Reviewed, UniProtKB/Swiss-Prot Q8BW41 (AGO61_MOUSE)

Names and origin

Protein names

Recommended name:
    Uncharacterized glycosyltransferase AGO61
    EC=2.4.-.-

Gene names

Name:

Ago61

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	605 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities	Belongs to the glycosyltransferase 61 family.
Sequence caution	The sequence BAC31348.1 differs from that shown. Reason: Erroneous termination at position 525. Translated as Trp.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Molecular function	transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BW41-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BW41-2)

The sequence of this isoform differs from the canonical sequence as follows:
     573-580: CRCAGVQH → ADVLVCST
     581-605: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 605	580	Uncharacterized glycosyltransferase AGO61		PRO_0000249015
Amino acid modifications
	Glycosylation	99	1	N-linked (GlcNAc...) Potential
	Glycosylation	276	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	573 – 580	8	CRCAGVQH → ADVLVCST in isoform 2.		VSP_020354
	Alternative sequence	581 – 605	25	Missing in isoform 2.		VSP_020355
Experimental info
	Sequence conflict	567	1	S → T in AAH30931. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 2A70A214653D9E12	FASTA	605	69,378
	10 20 30 40 50 60 MHLSAVFNAL LVSVLAAVLW KHVRLREHAA TLEEELALGQ QSLDPVLGLK IDYPKALQIL 70 80 90 100 110 120 MEGGTHMVCT GRTHTDRICR FKWLCYSNEA EEFIFFHGNS SVMLPNLGSR RFQPALLDLS 130 140 150 160 170 180 TVEDHNAQYF NFVELPAAAL RFMPKPVFVP DVALIANRFN PDNLMHVFHD DLLPLFYTLR 190 200 210 220 230 240 QFPGLAQEAR LFFMEGWGEG AHFDLYKLLS PKQPLLRAQL KTLGRLLCFS HAFVGLSKVT 250 260 270 280 290 300 TWYQYGFVQP QGPKANILVS GNEIRQFTRF MTERLNVSHA GAPLGEEYIL VFSRTQNRLI 310 320 330 340 350 360 LNEAELLLEL AQEFQMKTVT VSLEDHTFAD VVRLVSNASM LVSMHGAQLV TALFLPRGAT 370 380 390 400 410 420 VVELFPYAVN PDHYTPYKTL ATLPGMDLQY VAWRNMIREN TVTHPERPWD QGGITHLDRA 430 440 450 460 470 480 EQARILQSRE VPRHLCCRNP EWLFRIYQDT RVDIPSLMQS IRRVVKGRPG PRRQRWAISL 490 500 510 520 530 540 YPGKVREARC QASVQGATEA RLSVSWQIPW NLKYLKVREV KYEVWLQEQG ENTYVPYMLT 550 560 570 580 590 600 LQNHTFTENI KPFTTYLVWV RCIFNRSLLG PFCRCAGVQH VASRPWPGLW RAPLAGSAFP GPQFC
	Isoform 2. Checksum: A687B5A5BFB7F01D	FASTA	580	66,661
	10 20 30 40 50 60 MHLSAVFNAL LVSVLAAVLW KHVRLREHAA TLEEELALGQ QSLDPVLGLK IDYPKALQIL 70 80 90 100 110 120 MEGGTHMVCT GRTHTDRICR FKWLCYSNEA EEFIFFHGNS SVMLPNLGSR RFQPALLDLS 130 140 150 160 170 180 TVEDHNAQYF NFVELPAAAL RFMPKPVFVP DVALIANRFN PDNLMHVFHD DLLPLFYTLR 190 200 210 220 230 240 QFPGLAQEAR LFFMEGWGEG AHFDLYKLLS PKQPLLRAQL KTLGRLLCFS HAFVGLSKVT 250 260 270 280 290 300 TWYQYGFVQP QGPKANILVS GNEIRQFTRF MTERLNVSHA GAPLGEEYIL VFSRTQNRLI 310 320 330 340 350 360 LNEAELLLEL AQEFQMKTVT VSLEDHTFAD VVRLVSNASM LVSMHGAQLV TALFLPRGAT 370 380 390 400 410 420 VVELFPYAVN PDHYTPYKTL ATLPGMDLQY VAWRNMIREN TVTHPERPWD QGGITHLDRA 430 440 450 460 470 480 EQARILQSRE VPRHLCCRNP EWLFRIYQDT RVDIPSLMQS IRRVVKGRPG PRRQRWAISL 490 500 510 520 530 540 YPGKVREARC QASVQGATEA RLSVSWQIPW NLKYLKVREV KYEVWLQEQG ENTYVPYMLT 550 560 570 580 LQNHTFTENI KPFTTYLVWV RCIFNRSLLG PFADVLVCST

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Strain: C57BL/6J. Tissue: Embryo and Ovary.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: FVB/N. Tissue: Mammary tumor and Salivary gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK042747 mRNA. Translation: BAC31348.1. Sequence problems. AK054403 mRNA. Translation: BAC35765.1. AK133802 mRNA. Translation: BAE21851.1. BC025056 mRNA. Translation: AAH25056.1. BC030931 mRNA. Translation: AAH30931.1.
IPI	IPI00331178. IPI00785452.
RefSeq	NP_705768.3.
UniGene	Mm.402151
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT61. Glycosyltransferase Family 61.
Proteomic databases
PRIDE	Q8BW41.
Genome annotation databases
Ensembl	ENSMUSG00000066235. Mus musculus. [Contig view]
GeneID	215494.
KEGG	mmu:215494.
Organism-specific databases
MGI	MGI:2143424. C85492.
Phylogenomic databases
HOVERGEN	Q8BW41.
OMA	Q8BW41. EQGENTY.
Gene expression databases
ArrayExpress	Q8BW41.
Bgee	Q8BW41.
CleanEx	MM_C85492.
GermOnline	ENSMUSG00000066235. Mus musculus.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	374764.
SOURCE	Search...

Entry information

Entry name

AGO61_MOUSE

Accession

Primary (citable) accession number: Q8BW41
Secondary accession number(s): Q58F17, Q8BXZ9, Q8K0M5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	March 1, 2003
Last modified:	May 5, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)