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Q8BWQ1

- UD2A3_MOUSE

UniProt

Q8BWQ1 - UD2A3_MOUSE

Protein

UDP-glucuronosyltransferase 2A3

Gene

Ugt2a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular glucuronidation Source: Ensembl

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2A3 (EC:2.4.1.17)
    Short name:
    UDPGT 2A3
    Gene namesi
    Name:Ugt2a3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1919344. Ugt2a3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 534516UDP-glucuronosyltransferase 2A3PRO_0000299147Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Modified residuei135 – 1351N6-succinyllysine1 Publication
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8BWQ1.
    PaxDbiQ8BWQ1.
    PRIDEiQ8BWQ1.

    PTM databases

    PhosphoSiteiQ8BWQ1.

    Expressioni

    Tissue specificityi

    Highly expressed in liver, with lower levels in duodenum and jejunum.1 Publication

    Gene expression databases

    BgeeiQ8BWQ1.
    GenevestigatoriQ8BWQ1.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8BWQ1. 2 interactions.
    MINTiMINT-4118511.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BWQ1.
    SMRiQ8BWQ1. Positions 285-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 493475ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini515 – 53420CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    GeneTreeiENSGT00640000091260.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.
    InParanoidiQ8BWQ1.
    KOiK00699.
    OMAiPSIIIDQ.
    OrthoDBiEOG7GBFWS.
    PhylomeDBiQ8BWQ1.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BWQ1-1 [UniParc]FASTAAdd to Basket

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    MVSEKCVAAF FLLQLCWAGC GFCSKVLVWP CDMSHWLNLK TILEELGARG    50
    HEVTVLKYPS IIIDQSKRIP LHFENIPLLY EIETAENRLN EIANLAVNVI 100
    PNLSLWEAAK TLQDFFLQVT GDFESICRSV LYNQKFMDKL RDAQYDVVVI 150
    DPVVPCGELV AEVLQIPFVY TLRFSMGYYM EKHCGQLPIP LSYVPVVMSE 200
    LTDNMTFTER VKNMMFSLLF EYWLQQYDFA FWDQFYSETL GRPTTFCKTV 250
    GKADIWLIRT YWDVEFPRPY LPNFEFVGGL HCKPAKPLPK EMEEFVQSSG 300
    EHGVVVFSLG SMVKNLTEEK ANLIASVLAQ IPQKVLWRYS GKKPATLGSN 350
    TRLFNWIPQN DLLGHPKTKA FITHGGTNGI YEAIYHGVPM VGVPMLGDQP 400
    HNIAHMEAKG AALKVSISTM TSTDLLSAVR AVINEPSYKE NAMRLSRIHH 450
    DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLSWFQYHS LDVIGFLLLC 500
    VVTLTFIITK FCLFVCQKLY MKESKKMGNR KKKN 534
    Length:534
    Mass (Da):61,119
    Last modified:March 1, 2003 - v1
    Checksum:i3BF4F591395B1620
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti252 – 2521K → E in BAB25770. (PubMed:16141072)Curated
    Sequence conflicti284 – 2841P → S in AAH25795. (PubMed:15489334)Curated
    Sequence conflicti346 – 3461T → I in BAB25770. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008601 mRNA. Translation: BAB25770.1.
    AK050327 mRNA. Translation: BAC34191.1.
    BC025795 mRNA. Translation: AAH25795.1.
    CCDSiCCDS19387.1.
    RefSeqiNP_082370.2. NM_028094.3.
    UniGeneiMm.482739.

    Genome annotation databases

    EnsembliENSMUST00000031195; ENSMUSP00000031195; ENSMUSG00000035780.
    GeneIDi72094.
    KEGGimmu:72094.
    UCSCiuc008xyh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008601 mRNA. Translation: BAB25770.1 .
    AK050327 mRNA. Translation: BAC34191.1 .
    BC025795 mRNA. Translation: AAH25795.1 .
    CCDSi CCDS19387.1.
    RefSeqi NP_082370.2. NM_028094.3.
    UniGenei Mm.482739.

    3D structure databases

    ProteinModelPortali Q8BWQ1.
    SMRi Q8BWQ1. Positions 285-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BWQ1. 2 interactions.
    MINTi MINT-4118511.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei Q8BWQ1.

    Proteomic databases

    MaxQBi Q8BWQ1.
    PaxDbi Q8BWQ1.
    PRIDEi Q8BWQ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031195 ; ENSMUSP00000031195 ; ENSMUSG00000035780 .
    GeneIDi 72094.
    KEGGi mmu:72094.
    UCSCi uc008xyh.2. mouse.

    Organism-specific databases

    CTDi 79799.
    MGIi MGI:1919344. Ugt2a3.

    Phylogenomic databases

    eggNOGi COG1819.
    GeneTreei ENSGT00640000091260.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.
    InParanoidi Q8BWQ1.
    KOi K00699.
    OMAi PSIIIDQ.
    OrthoDBi EOG7GBFWS.
    PhylomeDBi Q8BWQ1.
    TreeFami TF315472.

    Miscellaneous databases

    ChiTaRSi UGT2A3. mouse.
    NextBioi 335422.
    PROi Q8BWQ1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BWQ1.
    Genevestigatori Q8BWQ1.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver and Small intestine.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    3. "Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice."
      Buckley D.B., Klaassen C.D.
      Drug Metab. Dispos. 35:121-127(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiUD2A3_MOUSE
    AccessioniPrimary (citable) accession number: Q8BWQ1
    Secondary accession number(s): Q8R129, Q9D811
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3