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Protein

Kelch-like protein 31

Gene

Klhl31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE) (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 31
Alternative name(s):
Kelch repeat and BTB domain-containing protein 1
Kelch-like protein KLHL
Gene namesi
Name:Klhl31
Synonyms:Kbtbd1, Klhl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3045305 Klhl31

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002710362 – 634Kelch-like protein 31Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanine; by NTM11 Publication1

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.1 Publication

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ8BWA5
PaxDbiQ8BWA5
PRIDEiQ8BWA5

PTM databases

iPTMnetiQ8BWA5
PhosphoSitePlusiQ8BWA5

Expressioni

Gene expression databases

CleanExiMM_KLHL31

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059643

Structurei

3D structure databases

ProteinModelPortaliQ8BWA5
SMRiQ8BWA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 137BTBPROSITE-ProRule annotationAdd BLAST65
Domaini172 – 273BACKAdd BLAST102
Repeati317 – 365Kelch 1Add BLAST49
Repeati366 – 419Kelch 2Add BLAST54
Repeati420 – 466Kelch 3Add BLAST47
Repeati468 – 513Kelch 4Add BLAST46
Repeati515 – 565Kelch 5Add BLAST51
Repeati566 – 614Kelch 6Add BLAST49

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
HOGENOMiHOG000231583
HOVERGENiHBG101156
InParanoidiQ8BWA5
KOiK10467
PhylomeDBiQ8BWA5

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BWA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKKTIKK NKAEINEMTI IVEDSPLSKL NALNGLLEGS NSLSCVSSEL
60 70 80 90 100
TDTSYGPNLL EGLSKMRQES FLCDLVIGTK TKSFDVHKSV MASCSEYFYN
110 120 130 140 150
ILKNDPSTKR VDLNDIAPLG LATVIAYAYT GKLTLSLYTI GSIISAAVYL
160 170 180 190 200
QIHTLVKMCS DFLIREISVE NCMYVVNIAE TYSLKNAKAT AQKFIRDNFI
210 220 230 240 250
EFAESEQFMK LTFEQINELL VDDDLQLPSE LVAFQIAMKW LEFDQKRVKH
260 270 280 290 300
AADLLSNIRF GTISAQDLVN YVQTVPRMMQ DADCHKLLVD AMNYHLLPYH
310 320 330 340 350
QNTLQSRRTR IRGGCRVLIT VGGRPGLTEK SLSRDILYRD PENGWSKLTE
360 370 380 390 400
MPAKSFNQCV AVMDGFLYVA GGEDQNDARN QAKHAVSNFC RYDPRFNTWI
410 420 430 440 450
HLGSMNQKRT HFSLSVFNGL LYAVGGRNSE GSLASLECYV PSTNQWQPKA
460 470 480 490 500
PLEVARCCHA SAVADGRVIV TGGYIGSAYS RSVCAYDPAL DAWQELPQLS
510 520 530 540 550
TPRGWHCAVA LGDRLYVMGG SQLGPRGERV DVLTVESFSP AARQWSFVAP
560 570 580 590 600
LPVGVSTAGV SALHGRAYLL GGWNEGDKKY KKCIQCFNPE LNEWTEDDEL
610 620 630
PEATVGVSCC TLAMPNSVSR ESRASSVSSV PVSI
Length:634
Mass (Da):70,181
Last modified:March 1, 2003 - v1
Checksum:iCDAA6821191AAF5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053085 mRNA Translation: BAC35261.1
CCDSiCCDS23352.1
RefSeqiNP_766513.2, NM_172925.2
UniGeneiMm.138238

Genome annotation databases

GeneIDi244923
KEGGimmu:244923

Similar proteinsi

Entry informationi

Entry nameiKLH31_MOUSE
AccessioniPrimary (citable) accession number: Q8BWA5
Secondary accession number(s): Q148Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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