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Protein

UDP-glucuronosyltransferase 2A3

Gene

Ugt2a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A3 (EC:2.4.1.17)
Short name:
UDPGT 2A3
Gene namesi
Name:Ugt2a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919344. Ugt2a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 493475ExtracellularSequence AnalysisAdd
BLAST
Transmembranei494 – 51421HelicalSequence AnalysisAdd
BLAST
Topological domaini515 – 53420CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 534516UDP-glucuronosyltransferase 2A3PRO_0000299147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Modified residuei135 – 1351N6-succinyllysine1 Publication
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BWQ1.
PaxDbiQ8BWQ1.
PRIDEiQ8BWQ1.

PTM databases

PhosphoSiteiQ8BWQ1.

Expressioni

Tissue specificityi

Highly expressed in liver, with lower levels in duodenum and jejunum.1 Publication

Gene expression databases

BgeeiQ8BWQ1.
GenevisibleiQ8BWQ1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BWQ1. 2 interactions.
MINTiMINT-4118511.
STRINGi10090.ENSMUSP00000031195.

Structurei

3D structure databases

ProteinModelPortaliQ8BWQ1.
SMRiQ8BWQ1. Positions 34-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ8BWQ1.
KOiK00699.
OMAiPSIIIDQ.
OrthoDBiEOG7GBFWS.
PhylomeDBiQ8BWQ1.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BWQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSEKCVAAF FLLQLCWAGC GFCSKVLVWP CDMSHWLNLK TILEELGARG
60 70 80 90 100
HEVTVLKYPS IIIDQSKRIP LHFENIPLLY EIETAENRLN EIANLAVNVI
110 120 130 140 150
PNLSLWEAAK TLQDFFLQVT GDFESICRSV LYNQKFMDKL RDAQYDVVVI
160 170 180 190 200
DPVVPCGELV AEVLQIPFVY TLRFSMGYYM EKHCGQLPIP LSYVPVVMSE
210 220 230 240 250
LTDNMTFTER VKNMMFSLLF EYWLQQYDFA FWDQFYSETL GRPTTFCKTV
260 270 280 290 300
GKADIWLIRT YWDVEFPRPY LPNFEFVGGL HCKPAKPLPK EMEEFVQSSG
310 320 330 340 350
EHGVVVFSLG SMVKNLTEEK ANLIASVLAQ IPQKVLWRYS GKKPATLGSN
360 370 380 390 400
TRLFNWIPQN DLLGHPKTKA FITHGGTNGI YEAIYHGVPM VGVPMLGDQP
410 420 430 440 450
HNIAHMEAKG AALKVSISTM TSTDLLSAVR AVINEPSYKE NAMRLSRIHH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLSWFQYHS LDVIGFLLLC
510 520 530
VVTLTFIITK FCLFVCQKLY MKESKKMGNR KKKN
Length:534
Mass (Da):61,119
Last modified:March 1, 2003 - v1
Checksum:i3BF4F591395B1620
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti252 – 2521K → E in BAB25770 (PubMed:16141072).Curated
Sequence conflicti284 – 2841P → S in AAH25795 (PubMed:15489334).Curated
Sequence conflicti346 – 3461T → I in BAB25770 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008601 mRNA. Translation: BAB25770.1.
AK050327 mRNA. Translation: BAC34191.1.
BC025795 mRNA. Translation: AAH25795.1.
CCDSiCCDS19387.1.
RefSeqiNP_082370.2. NM_028094.3.
UniGeneiMm.482739.

Genome annotation databases

EnsembliENSMUST00000031195; ENSMUSP00000031195; ENSMUSG00000035780.
GeneIDi72094.
KEGGimmu:72094.
UCSCiuc008xyh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008601 mRNA. Translation: BAB25770.1.
AK050327 mRNA. Translation: BAC34191.1.
BC025795 mRNA. Translation: AAH25795.1.
CCDSiCCDS19387.1.
RefSeqiNP_082370.2. NM_028094.3.
UniGeneiMm.482739.

3D structure databases

ProteinModelPortaliQ8BWQ1.
SMRiQ8BWQ1. Positions 34-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BWQ1. 2 interactions.
MINTiMINT-4118511.
STRINGi10090.ENSMUSP00000031195.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteiQ8BWQ1.

Proteomic databases

MaxQBiQ8BWQ1.
PaxDbiQ8BWQ1.
PRIDEiQ8BWQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031195; ENSMUSP00000031195; ENSMUSG00000035780.
GeneIDi72094.
KEGGimmu:72094.
UCSCiuc008xyh.2. mouse.

Organism-specific databases

CTDi79799.
MGIiMGI:1919344. Ugt2a3.

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ8BWQ1.
KOiK00699.
OMAiPSIIIDQ.
OrthoDBiEOG7GBFWS.
PhylomeDBiQ8BWQ1.
TreeFamiTF315472.

Miscellaneous databases

ChiTaRSiUgt2a3. mouse.
NextBioi335422.
PROiQ8BWQ1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BWQ1.
GenevisibleiQ8BWQ1. MM.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  3. "Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice."
    Buckley D.B., Klaassen C.D.
    Drug Metab. Dispos. 35:121-127(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiUD2A3_MOUSE
AccessioniPrimary (citable) accession number: Q8BWQ1
Secondary accession number(s): Q8R129, Q9D811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.