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Protein

Inositol hexakisphosphate kinase 3

Gene

Ip6k3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity).By similarity

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1855167 Synthesis of pyrophosphates in the cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 3 (EC:2.7.4.21)
Short name:
InsP6 kinase 3
Alternative name(s):
Inositol hexaphosphate kinase 3
Gene namesi
Name:Ip6k3
Synonyms:Ihpk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3045325 Ip6k3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668821 – 396Inositol hexakisphosphate kinase 3Add BLAST396

Proteomic databases

PaxDbiQ8BWD2
PRIDEiQ8BWD2

PTM databases

PhosphoSitePlusiQ8BWD2

Expressioni

Tissue specificityi

Highly expressed in cerebellum, brain cortex, kidney, thymus and lung. Detected at lower levels in hippocampus, testis, heart and olfactory bulb.1 Publication

Gene expression databases

BgeeiENSMUSG00000024210
CleanExiMM_IHPK3
GenevisibleiQ8BWD2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025046

Structurei

3D structure databases

ProteinModelPortaliQ8BWD2
SMRiQ8BWD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni206 – 214Substrate bindingBy similarity9

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IPEQ Eukaryota
ENOG4111UCF LUCA
GeneTreeiENSGT00390000014381
HOGENOMiHOG000007418
HOVERGENiHBG052140
InParanoidiQ8BWD2
KOiK07756
OMAiNEHTTYD
OrthoDBiEOG091G0JK2
PhylomeDBiQ8BWD2
TreeFamiTF314066

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BWD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVRHSSDKG KIGVGVPLEP FLHQVGGHLS VLQYDAYTVC KPLVSQEQKF
60 70 80 90 100
YESLPLAMKC FTPKYKGTIT VRLRRDSRGH LGLVANPLKE NLEPFQVSPE
110 120 130 140 150
SRAVALWQTL QQTTGSESSP CPLTQLARSL KESAAKVLLR SDCHLSTQAS
160 170 180 190 200
PLVESEDGSQ VERKGFNPWG LHCHQAHLTR LCSQYPEDKR HRFLLLENVV
210 220 230 240 250
SQYKQPCILD LKMGTRQHGD DASEEKKARH MKKCAQSTSA CLGVRICGMQ
260 270 280 290 300
VYQTDQKSFL CKDKYYGRKL SVEGFRQALS QFLHDGTRLR AELLEPILRR
310 320 330 340 350
LQALLTVIRS QSSYRFYSSS VLIIYDGEPP QTTQGSTSGG VTSGDPAKVD
360 370 380 390
VRMIDFAHTT FKGSWNEHTT YEGPDPGYIF GLENLIGILR DIQEGE
Length:396
Mass (Da):44,418
Last modified:March 1, 2003 - v1
Checksum:iDB98CB79B4B36EE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052857 mRNA Translation: BAC35176.1
CCDSiCCDS28562.1
RefSeqiNP_766615.1, NM_173027.2
UniGeneiMm.209679

Genome annotation databases

EnsembliENSMUST00000025046; ENSMUSP00000025046; ENSMUSG00000024210
GeneIDi271424
KEGGimmu:271424
UCSCiuc008bfl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIP6K3_MOUSE
AccessioniPrimary (citable) accession number: Q8BWD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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