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Q8BW70 (UBP38_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 38

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 38
Ubiquitin thioesterase 38
Ubiquitin-specific-processing protease 38
Gene names
Name:Usp38
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1042 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10421042Ubiquitin carboxyl-terminal hydrolase 38
PRO_0000080669

Regions

Domain445 – 949505USP

Sites

Active site4541Nucleophile By similarity
Active site8571Proton acceptor By similarity

Experimental info

Sequence conflict901Q → H in BAC35661. Ref.1
Sequence conflict2661S → G in BAC33659. Ref.1
Sequence conflict4421T → A in BAC34890. Ref.1
Sequence conflict7761V → A in BAC33659. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BW70 [UniParc].

Last modified October 10, 2003. Version 2.
Checksum: B039BCA53E16B178

FASTA1,042116,102
        10         20         30         40         50         60 
MDKILEGLVS SSHPLPLKRM IVRKVVEFAE HWLDEAQCEA MFDLTTRLIL EGQDPFQRQV 

        70         80         90        100        110        120 
GHQVLEAYAR YHRPEFESFF NKTFVLGLLQ QGYHSVDRKD VAILDYIHNG LKLIMSCPSV 

       130        140        150        160        170        180 
LDLFSLLQVE VLRMVCERPE PVLCARLSDL LTDFVQCVPK GKLSVTFCQQ LVRTIGHFQC 

       190        200        210        220        230        240 
VSTQEKELRE YVSQVTKVST LLQNIWKAEP STLLPSLQEV FASISSTDAS FEPSVALASL 

       250        260        270        280        290        300 
VQHIPLQMIT VLIRSLTTDP NVKDASMTQA LCRMIDWLSW PLAQHVDTWV IALLKGLAAV 

       310        320        330        340        350        360 
QKFTILIDVT LLKIELVFNR LWFPLVRPGA LAVLSHMLLS FQHSPEAFHV IVPHIVNLVH 

       370        380        390        400        410        420 
SFRSDGLPSS TAFLVQLTEL VHCMMYHYSG FPDLYEPILE AVKDFPKPSE EKIKLILNQS 

       430        440        450        460        470        480 
AWTSQSNALA SCLSRLSGKS ETGKTGLINL GNTCYMNSVL QALFMATEFR RQVLSLNLNG 

       490        500        510        520        530        540 
CNSLMKKLQH LFAFLAHTQR EAYAPRIFFE ASRPPWFTPR SQQDCSEYLR FLLDRLHEEE 

       550        560        570        580        590        600 
KILRVQSSHK PSEGLDCAET CLQEVTSKVA VPTESPGTGD SEKTLIEKMF GGKLRTHICC 

       610        620        630        640        650        660 
LNCGSTSHKV EAFTDLSLAF CPSPSVEDLS FQDTASLPSA QDDGLMQTSV ADPEEEPVVY 

       670        680        690        700        710        720 
NPATAAFVCD SVVNQRVLGS PPVEFHCAES SSVPEESAKI LISKDVPQNP GGESTTSVTD 

       730        740        750        760        770        780 
LLNYFLAPEV LTGENQYYCE SCASLQNAEK TMQITEEPEY LILTLLRFSY DQKYHVRRKI 

       790        800        810        820        830        840 
LDNVSLPLVL ELPVKRTASF SSLSQSWSVD VDFTDINENL PKKLKPSGTE EAFCPKLVPY 

       850        860        870        880        890        900 
LLSSVVVHSG VSSESGHYYS YARNITGTES SYQMCPQSES LALAPSQSCL LGVESPNTVI 

       910        920        930        940        950        960 
EQDLENKEMS QEWFLFNDSR VTFTSFQSVQ KITSRFPKDT AYVLLYKKQS RANGIDSDNP 

       970        980        990       1000       1010       1020 
ASGVWANGDP PLQKELMDAI TKDNKLYLQE QELNARARAL QAASASCSFR PNGFDDNDPP 

      1030       1040 
GSCGPTGGGG GGGFNTVGRL VF 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryonic heart, Embryonic stem cell and Oviduct.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain, Olfactory epithelium and Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK049287 mRNA. Translation: BAC33659.2.
AK052219 mRNA. Translation: BAC34890.1.
AK054116 mRNA. Translation: BAC35661.1.
BC054404 mRNA. Translation: AAH54404.1.
BC057122 mRNA. Translation: AAH57122.1.
BC058784 mRNA. Translation: AAH58784.1.
RefSeqNP_081830.2. NM_027554.2.
UniGeneMm.246018.

3D structure databases

ProteinModelPortalQ8BW70.
SMRQ8BW70. Positions 443-657, 714-946.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.056.

PTM databases

PhosphoSiteQ8BW70.

Proteomic databases

PaxDbQ8BW70.
PRIDEQ8BW70.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042724; ENSMUSP00000039943; ENSMUSG00000038250.
GeneID74841.
KEGGmmu:74841.
UCSCuc009mjd.1. mouse.

Organism-specific databases

CTD84640.
MGIMGI:1922091. Usp38.

Phylogenomic databases

eggNOGCOG5560.
GeneTreeENSGT00650000093027.
HOVERGENHBG060424.
InParanoidQ8BW70.
KOK11854.
OMAHYYSYAR.
OrthoDBEOG7327ND.
PhylomeDBQ8BW70.
TreeFamTF324529.

Gene expression databases

BgeeQ8BW70.
CleanExMM_USP38.
GenevestigatorQ8BW70.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio341642.
PROQ8BW70.
SOURCESearch...

Entry information

Entry nameUBP38_MOUSE
AccessionPrimary (citable) accession number: Q8BW70
Secondary accession number(s): Q8BWL1, Q8BX03
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: April 16, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot