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Q8BW74

- HLF_MOUSE

UniProt

Q8BW74 - HLF_MOUSE

Protein

Hepatic leukemia factor

Gene

Hlf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. rhythmic process Source: UniProtKB-KW
    2. skeletal muscle cell differentiation Source: MGI
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatic leukemia factor
    Gene namesi
    Name:Hlf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96108. Hlf.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Hepatic leukemia factorPRO_0000076511Add
    BLAST

    Proteomic databases

    PRIDEiQ8BW74.

    PTM databases

    PhosphoSiteiQ8BW74.

    Expressioni

    Inductioni

    Accumulates according to a robust circadian rhythm. Displays only a moderate amplitude in the liver (1.6-fold) and none in the brain.

    Gene expression databases

    BgeeiQ8BW74.
    CleanExiMM_HLF.
    GenevestigatoriQ8BW74.

    Interactioni

    Subunit structurei

    Binds DNA specifically as homodimer or heterodimer with other PAR factors.By similarity

    Protein-protein interaction databases

    BioGridi229842. 3 interactions.
    IntActiQ8BW74. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BW74.
    SMRiQ8BW74. Positions 231-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini225 – 28864bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni227 – 24721Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni248 – 2558Leucine-zipperPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi158 – 20952Pro-rich (proline/acidic region (PAR))Add
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. PAR subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG329624.
    GeneTreeiENSGT00440000039070.
    HOGENOMiHOG000234383.
    HOVERGENiHBG004983.
    InParanoidiQ8BW74.
    KOiK09057.
    OMAiLHPEDAF.
    OrthoDBiEOG712TZJ.
    TreeFamiTF315869.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF07716. bZIP_2. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BW74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKMSRQLPL NPTFIPPPYG VLRSLLENPL KLPLHPEDAF SKEKDKGKKL    50
    DDESSSPTVP QSAFLGPTLW DKTLPYDGDT FQLEYMDLEE FLSENGIPPS 100
    PSQHDHSPHP PGLQPASSTA PSVMDLSSRA TAPLHPGIPS PNCMQSPIRP 150
    GQLLPANRNT PSPIDPDTIQ VPVGYEPDPA DLALSSIPGQ EMFDPRKRKF 200
    SEEELKPQPM IKKARKVFIP DDLKDDKYWA RRRKNNMAAK RSRDARRLKE 250
    NQIAIRASFL EKENSALRQE VADLRKELGK CKNILAKYEA RHGPL 295
    Length:295
    Mass (Da):33,149
    Last modified:March 1, 2003 - v1
    Checksum:iD57CAB8601A954B4
    GO

    Sequence cautioni

    The sequence AAH57693.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 3812ENPLK…LHPED → KKQSSPFPFSSS in AAH57693. (PubMed:15489334)CuratedAdd
    BLAST
    Sequence conflicti224 – 2241K → KQ in AAH57693. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054062 mRNA. Translation: BAC35642.1.
    BC057693 mRNA. Translation: AAH57693.1. Different initiation.
    BC058705 mRNA. Translation: AAH58705.1.
    CCDSiCCDS25241.1.
    RefSeqiNP_766151.1. NM_172563.3.
    XP_006533068.1. XM_006533005.1.
    XP_006533069.1. XM_006533006.1.
    UniGeneiMm.158903.

    Genome annotation databases

    EnsembliENSMUST00000004051; ENSMUSP00000004051; ENSMUSG00000003949.
    GeneIDi217082.
    KEGGimmu:217082.
    UCSCiuc007kwr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054062 mRNA. Translation: BAC35642.1 .
    BC057693 mRNA. Translation: AAH57693.1 . Different initiation.
    BC058705 mRNA. Translation: AAH58705.1 .
    CCDSi CCDS25241.1.
    RefSeqi NP_766151.1. NM_172563.3.
    XP_006533068.1. XM_006533005.1.
    XP_006533069.1. XM_006533006.1.
    UniGenei Mm.158903.

    3D structure databases

    ProteinModelPortali Q8BW74.
    SMRi Q8BW74. Positions 231-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229842. 3 interactions.
    IntActi Q8BW74. 2 interactions.

    PTM databases

    PhosphoSitei Q8BW74.

    Proteomic databases

    PRIDEi Q8BW74.

    Protocols and materials databases

    DNASUi 217082.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004051 ; ENSMUSP00000004051 ; ENSMUSG00000003949 .
    GeneIDi 217082.
    KEGGi mmu:217082.
    UCSCi uc007kwr.1. mouse.

    Organism-specific databases

    CTDi 3131.
    MGIi MGI:96108. Hlf.

    Phylogenomic databases

    eggNOGi NOG329624.
    GeneTreei ENSGT00440000039070.
    HOGENOMi HOG000234383.
    HOVERGENi HBG004983.
    InParanoidi Q8BW74.
    KOi K09057.
    OMAi LHPEDAF.
    OrthoDBi EOG712TZJ.
    TreeFami TF315869.

    Miscellaneous databases

    ChiTaRSi HLF. mouse.
    NextBioi 375553.
    PROi Q8BW74.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BW74.
    CleanExi MM_HLF.
    Genevestigatori Q8BW74.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF07716. bZIP_2. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Diencephalon and Oviduct.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Liver.
    3. "The loss of circadian PAR bZip transcription factors results in epilepsy."
      Gachon F., Fonjallaz P., Damiola F., Gos P., Kodama T., Zakany J., Duboule D., Petit B., Tafti M., Schibler U.
      Genes Dev. 18:1397-1412(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN EPILEPSY.

    Entry informationi

    Entry nameiHLF_MOUSE
    AccessioniPrimary (citable) accession number: Q8BW74
    Secondary accession number(s): Q6PF83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Mice deficient for all three PAR bZIP proteins (DBP, HLF and TEF) display a dramatically shortened life span and are highly susceptible to generalized spontaneous and audiogenic epilepsies (due for example to the noise of a vacuum cleaner) that are frequently lethal. The down-regulation of pyridoxal kinase (Pdxk) expression in these mice may participate in this seizure phenotype.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3