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Protein

RNA-binding protein NOB1

Gene

Nob1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in mRNA degradation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi261Zinc1
Metal bindingi264Zinc1
Metal bindingi276Zinc1
Metal bindingi279Zinc1

GO - Molecular functioni

GO - Biological processi

  • cleavage involved in rRNA processing Source: GO_Central
  • maturation of SSU-rRNA Source: MGI
  • ribosomal small subunit biogenesis Source: MGI
  • visual perception Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein NOB1
Gene namesi
Name:Nob1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914869. Nob1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002332672 – 403RNA-binding protein NOB1Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei192PhosphoserineBy similarity1
Modified residuei316PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BW10.
MaxQBiQ8BW10.
PaxDbiQ8BW10.
PRIDEiQ8BW10.

PTM databases

iPTMnetiQ8BW10.
PhosphoSitePlusiQ8BW10.

Expressioni

Gene expression databases

BgeeiENSMUSG00000003848.
ExpressionAtlasiQ8BW10. baseline and differential.
GenevisibleiQ8BW10. MM.

Interactioni

Subunit structurei

May interact with UPF2.1 Publication

Protein-protein interaction databases

IntActiQ8BW10. 3 interactors.
MINTiMINT-4125154.
STRINGi10090.ENSMUSP00000003946.

Structurei

Secondary structure

1403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi257 – 260Combined sources4
Beta strandi262 – 264Combined sources3
Beta strandi267 – 269Combined sources3
Beta strandi277 – 279Combined sources3
Beta strandi285 – 288Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CONNMR-A251-316[»]
ProteinModelPortaliQ8BW10.
SMRiQ8BW10.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8BW10.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 108PINcAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 190Poly-Glu10

Sequence similaritiesi

Belongs to the NOB1 family.Curated
Contains 1 PINc domain.Curated

Phylogenomic databases

eggNOGiKOG2463. Eukaryota.
COG1439. LUCA.
GeneTreeiENSGT00390000015857.
HOGENOMiHOG000159692.
HOVERGENiHBG057385.
InParanoidiQ8BW10.
KOiK11883.
OMAiLHINWNR.
OrthoDBiEOG091G0C8H.
PhylomeDBiQ8BW10.
TreeFamiTF105838.

Family and domain databases

InterProiIPR014881. NOB1_Zn-bd.
IPR002716. PIN_dom.
IPR033411. Ribonuclease_PIN.
IPR033461. WRNPLPNID.
[Graphical view]
PfamiPF08772. NOB1_Zn_bind. 1 hit.
PF17146. PIN_6. 1 hit.
PF15017. WRNPLPNID. 1 hit.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
SUPFAMiSSF144206. SSF144206. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BW10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVEHVVAD AGAFLRDAPL QDIGKNIYTI REVVREIRDK ATRRRLAVLP
60 70 80 90 100
YQLRFKEPLP EYVRLVTEFS KKTGDYPSLS ATDIQVLALT YQLEAEFVGV
110 120 130 140 150
SHLKKEPEKA KVSSSIQHPE TALHISGFHL PSKSKPLQEA VDRGHAADGP
160 170 180 190 200
ENLEFSSFMF WRTPLPNIDR ELQELLIDGR EEEEEEEECE DSDDDGGGWI
210 220 230 240 250
TPSNIKQIQQ ELEQCDTPED VQVGCVTTDF AMQNVLLQMG LHVLAVNGML
260 270 280 290 300
VREARSYILR CHGCFKTTSD MNRVFCGHCG NKTLKKVSVT INDDGTLHMH
310 320 330 340 350
FSRNPKVLNP RGLRYSLPTP KGGKYAINPH LTEDQRFPQL RLSQKARQKT
360 370 380 390 400
DVFAPDYIAG VSPFAENDIS SRSAILQVRD GMLGAGRRRL NPNASRKKFV

KKR
Length:403
Mass (Da):45,464
Last modified:March 1, 2003 - v1
Checksum:i923A88BF2B2275FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075755 mRNA. Translation: BAC35933.1.
AK021194 mRNA. Translation: BAB32325.1.
BC054835 mRNA. Translation: AAH54835.1.
BC103793 mRNA. Translation: AAI03794.1.
CCDSiCCDS22649.1.
RefSeqiNP_080553.1. NM_026277.3.
UniGeneiMm.334793.
Mm.36817.

Genome annotation databases

EnsembliENSMUST00000003946; ENSMUSP00000003946; ENSMUSG00000003848.
GeneIDi67619.
KEGGimmu:67619.
UCSCiuc009nhr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075755 mRNA. Translation: BAC35933.1.
AK021194 mRNA. Translation: BAB32325.1.
BC054835 mRNA. Translation: AAH54835.1.
BC103793 mRNA. Translation: AAI03794.1.
CCDSiCCDS22649.1.
RefSeqiNP_080553.1. NM_026277.3.
UniGeneiMm.334793.
Mm.36817.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CONNMR-A251-316[»]
ProteinModelPortaliQ8BW10.
SMRiQ8BW10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BW10. 3 interactors.
MINTiMINT-4125154.
STRINGi10090.ENSMUSP00000003946.

PTM databases

iPTMnetiQ8BW10.
PhosphoSitePlusiQ8BW10.

Proteomic databases

EPDiQ8BW10.
MaxQBiQ8BW10.
PaxDbiQ8BW10.
PRIDEiQ8BW10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003946; ENSMUSP00000003946; ENSMUSG00000003848.
GeneIDi67619.
KEGGimmu:67619.
UCSCiuc009nhr.1. mouse.

Organism-specific databases

CTDi28987.
MGIiMGI:1914869. Nob1.

Phylogenomic databases

eggNOGiKOG2463. Eukaryota.
COG1439. LUCA.
GeneTreeiENSGT00390000015857.
HOGENOMiHOG000159692.
HOVERGENiHBG057385.
InParanoidiQ8BW10.
KOiK11883.
OMAiLHINWNR.
OrthoDBiEOG091G0C8H.
PhylomeDBiQ8BW10.
TreeFamiTF105838.

Miscellaneous databases

ChiTaRSiNob1. mouse.
EvolutionaryTraceiQ8BW10.
PROiQ8BW10.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003848.
ExpressionAtlasiQ8BW10. baseline and differential.
GenevisibleiQ8BW10. MM.

Family and domain databases

InterProiIPR014881. NOB1_Zn-bd.
IPR002716. PIN_dom.
IPR033411. Ribonuclease_PIN.
IPR033461. WRNPLPNID.
[Graphical view]
PfamiPF08772. NOB1_Zn_bind. 1 hit.
PF17146. PIN_6. 1 hit.
PF15017. WRNPLPNID. 1 hit.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
SUPFAMiSSF144206. SSF144206. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNOB1_MOUSE
AccessioniPrimary (citable) accession number: Q8BW10
Secondary accession number(s): Q7TPR3, Q9CRD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.