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Protein

UDP-glucuronosyltransferase 2A3

Gene

Ugt2a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A3 (EC:2.4.1.17)
Short name:
UDPGT 2A3
Gene namesi
Name:Ugt2a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919344. Ugt2a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 493ExtracellularSequence analysisAdd BLAST475
Transmembranei494 – 514HelicalSequence analysisAdd BLAST21
Topological domaini515 – 534CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000029914719 – 534UDP-glucuronosyltransferase 2A3Add BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Modified residuei135N6-succinyllysineCombined sources1
Glycosylationi204N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BWQ1.
PaxDbiQ8BWQ1.
PeptideAtlasiQ8BWQ1.
PRIDEiQ8BWQ1.

PTM databases

iPTMnetiQ8BWQ1.
PhosphoSitePlusiQ8BWQ1.

Expressioni

Tissue specificityi

Highly expressed in liver, with lower levels in duodenum and jejunum.1 Publication

Gene expression databases

BgeeiENSMUSG00000035780.
GenevisibleiQ8BWQ1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BWQ1. 2 interactors.
MINTiMINT-4118511.
STRINGi10090.ENSMUSP00000031195.

Structurei

3D structure databases

ProteinModelPortaliQ8BWQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ8BWQ1.
KOiK00699.
OMAiPSIIIDQ.
OrthoDBiEOG091G06JC.
PhylomeDBiQ8BWQ1.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BWQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSEKCVAAF FLLQLCWAGC GFCSKVLVWP CDMSHWLNLK TILEELGARG
60 70 80 90 100
HEVTVLKYPS IIIDQSKRIP LHFENIPLLY EIETAENRLN EIANLAVNVI
110 120 130 140 150
PNLSLWEAAK TLQDFFLQVT GDFESICRSV LYNQKFMDKL RDAQYDVVVI
160 170 180 190 200
DPVVPCGELV AEVLQIPFVY TLRFSMGYYM EKHCGQLPIP LSYVPVVMSE
210 220 230 240 250
LTDNMTFTER VKNMMFSLLF EYWLQQYDFA FWDQFYSETL GRPTTFCKTV
260 270 280 290 300
GKADIWLIRT YWDVEFPRPY LPNFEFVGGL HCKPAKPLPK EMEEFVQSSG
310 320 330 340 350
EHGVVVFSLG SMVKNLTEEK ANLIASVLAQ IPQKVLWRYS GKKPATLGSN
360 370 380 390 400
TRLFNWIPQN DLLGHPKTKA FITHGGTNGI YEAIYHGVPM VGVPMLGDQP
410 420 430 440 450
HNIAHMEAKG AALKVSISTM TSTDLLSAVR AVINEPSYKE NAMRLSRIHH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLSWFQYHS LDVIGFLLLC
510 520 530
VVTLTFIITK FCLFVCQKLY MKESKKMGNR KKKN
Length:534
Mass (Da):61,119
Last modified:March 1, 2003 - v1
Checksum:i3BF4F591395B1620
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252K → E in BAB25770 (PubMed:16141072).Curated1
Sequence conflicti284P → S in AAH25795 (PubMed:15489334).Curated1
Sequence conflicti346T → I in BAB25770 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008601 mRNA. Translation: BAB25770.1.
AK050327 mRNA. Translation: BAC34191.1.
BC025795 mRNA. Translation: AAH25795.1.
CCDSiCCDS19387.1.
RefSeqiNP_082370.2. NM_028094.3.
UniGeneiMm.482739.

Genome annotation databases

EnsembliENSMUST00000031195; ENSMUSP00000031195; ENSMUSG00000035780.
GeneIDi72094.
KEGGimmu:72094.
UCSCiuc008xyh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008601 mRNA. Translation: BAB25770.1.
AK050327 mRNA. Translation: BAC34191.1.
BC025795 mRNA. Translation: AAH25795.1.
CCDSiCCDS19387.1.
RefSeqiNP_082370.2. NM_028094.3.
UniGeneiMm.482739.

3D structure databases

ProteinModelPortaliQ8BWQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BWQ1. 2 interactors.
MINTiMINT-4118511.
STRINGi10090.ENSMUSP00000031195.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiQ8BWQ1.
PhosphoSitePlusiQ8BWQ1.

Proteomic databases

MaxQBiQ8BWQ1.
PaxDbiQ8BWQ1.
PeptideAtlasiQ8BWQ1.
PRIDEiQ8BWQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031195; ENSMUSP00000031195; ENSMUSG00000035780.
GeneIDi72094.
KEGGimmu:72094.
UCSCiuc008xyh.2. mouse.

Organism-specific databases

CTDi79799.
MGIiMGI:1919344. Ugt2a3.

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ8BWQ1.
KOiK00699.
OMAiPSIIIDQ.
OrthoDBiEOG091G06JC.
PhylomeDBiQ8BWQ1.
TreeFamiTF315472.

Miscellaneous databases

ChiTaRSiUgt2a3. mouse.
PROiQ8BWQ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035780.
GenevisibleiQ8BWQ1. MM.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD2A3_MOUSE
AccessioniPrimary (citable) accession number: Q8BWQ1
Secondary accession number(s): Q8R129, Q9D811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.