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Q8BWG9

- CRCM1_MOUSE

UniProt

Q8BWG9 - CRCM1_MOUSE

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Protein
Calcium release-activated calcium channel protein 1
Gene
Orai1, Cracm1, Tmem142a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. store-operated calcium channel activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. immune system process Source: UniProtKB-KW
  2. positive regulation of calcium ion transport Source: UniProtKB
  3. store-operated calcium entry Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Adaptive immunity, Calcium transport, Immunity, Ion transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding

Enzyme and pathway databases

ReactomeiREACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_227667. Elevation of cytosolic Ca2+ levels.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium release-activated calcium channel protein 1
Alternative name(s):
Protein orai-1
Transmembrane protein 142A
Gene namesi
Name:Orai1
Synonyms:Cracm1, Tmem142a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1925542. Orai1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8989Cytoplasmic By similarity
Add
BLAST
Transmembranei90 – 10718Helical; Reviewed prediction
Add
BLAST
Topological domaini108 – 12114Extracellular Reviewed prediction
Add
BLAST
Transmembranei122 – 14221Helical; Reviewed prediction
Add
BLAST
Topological domaini143 – 17533Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei176 – 19621Helical; Reviewed prediction
Add
BLAST
Topological domaini197 – 23741Extracellular Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Reviewed prediction
Add
BLAST
Topological domaini259 – 30446Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. membrane Source: MGI
  3. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Calcium release-activated calcium channel protein 1
PRO_0000234382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Modified residuei298 – 2981Phosphothreonine By similarity

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BWG9.
PRIDEiQ8BWG9.

PTM databases

PhosphoSiteiQ8BWG9.

Expressioni

Gene expression databases

ArrayExpressiQ8BWG9.
BgeeiQ8BWG9.
GenevestigatoriQ8BWG9.

Interactioni

Subunit structurei

Interacts with STIM1 and STIM2; this regulates channel activity. Interacts with CALM; this may displace STIM1 and STIM2 and might thereby modulate channel activity. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca2+. Forms a complex with EFCAB4B/CRACR2A and STIM1 at low concentration of Ca2+, the complex dissociates at elevated Ca2+ concentrations By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8BWG9.
SMRiQ8BWG9. Positions 76-295.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni72 – 9221Interaction with STIM1 By similarity
Add
BLAST
Regioni275 – 29521Interaction with STIM1 By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi43 – 508Poly-Pro

Sequence similaritiesi

Belongs to the Orai family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263788.
GeneTreeiENSGT00390000015354.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ8BWG9.
KOiK16056.
OMAiITSTSIM.
OrthoDBiEOG7G1V73.
PhylomeDBiQ8BWG9.
TreeFamiTF313576.

Family and domain databases

InterProiIPR012446. CRAC_channel.
[Graphical view]
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BWG9-1 [UniParc]FASTAAdd to Basket

« Hide

MHPEPAPPPS HSNPELPVSG GSSTSGSRRS RRRSGDGEPS GAPPLPPPPP    50
AVSYPDWIGQ SYSEVMSLNE HSMQALSWRK LYLSRAKLKA SSRTSALLSG 100
FAMVAMVEVQ LDTDHDYPPG LLIVFSACTT VLVAVHLFAL MISTCILPNI 150
EAVSNVHNLN SVKESPHERM HRHIELAWAF STVIGTLLFL AEVVLLCWVK 200
FLPLKRQAGQ PSPTKPPAES VIVANHSDSS GITPGEAAAI ASTAIMVPCG 250
LVFIVFAVHF YRSLVSHKTD RQFQELNELA EFARLQDQLD HRGDHSLTPG 300
THYA 304
Length:304
Mass (Da):33,062
Last modified:March 1, 2003 - v1
Checksum:i9743395B63D2E41F
GO

Sequence cautioni

The sequence AAH23149.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161L → F in AAH23149. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052573 mRNA. Translation: BAC35045.1.
AK085755 mRNA. Translation: BAC39533.1.
BC023149 mRNA. Translation: AAH23149.1. Different initiation.
CCDSiCCDS39261.1.
RefSeqiNP_780632.1. NM_175423.3.
UniGeneiMm.218582.

Genome annotation databases

EnsembliENSMUST00000051016; ENSMUSP00000058169; ENSMUSG00000049686.
ENSMUST00000121652; ENSMUSP00000113097; ENSMUSG00000049686.
GeneIDi109305.
KEGGimmu:109305.
UCSCiuc008zmy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052573 mRNA. Translation: BAC35045.1 .
AK085755 mRNA. Translation: BAC39533.1 .
BC023149 mRNA. Translation: AAH23149.1 . Different initiation.
CCDSi CCDS39261.1.
RefSeqi NP_780632.1. NM_175423.3.
UniGenei Mm.218582.

3D structure databases

ProteinModelPortali Q8BWG9.
SMRi Q8BWG9. Positions 76-295.
ModBasei Search...

PTM databases

PhosphoSitei Q8BWG9.

Proteomic databases

PaxDbi Q8BWG9.
PRIDEi Q8BWG9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000051016 ; ENSMUSP00000058169 ; ENSMUSG00000049686 .
ENSMUST00000121652 ; ENSMUSP00000113097 ; ENSMUSG00000049686 .
GeneIDi 109305.
KEGGi mmu:109305.
UCSCi uc008zmy.1. mouse.

Organism-specific databases

CTDi 84876.
MGIi MGI:1925542. Orai1.

Phylogenomic databases

eggNOGi NOG263788.
GeneTreei ENSGT00390000015354.
HOGENOMi HOG000246925.
HOVERGENi HBG081343.
InParanoidi Q8BWG9.
KOi K16056.
OMAi ITSTSIM.
OrthoDBi EOG7G1V73.
PhylomeDBi Q8BWG9.
TreeFami TF313576.

Enzyme and pathway databases

Reactomei REACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_227667. Elevation of cytosolic Ca2+ levels.

Miscellaneous databases

ChiTaRSi ORAI1. mouse.
NextBioi 361899.
PROi Q8BWG9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BWG9.
Bgeei Q8BWG9.
Genevestigatori Q8BWG9.

Family and domain databases

InterProi IPR012446. CRAC_channel.
[Graphical view ]
Pfami PF07856. Orai-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland and Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-304.
    Strain: Czech II.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCRCM1_MOUSE
AccessioniPrimary (citable) accession number: Q8BWG9
Secondary accession number(s): Q8BUD4, Q8R586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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