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Protein

Tripartite motif-containing protein 14

Gene

Trim14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 59B box-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 14
Alternative name(s):
PU.1-binding protein
Gene namesi
Name:Trim14
Synonyms:Kiaa0129, Pub
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1921985. Trim14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi51H → N: Loss of inhibition of SPI1-mediated transcriptional activation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002203711 – 440Tripartite motif-containing protein 14Add BLAST440

Proteomic databases

EPDiQ8BVW3.
PaxDbiQ8BVW3.
PeptideAtlasiQ8BVW3.
PRIDEiQ8BVW3.

PTM databases

iPTMnetiQ8BVW3.
PhosphoSitePlusiQ8BVW3.

Expressioni

Tissue specificityi

Expressed with high level in spleen, thymus, liver and testis. Expressed with low level in the brain, kidney, and skeletal muscle. Expressed in various differentiation stages of B-lymphocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000039853.
CleanExiMM_TRIM14.
ExpressionAtlasiQ8BVW3. baseline and differential.
GenevisibleiQ8BVW3. MM.

Interactioni

Subunit structurei

Interacts with SPI1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038719.

Structurei

3D structure databases

ProteinModelPortaliQ8BVW3.
SMRiQ8BVW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 440B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Domaini

The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation.

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 59B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJ3M. Eukaryota.
ENOG410YJX9. LUCA.
GeneTreeiENSGT00840000129835.
HOGENOMiHOG000013201.
HOVERGENiHBG054251.
InParanoidiQ8BVW3.
KOiK12004.
OMAiSIRTCKL.
OrthoDBiEOG091G09TT.
PhylomeDBiQ8BVW3.
TreeFamiTF351014.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BVW3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASETTEARA PFQPDGAYGW RCPEHSERPA ELFCRRCGRC VCALCPVLGA
60 70 80 90 100
HRGHPVGLAE EEAVRVQKLI QDCLECLATK KRQHADNIAH LEDAGERLKV
110 120 130 140 150
YADSSKAWLT QKFTELRLLL DEEEVLAKKF IDKSTQLTLQ VYREQAETCG
160 170 180 190 200
KQIEVMDDFS TRVWGIGQEP NPVQLLQAYI ATKTEMGQQM SPSELSHPVP
210 220 230 240 250
LSFEPVKNFF KEFVEAIGNT LQTPMDTRLK ENINCQLSNS SSTKPGALLK
260 270 280 290 300
TSPSPERALF LKYARTPTLD PDTMHARLRL SPDGLTVRCS LLGRLGPRPA
310 320 330 340 350
PRFDALRQVL GRDGFAAGRH YWEVDVQEAG VGWWVGAAYP SLRRRGASAA
360 370 380 390 400
ARLGCNRESW CVKRYDLEYW AFHDGQRSRL RPRRDPHRLG VFLDYEAGIL
410 420 430 440
AFYDVAGGMS HLHTFHAAFQ EPLYPALRLW EGPISIPRLP
Length:440
Mass (Da):49,641
Last modified:December 7, 2004 - v2
Checksum:i0B4A01FEAE79EF15
GO
Isoform 2 (identifier: Q8BVW3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-283: YARTPTLDPDTMHARLRLSPD → CETGEWEREVGWEQRWMGARK
     284-440: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):32,027
Checksum:iF7DD0FCC97A2799E
GO
Isoform 3 (identifier: Q8BVW3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: A → T
     179-440: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):20,141
Checksum:i8A13050EBDFE7389
GO

Sequence cautioni

The sequence BAD32173 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43A → T in BAB30988 (PubMed:16141072).Curated1
Sequence conflicti84H → P in BAC36286 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012053178A → T in isoform 3. 1 Publication1
Alternative sequenceiVSP_012054179 – 440Missing in isoform 3. 1 PublicationAdd BLAST262
Alternative sequenceiVSP_012055263 – 283YARTP…RLSPD → CETGEWEREVGWEQRWMGAR K in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_012056284 – 440Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB117644 mRNA. Translation: BAD02394.1.
AK172895 mRNA. Translation: BAD32173.1. Different initiation.
AK017887 mRNA. Translation: BAB30988.1.
AK076277 mRNA. Translation: BAC36286.1.
AL683884 Genomic DNA. Translation: CAM13793.1.
CCDSiCCDS18153.1. [Q8BVW3-1]
RefSeqiNP_083353.1. NM_029077.4. [Q8BVW3-1]
UniGeneiMm.240252.

Genome annotation databases

EnsembliENSMUST00000046897; ENSMUSP00000038719; ENSMUSG00000039853. [Q8BVW3-1]
ENSMUST00000102924; ENSMUSP00000099988; ENSMUSG00000039853. [Q8BVW3-2]
ENSMUST00000184112; ENSMUSP00000138876; ENSMUSG00000039853. [Q8BVW3-3]
GeneIDi74735.
KEGGimmu:74735.
UCSCiuc008stw.2. mouse. [Q8BVW3-1]
uc008sty.2. mouse. [Q8BVW3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB117644 mRNA. Translation: BAD02394.1.
AK172895 mRNA. Translation: BAD32173.1. Different initiation.
AK017887 mRNA. Translation: BAB30988.1.
AK076277 mRNA. Translation: BAC36286.1.
AL683884 Genomic DNA. Translation: CAM13793.1.
CCDSiCCDS18153.1. [Q8BVW3-1]
RefSeqiNP_083353.1. NM_029077.4. [Q8BVW3-1]
UniGeneiMm.240252.

3D structure databases

ProteinModelPortaliQ8BVW3.
SMRiQ8BVW3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038719.

PTM databases

iPTMnetiQ8BVW3.
PhosphoSitePlusiQ8BVW3.

Proteomic databases

EPDiQ8BVW3.
PaxDbiQ8BVW3.
PeptideAtlasiQ8BVW3.
PRIDEiQ8BVW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046897; ENSMUSP00000038719; ENSMUSG00000039853. [Q8BVW3-1]
ENSMUST00000102924; ENSMUSP00000099988; ENSMUSG00000039853. [Q8BVW3-2]
ENSMUST00000184112; ENSMUSP00000138876; ENSMUSG00000039853. [Q8BVW3-3]
GeneIDi74735.
KEGGimmu:74735.
UCSCiuc008stw.2. mouse. [Q8BVW3-1]
uc008sty.2. mouse. [Q8BVW3-2]

Organism-specific databases

CTDi9830.
MGIiMGI:1921985. Trim14.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJ3M. Eukaryota.
ENOG410YJX9. LUCA.
GeneTreeiENSGT00840000129835.
HOGENOMiHOG000013201.
HOVERGENiHBG054251.
InParanoidiQ8BVW3.
KOiK12004.
OMAiSIRTCKL.
OrthoDBiEOG091G09TT.
PhylomeDBiQ8BVW3.
TreeFamiTF351014.

Miscellaneous databases

PROiQ8BVW3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039853.
CleanExiMM_TRIM14.
ExpressionAtlasiQ8BVW3. baseline and differential.
GenevisibleiQ8BVW3. MM.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI14_MOUSE
AccessioniPrimary (citable) accession number: Q8BVW3
Secondary accession number(s): B1AVH3
, Q6A0C3, Q762I6, Q9D3G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.