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Q8BW70

- UBP38_MOUSE

UniProt

Q8BW70 - UBP38_MOUSE

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Protein

Ubiquitin carboxyl-terminal hydrolase 38

Gene
Usp38
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei454 – 4541Nucleophile By similarity
Active sitei857 – 8571Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.056.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 38 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 38
Ubiquitin thioesterase 38
Ubiquitin-specific-processing protease 38
Gene namesi
Name:Usp38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1922091. Usp38.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10421042Ubiquitin carboxyl-terminal hydrolase 38PRO_0000080669Add
BLAST

Proteomic databases

MaxQBiQ8BW70.
PaxDbiQ8BW70.
PRIDEiQ8BW70.

PTM databases

PhosphoSiteiQ8BW70.

Expressioni

Gene expression databases

BgeeiQ8BW70.
CleanExiMM_USP38.
GenevestigatoriQ8BW70.

Structurei

3D structure databases

ProteinModelPortaliQ8BW70.
SMRiQ8BW70. Positions 443-657, 714-946.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini445 – 949505USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00650000093027.
HOVERGENiHBG060424.
InParanoidiQ8BW70.
KOiK11854.
OMAiHYYSYAR.
OrthoDBiEOG7327ND.
PhylomeDBiQ8BW70.
TreeFamiTF324529.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BW70-1 [UniParc]FASTAAdd to Basket

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MDKILEGLVS SSHPLPLKRM IVRKVVEFAE HWLDEAQCEA MFDLTTRLIL     50
EGQDPFQRQV GHQVLEAYAR YHRPEFESFF NKTFVLGLLQ QGYHSVDRKD 100
VAILDYIHNG LKLIMSCPSV LDLFSLLQVE VLRMVCERPE PVLCARLSDL 150
LTDFVQCVPK GKLSVTFCQQ LVRTIGHFQC VSTQEKELRE YVSQVTKVST 200
LLQNIWKAEP STLLPSLQEV FASISSTDAS FEPSVALASL VQHIPLQMIT 250
VLIRSLTTDP NVKDASMTQA LCRMIDWLSW PLAQHVDTWV IALLKGLAAV 300
QKFTILIDVT LLKIELVFNR LWFPLVRPGA LAVLSHMLLS FQHSPEAFHV 350
IVPHIVNLVH SFRSDGLPSS TAFLVQLTEL VHCMMYHYSG FPDLYEPILE 400
AVKDFPKPSE EKIKLILNQS AWTSQSNALA SCLSRLSGKS ETGKTGLINL 450
GNTCYMNSVL QALFMATEFR RQVLSLNLNG CNSLMKKLQH LFAFLAHTQR 500
EAYAPRIFFE ASRPPWFTPR SQQDCSEYLR FLLDRLHEEE KILRVQSSHK 550
PSEGLDCAET CLQEVTSKVA VPTESPGTGD SEKTLIEKMF GGKLRTHICC 600
LNCGSTSHKV EAFTDLSLAF CPSPSVEDLS FQDTASLPSA QDDGLMQTSV 650
ADPEEEPVVY NPATAAFVCD SVVNQRVLGS PPVEFHCAES SSVPEESAKI 700
LISKDVPQNP GGESTTSVTD LLNYFLAPEV LTGENQYYCE SCASLQNAEK 750
TMQITEEPEY LILTLLRFSY DQKYHVRRKI LDNVSLPLVL ELPVKRTASF 800
SSLSQSWSVD VDFTDINENL PKKLKPSGTE EAFCPKLVPY LLSSVVVHSG 850
VSSESGHYYS YARNITGTES SYQMCPQSES LALAPSQSCL LGVESPNTVI 900
EQDLENKEMS QEWFLFNDSR VTFTSFQSVQ KITSRFPKDT AYVLLYKKQS 950
RANGIDSDNP ASGVWANGDP PLQKELMDAI TKDNKLYLQE QELNARARAL 1000
QAASASCSFR PNGFDDNDPP GSCGPTGGGG GGGFNTVGRL VF 1042
Length:1,042
Mass (Da):116,102
Last modified:October 10, 2003 - v2
Checksum:iB039BCA53E16B178
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901Q → H in BAC35661. 1 Publication
Sequence conflicti266 – 2661S → G in BAC33659. 1 Publication
Sequence conflicti442 – 4421T → A in BAC34890. 1 Publication
Sequence conflicti776 – 7761V → A in BAC33659. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK049287 mRNA. Translation: BAC33659.2.
AK052219 mRNA. Translation: BAC34890.1.
AK054116 mRNA. Translation: BAC35661.1.
BC054404 mRNA. Translation: AAH54404.1.
BC057122 mRNA. Translation: AAH57122.1.
BC058784 mRNA. Translation: AAH58784.1.
CCDSiCCDS22444.1.
RefSeqiNP_081830.2. NM_027554.2.
UniGeneiMm.246018.

Genome annotation databases

EnsembliENSMUST00000042724; ENSMUSP00000039943; ENSMUSG00000038250.
GeneIDi74841.
KEGGimmu:74841.
UCSCiuc009mjd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK049287 mRNA. Translation: BAC33659.2 .
AK052219 mRNA. Translation: BAC34890.1 .
AK054116 mRNA. Translation: BAC35661.1 .
BC054404 mRNA. Translation: AAH54404.1 .
BC057122 mRNA. Translation: AAH57122.1 .
BC058784 mRNA. Translation: AAH58784.1 .
CCDSi CCDS22444.1.
RefSeqi NP_081830.2. NM_027554.2.
UniGenei Mm.246018.

3D structure databases

ProteinModelPortali Q8BW70.
SMRi Q8BW70. Positions 443-657, 714-946.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.056.

PTM databases

PhosphoSitei Q8BW70.

Proteomic databases

MaxQBi Q8BW70.
PaxDbi Q8BW70.
PRIDEi Q8BW70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042724 ; ENSMUSP00000039943 ; ENSMUSG00000038250 .
GeneIDi 74841.
KEGGi mmu:74841.
UCSCi uc009mjd.1. mouse.

Organism-specific databases

CTDi 84640.
MGIi MGI:1922091. Usp38.

Phylogenomic databases

eggNOGi COG5560.
GeneTreei ENSGT00650000093027.
HOVERGENi HBG060424.
InParanoidi Q8BW70.
KOi K11854.
OMAi HYYSYAR.
OrthoDBi EOG7327ND.
PhylomeDBi Q8BW70.
TreeFami TF324529.

Miscellaneous databases

NextBioi 341642.
PROi Q8BW70.
SOURCEi Search...

Gene expression databases

Bgeei Q8BW70.
CleanExi MM_USP38.
Genevestigatori Q8BW70.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic heart, Embryonic stem cell and Oviduct.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain, Olfactory epithelium and Retina.

Entry informationi

Entry nameiUBP38_MOUSE
AccessioniPrimary (citable) accession number: Q8BW70
Secondary accession number(s): Q8BWL1, Q8BX03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: September 3, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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