Dclk3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei543 – 5431ATPPROSITE-ProRule annotation
Active sitei635 – 6351Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi520 – 5289ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • negative regulation of protein localization to nucleus Source: MGI
  • peptidyl-serine phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase DCLK3 (EC:2.7.11.1)
Alternative name(s):
CLICK-I and II-related
Short name:
CLr
Doublecortin-like and CAM kinase-like 3
Doublecortin-like kinase 3
Gene namesi
Name:Dclk3
Synonyms:Dcamkl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3039580. Dclk3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 790790Serine/threonine-protein kinase DCLK3PRO_0000252255Add
BLAST

Proteomic databases

EPDiQ8BWQ5.
PaxDbiQ8BWQ5.
PRIDEiQ8BWQ5.

PTM databases

PhosphoSiteiQ8BWQ5.

Expressioni

Tissue specificityi

Highly expressed in brain and to a lower extent in liver and kidney.1 Publication

Gene expression databases

BgeeiQ8BWQ5.
CleanExiMM_DCLK3.
GenevisibleiQ8BWQ5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107510.

Structurei

3D structure databases

ProteinModelPortaliQ8BWQ5.
SMRiQ8BWQ5. Positions 509-771.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 18387DoublecortinPROSITE-ProRule annotationAdd
BLAST
Domaini514 – 771258Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 8079Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 doublecortin domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0615. Eukaryota.
ENOG410YA63. LUCA.
GeneTreeiENSGT00840000129744.
HOGENOMiHOG000112176.
HOVERGENiHBG101914.
InParanoidiQ8BWQ5.
KOiK17530.
OMAiTQEETHA.
OrthoDBiEOG7M98FQ.
TreeFamiTF318770.

Family and domain databases

Gene3Di3.10.20.230. 1 hit.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533. Doublecortin_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 2 hits.
PfamiPF03607. DCX. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00537. DCX. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50309. DC. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BWQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAAPVLRPP PPPATPAPPA PSRPAPPIPG HRGPCDHSLK CLSSKISERK
60 70 80 90 100
LPGPWLPAGR GPLEKPVLGP RGAVMPLFSP QSSLHSVRAE HSPLKPRVVT
110 120 130 140 150
VVKLGGQPLR KATLLLNRRS VQTFEQLLSD ISEALGFPRW KNDRVRKLFT
160 170 180 190 200
LKGREVKSVS DFFREGDAFI AMGKEPLTLK SIQLAMEELY PKNRALALAP
210 220 230 240 250
HSRVPSPRLR SRLPSKLLKG SHRCGEAGSY SAEMESKAVS RHQGKTSTVL
260 270 280 290 300
APEDKARAQK WVRGKQESEP GGPPSPGAAT QEETHASGEK HLGVEIEKTS
310 320 330 340 350
GEIVRCEKCK RERELQLGLQ REPCPLGTSE LDLGRAQKRD SEKLVRTKSC
360 370 380 390 400
RRPSEAKSTD GEEGWKGDSH RGSPRDPPQE LRRPNSNSDK KEIRGSESQD
410 420 430 440 450
SHPQGAPKAQ KDLVEGPPAV EEGPIDMRRE DRHTCRSKHA AWLRREQQAE
460 470 480 490 500
PPQLPRTRGE EKQAEHEKKP GGLGERRAPE KESKRKLEEK RPERPSGRKP
510 520 530 540 550
RPKGIISADV EKHYDIGGVI GDGNFATVKE CRHRETKQAY AMKMIDKSQL
560 570 580 590 600
KGKEDIVDSE ILIIQSLSHP NIVKLHEVYE TEAEIYLIME YVQGGDLFDA
610 620 630 640 650
IVENVKFPEP EAAVMITDLC KALVHMHDKN IVHRDVKPEN LLVQRNEDKS
660 670 680 690 700
ITLKLADFGL AKYVVRPIFT VCGTPTYVAP EILSEKGYGL EVDMWAAGVI
710 720 730 740 750
LYILLCGFPP FRSPERDQDE LFNIIQVGQF EFLSPYWDNI SDAAKDLVRN
760 770 780 790
LLEVDPKKRY TAEQVLQHPW IEMVGHTNTG NSQKEESPNS
Length:790
Mass (Da):88,228
Last modified:May 31, 2011 - v2
Checksum:i23A56EBD3453BBAD
GO

Sequence cautioni

The sequence AAH56929.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC34182.1 differs from that shown. Reason: Frameshift at position 138. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ286388 mRNA. Translation: ABB89470.1.
AK050312 mRNA. Translation: BAC34182.1. Frameshift.
BC056929 mRNA. Translation: AAH56929.1. Different initiation.
CCDSiCCDS23585.2.
RefSeqiNP_766516.2. NM_172928.5.
UniGeneiMm.26361.

Genome annotation databases

EnsembliENSMUST00000111879; ENSMUSP00000107510; ENSMUSG00000032500.
GeneIDi245038.
KEGGimmu:245038.
UCSCiuc009rvv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ286388 mRNA. Translation: ABB89470.1.
AK050312 mRNA. Translation: BAC34182.1. Frameshift.
BC056929 mRNA. Translation: AAH56929.1. Different initiation.
CCDSiCCDS23585.2.
RefSeqiNP_766516.2. NM_172928.5.
UniGeneiMm.26361.

3D structure databases

ProteinModelPortaliQ8BWQ5.
SMRiQ8BWQ5. Positions 509-771.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107510.

PTM databases

PhosphoSiteiQ8BWQ5.

Proteomic databases

EPDiQ8BWQ5.
PaxDbiQ8BWQ5.
PRIDEiQ8BWQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111879; ENSMUSP00000107510; ENSMUSG00000032500.
GeneIDi245038.
KEGGimmu:245038.
UCSCiuc009rvv.2. mouse.

Organism-specific databases

CTDi85443.
MGIiMGI:3039580. Dclk3.

Phylogenomic databases

eggNOGiKOG0615. Eukaryota.
ENOG410YA63. LUCA.
GeneTreeiENSGT00840000129744.
HOGENOMiHOG000112176.
HOVERGENiHBG101914.
InParanoidiQ8BWQ5.
KOiK17530.
OMAiTQEETHA.
OrthoDBiEOG7M98FQ.
TreeFamiTF318770.

Miscellaneous databases

PROiQ8BWQ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BWQ5.
CleanExiMM_DCLK3.
GenevisibleiQ8BWQ5. MM.

Family and domain databases

Gene3Di3.10.20.230. 1 hit.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533. Doublecortin_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 2 hits.
PfamiPF03607. DCX. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00537. DCX. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50309. DC. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV."
    Ohmae S., Takemoto-Kimura S., Okamura M., Adachi-Morishima A., Nonaka M., Fuse T., Kida S., Tanji M., Furuyashiki T., Arakawa Y., Narumiya S., Okuno H., Bito H.
    J. Biol. Chem. 281:20427-20439(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-790.
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiDCLK3_MOUSE
AccessioniPrimary (citable) accession number: Q8BWQ5
Secondary accession number(s): Q1A748
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 31, 2011
Last modified: June 8, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.