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Q8BW93

- C5AR2_MOUSE

UniProt

Q8BW93 - C5AR2_MOUSE

Protein

C5a anaphylatoxin chemotactic receptor 2

Gene

C5ar2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways By similarity.By similarity

    GO - Molecular functioni

    1. C5a anaphylatoxin receptor activity Source: InterPro

    GO - Biological processi

    1. chemotaxis Source: InterPro
    2. inflammatory response Source: InterPro
    3. negative regulation of interleukin-6 secretion Source: UniProtKB
    4. negative regulation of neutrophil chemotaxis Source: UniProtKB
    5. negative regulation of tumor necrosis factor production Source: UniProtKB
    6. positive regulation of epithelial cell proliferation Source: InterPro
    7. positive regulation of ERK1 and ERK2 cascade Source: InterPro
    8. regulation of interleukin-8 secretion Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C5a anaphylatoxin chemotactic receptor 2
    Alternative name(s):
    Complement component 5a receptor 2
    G-protein coupled receptor 77
    Gene namesi
    Name:C5ar2
    Synonyms:C5l2, Gpr77
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2442013. C5ar2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: UniProtKB
    2. basal plasma membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344C5a anaphylatoxin chemotactic receptor 2PRO_0000303083Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi113 ↔ 192PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8BW93.

    PTM databases

    PhosphoSiteiQ8BW93.

    Expressioni

    Tissue specificityi

    Highly expressed in liver and spleen. Lower levels in intestine, brain and kidney. Also expressed in adipose tissues with highest levels in gonadal and ingual fat depots. Lower levels in brown tissue.1 Publication

    Gene expression databases

    BgeeiQ8BW93.
    CleanExiMM_GPR77.
    GenevestigatoriQ8BW93.

    Interactioni

    Subunit structurei

    Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.By similarity

    Protein-protein interaction databases

    IntActiQ8BW93. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BW93.
    SMRiQ8BW93. Positions 42-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 7811CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini102 – 12019ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini144 – 15512CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 20830ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini232 – 24312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini267 – 28014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini301 – 34444CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6723Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei79 – 10123Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei121 – 14323Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17823Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 23123Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26623Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG151055.
    HOGENOMiHOG000234122.
    HOVERGENiHBG107547.
    InParanoidiB2RQI1.
    KOiK04171.
    PhylomeDBiQ8BW93.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001274. Anaphtx_C5AR1/C5AR2.
    IPR027809. Anaphtx_C5AR2.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF1. PTHR24225:SF1. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00426. C5ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BW93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMNHTTSEYY DYEYDHEHYS DLPDVPVDCP AGTCFTSDVY LIVLLVLYAA    50
    VFLVGVPGNT LVAWVTWKES RHRLGASWFL HLTMADLLCC VSLPFLAVPI 100
    AQKGHWPYGA AGCWLLSSIT ILSMYASVLL LTGLSGDLFL LAFRPSWKGA 150
    DHRTFGVRVV QASSWMLGLL LTVPSAVYRR LLQEHYPPRL VCGIDYGGSV 200
    SAEVAITTVR FLFGFLGPLV FMAGCHGILQ RQMARRHWPL GTAVVVGFFI 250
    CWTPYHVLRV IIAAAPPHSL LLARVLEAEP LFNGLALAHS ALNPIMFLYF 300
    GRKQLCKSLQ AACHWALRDP QDEESAVTKV SISTSHEMVS EMPV 344
    Length:344
    Mass (Da):38,199
    Last modified:March 1, 2003 - v1
    Checksum:i508FFD23F01B31C8
    GO

    Sequence cautioni

    The sequence BAE35590.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61T → N in BAE35590. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053187 mRNA. Translation: BAC35303.1.
    AK160050 mRNA. Translation: BAE35590.1. Different initiation.
    BC137941 mRNA. Translation: AAI37942.1.
    BC145834 mRNA. Translation: AAI45835.1.
    RefSeqiNP_001139477.1. NM_001146005.1.
    NP_795886.2. NM_176912.4.
    XP_006540115.1. XM_006540052.1.
    XP_006540116.1. XM_006540053.1.
    XP_006540117.1. XM_006540054.1.
    XP_006540118.1. XM_006540055.1.
    XP_006540119.1. XM_006540056.1.
    XP_006540120.1. XM_006540057.1.
    UniGeneiMm.239570.

    Genome annotation databases

    GeneIDi319430.
    KEGGimmu:319430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053187 mRNA. Translation: BAC35303.1 .
    AK160050 mRNA. Translation: BAE35590.1 . Different initiation.
    BC137941 mRNA. Translation: AAI37942.1 .
    BC145834 mRNA. Translation: AAI45835.1 .
    RefSeqi NP_001139477.1. NM_001146005.1.
    NP_795886.2. NM_176912.4.
    XP_006540115.1. XM_006540052.1.
    XP_006540116.1. XM_006540053.1.
    XP_006540117.1. XM_006540054.1.
    XP_006540118.1. XM_006540055.1.
    XP_006540119.1. XM_006540056.1.
    XP_006540120.1. XM_006540057.1.
    UniGenei Mm.239570.

    3D structure databases

    ProteinModelPortali Q8BW93.
    SMRi Q8BW93. Positions 42-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BW93. 1 interaction.

    Chemistry

    GuidetoPHARMACOLOGYi 33.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8BW93.

    Proteomic databases

    PRIDEi Q8BW93.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 319430.
    KEGGi mmu:319430.

    Organism-specific databases

    CTDi 27202.
    MGIi MGI:2442013. C5ar2.

    Phylogenomic databases

    eggNOGi NOG151055.
    HOGENOMi HOG000234122.
    HOVERGENi HBG107547.
    InParanoidi B2RQI1.
    KOi K04171.
    PhylomeDBi Q8BW93.

    Miscellaneous databases

    NextBioi 394718.
    PROi Q8BW93.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BW93.
    CleanExi MM_GPR77.
    Genevestigatori Q8BW93.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001274. Anaphtx_C5AR1/C5AR2.
    IPR027809. Anaphtx_C5AR2.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF1. PTHR24225:SF1. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00426. C5ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "C5L2 is a functional receptor for acylation-stimulating protein."
      Kalant D., MacLaren R., Cui W., Samanta R., Monk P.N., Laporte S.A., Cianflone K.
      J. Biol. Chem. 280:23936-23944(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiC5AR2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BW93
    Secondary accession number(s): B2RQI1, Q3TVM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3