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Q8BW75

- AOFB_MOUSE

UniProt

Q8BW75 - AOFB_MOUSE

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Protein
Amine oxidase [flavin-containing] B
Gene
Maob
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine By similarity.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561Important for catalytic activity By similarity
Sitei365 – 3651Important for catalytic activity By similarity
Sitei382 – 3821Important for catalytic activity By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: Ensembl
  2. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of serotonin secretion Source: Ensembl
  2. positive regulation of dopamine metabolic process Source: Ensembl
  3. response to aluminum ion Source: Ensembl
  4. response to corticosterone Source: Ensembl
  5. response to drug Source: Ensembl
  6. response to ethanol Source: Ensembl
  7. response to lipopolysaccharide Source: Ensembl
  8. response to selenium ion Source: Ensembl
  9. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.4.3.4. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] B (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type B
Short name:
MAO-B
Gene namesi
Name:Maob
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:96916. Maob.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 489488Cytoplasmic By similarity
Add
BLAST
Transmembranei490 – 51627Helical; Anchor for type IV membrane protein; By similarity
Add
BLAST
Topological domaini517 – 5204Mitochondrial intermembrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrial outer membrane Source: UniProtKB-SubCell
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 520519Amine oxidase [flavin-containing] B
PRO_0000099860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei52 – 521N6-acetyllysine1 Publication
Modified residuei248 – 2481N6-acetyllysine1 Publication
Modified residuei397 – 3971S-8alpha-FAD cysteine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8BW75.
PaxDbiQ8BW75.
PRIDEiQ8BW75.

PTM databases

PhosphoSiteiQ8BW75.

Expressioni

Gene expression databases

ArrayExpressiQ8BW75.
BgeeiQ8BW75.
CleanExiMM_MAOB.
GenevestigatoriQ8BW75.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Protein-protein interaction databases

IntActiQ8BW75. 2 interactions.
MINTiMINT-1861050.

Structurei

3D structure databases

ProteinModelPortaliQ8BW75.
SMRiQ8BW75. Positions 3-495.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 5217Arg/Lys-rich (basic)
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiQ14CG9.
KOiK00274.
OMAiIPPILGM.
OrthoDBiEOG7K6PTP.
TreeFamiTF313314.

Family and domain databases

InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BW75-1 [UniParc]FASTAAdd to Basket

« Hide

MSNKSDVIVV GGGISGMAAA KLLHDCGLSV VVLEARDRVG GRTYTIRNKN    50
VKYVDLGGSY VGPTQNRILR LAKELGLETY KVNEVERLIH FVKGKSYAFR 100
GPFPPVWNPI TYLDNNNLWR TMDEMGQEIP SDAPWKAPLA EEWDYMTMKE 150
LLDKICWTKS TKQIATLFVN LCVTAETHEV SALWFLWYVK QCGGTTRIIS 200
TTNGGQERKF IGGSGQVSER IKDILGDRVK LERPVIHIDQ TGENVIVKTL 250
NHEIYEAKYV ISAIPPALGM KIHYSPPLPM LRNQLISRVP LGSVIKCMVY 300
YKEPFWRKKD FCGTMVIEGE EAPIAYTLDD TKPDGTYAAI MGFILAHKAR 350
KLVRLTKEER LRKLCELYAK VLNSQEALQP VHYEEKNWCE EQYSGGCYTT 400
YFPPGILTQY GRVLRQPVGK IFFAGTETAS HWSGYMEGAV EAGERAAREI 450
LHAIGKIPED EIWQPEPESL DVPARPITST FLERHLPSVP GLLKLFGLTT 500
ILSATALGFL AHKRGLFVHF 520
Length:520
Mass (Da):58,558
Last modified:July 27, 2011 - v4
Checksum:iA5982EBBF5C4BD62
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti408 – 4081T → S in BAC35634. 1 Publication
Sequence conflicti482 – 4821L → M in BAC27571. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031833 mRNA. Translation: BAC27571.1.
AK054050 mRNA. Translation: BAC35634.1.
AL732321, AL831729 Genomic DNA. Translation: CAM16088.1.
AL831729, AL732321 Genomic DNA. Translation: CAM26633.1.
CH466584 Genomic DNA. Translation: EDL35718.1.
BC113182 mRNA. Translation: AAI13183.1.
BC113788 mRNA. Translation: AAI13789.1.
CCDSiCCDS40882.1.
RefSeqiNP_766366.2. NM_172778.2.
UniGeneiMm.241656.

Genome annotation databases

EnsembliENSMUST00000040820; ENSMUSP00000040550; ENSMUSG00000040147.
GeneIDi109731.
KEGGimmu:109731.
UCSCiuc009ssb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031833 mRNA. Translation: BAC27571.1 .
AK054050 mRNA. Translation: BAC35634.1 .
AL732321 , AL831729 Genomic DNA. Translation: CAM16088.1 .
AL831729 , AL732321 Genomic DNA. Translation: CAM26633.1 .
CH466584 Genomic DNA. Translation: EDL35718.1 .
BC113182 mRNA. Translation: AAI13183.1 .
BC113788 mRNA. Translation: AAI13789.1 .
CCDSi CCDS40882.1.
RefSeqi NP_766366.2. NM_172778.2.
UniGenei Mm.241656.

3D structure databases

ProteinModelPortali Q8BW75.
SMRi Q8BW75. Positions 3-495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BW75. 2 interactions.
MINTi MINT-1861050.

Chemistry

BindingDBi Q8BW75.
ChEMBLi CHEMBL2111442.

PTM databases

PhosphoSitei Q8BW75.

Proteomic databases

MaxQBi Q8BW75.
PaxDbi Q8BW75.
PRIDEi Q8BW75.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040820 ; ENSMUSP00000040550 ; ENSMUSG00000040147 .
GeneIDi 109731.
KEGGi mmu:109731.
UCSCi uc009ssb.2. mouse.

Organism-specific databases

CTDi 4129.
MGIi MGI:96916. Maob.

Phylogenomic databases

eggNOGi COG1231.
GeneTreei ENSGT00730000110903.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi Q14CG9.
KOi K00274.
OMAi IPPILGM.
OrthoDBi EOG7K6PTP.
TreeFami TF313314.

Enzyme and pathway databases

BRENDAi 1.4.3.4. 3474.

Miscellaneous databases

NextBioi 362651.
PROi Q8BW75.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BW75.
Bgeei Q8BW75.
CleanExi MM_MAOB.
Genevestigatori Q8BW75.

Family and domain databases

InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Medulla oblongata and Oviduct.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-52 AND LYS-248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiAOFB_MOUSE
AccessioniPrimary (citable) accession number: Q8BW75
Secondary accession number(s): Q14CG9, Q8C0B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 92 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi