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Protein

Rho guanine nucleotide exchange factor 19

Gene

Arhgef19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase.1 Publication

GO - Molecular functioni

GO - Biological processi

  • positive regulation of GTPase activity Source: MGI
  • regulation of actin cytoskeleton organization Source: MGI
  • regulation of Rho protein signal transduction Source: InterPro
  • wound healing Source: MGI

Keywordsi

Molecular functionGTPase activation, Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 19
Alternative name(s):
Ephexin-2
Weakly similar to Rho GEF 5
Gene namesi
Name:Arhgef19
Synonyms:Wgef
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1925912 Arhgef19

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002851321 – 802Rho guanine nucleotide exchange factor 19Add BLAST802

Proteomic databases

MaxQBiQ8BWA8
PaxDbiQ8BWA8
PRIDEiQ8BWA8

PTM databases

iPTMnetiQ8BWA8
PhosphoSitePlusiQ8BWA8

Expressioni

Tissue specificityi

Highly expressed in intestine, and at lower levels in liver, heart and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000028919
CleanExiMM_ARHGEF19
ExpressionAtlasiQ8BWA8 baseline and differential
GenevisibleiQ8BWA8 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006618

Structurei

3D structure databases

ProteinModelPortaliQ8BWA8
SMRiQ8BWA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini376 – 560DHPROSITE-ProRule annotationAdd BLAST185
Domaini592 – 704PHPROSITE-ProRule annotationAdd BLAST113
Domaini715 – 776SH3PROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG3523 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00550000074493
HOGENOMiHOG000007536
HOVERGENiHBG058673
InParanoidiQ8BWA8
KOiK20691
OMAiHPVAVCQ
OrthoDBiEOG091G03C1
PhylomeDBiQ8BWA8
TreeFamiTF316357

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BWA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCGPPATLQ PHLAGPPGTA RRPVAVCQQE SLSFVELPPS RLCVDLFPIA
60 70 80 90 100
PEELQAPGSR WSLATPAPLQ GLLWPTSPGG PDTHIASTSG GMRPGRAGSW
110 120 130 140 150
PHCPGAQPPT LVEPWSSQHM QPQRRASHSG SEKSAWRKMQ VYHNEEATGT
160 170 180 190 200
ETPTGLLETG QAAQEQALCA LEPGPQELSG NARGGLEAPE RRRFSASELM
210 220 230 240 250
TRLHSSLRLG RSTATRVLTS GSGAGAIREG KLPVRESRRA ETRADSVSLP
260 270 280 290 300
GPVDLNEVHG GLVEPRLDTQ DKPTQDPSSA TERRQSRFLL NSVLYQEYSD
310 320 330 340 350
VASARELRRQ QREEEGPGDG AEGAEEGPGP PRANLSPSSS FRAQRSTRGS
360 370 380 390 400
TFSLWQDIPD VRGSGVLATL SLRDCKLQEA KFELITSEAS YIHSLSVAVG
410 420 430 440 450
HFLGSVELSE CLGTQDKQWL FSKLPEVKST SERFLHDLEQ RLEADVLRFS
460 470 480 490 500
VCDVVLHHCP AFRRVYLPYV TNQAYQERTY QRLLLENPKF PGILARLEES
510 520 530 540 550
PVCQRLPLTS FLILPFQRVT RLKMLVENIL KRTAPGSQDE DMATKAFSAL
560 570 580 590 600
KELVQECNAS VQSMKRTEEL IHLSKKIHFE GKIFPLISQA RWLVRHGELV
610 620 630 640 650
ELAPLPAAPP AKLKLSSKAV YLHLFNDCLL LSRRKELGKF AVFVHANMAE
660 670 680 690 700
LQVRDLSLKL QGIPGHVFLL RLLHGQRARH QLLLRARTES EKQRWISALR
710 720 730 740 750
PSSPQEDKEI TCDGEDRPQV QCVRTYKALQ PDELTLEKTD ILAVKTRTSD
760 770 780 790 800
GWLEGVRLAD GEKGWVPQAH VVEISSLSAR LRNLREYKRV SNASSKLGDP

PA
Length:802
Mass (Da):88,851
Last modified:March 1, 2003 - v1
Checksum:i9066207998966E77
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti492G → S in AAH60376 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053075 mRNA Translation: BAC35256.1
AL607087 Genomic DNA No translation available.
BC060376 mRNA Translation: AAH60376.1
CCDSiCCDS18868.1
RefSeqiNP_766108.1, NM_172520.2
XP_006538767.1, XM_006538704.2
XP_006538768.1, XM_006538705.2
XP_006538769.1, XM_006538706.3
XP_006538770.1, XM_006538707.3
XP_006538771.1, XM_006538708.3
XP_006538772.1, XM_006538709.3
XP_011248527.1, XM_011250225.1
XP_017175587.1, XM_017320098.1
UniGeneiMm.134460

Genome annotation databases

EnsembliENSMUST00000006618; ENSMUSP00000006618; ENSMUSG00000028919
GeneIDi213649
KEGGimmu:213649
UCSCiuc008vob.1 mouse

Similar proteinsi

Entry informationi

Entry nameiARHGJ_MOUSE
AccessioniPrimary (citable) accession number: Q8BWA8
Secondary accession number(s): Q6PAC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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