Reviewed,
UniProtKB/Swiss-Prot Q8BWD8 (CD2L6_MOUSE)
Last modified
November 3, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Cell division cycle 2-like protein kinase 6 EC=2.7.11.22 Alternative name(s): CDC2-related protein kinase 6 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 501 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 501 | 501 | Cell division cycle 2-like protein kinase 6 | PRO_0000085714 | |||||
Regions | |||||||||
| Domain | 21 – 335 | 315 | Protein kinase | ||||||
| Nucleotide binding | 27 – 35 | 9 | ATP By similarity | ||||||
| Compositional bias | 372 – 404 | 33 | Gln-rich | ||||||
| Compositional bias | 415 – 422 | 8 | Poly-Gly | ||||||
| Compositional bias | 461 – 495 | 35 | Ser-rich | ||||||
Sites | |||||||||
| Active site | 151 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 52 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 449 | 1 | Phosphoserine By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland. |
| [2] | "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed: 12693553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AK052818 mRNA. Translation: BAC35159.1. AK122421 mRNA. Translation: BAC65703.1. Different initiation. | |
| IPI | IPI00226248. |
| UniGene | Mm.200924 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1OIT based on UniProtKB P24941. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8BWD8. |
PTM databases | |
| PhosphoSite | Q8BWD8. |
Proteomic databases | |
| PRIDE | Q8BWD8. |
Genome annotation databases | |
| Ensembl | ENSMUST00000044672; ENSMUSP00000040936; ENSMUSG00000038481; Mus musculus. [Genome view] |
| UCSC | uc007eww.1. mouse. |
Organism-specific databases | |
| MGI | MGI:1925584. Cdc2l6. |
| Rouge | Search... |
Phylogenomic databases | |
| HOGENOM | Q8BWD8. |
| HOVERGEN | Q8BWD8. |
| OMA | QSTQYHP. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.22. 244. |
Gene expression databases | |
| ArrayExpress | Q8BWD8. |
| Bgee | Q8BWD8. |
| CleanEx | MM_CDC2L6. |
| Genevestigator | Q8BWD8. |
| GermOnline | ENSMUSG00000038481. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | CD2L6_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8BWD8 Secondary accession number(s): Q80TM1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


