Reviewed,
UniProtKB/Swiss-Prot Q8BWP8 (B3GN1_MOUSE)
Last modified
January 19, 2010.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase EC=2.4.1.149 Alternative name(s): Poly-N-acetyllactosamine extension enzyme I-beta-1,3-N-acetylglucosaminyltransferase Short name=iGnT UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 415 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans By similarity. |
| Catalytic activity | UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R. |
| Pathway | |
| Subcellular location | Golgi apparatus membrane; Single-pass type II membrane protein By similarity. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Signal-anchor Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Cellular component | Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8BWP8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8BWP8-2) The sequence of this isoform differs from the canonical sequence as follows: 353-379: ACELHVAGFNFEVLNEGFLVHKGFKEA → VLKRERACRTKTGGVSGVKWPLVERRQ 380-415: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 415 | 415 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase | PRO_0000080556 | |||||
Regions | |||||||||
| Topological domain | 1 – 8 | 8 | Cytoplasmic Potential | ||||||
| Transmembrane | 9 – 36 | 28 | Signal-anchor for type II membrane protein Potential | ||||||
| Topological domain | 37 – 415 | 379 | Lumenal Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 204 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 300 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 353 – 379 | 27 | ACELH…GFKEA → VLKRERACRTKTGGVSGVKW PLVERRQ in isoform 2. | VSP_014004 | |||||
| Alternative sequence | 380 – 415 | 36 | Missing in isoform 2. | VSP_014005 | |||||
Experimental info | |||||||||
| Sequence conflict | 175 – 176 | 2 | EF → RV in AAH02191. Ref.2 | ||||||
Sequences
| ||||||||||||||||||||||||
References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J. Tissue: Liver, Spinal ganglion and Visual cortex. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: Czech II and FVB/N. Tissue: Mammary tumor. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK050347 mRNA. Translation: BAC34203.1. AK083857 mRNA. Translation: BAC39041.1. AK158899 mRNA. Translation: BAE34720.1. BC002191 mRNA. Translation: AAH02191.1. BC069927 mRNA. Translation: AAH69927.1. |
| IPI | IPI00226360. IPI00457635. |
| RefSeq | NP_780592.1. |
| UniGene | Mm.478323 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8BWP8. |
Protein family/group databases | |
| CAZy | GT49. Glycosyltransferase Family 49. |
Proteomic databases | |
| PRIDE | Q8BWP8. |
Genome annotation databases | |
| Ensembl | ENSMUST00000053705; ENSMUSP00000062016; ENSMUSG00000047379; Mus musculus. [Genome view] |
| GeneID | 108902. |
| KEGG | mmu:108902. |
| UCSC | uc008gbx.1. mouse. |
Organism-specific databases | |
| CTD | 108902. |
| MGI | MGI:1919680. B3gnt1. |
Phylogenomic databases | |
| eggNOG | roNOG05871. |
| HOGENOM | HBG716579. |
| HOVERGEN | Q8BWP8. |
| InParanoid | Q8BWP8. |
| OMA | AKYPDSP. |
| OrthoDB | EOG973S9Z. |
| PhylomeDB | Q8BWP8. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.149. 244. |
Gene expression databases | |
| ArrayExpress | Q8BWP8. |
| Bgee | Q8BWP8. |
| Genevestigator | Q8BWP8. |
| GermOnline | ENSMUSG00000047379. Mus musculus. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 361433. |
| SOURCE | Search... |
Entry information
| Entry name | B3GN1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8BWP8 Secondary accession number(s): Q3TY43, Q8BJH9, Q99LW7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |

Clusters with


