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Protein

Putative inactive serine protease 58

Gene

Prss58

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Thr-195 is present instead of the conserved Ser which is expected to be an active site residue. It is therefore unsure if this protein has kept its catalytic activity.Curated

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56Charge relay systemBy similarity1
Active sitei101Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.984

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inactive serine protease 58 (EC:3.4.21.4)
Alternative name(s):
Trypsin-X3
Gene namesi
Name:Prss58
Synonyms:Tryx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:3608323 Prss58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000031776418 – 241Putative inactive serine protease 58Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 57PROSITE-ProRule annotation
Disulfide bondi133 ↔ 201PROSITE-ProRule annotation
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 180PROSITE-ProRule annotation
Disulfide bondi191 ↔ 215PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BW11
PRIDEiQ8BW11

PTM databases

iPTMnetiQ8BW11
PhosphoSitePlusiQ8BW11

Expressioni

Gene expression databases

BgeeiENSMUSG00000051936
CleanExiMM_BC048599
GenevisibleiQ8BW11 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069833

Structurei

3D structure databases

ProteinModelPortaliQ8BW11
SMRiQ8BW11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 239Peptidase S1PROSITE-ProRule annotationAdd BLAST222

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00770000120601
HOVERGENiHBG013304
InParanoidiQ8BW11
KOiK22367
OMAiTWAYNLC
OrthoDBiEOG091G0MM8
PhylomeDBiQ8BW11
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BW11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAFLCILS TLLRTFAYNP DHIAGTTPPY LVYLKSDYLP CTGVLIHPLW
60 70 80 90 100
VITAAHCNLP NLQVILGITN PADPMERDVE VSDYEKIFHH PNFLVSSISH
110 120 130 140 150
DLLLIKLKRR IKHSNYAKAV KLPQHIVSVN AMCSVSTWAY NLCDVTKDPD
160 170 180 190 200
SLQTVNVTVI SKAECRNAYK AFDITENMIC VGIVPGRRLP CKEVTAAPAV
210 220 230 240
CNGVLYGILS YADGCVLRAD VGIYASIFHY LPWIEDTMKN N
Length:241
Mass (Da):26,865
Last modified:March 1, 2003 - v1
Checksum:i8FC9D0D994A4AE7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000663 Genomic DNA Translation: AAB69042.1
AK075754 mRNA Translation: BAC35932.1
BC048599 mRNA Translation: AAH48599.1
CCDSiCCDS20040.1
RefSeqiNP_778185.1, NM_175020.3
UniGeneiMm.56997

Genome annotation databases

EnsembliENSMUST00000063523; ENSMUSP00000069833; ENSMUSG00000051936
GeneIDi232717
KEGGimmu:232717
UCSCiuc009bnk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPRS58_MOUSE
AccessioniPrimary (citable) accession number: Q8BW11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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