ID   IL33_MOUSE              Reviewed;         266 AA.
AC   Q8BVZ5; Q2YEJ4; Q3TQN0; Q99L46;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-NOV-2009, entry version 51.
DE   RecName: Full=Interleukin-33;
DE            Short=IL-33;
DE   Flags: Precursor;
GN   Name=Il33;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=BALB/c;
RX   PubMed=16286016; DOI=10.1016/j.immuni.2005.09.015;
RA   Schmitz J., Owyang A., Oldham E., Song Y., Murphy E., McClanahan T.K.,
RA   Zurawski G., Moshrefi M., Qin J., Li X., Gorman D.M., Bazan J.F.,
RA   Kastelein R.A.;
RT   "IL-33, an interleukin-1-like cytokine that signals via the IL-1
RT   receptor-related protein ST 2 and induces T helper type 2-associated
RT   cytokines.";
RL   Immunity 23:479-490(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Gastric mucosa;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cytokine that binds to and signals through IL1RL1/ST2
CC       and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6,
CC       followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2,
CC       MAPK14, and MAPK8 (By similarity). Induces T helper type 2-
CC       associated cytokines.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Proteolytically converted to a mature form by CASP1 (By
CC       similarity).
CC   -!- MISCELLANEOUS: Intraperitoneal injections of IL-33 induce the
CC       expression of IL-4, IL-5, and IL-13 and lead to severe
CC       pathological changes in mucosal organs.
CC   -!- SIMILARITY: Belongs to the IL-1 family. Highly divergent.
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DR   EMBL; AY905582; AAX86999.1; -; mRNA.
DR   EMBL; AK075849; BAC36003.1; -; mRNA.
DR   EMBL; AK163464; BAE37352.1; -; mRNA.
DR   EMBL; BC003847; AAH03847.1; -; mRNA.
DR   IPI; IPI00116304; -.
DR   RefSeq; NP_001158196.1; -.
DR   RefSeq; NP_598536.2; -.
DR   UniGene; Mm.182359; -.
DR   STRING; Q8BVZ5; -.
DR   PRIDE; Q8BVZ5; -.
DR   Ensembl; ENSMUST00000025724; ENSMUSP00000025724; ENSMUSG00000024810; Mus musculus.
DR   Ensembl; ENSMUST00000120388; ENSMUSP00000113829; ENSMUSG00000024810; Mus musculus.
DR   GeneID; 77125; -.
DR   KEGG; mmu:77125; -.
DR   UCSC; uc008hec.1; mouse.
DR   CTD; 77125; -.
DR   MGI; MGI:1924375; Il33.
DR   HOVERGEN; Q8BVZ5; -.
DR   OMA; GVKDNHL; -.
DR   NextBio; 346526; -.
DR   ArrayExpress; Q8BVZ5; -.
DR   Bgee; Q8BVZ5; -.
DR   CleanEx; MM_IL33; -.
DR   Genevestigator; Q8BVZ5; -.
DR   GermOnline; ENSMUSG00000024810; Mus musculus.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IPI:MGI.
PE   2: Evidence at transcript level;
KW   Cytokine; Secreted.
FT   PROPEP        1      ?       Potential.
FT                                /FTId=PRO_0000248846.
FT   CHAIN         ?    266       Interleukin-33.
FT                                /FTId=PRO_0000096791.
FT   CONFLICT     24     25       AL -> RS (in Ref. 1; AAX86999).
FT   CONFLICT    179    179       L -> V (in Ref. 3; AAH03847).
FT   CONFLICT    185    185       P -> S (in Ref. 1; AAX86999).
SQ   SEQUENCE   266 AA;  29991 MW;  E03C2C297EB43E23 CRC64;
     MRPRMKYSNS KISPAKFSST AGEALVPPCK IRRSQQKTKE FCHVYCMRLR SGLTIRKETS
     YFRKEPTKRY SLKSGTKHEE NFSAYPRDSR KRSLLGSIQA FAASVDTLSI QGTSLLTQSP
     ASLSTYNDQS VSFVLENGCY VINVDDSGKD QEQDQVLLRY YESPCPASQS GDGVDGKKLM
     VNMSPIKDTD IWLHANDKDY SVELQRGDVS PPEQAFFVLH KKSSDFVSFE CKNLPGTYIG
     VKDNQLALVE EKDESCNNIM FKLSKI
//