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Protein

Hepatic leukemia factor

Gene

Hlf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • rhythmic process Source: UniProtKB-KW
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatic leukemia factor
Gene namesi
Name:Hlf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96108. Hlf.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Hepatic leukemia factorPRO_0000076511Add
BLAST

Proteomic databases

PRIDEiQ8BW74.

PTM databases

PhosphoSiteiQ8BW74.

Expressioni

Inductioni

Accumulates according to a robust circadian rhythm. Displays only a moderate amplitude in the liver (1.6-fold) and none in the brain.

Gene expression databases

BgeeiQ8BW74.
CleanExiMM_HLF.
GenevestigatoriQ8BW74.

Interactioni

Subunit structurei

Binds DNA specifically as homodimer or heterodimer with other PAR factors.By similarity

Protein-protein interaction databases

BioGridi229842. 3 interactions.
IntActiQ8BW74. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8BW74.
SMRiQ8BW74. Positions 253-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 28864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni227 – 24721Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni248 – 2558Leucine-zipperPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi158 – 20952Pro-rich (proline/acidic region (PAR))Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG329624.
GeneTreeiENSGT00440000039070.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiQ8BW74.
KOiK09057.
OMAiMEKMSRQ.
OrthoDBiEOG712TZJ.
TreeFamiTF315869.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029829. HLF.
[Graphical view]
PANTHERiPTHR11988:SF28. PTHR11988:SF28. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BW74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKMSRQLPL NPTFIPPPYG VLRSLLENPL KLPLHPEDAF SKEKDKGKKL
60 70 80 90 100
DDESSSPTVP QSAFLGPTLW DKTLPYDGDT FQLEYMDLEE FLSENGIPPS
110 120 130 140 150
PSQHDHSPHP PGLQPASSTA PSVMDLSSRA TAPLHPGIPS PNCMQSPIRP
160 170 180 190 200
GQLLPANRNT PSPIDPDTIQ VPVGYEPDPA DLALSSIPGQ EMFDPRKRKF
210 220 230 240 250
SEEELKPQPM IKKARKVFIP DDLKDDKYWA RRRKNNMAAK RSRDARRLKE
260 270 280 290
NQIAIRASFL EKENSALRQE VADLRKELGK CKNILAKYEA RHGPL
Length:295
Mass (Da):33,149
Last modified:March 1, 2003 - v1
Checksum:iD57CAB8601A954B4
GO

Sequence cautioni

The sequence AAH57693.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 3812ENPLK…LHPED → KKQSSPFPFSSS in AAH57693 (PubMed:15489334).CuratedAdd
BLAST
Sequence conflicti224 – 2241K → KQ in AAH57693 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054062 mRNA. Translation: BAC35642.1.
BC057693 mRNA. Translation: AAH57693.1. Different initiation.
BC058705 mRNA. Translation: AAH58705.1.
CCDSiCCDS25241.1.
RefSeqiNP_766151.1. NM_172563.3.
XP_006533068.1. XM_006533005.2.
XP_006533069.1. XM_006533006.1.
UniGeneiMm.158903.

Genome annotation databases

EnsembliENSMUST00000004051; ENSMUSP00000004051; ENSMUSG00000003949.
GeneIDi217082.
KEGGimmu:217082.
UCSCiuc007kwr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054062 mRNA. Translation: BAC35642.1.
BC057693 mRNA. Translation: AAH57693.1. Different initiation.
BC058705 mRNA. Translation: AAH58705.1.
CCDSiCCDS25241.1.
RefSeqiNP_766151.1. NM_172563.3.
XP_006533068.1. XM_006533005.2.
XP_006533069.1. XM_006533006.1.
UniGeneiMm.158903.

3D structure databases

ProteinModelPortaliQ8BW74.
SMRiQ8BW74. Positions 253-286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229842. 3 interactions.
IntActiQ8BW74. 2 interactions.

PTM databases

PhosphoSiteiQ8BW74.

Proteomic databases

PRIDEiQ8BW74.

Protocols and materials databases

DNASUi217082.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004051; ENSMUSP00000004051; ENSMUSG00000003949.
GeneIDi217082.
KEGGimmu:217082.
UCSCiuc007kwr.1. mouse.

Organism-specific databases

CTDi3131.
MGIiMGI:96108. Hlf.

Phylogenomic databases

eggNOGiNOG329624.
GeneTreeiENSGT00440000039070.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiQ8BW74.
KOiK09057.
OMAiMEKMSRQ.
OrthoDBiEOG712TZJ.
TreeFamiTF315869.

Miscellaneous databases

ChiTaRSiHlf. mouse.
NextBioi375553.
PROiQ8BW74.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BW74.
CleanExiMM_HLF.
GenevestigatoriQ8BW74.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029829. HLF.
[Graphical view]
PANTHERiPTHR11988:SF28. PTHR11988:SF28. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon and Oviduct.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Liver.
  3. "The loss of circadian PAR bZip transcription factors results in epilepsy."
    Gachon F., Fonjallaz P., Damiola F., Gos P., Kodama T., Zakany J., Duboule D., Petit B., Tafti M., Schibler U.
    Genes Dev. 18:1397-1412(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN EPILEPSY.

Entry informationi

Entry nameiHLF_MOUSE
AccessioniPrimary (citable) accession number: Q8BW74
Secondary accession number(s): Q6PF83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: April 1, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mice deficient for all three PAR bZIP proteins (DBP, HLF and TEF) display a dramatically shortened life span and are highly susceptible to generalized spontaneous and audiogenic epilepsies (due for example to the noise of a vacuum cleaner) that are frequently lethal. The down-regulation of pyridoxal kinase (Pdxk) expression in these mice may participate in this seizure phenotype.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.