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Q8BWD8

- CDK19_MOUSE

UniProt

Q8BWD8 - CDK19_MOUSE

Protein

Cyclin-dependent kinase 19

Gene

Cdk19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei52 – 521ATPPROSITE-ProRule annotation
    Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi27 – 359ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198602. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 19 (EC:2.7.11.22)
    Alternative name(s):
    CDC2-related protein kinase 6
    Cell division cycle 2-like protein kinase 6
    Cell division protein kinase 19
    Gene namesi
    Name:Cdk19
    Synonyms:Cdc2l6, Kiaa1028
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1925584. Cdk19.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Cyclin-dependent kinase 19PRO_0000085714Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei449 – 4491PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ8BWD8.
    PRIDEiQ8BWD8.

    PTM databases

    PhosphoSiteiQ8BWD8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BWD8.
    BgeeiQ8BWD8.
    CleanExiMM_CDC2L6.
    GenevestigatoriQ8BWD8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BWD8.
    SMRiQ8BWD8. Positions 1-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 335315Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi372 – 40433Gln-richAdd
    BLAST
    Compositional biasi415 – 4228Poly-Gly
    Compositional biasi461 – 49535Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00530000064012.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ8BWD8.
    KOiK02208.
    OMAiSQSTMGY.
    OrthoDBiEOG76739K.
    PhylomeDBiQ8BWD8.
    TreeFamiTF101025.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BWD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYDFKAKLA AERERVEDLF EYEGCKVGRG TYGHVYKARR KDGKDEKEYA    50
    LKQIEGTGIS MSACREIALL RELKHPNVIA LQKVFLSHSD RKVWLLFDYA 100
    EHDLWHIIKF HRASKANKKP MQLPRSMVKS LLYQILDGIH YLHANWVLHR 150
    DLKPANILVM GEGPERGRVK IADMGFARLF NSPLKPLADL DPVVVTFWYR 200
    APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED IKTSNPFHHD 250
    QLDRIFSVMG FPADKDWEDI RKMPEYPTLQ KDFRRTTYAN SSLIKYMEKH 300
    KVKPDSKVFL LLQKLLTMDP TKRITSEQAL QDPYFQEDPL PTLDVFAGCQ 350
    IPYPKREFLN EDEPEEKGDK NQPQQQNPHQ QPAAPAQQTA APPQAPPPQQ 400
    SSAQTNGTAG GATAGGGGAG AGLQHSQDPG LNQVPPNKKP RIGPSGANSG 450
    GPVMPSDYQH SSSRLNYQSS VQGSSQSQST LGYSSSQQST QYHSSHQTHR 500
    Y 501
    Length:501
    Mass (Da):56,570
    Last modified:March 1, 2003 - v1
    Checksum:i210647473CE4527D
    GO

    Sequence cautioni

    The sequence BAC65703.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052818 mRNA. Translation: BAC35159.1.
    AK122421 mRNA. Translation: BAC65703.1. Different initiation.
    CCDSiCCDS48545.1.
    RefSeqiNP_001161776.1. NM_001168304.1.
    UniGeneiMm.200924.

    Genome annotation databases

    EnsembliENSMUST00000044672; ENSMUSP00000040936; ENSMUSG00000038481.
    GeneIDi78334.
    KEGGimmu:78334.
    UCSCiuc007ewt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052818 mRNA. Translation: BAC35159.1 .
    AK122421 mRNA. Translation: BAC65703.1 . Different initiation.
    CCDSi CCDS48545.1.
    RefSeqi NP_001161776.1. NM_001168304.1.
    UniGenei Mm.200924.

    3D structure databases

    ProteinModelPortali Q8BWD8.
    SMRi Q8BWD8. Positions 1-359.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BWD8.

    Proteomic databases

    PaxDbi Q8BWD8.
    PRIDEi Q8BWD8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044672 ; ENSMUSP00000040936 ; ENSMUSG00000038481 .
    GeneIDi 78334.
    KEGGi mmu:78334.
    UCSCi uc007ewt.2. mouse.

    Organism-specific databases

    CTDi 23097.
    MGIi MGI:1925584. Cdk19.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00530000064012.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q8BWD8.
    KOi K02208.
    OMAi SQSTMGY.
    OrthoDBi EOG76739K.
    PhylomeDBi Q8BWD8.
    TreeFami TF101025.

    Enzyme and pathway databases

    Reactomei REACT_198602. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 348719.
    PROi Q8BWD8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BWD8.
    Bgeei Q8BWD8.
    CleanExi MM_CDC2L6.
    Genevestigatori Q8BWD8.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCDK19_MOUSE
    AccessioniPrimary (citable) accession number: Q8BWD8
    Secondary accession number(s): Q80TM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3