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Protein

Amine oxidase [flavin-containing] B

Gene

Maob

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity).By similarity

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei156Important for catalytic activityBy similarity1
Sitei365Important for catalytic activityBy similarity1
Sitei382Important for catalytic activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.4.3.4 3474
ReactomeiR-MMU-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] B (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type B
Short name:
MAO-B
Gene namesi
Name:Maob
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:96916 Maob

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 489CytoplasmicBy similarityAdd BLAST488
Transmembranei490 – 516Helical; Anchor for type IV membrane proteinBy similarityAdd BLAST27
Topological domaini517 – 520Mitochondrial intermembraneBy similarity4

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3050

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000998602 – 520Amine oxidase [flavin-containing] BAdd BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei52N6-acetyllysineCombined sources1
Modified residuei248N6-acetyllysineCombined sources1
Modified residuei397S-8alpha-FAD cysteineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8BW75
PaxDbiQ8BW75
PeptideAtlasiQ8BW75
PRIDEiQ8BW75

PTM databases

iPTMnetiQ8BW75
PhosphoSitePlusiQ8BW75
SwissPalmiQ8BW75

Expressioni

Gene expression databases

BgeeiENSMUSG00000040147
CleanExiMM_MAOB
ExpressionAtlasiQ8BW75 baseline and differential
GenevisibleiQ8BW75 MM

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi224990, 1 interactor
IntActiQ8BW75, 3 interactors
MINTiQ8BW75
STRINGi10090.ENSMUSP00000040550

Chemistry databases

BindingDBiQ8BW75

Structurei

3D structure databases

ProteinModelPortaliQ8BW75
SMRiQ8BW75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 52Arg/Lys-rich (basic)Add BLAST17

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
GeneTreeiENSGT00730000110903
HOGENOMiHOG000221615
HOVERGENiHBG004255
InParanoidiQ8BW75
KOiK00274
OMAiPWKAPLA
OrthoDBiEOG091G0G7P
TreeFamiTF313314

Family and domain databases

Gene3Di3.50.50.60, 4 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PRINTSiPR00757 AMINEOXDASEF
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BW75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKSDVIVV GGGISGMAAA KLLHDCGLSV VVLEARDRVG GRTYTIRNKN
60 70 80 90 100
VKYVDLGGSY VGPTQNRILR LAKELGLETY KVNEVERLIH FVKGKSYAFR
110 120 130 140 150
GPFPPVWNPI TYLDNNNLWR TMDEMGQEIP SDAPWKAPLA EEWDYMTMKE
160 170 180 190 200
LLDKICWTKS TKQIATLFVN LCVTAETHEV SALWFLWYVK QCGGTTRIIS
210 220 230 240 250
TTNGGQERKF IGGSGQVSER IKDILGDRVK LERPVIHIDQ TGENVIVKTL
260 270 280 290 300
NHEIYEAKYV ISAIPPALGM KIHYSPPLPM LRNQLISRVP LGSVIKCMVY
310 320 330 340 350
YKEPFWRKKD FCGTMVIEGE EAPIAYTLDD TKPDGTYAAI MGFILAHKAR
360 370 380 390 400
KLVRLTKEER LRKLCELYAK VLNSQEALQP VHYEEKNWCE EQYSGGCYTT
410 420 430 440 450
YFPPGILTQY GRVLRQPVGK IFFAGTETAS HWSGYMEGAV EAGERAAREI
460 470 480 490 500
LHAIGKIPED EIWQPEPESL DVPARPITST FLERHLPSVP GLLKLFGLTT
510 520
ILSATALGFL AHKRGLFVHF
Length:520
Mass (Da):58,558
Last modified:July 27, 2011 - v4
Checksum:iA5982EBBF5C4BD62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti408T → S in BAC35634 (PubMed:16141072).Curated1
Sequence conflicti482L → M in BAC27571 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031833 mRNA Translation: BAC27571.1
AK054050 mRNA Translation: BAC35634.1
AL732321, AL831729 Genomic DNA Translation: CAM16088.1
AL831729, AL732321 Genomic DNA Translation: CAM26633.1
CH466584 Genomic DNA Translation: EDL35718.1
BC113182 mRNA Translation: AAI13183.1
BC113788 mRNA Translation: AAI13789.1
CCDSiCCDS40882.1
RefSeqiNP_766366.2, NM_172778.2
UniGeneiMm.241656

Genome annotation databases

EnsembliENSMUST00000040820; ENSMUSP00000040550; ENSMUSG00000040147
GeneIDi109731
KEGGimmu:109731
UCSCiuc009ssb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAOFB_MOUSE
AccessioniPrimary (citable) accession number: Q8BW75
Secondary accession number(s): Q14CG9, Q8C0B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 122 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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