Q8BVZ5 (IL33_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-33
Short name=IL-33

Gene names

Name:

Il33

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 By similarity. Induces T helper type 2-associated cytokines. Ref.1
Subcellular location	Secreted.
Post-translational modification	Proteolytically converted to a mature form by CASP1 in vitro and calpains in vivo By similarity.
Miscellaneous	Intraperitoneal injections of IL-33 induce the expression of IL-4, IL-5, and IL-13 and lead to severe pathological changes in mucosal organs.
Sequence similarities	Belongs to the IL-1 family. Highly divergent.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Cytokine
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of T-helper 1 type immune response Inferred from genetic interaction. Source: BHF-UCL negative regulation of immunoglobulin secretion Inferred from genetic interaction. Source: BHF-UCL negative regulation of interferon-gamma production Inferred from genetic interaction. Source: BHF-UCL negative regulation of leukocyte migration Inferred from genetic interaction. Source: BHF-UCL positive regulation of chemokine secretion Inferred from direct assay. Source: BHF-UCL positive regulation of immunoglobulin secretion Inferred from genetic interaction. Source: BHF-UCL positive regulation of inflammatory response Inferred from direct assay. Source: BHF-UCL positive regulation of interleukin-13 production Inferred from genetic interaction. Source: BHF-UCL positive regulation of interleukin-4 production Inferred from genetic interaction. Source: BHF-UCL positive regulation of interleukin-5 production Inferred from genetic interaction. Source: BHF-UCL positive regulation of interleukin-6 production Inferred from genetic interaction. Source: BHF-UCL positive regulation of macrophage activation Inferred from direct assay. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: BHF-UCL positive regulation of type 2 immune response Inferred from genetic interaction. Source: BHF-UCL
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from direct assay. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 108	108	By similarity		PRO_0000248846
	Chain	109 – 266	158	Interleukin-33		PRO_0000096791
Experimental info
	Sequence conflict	24 – 25	2	AL → RS in AAX86999. Ref.1
	Sequence conflict	179	1	L → V in AAH03847. Ref.3
	Sequence conflict	185	1	P → S in AAX86999. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8BVZ5 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: E03C2C297EB43E23	FASTA	266	29,991
	10 20 30 40 50 60 MRPRMKYSNS KISPAKFSST AGEALVPPCK IRRSQQKTKE FCHVYCMRLR SGLTIRKETS 70 80 90 100 110 120 YFRKEPTKRY SLKSGTKHEE NFSAYPRDSR KRSLLGSIQA FAASVDTLSI QGTSLLTQSP 130 140 150 160 170 180 ASLSTYNDQS VSFVLENGCY VINVDDSGKD QEQDQVLLRY YESPCPASQS GDGVDGKKLM 190 200 210 220 230 240 VNMSPIKDTD IWLHANDKDY SVELQRGDVS PPEQAFFVLH KKSSDFVSFE CKNLPGTYIG 250 260 VKDNQLALVE EKDESCNNIM FKLSKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines." Schmitz J., Owyang A., Oldham E., Song Y., Murphy E., McClanahan T.K., Zurawski G., Moshrefi M., Qin J., Li X., Gorman D.M., Bazan J.F., Kastelein R.A. Immunity 23:479-490(2005) [PubMed: 16286016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Strain: BALB/c.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Corpora quadrigemina and Gastric mucosa.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY905582 mRNA. Translation: AAX86999.1. AK075849 mRNA. Translation: BAC36003.1. AK163464 mRNA. Translation: BAE37352.1. BC003847 mRNA. Translation: AAH03847.1.
IPI	IPI00116304.
RefSeq	NP_001158196.1. NM_001164724.1. NP_598536.2. NM_133775.2.
UniGene	Mm.182359.
3D structure databases
ProteinModelPortal	Q8BVZ5.
SMR	Q8BVZ5. Positions 108-266.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8BVZ5. 1 interaction.
STRING	Q8BVZ5.
Proteomic databases
PRIDE	Q8BVZ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025724; ENSMUSP00000025724; ENSMUSG00000024810. ENSMUST00000120388; ENSMUSP00000113829; ENSMUSG00000024810.
GeneID	77125.
KEGG	mmu:77125.
UCSC	uc008hec.2. mouse.
Organism-specific databases
CTD	90865.
MGI	MGI:1924375. Il33.
Phylogenomic databases
eggNOG	roNOG06681.
GeneTree	ENSGT00390000005185.
HOGENOM	HBG125786.
HOVERGEN	HBG081791.
InParanoid	Q8BVZ5.
OMA	GVKDNHL.
OrthoDB	EOG4FXR8C.
PhylomeDB	Q8BVZ5.
Gene expression databases
ArrayExpress	Q8BVZ5.
Bgee	Q8BVZ5.
CleanEx	MM_IL33.
Genevestigator	Q8BVZ5.
GermOnline	ENSMUSG00000024810. Mus musculus.
Family and domain databases
KO	K12967.
ProtoNet	Search...
Other
NextBio	346526.
SOURCE	Search...

Entry information

Entry name

IL33_MOUSE

Accession

Primary (citable) accession number: Q8BVZ5
Secondary accession number(s): Q2YEJ4, Q3TQN0, Q99L46

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program