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Q8BWQ1

- UD2A3_MOUSE

UniProt

Q8BWQ1 - UD2A3_MOUSE

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Protein

UDP-glucuronosyltransferase 2A3

Gene
Ugt2a3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular glucuronidation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A3 (EC:2.4.1.17)
Short name:
UDPGT 2A3
Gene namesi
Name:Ugt2a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1919344. Ugt2a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 493475Extracellular Reviewed predictionAdd
BLAST
Transmembranei494 – 51421Helical; Reviewed predictionAdd
BLAST
Topological domaini515 – 53420Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 534516UDP-glucuronosyltransferase 2A3PRO_0000299147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Modified residuei135 – 1351N6-succinyllysine1 Publication
Glycosylationi204 – 2041N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BWQ1.
PaxDbiQ8BWQ1.
PRIDEiQ8BWQ1.

PTM databases

PhosphoSiteiQ8BWQ1.

Expressioni

Tissue specificityi

Highly expressed in liver, with lower levels in duodenum and jejunum.1 Publication

Gene expression databases

BgeeiQ8BWQ1.
GenevestigatoriQ8BWQ1.

Interactioni

Protein-protein interaction databases

IntActiQ8BWQ1. 2 interactions.
MINTiMINT-4118511.

Structurei

3D structure databases

ProteinModelPortaliQ8BWQ1.
SMRiQ8BWQ1. Positions 285-446.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00640000091260.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ8BWQ1.
KOiK00699.
OMAiPSIIIDQ.
OrthoDBiEOG7GBFWS.
PhylomeDBiQ8BWQ1.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BWQ1-1 [UniParc]FASTAAdd to Basket

« Hide

MVSEKCVAAF FLLQLCWAGC GFCSKVLVWP CDMSHWLNLK TILEELGARG    50
HEVTVLKYPS IIIDQSKRIP LHFENIPLLY EIETAENRLN EIANLAVNVI 100
PNLSLWEAAK TLQDFFLQVT GDFESICRSV LYNQKFMDKL RDAQYDVVVI 150
DPVVPCGELV AEVLQIPFVY TLRFSMGYYM EKHCGQLPIP LSYVPVVMSE 200
LTDNMTFTER VKNMMFSLLF EYWLQQYDFA FWDQFYSETL GRPTTFCKTV 250
GKADIWLIRT YWDVEFPRPY LPNFEFVGGL HCKPAKPLPK EMEEFVQSSG 300
EHGVVVFSLG SMVKNLTEEK ANLIASVLAQ IPQKVLWRYS GKKPATLGSN 350
TRLFNWIPQN DLLGHPKTKA FITHGGTNGI YEAIYHGVPM VGVPMLGDQP 400
HNIAHMEAKG AALKVSISTM TSTDLLSAVR AVINEPSYKE NAMRLSRIHH 450
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLSWFQYHS LDVIGFLLLC 500
VVTLTFIITK FCLFVCQKLY MKESKKMGNR KKKN 534
Length:534
Mass (Da):61,119
Last modified:March 1, 2003 - v1
Checksum:i3BF4F591395B1620
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti252 – 2521K → E in BAB25770. 1 Publication
Sequence conflicti284 – 2841P → S in AAH25795. 1 Publication
Sequence conflicti346 – 3461T → I in BAB25770. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008601 mRNA. Translation: BAB25770.1.
AK050327 mRNA. Translation: BAC34191.1.
BC025795 mRNA. Translation: AAH25795.1.
CCDSiCCDS19387.1.
RefSeqiNP_082370.2. NM_028094.3.
UniGeneiMm.482739.

Genome annotation databases

EnsembliENSMUST00000031195; ENSMUSP00000031195; ENSMUSG00000035780.
GeneIDi72094.
KEGGimmu:72094.
UCSCiuc008xyh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008601 mRNA. Translation: BAB25770.1 .
AK050327 mRNA. Translation: BAC34191.1 .
BC025795 mRNA. Translation: AAH25795.1 .
CCDSi CCDS19387.1.
RefSeqi NP_082370.2. NM_028094.3.
UniGenei Mm.482739.

3D structure databases

ProteinModelPortali Q8BWQ1.
SMRi Q8BWQ1. Positions 285-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BWQ1. 2 interactions.
MINTi MINT-4118511.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei Q8BWQ1.

Proteomic databases

MaxQBi Q8BWQ1.
PaxDbi Q8BWQ1.
PRIDEi Q8BWQ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031195 ; ENSMUSP00000031195 ; ENSMUSG00000035780 .
GeneIDi 72094.
KEGGi mmu:72094.
UCSCi uc008xyh.2. mouse.

Organism-specific databases

CTDi 79799.
MGIi MGI:1919344. Ugt2a3.

Phylogenomic databases

eggNOGi COG1819.
GeneTreei ENSGT00640000091260.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
InParanoidi Q8BWQ1.
KOi K00699.
OMAi PSIIIDQ.
OrthoDBi EOG7GBFWS.
PhylomeDBi Q8BWQ1.
TreeFami TF315472.

Miscellaneous databases

ChiTaRSi UGT2A3. mouse.
NextBioi 335422.
PROi Q8BWQ1.
SOURCEi Search...

Gene expression databases

Bgeei Q8BWQ1.
Genevestigatori Q8BWQ1.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  3. "Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice."
    Buckley D.B., Klaassen C.D.
    Drug Metab. Dispos. 35:121-127(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiUD2A3_MOUSE
AccessioniPrimary (citable) accession number: Q8BWQ1
Secondary accession number(s): Q8R129, Q9D811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi