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Protein

Rho guanine nucleotide exchange factor 19

Gene

Arhgef19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase.1 Publication

GO - Molecular functioni

GO - Biological processi

  • positive regulation of GTPase activity Source: MGI
  • regulation of actin cytoskeleton organization Source: MGI
  • regulation of Rho protein signal transduction Source: InterPro
  • wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 19
Alternative name(s):
Ephexin-2
Weakly similar to Rho GEF 5
Gene namesi
Name:Arhgef19
Synonyms:Wgef
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1925912. Arhgef19.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Rho guanine nucleotide exchange factor 19PRO_0000285132Add
BLAST

Proteomic databases

PaxDbiQ8BWA8.
PRIDEiQ8BWA8.

PTM databases

PhosphoSiteiQ8BWA8.

Expressioni

Tissue specificityi

Highly expressed in intestine, and at lower levels in liver, heart and kidney.1 Publication

Gene expression databases

BgeeiQ8BWA8.
CleanExiMM_ARHGEF19.
ExpressionAtlasiQ8BWA8. baseline and differential.
GenevisibleiQ8BWA8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006618.

Structurei

3D structure databases

ProteinModelPortaliQ8BWA8.
SMRiQ8BWA8. Positions 366-703, 716-779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini376 – 560185DHPROSITE-ProRule annotationAdd
BLAST
Domaini592 – 704113PHPROSITE-ProRule annotationAdd
BLAST
Domaini715 – 77662SH3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG3523. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00550000074493.
HOGENOMiHOG000007536.
HOVERGENiHBG058673.
InParanoidiQ8BWA8.
OMAiHPVAVCQ.
OrthoDBiEOG7H4DSV.
PhylomeDBiQ8BWA8.
TreeFamiTF316357.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BWA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCGPPATLQ PHLAGPPGTA RRPVAVCQQE SLSFVELPPS RLCVDLFPIA
60 70 80 90 100
PEELQAPGSR WSLATPAPLQ GLLWPTSPGG PDTHIASTSG GMRPGRAGSW
110 120 130 140 150
PHCPGAQPPT LVEPWSSQHM QPQRRASHSG SEKSAWRKMQ VYHNEEATGT
160 170 180 190 200
ETPTGLLETG QAAQEQALCA LEPGPQELSG NARGGLEAPE RRRFSASELM
210 220 230 240 250
TRLHSSLRLG RSTATRVLTS GSGAGAIREG KLPVRESRRA ETRADSVSLP
260 270 280 290 300
GPVDLNEVHG GLVEPRLDTQ DKPTQDPSSA TERRQSRFLL NSVLYQEYSD
310 320 330 340 350
VASARELRRQ QREEEGPGDG AEGAEEGPGP PRANLSPSSS FRAQRSTRGS
360 370 380 390 400
TFSLWQDIPD VRGSGVLATL SLRDCKLQEA KFELITSEAS YIHSLSVAVG
410 420 430 440 450
HFLGSVELSE CLGTQDKQWL FSKLPEVKST SERFLHDLEQ RLEADVLRFS
460 470 480 490 500
VCDVVLHHCP AFRRVYLPYV TNQAYQERTY QRLLLENPKF PGILARLEES
510 520 530 540 550
PVCQRLPLTS FLILPFQRVT RLKMLVENIL KRTAPGSQDE DMATKAFSAL
560 570 580 590 600
KELVQECNAS VQSMKRTEEL IHLSKKIHFE GKIFPLISQA RWLVRHGELV
610 620 630 640 650
ELAPLPAAPP AKLKLSSKAV YLHLFNDCLL LSRRKELGKF AVFVHANMAE
660 670 680 690 700
LQVRDLSLKL QGIPGHVFLL RLLHGQRARH QLLLRARTES EKQRWISALR
710 720 730 740 750
PSSPQEDKEI TCDGEDRPQV QCVRTYKALQ PDELTLEKTD ILAVKTRTSD
760 770 780 790 800
GWLEGVRLAD GEKGWVPQAH VVEISSLSAR LRNLREYKRV SNASSKLGDP

PA
Length:802
Mass (Da):88,851
Last modified:March 1, 2003 - v1
Checksum:i9066207998966E77
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti492 – 4921G → S in AAH60376 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053075 mRNA. Translation: BAC35256.1.
AL607087 Genomic DNA. Translation: CAM16998.1.
BC060376 mRNA. Translation: AAH60376.1.
CCDSiCCDS18868.1.
RefSeqiNP_766108.1. NM_172520.2.
XP_006538767.1. XM_006538704.2.
XP_006538768.1. XM_006538705.2.
XP_006538769.1. XM_006538706.2.
XP_006538770.1. XM_006538707.2.
XP_006538771.1. XM_006538708.2.
XP_006538772.1. XM_006538709.2.
XP_011248527.1. XM_011250225.1.
XP_011248528.1. XM_011250226.1.
UniGeneiMm.134460.

Genome annotation databases

EnsembliENSMUST00000006618; ENSMUSP00000006618; ENSMUSG00000028919.
GeneIDi213649.
KEGGimmu:213649.
UCSCiuc008vob.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053075 mRNA. Translation: BAC35256.1.
AL607087 Genomic DNA. Translation: CAM16998.1.
BC060376 mRNA. Translation: AAH60376.1.
CCDSiCCDS18868.1.
RefSeqiNP_766108.1. NM_172520.2.
XP_006538767.1. XM_006538704.2.
XP_006538768.1. XM_006538705.2.
XP_006538769.1. XM_006538706.2.
XP_006538770.1. XM_006538707.2.
XP_006538771.1. XM_006538708.2.
XP_006538772.1. XM_006538709.2.
XP_011248527.1. XM_011250225.1.
XP_011248528.1. XM_011250226.1.
UniGeneiMm.134460.

3D structure databases

ProteinModelPortaliQ8BWA8.
SMRiQ8BWA8. Positions 366-703, 716-779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006618.

PTM databases

PhosphoSiteiQ8BWA8.

Proteomic databases

PaxDbiQ8BWA8.
PRIDEiQ8BWA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006618; ENSMUSP00000006618; ENSMUSG00000028919.
GeneIDi213649.
KEGGimmu:213649.
UCSCiuc008vob.1. mouse.

Organism-specific databases

CTDi128272.
MGIiMGI:1925912. Arhgef19.

Phylogenomic databases

eggNOGiKOG3523. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00550000074493.
HOGENOMiHOG000007536.
HOVERGENiHBG058673.
InParanoidiQ8BWA8.
OMAiHPVAVCQ.
OrthoDBiEOG7H4DSV.
PhylomeDBiQ8BWA8.
TreeFamiTF316357.

Miscellaneous databases

NextBioi374066.
PROiQ8BWA8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BWA8.
CleanExiMM_ARHGEF19.
ExpressionAtlasiQ8BWA8. baseline and differential.
GenevisibleiQ8BWA8. MM.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary tumor.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 522-531, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiARHGJ_MOUSE
AccessioniPrimary (citable) accession number: Q8BWA8
Secondary accession number(s): Q6PAC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.