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Q8BW93

- C5AR2_MOUSE

UniProt

Q8BW93 - C5AR2_MOUSE

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Protein

C5a anaphylatoxin chemotactic receptor 2

Gene

C5ar2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways (By similarity).By similarity

GO - Molecular functioni

  1. C5a anaphylatoxin receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: InterPro
  2. inflammatory response Source: InterPro
  3. negative regulation of interleukin-6 secretion Source: UniProtKB
  4. negative regulation of neutrophil chemotaxis Source: UniProtKB
  5. negative regulation of tumor necrosis factor production Source: UniProtKB
  6. positive regulation of epithelial cell proliferation Source: InterPro
  7. positive regulation of ERK1 and ERK2 cascade Source: InterPro
  8. regulation of interleukin-8 secretion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 2
Alternative name(s):
Complement component 5a receptor 2
G-protein coupled receptor 77
Gene namesi
Name:C5ar2
Synonyms:C5l2, Gpr77
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2442013. C5ar2.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: UniProtKB
  2. basal plasma membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344C5a anaphylatoxin chemotactic receptor 2PRO_0000303083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi113 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8BW93.

PTM databases

PhosphoSiteiQ8BW93.

Expressioni

Tissue specificityi

Highly expressed in liver and spleen. Lower levels in intestine, brain and kidney. Also expressed in adipose tissues with highest levels in gonadal and ingual fat depots. Lower levels in brown tissue.1 Publication

Gene expression databases

BgeeiQ8BW93.
CleanExiMM_GPR77.
ExpressionAtlasiQ8BW93. baseline and differential.
GenevestigatoriQ8BW93.

Interactioni

Subunit structurei

Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.By similarity

Protein-protein interaction databases

IntActiQ8BW93. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8BW93.
SMRiQ8BW93. Positions 42-300.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
BLAST
Topological domaini68 – 7811CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini102 – 12019ExtracellularSequence AnalysisAdd
BLAST
Topological domaini144 – 15512CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini179 – 20830ExtracellularSequence AnalysisAdd
BLAST
Topological domaini232 – 24312CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini267 – 28014ExtracellularSequence AnalysisAdd
BLAST
Topological domaini301 – 34444CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6723Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei79 – 10123Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei121 – 14323Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei156 – 17823Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei209 – 23123Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei244 – 26623Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei281 – 30020Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151055.
HOGENOMiHOG000234122.
HOVERGENiHBG107547.
InParanoidiQ8BW93.
KOiK04171.
PhylomeDBiQ8BW93.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001274. Anaphtx_C5AR1/C5AR2.
IPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BW93 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMNHTTSEYY DYEYDHEHYS DLPDVPVDCP AGTCFTSDVY LIVLLVLYAA
60 70 80 90 100
VFLVGVPGNT LVAWVTWKES RHRLGASWFL HLTMADLLCC VSLPFLAVPI
110 120 130 140 150
AQKGHWPYGA AGCWLLSSIT ILSMYASVLL LTGLSGDLFL LAFRPSWKGA
160 170 180 190 200
DHRTFGVRVV QASSWMLGLL LTVPSAVYRR LLQEHYPPRL VCGIDYGGSV
210 220 230 240 250
SAEVAITTVR FLFGFLGPLV FMAGCHGILQ RQMARRHWPL GTAVVVGFFI
260 270 280 290 300
CWTPYHVLRV IIAAAPPHSL LLARVLEAEP LFNGLALAHS ALNPIMFLYF
310 320 330 340
GRKQLCKSLQ AACHWALRDP QDEESAVTKV SISTSHEMVS EMPV
Length:344
Mass (Da):38,199
Last modified:March 1, 2003 - v1
Checksum:i508FFD23F01B31C8
GO

Sequence cautioni

The sequence BAE35590.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61T → N in BAE35590. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK053187 mRNA. Translation: BAC35303.1.
AK160050 mRNA. Translation: BAE35590.1. Different initiation.
BC137941 mRNA. Translation: AAI37942.1.
BC145834 mRNA. Translation: AAI45835.1.
RefSeqiNP_001139477.1. NM_001146005.1.
NP_795886.2. NM_176912.4.
XP_006540115.1. XM_006540052.1.
XP_006540116.1. XM_006540053.1.
XP_006540117.1. XM_006540054.1.
XP_006540118.1. XM_006540055.1.
XP_006540119.1. XM_006540056.1.
XP_006540120.1. XM_006540057.1.
UniGeneiMm.239570.

Genome annotation databases

GeneIDi319430.
KEGGimmu:319430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK053187 mRNA. Translation: BAC35303.1 .
AK160050 mRNA. Translation: BAE35590.1 . Different initiation.
BC137941 mRNA. Translation: AAI37942.1 .
BC145834 mRNA. Translation: AAI45835.1 .
RefSeqi NP_001139477.1. NM_001146005.1.
NP_795886.2. NM_176912.4.
XP_006540115.1. XM_006540052.1.
XP_006540116.1. XM_006540053.1.
XP_006540117.1. XM_006540054.1.
XP_006540118.1. XM_006540055.1.
XP_006540119.1. XM_006540056.1.
XP_006540120.1. XM_006540057.1.
UniGenei Mm.239570.

3D structure databases

ProteinModelPortali Q8BW93.
SMRi Q8BW93. Positions 42-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BW93. 1 interaction.

Chemistry

GuidetoPHARMACOLOGYi 33.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8BW93.

Proteomic databases

PRIDEi Q8BW93.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 319430.
KEGGi mmu:319430.

Organism-specific databases

CTDi 27202.
MGIi MGI:2442013. C5ar2.

Phylogenomic databases

eggNOGi NOG151055.
HOGENOMi HOG000234122.
HOVERGENi HBG107547.
InParanoidi Q8BW93.
KOi K04171.
PhylomeDBi Q8BW93.

Miscellaneous databases

NextBioi 394718.
PROi Q8BW93.
SOURCEi Search...

Gene expression databases

Bgeei Q8BW93.
CleanExi MM_GPR77.
ExpressionAtlasi Q8BW93. baseline and differential.
Genevestigatori Q8BW93.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001274. Anaphtx_C5AR1/C5AR2.
IPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "C5L2 is a functional receptor for acylation-stimulating protein."
    Kalant D., MacLaren R., Cui W., Samanta R., Monk P.N., Laporte S.A., Cianflone K.
    J. Biol. Chem. 280:23936-23944(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiC5AR2_MOUSE
AccessioniPrimary (citable) accession number: Q8BW93
Secondary accession number(s): B2RQI1, Q3TVM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3