Reviewed,
UniProtKB/Swiss-Prot Q8BW11 (TRYX3_MOUSE)
Last modified
June 16, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative trypsin-X3 EC=3.4.21.4 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 241 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. |
| Subcellular location | Secreted Potential. |
| Sequence similarities | Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. |
| Caution | Thr-195 is present instead of the conserved Ser which is expected to be an active site residue. It is therefore unsure if this protein has kept its catalytic activity. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hydrolase Protease Serine protease |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 17 | 17 | Potential | ||||||||
| Chain | 18 – 241 | 224 | Putative trypsin-X3 | PRO_0000317764 | |||||||
Regions | |||||||||||
| Domain | 18 – 239 | 222 | Peptidase S1 | ||||||||
Sites | |||||||||||
| Active site | 56 | 1 | Charge relay system By similarity | ||||||||
| Active site | 101 | 1 | Charge relay system By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 156 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 41 ↔ 57 | By similarity | |||||||||
| Disulfide bond | 133 ↔ 201 | By similarity | |||||||||
| Disulfide bond | 165 ↔ 180 | By similarity | |||||||||
| Disulfide bond | 191 ↔ 215 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Differential transcriptional regulation of individual TCR V beta segments before gene rearrangement." Chen F., Rowen L., Hood L., Rothenberg E.V. J. Immunol. 166:1771-1780(2001) [PubMed: 11160223] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Testis. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
Cross-references
Sequence databases | |
|---|---|
| AE000663 Genomic DNA. Translation: AAB69042.1. AK075754 mRNA. Translation: BAC35932.1. BC048599 mRNA. Translation: AAH48599.1. | |
| IPI | IPI00225978. |
| RefSeq | NP_778185.1. |
| UniGene | Mm.56997 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2HNT based on UniProtKB P00734. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S01.984. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000051936. Mus musculus. [Contig view] |
| GeneID | 232717. |
| KEGG | mmu:232717. |
Organism-specific databases | |
| MGI | MGI:3608323. BC048599. |
Phylogenomic databases | |
| HOGENOM | Q8BW11. |
| HOVERGEN | Q8BW11. |
| OMA | Q8BW11. VSTWAYN. |
Enzyme and pathway databases | |
| BRENDA | 3.4.21.4. 244. |
Gene expression databases | |
| ArrayExpress | Q8BW11. |
| Bgee | Q8BW11. |
| CleanEx | MM_BC048599. |
Family and domain databases | |
| InterPro | IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view] |
| Pfam | PF00089. Trypsin. 1 hit. [Graphical view] |
| PRINTS | PR00722. CHYMOTRYPSIN. |
| SMART | SM00020. Tryp_SPc. 1 hit. [Graphical view] |
| PROSITE | PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 381207. |
| SOURCE | Search... |
Entry information
| Entry name | TRYX3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8BW11 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


