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Protein

Hepatic leukemia factor

Gene

Hlf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Mice deficient for all three PAR bZIP proteins (DBP, HLF and TEF) display a dramatically shortened life span and are highly susceptible to generalized spontaneous and audiogenic epilepsies (due for example to the noise of a vacuum cleaner) that are frequently lethal. The down-regulation of pyridoxal kinase (Pdxk) expression in these mice may participate in this seizure phenotype.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: MGI
  • rhythmic process Source: UniProtKB-KW
  • skeletal muscle cell differentiation Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatic leukemia factor
Gene namesi
Name:Hlf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96108 Hlf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765111 – 295Hepatic leukemia factorAdd BLAST295

Proteomic databases

PaxDbiQ8BW74
PRIDEiQ8BW74

PTM databases

CarbonylDBiQ8BW74
iPTMnetiQ8BW74
PhosphoSitePlusiQ8BW74

Expressioni

Inductioni

Accumulates according to a robust circadian rhythm. Displays only a moderate amplitude in the liver (1.6-fold) and none in the brain.

Gene expression databases

BgeeiENSMUSG00000003949
CleanExiMM_HLF
ExpressionAtlasiQ8BW74 baseline and differential
GenevisibleiQ8BW74 MM

Interactioni

Subunit structurei

Binds DNA specifically as homodimer or heterodimer with other PAR factors.By similarity

Protein-protein interaction databases

BioGridi229842, 3 interactors
IntActiQ8BW74, 2 interactors
STRINGi10090.ENSMUSP00000004051

Structurei

3D structure databases

ProteinModelPortaliQ8BW74
SMRiQ8BW74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini225 – 288bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 247Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni248 – 255Leucine-zipperPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 209Pro-rich (proline/acidic region (PAR))Add BLAST52

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.Curated

Phylogenomic databases

eggNOGiKOG3119 Eukaryota
ENOG410YJ8G LUCA
GeneTreeiENSGT00440000039070
HOGENOMiHOG000234383
HOVERGENiHBG004983
InParanoidiQ8BW74
KOiK09057
OMAiMEKMSRQ
OrthoDBiEOG091G0EO0
TreeFamiTF315869

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029829 HLF
PANTHERiPTHR11988:SF28 PTHR11988:SF28, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BW74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKMSRQLPL NPTFIPPPYG VLRSLLENPL KLPLHPEDAF SKEKDKGKKL
60 70 80 90 100
DDESSSPTVP QSAFLGPTLW DKTLPYDGDT FQLEYMDLEE FLSENGIPPS
110 120 130 140 150
PSQHDHSPHP PGLQPASSTA PSVMDLSSRA TAPLHPGIPS PNCMQSPIRP
160 170 180 190 200
GQLLPANRNT PSPIDPDTIQ VPVGYEPDPA DLALSSIPGQ EMFDPRKRKF
210 220 230 240 250
SEEELKPQPM IKKARKVFIP DDLKDDKYWA RRRKNNMAAK RSRDARRLKE
260 270 280 290
NQIAIRASFL EKENSALRQE VADLRKELGK CKNILAKYEA RHGPL
Length:295
Mass (Da):33,149
Last modified:March 1, 2003 - v1
Checksum:iD57CAB8601A954B4
GO

Sequence cautioni

The sequence AAH57693 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 38ENPLK…LHPED → KKQSSPFPFSSS in AAH57693 (PubMed:15489334).CuratedAdd BLAST12
Sequence conflicti224K → KQ in AAH57693 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054062 mRNA Translation: BAC35642.1
BC057693 mRNA Translation: AAH57693.1 Different initiation.
BC058705 mRNA Translation: AAH58705.1
CCDSiCCDS25241.1
RefSeqiNP_766151.1, NM_172563.3
XP_006533068.1, XM_006533005.3
XP_006533069.1, XM_006533006.1
UniGeneiMm.158903

Genome annotation databases

EnsembliENSMUST00000004051; ENSMUSP00000004051; ENSMUSG00000003949
GeneIDi217082
KEGGimmu:217082
UCSCiuc007kwr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHLF_MOUSE
AccessioniPrimary (citable) accession number: Q8BW74
Secondary accession number(s): Q6PF83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health