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Protein

Succinate-semialdehyde dehydrogenase, mitochondrial

Gene

Aldh5a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).By similarity

Catalytic activityi

Succinate semialdehyde + NAD+ + H2O = succinate + NADH.

Enzyme regulationi

Redox-regulated. Inhibited under oxydizing conditions (By similarity).By similarity

Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei193Transition state stabilizerBy similarity1
Binding sitei201NADBy similarity1
Binding sitei201SubstrateBy similarity1
Active sitei294Proton acceptorPROSITE-ProRule annotation1
Binding sitei322SubstrateBy similarity1
Active sitei328NucleophilePROSITE-ProRule annotation1
Binding sitei486SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi216 – 219NADBy similarity4
Nucleotide bindingi272 – 277NADBy similarity6

GO - Molecular functioni

GO - Biological processi

  • acetate metabolic process Source: MGI
  • central nervous system development Source: UniProtKB
  • galactosylceramide metabolic process Source: MGI
  • gamma-aminobutyric acid catabolic process Source: UniProtKB
  • gamma-aminobutyric acid metabolic process Source: MGI
  • glucose metabolic process Source: MGI
  • glucosylceramide metabolic process Source: MGI
  • glutamate metabolic process Source: MGI
  • glutamine metabolic process Source: MGI
  • glutathione metabolic process Source: MGI
  • glycerophospholipid metabolic process Source: MGI
  • neurotransmitter catabolic process Source: MGI
  • oxidation-reduction process Source: UniProtKB
  • post-embryonic development Source: MGI
  • protein homotetramerization Source: MGI
  • respiratory electron transport chain Source: MGI
  • short-chain fatty acid metabolic process Source: MGI
  • succinate metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.24. 3474.
ReactomeiR-MMU-916853. Degradation of GABA.
UniPathwayiUPA00733.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate-semialdehyde dehydrogenase, mitochondrial (EC:1.2.1.24)
Alternative name(s):
Aldehyde dehydrogenase family 5 member A1
NAD(+)-dependent succinic semialdehyde dehydrogenase
Gene namesi
Name:Aldh5a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2441982. Aldh5a1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionBy similarityAdd BLAST35
ChainiPRO_000000718536 – 523Succinate-semialdehyde dehydrogenase, mitochondrialAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74N6-acetyllysineCombined sources1
Modified residuei114N6-acetyllysine; alternateCombined sources1
Modified residuei114N6-succinyllysine; alternateCombined sources1
Modified residuei123N6-succinyllysineCombined sources1
Modified residuei128N6-acetyllysineCombined sources1
Modified residuei172N6-succinyllysineCombined sources1
Modified residuei253N6-acetyllysine; alternateCombined sources1
Modified residuei253N6-succinyllysine; alternateCombined sources1
Disulfide bondi328 ↔ 330In inhibited formBy similarity
Modified residuei347N6-acetyllysine; alternateCombined sources1
Modified residuei347N6-succinyllysine; alternateCombined sources1
Modified residuei353N6-acetyllysineCombined sources1
Modified residuei390N6-succinyllysineCombined sources1
Modified residuei399N6-acetyllysineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei487PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ8BWF0.
PaxDbiQ8BWF0.
PeptideAtlasiQ8BWF0.
PRIDEiQ8BWF0.

PTM databases

iPTMnetiQ8BWF0.
PhosphoSitePlusiQ8BWF0.
SwissPalmiQ8BWF0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035936.
CleanExiMM_ALDH5A1.
ExpressionAtlasiQ8BWF0. baseline and differential.
GenevisibleiQ8BWF0. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ8BWF0. 3 interactors.
MINTiMINT-1861868.
STRINGi10090.ENSMUSP00000040591.

Structurei

3D structure databases

ProteinModelPortaliQ8BWF0.
SMRiQ8BWF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2451. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00840000129936.
HOGENOMiHOG000271509.
HOVERGENiHBG108515.
InParanoidiQ8BWF0.
KOiK00139.
OMAiIKYICMS.
OrthoDBiEOG091G056Z.
PhylomeDBiQ8BWF0.
TreeFamiTF352906.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01780. SSADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BWF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCFLLRSF WAARPALPPP GRFRPEPAGT PRRSYASGPG GLHADLLRGD
60 70 80 90 100
SFVGGRWLPA PATFPVYDPA SGAKLGTVAD CGVPEARAAV RAAYDAFNSW
110 120 130 140 150
KGVSVKERSL LLRKWYDLMI QNKDDLAKII TAESGKPLKE AQGEILYSAL
160 170 180 190 200
FLEWFSEEAR RIYGDIIYTS AKDKRGLVLK QPVGVAAIIT PWNFPSAMIT
210 220 230 240 250
RKVGAALAAG CTVVVKPAED TPYSALALAQ LANQAGIPAG VYNVIPCSRN
260 270 280 290 300
KAKEVGEVLC TDPLVSKISF TGSTATGKIL LHHAANSVKR VSMELGGLAP
310 320 330 340 350
FIVFDSANVD QAVAGAMASK FRNAGQTCVC SNRFLVQRGI HDSFVTKFAE
360 370 380 390 400
AMKKSLRVGN GFEEGTTQGP LINEKAVEKV EKQVNDAVAK GATVVTGGKR
410 420 430 440 450
HQSGGNFFEP TLLSNVTRDM LCITEETFGP LAPVIKFDKE EEAVAIANAA
460 470 480 490 500
EVGLAGYFYS QDPAQIWRVA EQLEVGMVGV NEGLISSVEC PFGGVKQSGL
510 520
GREGSKYGID EYLEVKYVCY GGL
Length:523
Mass (Da):55,968
Last modified:March 1, 2003 - v1
Checksum:iE0CF82E4F4FAE9D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052703 mRNA. Translation: BAC35105.1.
AK144030 mRNA. Translation: BAE25663.1.
AL589699 Genomic DNA. Translation: CAI26086.1.
CCDSiCCDS26383.1.
RefSeqiNP_766120.1. NM_172532.3.
UniGeneiMm.393311.

Genome annotation databases

EnsembliENSMUST00000037615; ENSMUSP00000040591; ENSMUSG00000035936.
GeneIDi214579.
KEGGimmu:214579.
UCSCiuc007pwp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052703 mRNA. Translation: BAC35105.1.
AK144030 mRNA. Translation: BAE25663.1.
AL589699 Genomic DNA. Translation: CAI26086.1.
CCDSiCCDS26383.1.
RefSeqiNP_766120.1. NM_172532.3.
UniGeneiMm.393311.

3D structure databases

ProteinModelPortaliQ8BWF0.
SMRiQ8BWF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BWF0. 3 interactors.
MINTiMINT-1861868.
STRINGi10090.ENSMUSP00000040591.

PTM databases

iPTMnetiQ8BWF0.
PhosphoSitePlusiQ8BWF0.
SwissPalmiQ8BWF0.

Proteomic databases

MaxQBiQ8BWF0.
PaxDbiQ8BWF0.
PeptideAtlasiQ8BWF0.
PRIDEiQ8BWF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037615; ENSMUSP00000040591; ENSMUSG00000035936.
GeneIDi214579.
KEGGimmu:214579.
UCSCiuc007pwp.2. mouse.

Organism-specific databases

CTDi7915.
MGIiMGI:2441982. Aldh5a1.

Phylogenomic databases

eggNOGiKOG2451. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00840000129936.
HOGENOMiHOG000271509.
HOVERGENiHBG108515.
InParanoidiQ8BWF0.
KOiK00139.
OMAiIKYICMS.
OrthoDBiEOG091G056Z.
PhylomeDBiQ8BWF0.
TreeFamiTF352906.

Enzyme and pathway databases

UniPathwayiUPA00733.
BRENDAi1.2.1.24. 3474.
ReactomeiR-MMU-916853. Degradation of GABA.

Miscellaneous databases

ChiTaRSiAldh5a1. mouse.
PROiQ8BWF0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035936.
CleanExiMM_ALDH5A1.
ExpressionAtlasiQ8BWF0. baseline and differential.
GenevisibleiQ8BWF0. MM.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01780. SSADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSDH_MOUSE
AccessioniPrimary (citable) accession number: Q8BWF0
Secondary accession number(s): Q5SZW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.