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Protein

C5a anaphylatoxin chemotactic receptor 2

Gene

C5ar2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 2
Alternative name(s):
Complement component 5a receptor 2
G-protein coupled receptor 77
Gene namesi
Name:C5ar2
Synonyms:C5l2, Gpr77
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442013. C5ar2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 67Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini68 – 78CytoplasmicSequence analysisAdd BLAST11
Transmembranei79 – 101Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini102 – 120ExtracellularSequence analysisAdd BLAST19
Transmembranei121 – 143Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini144 – 155CytoplasmicSequence analysisAdd BLAST12
Transmembranei156 – 178Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini179 – 208ExtracellularSequence analysisAdd BLAST30
Transmembranei209 – 231Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini232 – 243CytoplasmicSequence analysisAdd BLAST12
Transmembranei244 – 266Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini267 – 280ExtracellularSequence analysisAdd BLAST14
Transmembranei281 – 300Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini301 – 344CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi33.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003030831 – 344C5a anaphylatoxin chemotactic receptor 2Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 192PROSITE-ProRule annotation
Modified residuei325PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BW93.
PaxDbiQ8BW93.
PRIDEiQ8BW93.

PTM databases

PhosphoSitePlusiQ8BW93.

Expressioni

Tissue specificityi

Highly expressed in liver and spleen. Lower levels in intestine, brain and kidney. Also expressed in adipose tissues with highest levels in gonadal and ingual fat depots. Lower levels in brown tissue.1 Publication

Gene expression databases

CleanExiMM_GPR77.

Interactioni

Subunit structurei

Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.By similarity

Protein-protein interaction databases

IntActiQ8BW93. 1 interactor.
STRINGi10090.ENSMUSP00000096389.

Structurei

3D structure databases

ProteinModelPortaliQ8BW93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHWH. Eukaryota.
ENOG4111DWV. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG107547.
InParanoidiQ8BW93.
KOiK04171.
PhylomeDBiQ8BW93.

Family and domain databases

InterProiView protein in InterPro
IPR001274. Anaphtx_C5AR1/C5AR2.
IPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 2 hits.
PRINTSiPR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BW93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNHTTSEYY DYEYDHEHYS DLPDVPVDCP AGTCFTSDVY LIVLLVLYAA
60 70 80 90 100
VFLVGVPGNT LVAWVTWKES RHRLGASWFL HLTMADLLCC VSLPFLAVPI
110 120 130 140 150
AQKGHWPYGA AGCWLLSSIT ILSMYASVLL LTGLSGDLFL LAFRPSWKGA
160 170 180 190 200
DHRTFGVRVV QASSWMLGLL LTVPSAVYRR LLQEHYPPRL VCGIDYGGSV
210 220 230 240 250
SAEVAITTVR FLFGFLGPLV FMAGCHGILQ RQMARRHWPL GTAVVVGFFI
260 270 280 290 300
CWTPYHVLRV IIAAAPPHSL LLARVLEAEP LFNGLALAHS ALNPIMFLYF
310 320 330 340
GRKQLCKSLQ AACHWALRDP QDEESAVTKV SISTSHEMVS EMPV
Length:344
Mass (Da):38,199
Last modified:March 1, 2003 - v1
Checksum:i508FFD23F01B31C8
GO

Sequence cautioni

Q8BW93: The sequence BAE35590 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6T → N in BAE35590 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053187 mRNA. Translation: BAC35303.1.
AK160050 mRNA. Translation: BAE35590.1. Different initiation.
BC137941 mRNA. Translation: AAI37942.1.
BC145834 mRNA. Translation: AAI45835.1.
RefSeqiNP_001139477.1. NM_001146005.1.
NP_795886.2. NM_176912.4.
XP_006540112.2. XM_006540049.2.
XP_006540115.1. XM_006540052.3.
XP_006540116.1. XM_006540053.3.
XP_006540117.1. XM_006540054.3.
XP_006540118.1. XM_006540055.3.
XP_006540119.1. XM_006540056.2.
UniGeneiMm.239570.

Genome annotation databases

GeneIDi319430.
KEGGimmu:319430.

Similar proteinsi

Entry informationi

Entry nameiC5AR2_MOUSE
AccessioniPrimary (citable) accession number: Q8BW93
Secondary accession number(s): B2RQI1, Q3TVM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families