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Protein

Ubiquitin carboxyl-terminal hydrolase 38

Gene

Usp38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei454 – 4541NucleophilePROSITE-ProRule annotation
Active sitei857 – 8571Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 38 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 38
Ubiquitin thioesterase 38
Ubiquitin-specific-processing protease 38
Gene namesi
Name:Usp38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1922091. Usp38.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10421042Ubiquitin carboxyl-terminal hydrolase 38PRO_0000080669Add
BLAST

Proteomic databases

MaxQBiQ8BW70.
PaxDbiQ8BW70.
PRIDEiQ8BW70.

PTM databases

PhosphoSiteiQ8BW70.

Expressioni

Gene expression databases

BgeeiQ8BW70.
CleanExiMM_USP38.
GenevisibleiQ8BW70. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039943.

Structurei

3D structure databases

ProteinModelPortaliQ8BW70.
SMRiQ8BW70. Positions 1-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini445 – 949505USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00650000093027.
HOVERGENiHBG060424.
InParanoidiQ8BW70.
KOiK11854.
OMAiHYYSYAR.
OrthoDBiEOG7327ND.
PhylomeDBiQ8BW70.
TreeFamiTF324529.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BW70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKILEGLVS SSHPLPLKRM IVRKVVEFAE HWLDEAQCEA MFDLTTRLIL
60 70 80 90 100
EGQDPFQRQV GHQVLEAYAR YHRPEFESFF NKTFVLGLLQ QGYHSVDRKD
110 120 130 140 150
VAILDYIHNG LKLIMSCPSV LDLFSLLQVE VLRMVCERPE PVLCARLSDL
160 170 180 190 200
LTDFVQCVPK GKLSVTFCQQ LVRTIGHFQC VSTQEKELRE YVSQVTKVST
210 220 230 240 250
LLQNIWKAEP STLLPSLQEV FASISSTDAS FEPSVALASL VQHIPLQMIT
260 270 280 290 300
VLIRSLTTDP NVKDASMTQA LCRMIDWLSW PLAQHVDTWV IALLKGLAAV
310 320 330 340 350
QKFTILIDVT LLKIELVFNR LWFPLVRPGA LAVLSHMLLS FQHSPEAFHV
360 370 380 390 400
IVPHIVNLVH SFRSDGLPSS TAFLVQLTEL VHCMMYHYSG FPDLYEPILE
410 420 430 440 450
AVKDFPKPSE EKIKLILNQS AWTSQSNALA SCLSRLSGKS ETGKTGLINL
460 470 480 490 500
GNTCYMNSVL QALFMATEFR RQVLSLNLNG CNSLMKKLQH LFAFLAHTQR
510 520 530 540 550
EAYAPRIFFE ASRPPWFTPR SQQDCSEYLR FLLDRLHEEE KILRVQSSHK
560 570 580 590 600
PSEGLDCAET CLQEVTSKVA VPTESPGTGD SEKTLIEKMF GGKLRTHICC
610 620 630 640 650
LNCGSTSHKV EAFTDLSLAF CPSPSVEDLS FQDTASLPSA QDDGLMQTSV
660 670 680 690 700
ADPEEEPVVY NPATAAFVCD SVVNQRVLGS PPVEFHCAES SSVPEESAKI
710 720 730 740 750
LISKDVPQNP GGESTTSVTD LLNYFLAPEV LTGENQYYCE SCASLQNAEK
760 770 780 790 800
TMQITEEPEY LILTLLRFSY DQKYHVRRKI LDNVSLPLVL ELPVKRTASF
810 820 830 840 850
SSLSQSWSVD VDFTDINENL PKKLKPSGTE EAFCPKLVPY LLSSVVVHSG
860 870 880 890 900
VSSESGHYYS YARNITGTES SYQMCPQSES LALAPSQSCL LGVESPNTVI
910 920 930 940 950
EQDLENKEMS QEWFLFNDSR VTFTSFQSVQ KITSRFPKDT AYVLLYKKQS
960 970 980 990 1000
RANGIDSDNP ASGVWANGDP PLQKELMDAI TKDNKLYLQE QELNARARAL
1010 1020 1030 1040
QAASASCSFR PNGFDDNDPP GSCGPTGGGG GGGFNTVGRL VF
Length:1,042
Mass (Da):116,102
Last modified:October 10, 2003 - v2
Checksum:iB039BCA53E16B178
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901Q → H in BAC35661 (PubMed:16141072).Curated
Sequence conflicti266 – 2661S → G in BAC33659 (PubMed:16141072).Curated
Sequence conflicti442 – 4421T → A in BAC34890 (PubMed:16141072).Curated
Sequence conflicti776 – 7761V → A in BAC33659 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049287 mRNA. Translation: BAC33659.2.
AK052219 mRNA. Translation: BAC34890.1.
AK054116 mRNA. Translation: BAC35661.1.
BC054404 mRNA. Translation: AAH54404.1.
BC057122 mRNA. Translation: AAH57122.1.
BC058784 mRNA. Translation: AAH58784.1.
CCDSiCCDS22444.1.
RefSeqiNP_081830.2. NM_027554.2.
UniGeneiMm.246018.

Genome annotation databases

EnsembliENSMUST00000042724; ENSMUSP00000039943; ENSMUSG00000038250.
GeneIDi74841.
KEGGimmu:74841.
UCSCiuc009mjd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049287 mRNA. Translation: BAC33659.2.
AK052219 mRNA. Translation: BAC34890.1.
AK054116 mRNA. Translation: BAC35661.1.
BC054404 mRNA. Translation: AAH54404.1.
BC057122 mRNA. Translation: AAH57122.1.
BC058784 mRNA. Translation: AAH58784.1.
CCDSiCCDS22444.1.
RefSeqiNP_081830.2. NM_027554.2.
UniGeneiMm.246018.

3D structure databases

ProteinModelPortaliQ8BW70.
SMRiQ8BW70. Positions 1-425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039943.

PTM databases

PhosphoSiteiQ8BW70.

Proteomic databases

MaxQBiQ8BW70.
PaxDbiQ8BW70.
PRIDEiQ8BW70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042724; ENSMUSP00000039943; ENSMUSG00000038250.
GeneIDi74841.
KEGGimmu:74841.
UCSCiuc009mjd.1. mouse.

Organism-specific databases

CTDi84640.
MGIiMGI:1922091. Usp38.

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00650000093027.
HOVERGENiHBG060424.
InParanoidiQ8BW70.
KOiK11854.
OMAiHYYSYAR.
OrthoDBiEOG7327ND.
PhylomeDBiQ8BW70.
TreeFamiTF324529.

Miscellaneous databases

NextBioi341642.
PROiQ8BW70.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BW70.
CleanExiMM_USP38.
GenevisibleiQ8BW70. MM.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic heart, Embryonic stem cell and Oviduct.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain, Olfactory epithelium and Retina.

Entry informationi

Entry nameiUBP38_MOUSE
AccessioniPrimary (citable) accession number: Q8BW70
Secondary accession number(s): Q8BWL1, Q8BX03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 24, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.