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Q8BW41 (AGO61_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized glycosyltransferase AGO61
EC=2.4.-.-
Gene names
Name:Ago61
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length605 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the glycosyltransferase 61 family.

Sequence caution

The sequence BAC31348.1 differs from that shown. Reason: Erroneous termination at position 525. Translated as Trp.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionTransferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiontransferase activity, transferring glycosyl groups

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BW41-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BW41-2)

The sequence of this isoform differs from the canonical sequence as follows:
     573-580: CRCAGVQH → ADVLVCST
     581-605: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 605580Uncharacterized glycosyltransferase AGO61
PRO_0000249015

Amino acid modifications

Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation2761N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence573 – 5808CRCAGVQH → ADVLVCST in isoform 2.
VSP_020354
Alternative sequence581 – 60525Missing in isoform 2.
VSP_020355

Experimental info

Sequence conflict5671S → T in AAH30931. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 2A70A214653D9E12

FASTA60569,378
        10         20         30         40         50         60 
MHLSAVFNAL LVSVLAAVLW KHVRLREHAA TLEEELALGQ QSLDPVLGLK IDYPKALQIL 

        70         80         90        100        110        120 
MEGGTHMVCT GRTHTDRICR FKWLCYSNEA EEFIFFHGNS SVMLPNLGSR RFQPALLDLS 

       130        140        150        160        170        180 
TVEDHNAQYF NFVELPAAAL RFMPKPVFVP DVALIANRFN PDNLMHVFHD DLLPLFYTLR 

       190        200        210        220        230        240 
QFPGLAQEAR LFFMEGWGEG AHFDLYKLLS PKQPLLRAQL KTLGRLLCFS HAFVGLSKVT 

       250        260        270        280        290        300 
TWYQYGFVQP QGPKANILVS GNEIRQFTRF MTERLNVSHA GAPLGEEYIL VFSRTQNRLI 

       310        320        330        340        350        360 
LNEAELLLEL AQEFQMKTVT VSLEDHTFAD VVRLVSNASM LVSMHGAQLV TALFLPRGAT 

       370        380        390        400        410        420 
VVELFPYAVN PDHYTPYKTL ATLPGMDLQY VAWRNMIREN TVTHPERPWD QGGITHLDRA 

       430        440        450        460        470        480 
EQARILQSRE VPRHLCCRNP EWLFRIYQDT RVDIPSLMQS IRRVVKGRPG PRRQRWAISL 

       490        500        510        520        530        540 
YPGKVREARC QASVQGATEA RLSVSWQIPW NLKYLKVREV KYEVWLQEQG ENTYVPYMLT 

       550        560        570        580        590        600 
LQNHTFTENI KPFTTYLVWV RCIFNRSLLG PFCRCAGVQH VASRPWPGLW RAPLAGSAFP 


GPQFC

« Hide

Isoform 2 [UniParc].

Checksum: A687B5A5BFB7F01D
Show »

FASTA58066,661

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Embryo and Ovary.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: FVB/N.
Tissue: Mammary tumor and Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK042747 mRNA. Translation: BAC31348.1. Sequence problems.
AK054403 mRNA. Translation: BAC35765.1.
AK133802 mRNA. Translation: BAE21851.1.
BC025056 mRNA. Translation: AAH25056.1.
BC030931 mRNA. Translation: AAH30931.1.
IPIIPI00331178.
IPI00785452.
RefSeqNP_705768.4. NM_153540.4.
UniGeneMm.402151.

3D structure databases

ModBaseSearch...

Protein family/group databases

CAZyGT61. Glycosyltransferase Family 61.

Proteomic databases

PRIDEQ8BW41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000084743; ENSMUSP00000095868; ENSMUSG00000066235.
GeneID215494.
KEGGmmu:215494.
UCSCuc009sek.2. mouse.

Organism-specific databases

CTD215494.
MGIMGI:2143424. C85492.

Phylogenomic databases

eggNOGroNOG12459.
GeneTreeENSGT00390000018454.
HOGENOMHBG283724.
HOVERGENHBG054852.
InParanoidQ8BW41.
OMAFPYAVNP.
OrthoDBEOG4TQM8N.

Gene expression databases

ArrayExpressQ8BW41.
BgeeQ8BW41.
CleanExMM_C85492.
GenevestigatorQ8BW41.
GermOnlineENSMUSG00000066235. Mus musculus.

Family and domain databases

InterProIPR003961. Fibronectin_type3.
IPR007657. Glycosyltransferase_AER61.
IPR013783. Ig-like_fold.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF04577. DUF563. 1 hit.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 1 hit.
ProtoNetSearch...

Other

NextBio374764.
SOURCESearch...

Entry information

Entry nameAGO61_MOUSE
AccessionPrimary (citable) accession number: Q8BW41
Secondary accession number(s): Q58F17, Q8BXZ9, Q8K0M5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2003
Last modified: October 19, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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