SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8BWD2

- IP6K3_MOUSE

UniProt

Q8BWD2 - IP6K3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Inositol hexakisphosphate kinase 3

Gene
Ip6k3, Ihpk3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 By similarity.

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
  3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
  4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
  5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC
  6. inositol hexakisphosphate 6-kinase activity Source: Ensembl

GO - Biological processi

  1. inositol phosphate biosynthetic process Source: Ensembl
  2. phosphatidylinositol metabolic process Source: Ensembl
  3. protein phosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196482. Synthesis of pyrophosphates in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 3 (EC:2.7.4.21)
Short name:
InsP6 kinase 3
Alternative name(s):
Inositol hexaphosphate kinase 3
Gene namesi
Name:Ip6k3
Synonyms:Ihpk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:3045325. Ip6k3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Inositol hexakisphosphate kinase 3PRO_0000066882Add
BLAST

Proteomic databases

PRIDEiQ8BWD2.

PTM databases

PhosphoSiteiQ8BWD2.

Expressioni

Tissue specificityi

Highly expressed in cerebellum, brain cortex, kidney, thymus and lung. Detected at lower levels in hippocampus, testis, heart and olfactory bulb.1 Publication

Gene expression databases

BgeeiQ8BWD2.
CleanExiMM_IHPK3.
GenevestigatoriQ8BWD2.

Structurei

3D structure databases

ProteinModelPortaliQ8BWD2.
SMRiQ8BWD2. Positions 194-392.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni206 – 2149Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ8BWD2.
KOiK07756.
OMAiEHTTYDG.
OrthoDBiEOG747PHX.
PhylomeDBiQ8BWD2.
TreeFamiTF314066.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BWD2-1 [UniParc]FASTAAdd to Basket

« Hide

MVVRHSSDKG KIGVGVPLEP FLHQVGGHLS VLQYDAYTVC KPLVSQEQKF    50
YESLPLAMKC FTPKYKGTIT VRLRRDSRGH LGLVANPLKE NLEPFQVSPE 100
SRAVALWQTL QQTTGSESSP CPLTQLARSL KESAAKVLLR SDCHLSTQAS 150
PLVESEDGSQ VERKGFNPWG LHCHQAHLTR LCSQYPEDKR HRFLLLENVV 200
SQYKQPCILD LKMGTRQHGD DASEEKKARH MKKCAQSTSA CLGVRICGMQ 250
VYQTDQKSFL CKDKYYGRKL SVEGFRQALS QFLHDGTRLR AELLEPILRR 300
LQALLTVIRS QSSYRFYSSS VLIIYDGEPP QTTQGSTSGG VTSGDPAKVD 350
VRMIDFAHTT FKGSWNEHTT YEGPDPGYIF GLENLIGILR DIQEGE 396
Length:396
Mass (Da):44,418
Last modified:March 1, 2003 - v1
Checksum:iDB98CB79B4B36EE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052857 mRNA. Translation: BAC35176.1.
CCDSiCCDS28562.1.
RefSeqiNP_766615.1. NM_173027.2.
UniGeneiMm.209679.

Genome annotation databases

EnsembliENSMUST00000025046; ENSMUSP00000025046; ENSMUSG00000024210.
GeneIDi271424.
KEGGimmu:271424.
UCSCiuc008bfl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052857 mRNA. Translation: BAC35176.1 .
CCDSi CCDS28562.1.
RefSeqi NP_766615.1. NM_173027.2.
UniGenei Mm.209679.

3D structure databases

ProteinModelPortali Q8BWD2.
SMRi Q8BWD2. Positions 194-392.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BWD2.

Proteomic databases

PRIDEi Q8BWD2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025046 ; ENSMUSP00000025046 ; ENSMUSG00000024210 .
GeneIDi 271424.
KEGGi mmu:271424.
UCSCi uc008bfl.1. mouse.

Organism-specific databases

CTDi 117283.
MGIi MGI:3045325. Ip6k3.

Phylogenomic databases

eggNOGi NOG274869.
GeneTreei ENSGT00390000014381.
HOGENOMi HOG000007418.
HOVERGENi HBG052140.
InParanoidi Q8BWD2.
KOi K07756.
OMAi EHTTYDG.
OrthoDBi EOG747PHX.
PhylomeDBi Q8BWD2.
TreeFami TF314066.

Enzyme and pathway databases

Reactomei REACT_196482. Synthesis of pyrophosphates in the cytosol.

Miscellaneous databases

NextBioi 393458.
PROi Q8BWD2.
SOURCEi Search...

Gene expression databases

Bgeei Q8BWD2.
CleanExi MM_IHPK3.
Genevestigatori Q8BWD2.

Family and domain databases

InterProi IPR005522. IPK.
[Graphical view ]
PANTHERi PTHR12400. PTHR12400. 1 hit.
Pfami PF03770. IPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  2. "Identification and characterization of a novel inositol hexakisphosphate kinase."
    Saiardi A., Nagata E., Luo H.R., Snowman A.M., Snyder S.H.
    J. Biol. Chem. 276:39179-39185(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiIP6K3_MOUSE
AccessioniPrimary (citable) accession number: Q8BWD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi