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Protein

Prostaglandin E synthase 2

Gene

Ptges2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.1 PublicationBy similarity

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.By similarity

Enzyme regulationi

Isomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by glutathione (GSH) and 2-mercaptoethanol.By similarity

Pathwayi: prostaglandin biosynthesis

This protein is involved in the pathway prostaglandin biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway prostaglandin biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei147Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • positive regulation of transcription, DNA-templated Source: MGI
  • prostaglandin biosynthetic process Source: UniProtKB-UniPathway
  • secretion Source: MGI

Keywordsi

Molecular functionIsomerase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

ReactomeiR-MMU-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-MMU-6798695 Neutrophil degranulation
UniPathwayiUPA00662

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E synthase 2 (EC:5.3.99.3By similarity)
Alternative name(s):
GATE-binding factor 11 Publication
Short name:
GBF-11 Publication
Microsomal prostaglandin E synthase 2
Short name:
mPGES-2
Cleaved into the following chain:
Gene namesi
Name:Ptges2
Synonyms:Gbf1, Pges2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1917592 Ptges2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56LumenalSequence analysisAdd BLAST56
Transmembranei57 – 73HelicalSequence analysisAdd BLAST17
Topological domaini74 – 384CytoplasmicSequence analysisAdd BLAST311

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000131311 – 384Prostaglandin E synthase 2Add BLAST384
ChainiPRO_000001313287 – 384Prostaglandin E synthase 2 truncated formBy similarityAdd BLAST298

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei86 – 87CleavageBy similarity2

Proteomic databases

EPDiQ8BWM0
MaxQBiQ8BWM0
PaxDbiQ8BWM0
PeptideAtlasiQ8BWM0
PRIDEiQ8BWM0

PTM databases

iPTMnetiQ8BWM0
PhosphoSitePlusiQ8BWM0
SwissPalmiQ8BWM0

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, heart, liver, colon and lung.2 Publications

Inductioni

Constitutively expressed. Not induced during tissue inflammation. Down-regulated in the absence of Ptges.2 Publications

Gene expression databases

BgeeiENSMUSG00000026820
CleanExiMM_PTGES2
ExpressionAtlasiQ8BWM0 baseline and differential
GenevisibleiQ8BWM0 MM

Interactioni

Subunit structurei

Homodimer. Interacts with EXOSC10 (By similarity). May interact with CEBPB.By similarity1 Publication

Protein-protein interaction databases

BioGridi220557, 1 interactor
IntActiQ8BWM0, 3 interactors
MINTiQ8BWM0
STRINGi10090.ENSMUSP00000028162

Structurei

3D structure databases

ProteinModelPortaliQ8BWM0
SMRiQ8BWM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 192GlutaredoxinPROSITE-ProRule annotationAdd BLAST104
Domaini262 – 376GST C-terminalAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 164Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3029 Eukaryota
ENOG410XS2X LUCA
GeneTreeiENSGT00390000000224
HOGENOMiHOG000231901
HOVERGENiHBG069136
InParanoidiQ8BWM0
KOiK05309
OMAiWYLRVEK
OrthoDBiEOG091G0AEH
TreeFamiTF314304

Family and domain databases

CDDicd03197 GST_C_mPGES2, 1 hit
InterProiView protein in InterPro
IPR002109 Glutaredoxin
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR034334 PGES2
IPR034335 PGES2_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
SFLDiSFLDG01203 Prostaglandin_E_synthase_like1, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00195 GLUTAREDOXIN_1, 1 hit
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BWM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAARLSWV LVSSRCALTE GLLTRPWQPL SAQSRAGFTR VAAGSRGAAV
60 70 80 90 100
RKGSPRLLGA AALALGGALG LYHTVRWHQR SQDLRAERSA AQLPLSNSLQ
110 120 130 140 150
LTLYQYKTCP FCSKVRAFLD FHSLPYQVVE VNPVRRTEIK FSSYRKVPIL
160 170 180 190 200
VAQEGDSLQQ LNDSSVIISA LKTYLVSGQP LEEVITYYPP MKAMNDQGKE
210 220 230 240 250
VTEFCNKYWL MLDEKEAQQM YGGKEARTEE MKWRQWADDW LVHLISPNVY
260 270 280 290 300
RTPAEALASF DYIVREGKFG AVEAAMAKYV GAAAMYLISK RLKSRHHLQD
310 320 330 340 350
DVRVDLYEAA NKWVTAVGKD RPFMGGQKPN LADLAVYGVL RVMEGLEAFD
360 370 380
DLMRHSHIQP WYLRMERAIE EAPSVHHVNP SCKD
Length:384
Mass (Da):43,324
Last modified:July 27, 2011 - v3
Checksum:i5A737A01466582CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210L → P in AAH04846 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050616 mRNA Translation: BAC34345.1
AL928669 Genomic DNA Translation: CAM22503.1
CH466542 Genomic DNA Translation: EDL08547.1
BC004846 mRNA Translation: AAH04846.1
CCDSiCCDS15914.1
RefSeqiNP_598544.2, NM_133783.2
UniGeneiMm.28048

Genome annotation databases

EnsembliENSMUST00000028162; ENSMUSP00000028162; ENSMUSG00000026820
GeneIDi96979
KEGGimmu:96979
UCSCiuc008jfm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPGES2_MOUSE
AccessioniPrimary (citable) accession number: Q8BWM0
Secondary accession number(s): A2ASQ2, Q99J30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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