Reviewed,
UniProtKB/Swiss-Prot Q8BW75 (AOFB_MOUSE)
Last modified
November 25, 2008.
Version 43.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Amine oxidase [flavin-containing] B EC=1.4.3.4 Alternative name(s): Monoamine oxidase type B Short name=MAO-B | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 520 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine By similarity. |
| Catalytic activity | RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2). |
| Cofactor | FAD By similarity. |
| Subunit structure | Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity. |
| Subcellular location | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic sideBy similarity. |
| Sequence similarities | Belongs to the flavin monoamine oxidase family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane Mitochondrion Mitochondrion outer membrane |
| Domain | Transmembrane |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| PTM | Acetylation |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membraneInferred from direct assay. Source: MGI mitochondrial outer membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | amine oxidase activity Inferred from electronic annotation. Source: EC electron carrier activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 520 | 519 | Amine oxidase [flavin-containing] B | PRO_0000099860 | |||||
Regions | |||||||||
| Topological domain | 2 – 489 | 488 | Cytoplasmic By similarity | ||||||
| Transmembrane | 490 – 516 | 27 | Anchor for type IV membrane protein By similarity | ||||||
| Topological domain | 517 – 520 | 4 | Mitochondrial intermembrane By similarity | ||||||
| Compositional bias | 36 – 52 | 17 | Arg/Lys-rich (basic) | ||||||
Sites | |||||||||
| Site | 156 | 1 | Important for catalytic activity By similarity | ||||||
| Site | 365 | 1 | Important for catalytic activity By similarity | ||||||
| Site | 382 | 1 | Important for catalytic activity By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylserine By similarity | ||||||
| Modified residue | 52 | 1 | N6-acetyllysine | ||||||
| Modified residue | 397 | 1 | S-8alpha-FAD cysteine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 408 | 1 | S → T in BAC27571. Ref.1 | ||||||
| Sequence conflict | 482 | 1 | L → M in BAC27571. Ref.1 | ||||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Medulla oblongata and Oviduct. |
| [2] | "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey." Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y. Mol. Cell 23:607-618(2006) [PubMed: 16916647] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-52, MASS SPECTROMETRY. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AK031833 mRNA. Translation: BAC27571.1. AK054050 mRNA. Translation: BAC35634.1. | |
| RefSeq | NP_766366.1. |
| UniGene | Mm.465301 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GOS based on UniProtKB P27338. |
| SMR | Q8BW75. Positions 2-500, 3-501. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q8BW75. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000040147. Mus musculus. [Contig view] |
| GeneID | 109731. |
| KEGG | mmu:109731. |
Organism-specific databases | |
| MGI | MGI:96916. Maob. |
Phylogenomic databases | |
| HOGENOM | Q8BW75. |
| HOVERGEN | Q8BW75. |
Gene expression databases | |
| ArrayExpress | Q8BW75. |
| CleanEx | MM_MAOB. |
| GermOnline | ENSMUSG00000040147. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001613. Amineoxid_fl. IPR002937. Amino_oxidase. [Graphical view] |
| Pfam | PF01593. Amino_oxidase. 1 hit. [Graphical view] |
| PRINTS | PR00757. AMINEOXDASEF. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 362651. |
| SOURCE | Search... |
Entry information
| Entry name | AOFB_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8BW75 Secondary accession number(s): Q8C0B2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

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