Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8BW93 (C5AR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C5a anaphylatoxin chemotactic receptor 2
Alternative name(s):
Complement component 5a receptor 2
G-protein coupled receptor 77
Gene names
Name:C5ar2
Synonyms:C5l2, Gpr77
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways By similarity.

Subunit structure

Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in liver and spleen. Lower levels in intestine, brain and kidney. Also expressed in adipose tissues with highest levels in gonadal and ingual fat depots. Lower levels in brown tissue. Ref.3

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAE35590.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344C5a anaphylatoxin chemotactic receptor 2
PRO_0000303083

Regions

Topological domain1 – 4444Extracellular Potential
Transmembrane45 – 6723Helical; Name=1; Potential
Topological domain68 – 7811Cytoplasmic Potential
Transmembrane79 – 10123Helical; Name=2; Potential
Topological domain102 – 12019Extracellular Potential
Transmembrane121 – 14323Helical; Name=3; Potential
Topological domain144 – 15512Cytoplasmic Potential
Transmembrane156 – 17823Helical; Name=4; Potential
Topological domain179 – 20830Extracellular Potential
Transmembrane209 – 23123Helical; Name=5; Potential
Topological domain232 – 24312Cytoplasmic Potential
Transmembrane244 – 26623Helical; Name=6; Potential
Topological domain267 – 28014Extracellular Potential
Transmembrane281 – 30020Helical; Name=7; Potential
Topological domain301 – 34444Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Disulfide bond113 ↔ 192 By similarity

Experimental info

Sequence conflict61T → N in BAE35590. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BW93 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 508FFD23F01B31C8

FASTA34438,199
        10         20         30         40         50         60 
MMNHTTSEYY DYEYDHEHYS DLPDVPVDCP AGTCFTSDVY LIVLLVLYAA VFLVGVPGNT 

        70         80         90        100        110        120 
LVAWVTWKES RHRLGASWFL HLTMADLLCC VSLPFLAVPI AQKGHWPYGA AGCWLLSSIT 

       130        140        150        160        170        180 
ILSMYASVLL LTGLSGDLFL LAFRPSWKGA DHRTFGVRVV QASSWMLGLL LTVPSAVYRR 

       190        200        210        220        230        240 
LLQEHYPPRL VCGIDYGGSV SAEVAITTVR FLFGFLGPLV FMAGCHGILQ RQMARRHWPL 

       250        260        270        280        290        300 
GTAVVVGFFI CWTPYHVLRV IIAAAPPHSL LLARVLEAEP LFNGLALAHS ALNPIMFLYF 

       310        320        330        340 
GRKQLCKSLQ AACHWALRDP QDEESAVTKV SISTSHEMVS EMPV 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"C5L2 is a functional receptor for acylation-stimulating protein."
Kalant D., MacLaren R., Cui W., Samanta R., Monk P.N., Laporte S.A., Cianflone K.
J. Biol. Chem. 280:23936-23944(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK053187 mRNA. Translation: BAC35303.1.
AK160050 mRNA. Translation: BAE35590.1. Different initiation.
BC137941 mRNA. Translation: AAI37942.1.
BC145834 mRNA. Translation: AAI45835.1.
RefSeqNP_001139477.1. NM_001146005.1.
NP_795886.2. NM_176912.4.
XP_006540115.1. XM_006540052.1.
XP_006540116.1. XM_006540053.1.
XP_006540117.1. XM_006540054.1.
XP_006540118.1. XM_006540055.1.
XP_006540119.1. XM_006540056.1.
XP_006540120.1. XM_006540057.1.
UniGeneMm.239570.

3D structure databases

ProteinModelPortalQ8BW93.
SMRQ8BW93. Positions 42-300.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8BW93. 1 interaction.

Chemistry

GuidetoPHARMACOLOGY33.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8BW93.

Proteomic databases

PRIDEQ8BW93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID319430.
KEGGmmu:319430.

Organism-specific databases

CTD27202.
MGIMGI:2442013. C5ar2.

Phylogenomic databases

eggNOGNOG151055.
HOGENOMHOG000234122.
HOVERGENHBG107547.
InParanoidB2RQI1.
KOK04171.
PhylomeDBQ8BW93.

Gene expression databases

BgeeQ8BW93.
CleanExMM_GPR77.
GenevestigatorQ8BW93.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001274. Anaphtx_C5AR1/C5AR2.
IPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio394718.
PROQ8BW93.
SOURCESearch...

Entry information

Entry nameC5AR2_MOUSE
AccessionPrimary (citable) accession number: Q8BW93
Secondary accession number(s): B2RQI1, Q3TVM8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries