Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C5a anaphylatoxin chemotactic receptor 2

Gene

C5ar2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 2
Alternative name(s):
Complement component 5a receptor 2
G-protein coupled receptor 77
Gene namesi
Name:C5ar2
Synonyms:C5l2, Gpr77
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442013. C5ar2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 67Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini68 – 78CytoplasmicSequence analysisAdd BLAST11
Transmembranei79 – 101Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini102 – 120ExtracellularSequence analysisAdd BLAST19
Transmembranei121 – 143Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini144 – 155CytoplasmicSequence analysisAdd BLAST12
Transmembranei156 – 178Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini179 – 208ExtracellularSequence analysisAdd BLAST30
Transmembranei209 – 231Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini232 – 243CytoplasmicSequence analysisAdd BLAST12
Transmembranei244 – 266Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini267 – 280ExtracellularSequence analysisAdd BLAST14
Transmembranei281 – 300Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini301 – 344CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi33.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003030831 – 344C5a anaphylatoxin chemotactic receptor 2Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi113 ↔ 192PROSITE-ProRule annotation
Modified residuei325PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BW93.
PRIDEiQ8BW93.

PTM databases

PhosphoSitePlusiQ8BW93.

Expressioni

Tissue specificityi

Highly expressed in liver and spleen. Lower levels in intestine, brain and kidney. Also expressed in adipose tissues with highest levels in gonadal and ingual fat depots. Lower levels in brown tissue.1 Publication

Gene expression databases

BgeeiENSMUSG00000074361.
CleanExiMM_GPR77.

Interactioni

Subunit structurei

Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.By similarity

Protein-protein interaction databases

IntActiQ8BW93. 1 interactor.
STRINGi10090.ENSMUSP00000096389.

Structurei

3D structure databases

ProteinModelPortaliQ8BW93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHWH. Eukaryota.
ENOG4111DWV. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG107547.
InParanoidiQ8BW93.
KOiK04171.
PhylomeDBiQ8BW93.

Family and domain databases

InterProiIPR001274. Anaphtx_C5AR1/C5AR2.
IPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BW93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNHTTSEYY DYEYDHEHYS DLPDVPVDCP AGTCFTSDVY LIVLLVLYAA
60 70 80 90 100
VFLVGVPGNT LVAWVTWKES RHRLGASWFL HLTMADLLCC VSLPFLAVPI
110 120 130 140 150
AQKGHWPYGA AGCWLLSSIT ILSMYASVLL LTGLSGDLFL LAFRPSWKGA
160 170 180 190 200
DHRTFGVRVV QASSWMLGLL LTVPSAVYRR LLQEHYPPRL VCGIDYGGSV
210 220 230 240 250
SAEVAITTVR FLFGFLGPLV FMAGCHGILQ RQMARRHWPL GTAVVVGFFI
260 270 280 290 300
CWTPYHVLRV IIAAAPPHSL LLARVLEAEP LFNGLALAHS ALNPIMFLYF
310 320 330 340
GRKQLCKSLQ AACHWALRDP QDEESAVTKV SISTSHEMVS EMPV
Length:344
Mass (Da):38,199
Last modified:March 1, 2003 - v1
Checksum:i508FFD23F01B31C8
GO

Sequence cautioni

The sequence BAE35590 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6T → N in BAE35590 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053187 mRNA. Translation: BAC35303.1.
AK160050 mRNA. Translation: BAE35590.1. Different initiation.
BC137941 mRNA. Translation: AAI37942.1.
BC145834 mRNA. Translation: AAI45835.1.
RefSeqiNP_001139477.1. NM_001146005.1.
NP_795886.2. NM_176912.4.
XP_006540112.2. XM_006540049.2.
XP_006540115.1. XM_006540052.3.
XP_006540116.1. XM_006540053.3.
XP_006540117.1. XM_006540054.3.
XP_006540118.1. XM_006540055.3.
XP_006540119.1. XM_006540056.2.
UniGeneiMm.239570.

Genome annotation databases

GeneIDi319430.
KEGGimmu:319430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053187 mRNA. Translation: BAC35303.1.
AK160050 mRNA. Translation: BAE35590.1. Different initiation.
BC137941 mRNA. Translation: AAI37942.1.
BC145834 mRNA. Translation: AAI45835.1.
RefSeqiNP_001139477.1. NM_001146005.1.
NP_795886.2. NM_176912.4.
XP_006540112.2. XM_006540049.2.
XP_006540115.1. XM_006540052.3.
XP_006540116.1. XM_006540053.3.
XP_006540117.1. XM_006540054.3.
XP_006540118.1. XM_006540055.3.
XP_006540119.1. XM_006540056.2.
UniGeneiMm.239570.

3D structure databases

ProteinModelPortaliQ8BW93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BW93. 1 interactor.
STRINGi10090.ENSMUSP00000096389.

Chemistry databases

GuidetoPHARMACOLOGYi33.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8BW93.

Proteomic databases

PaxDbiQ8BW93.
PRIDEiQ8BW93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi319430.
KEGGimmu:319430.

Organism-specific databases

CTDi27202.
MGIiMGI:2442013. C5ar2.

Phylogenomic databases

eggNOGiENOG410IHWH. Eukaryota.
ENOG4111DWV. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG107547.
InParanoidiQ8BW93.
KOiK04171.
PhylomeDBiQ8BW93.

Miscellaneous databases

PROiQ8BW93.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074361.
CleanExiMM_GPR77.

Family and domain databases

InterProiIPR001274. Anaphtx_C5AR1/C5AR2.
IPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC5AR2_MOUSE
AccessioniPrimary (citable) accession number: Q8BW93
Secondary accession number(s): B2RQI1, Q3TVM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.