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Protein

Kelch-like protein 31

Gene

Klhl31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE) (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 31
Alternative name(s):
Kelch repeat and BTB domain-containing protein 1
Kelch-like protein KLHL
Gene namesi
Name:Klhl31
Synonyms:Kbtbd1, Klhl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3045305. Klhl31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 634633Kelch-like protein 31PRO_0000271036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N,N,N-trimethylalanine; by NTM11 Publication

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.1 Publication

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ8BWA5.
PaxDbiQ8BWA5.
PRIDEiQ8BWA5.

PTM databases

iPTMnetiQ8BWA5.
PhosphoSiteiQ8BWA5.

Expressioni

Gene expression databases

CleanExiMM_KLHL31.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059643.

Structurei

3D structure databases

ProteinModelPortaliQ8BWA5.
SMRiQ8BWA5. Positions 53-595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 13765BTBPROSITE-ProRule annotationAdd
BLAST
Domaini172 – 273102BACKAdd
BLAST
Repeati317 – 36549Kelch 1Add
BLAST
Repeati366 – 41954Kelch 2Add
BLAST
Repeati420 – 46647Kelch 3Add
BLAST
Repeati468 – 51346Kelch 4Add
BLAST
Repeati515 – 56551Kelch 5Add
BLAST
Repeati566 – 61449Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
HOGENOMiHOG000231583.
HOVERGENiHBG101156.
InParanoidiQ8BWA5.
KOiK10467.
PhylomeDBiQ8BWA5.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030604. KLHL31.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF247. PTHR24412:SF247. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BWA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKKTIKK NKAEINEMTI IVEDSPLSKL NALNGLLEGS NSLSCVSSEL
60 70 80 90 100
TDTSYGPNLL EGLSKMRQES FLCDLVIGTK TKSFDVHKSV MASCSEYFYN
110 120 130 140 150
ILKNDPSTKR VDLNDIAPLG LATVIAYAYT GKLTLSLYTI GSIISAAVYL
160 170 180 190 200
QIHTLVKMCS DFLIREISVE NCMYVVNIAE TYSLKNAKAT AQKFIRDNFI
210 220 230 240 250
EFAESEQFMK LTFEQINELL VDDDLQLPSE LVAFQIAMKW LEFDQKRVKH
260 270 280 290 300
AADLLSNIRF GTISAQDLVN YVQTVPRMMQ DADCHKLLVD AMNYHLLPYH
310 320 330 340 350
QNTLQSRRTR IRGGCRVLIT VGGRPGLTEK SLSRDILYRD PENGWSKLTE
360 370 380 390 400
MPAKSFNQCV AVMDGFLYVA GGEDQNDARN QAKHAVSNFC RYDPRFNTWI
410 420 430 440 450
HLGSMNQKRT HFSLSVFNGL LYAVGGRNSE GSLASLECYV PSTNQWQPKA
460 470 480 490 500
PLEVARCCHA SAVADGRVIV TGGYIGSAYS RSVCAYDPAL DAWQELPQLS
510 520 530 540 550
TPRGWHCAVA LGDRLYVMGG SQLGPRGERV DVLTVESFSP AARQWSFVAP
560 570 580 590 600
LPVGVSTAGV SALHGRAYLL GGWNEGDKKY KKCIQCFNPE LNEWTEDDEL
610 620 630
PEATVGVSCC TLAMPNSVSR ESRASSVSSV PVSI
Length:634
Mass (Da):70,181
Last modified:March 1, 2003 - v1
Checksum:iCDAA6821191AAF5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053085 mRNA. Translation: BAC35261.1.
CCDSiCCDS23352.1.
RefSeqiNP_766513.2. NM_172925.2.
UniGeneiMm.138238.

Genome annotation databases

GeneIDi244923.
KEGGimmu:244923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053085 mRNA. Translation: BAC35261.1.
CCDSiCCDS23352.1.
RefSeqiNP_766513.2. NM_172925.2.
UniGeneiMm.138238.

3D structure databases

ProteinModelPortaliQ8BWA5.
SMRiQ8BWA5. Positions 53-595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059643.

PTM databases

iPTMnetiQ8BWA5.
PhosphoSiteiQ8BWA5.

Proteomic databases

MaxQBiQ8BWA5.
PaxDbiQ8BWA5.
PRIDEiQ8BWA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi244923.
KEGGimmu:244923.

Organism-specific databases

CTDi401265.
MGIiMGI:3045305. Klhl31.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
HOGENOMiHOG000231583.
HOVERGENiHBG101156.
InParanoidiQ8BWA5.
KOiK10467.
PhylomeDBiQ8BWA5.

Miscellaneous databases

PROiQ8BWA5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_KLHL31.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030604. KLHL31.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF247. PTHR24412:SF247. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH31_MOUSE
AccessioniPrimary (citable) accession number: Q8BWA5
Secondary accession number(s): Q148Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.