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Q8BVW0

- GANC_MOUSE

UniProt

Q8BVW0 - GANC_MOUSE

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Protein

Neutral alpha-glucosidase C

Gene

Ganc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Has alpha-glucosidase activity.By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing 1,4-linked D-glucose residues with release of D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei495 – 4951NucleophilePROSITE-ProRule annotation
Active sitei498 – 4981By similarity
Active sitei571 – 5711Proton donorBy similarity

GO - Molecular functioni

  1. alpha-1,4-glucosidase activity Source: MGI
  2. carbohydrate binding Source: InterPro

GO - Biological processi

  1. glucose metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral alpha-glucosidase C (EC:3.2.1.-)
Gene namesi
Name:Ganc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1923301. Ganc.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 898898Neutral alpha-glucosidase CPRO_0000185366Add
BLAST

Proteomic databases

MaxQBiQ8BVW0.
PaxDbiQ8BVW0.
PRIDEiQ8BVW0.

PTM databases

PhosphoSiteiQ8BVW0.

Expressioni

Gene expression databases

CleanExiMM_GANC.
GenevestigatoriQ8BVW0.

Interactioni

Protein-protein interaction databases

IntActiQ8BVW0. 1 interaction.
MINTiMINT-4095605.
STRINGi10090.ENSMUSP00000116898.

Structurei

3D structure databases

ProteinModelPortaliQ8BVW0.
SMRiQ8BVW0. Positions 208-896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Phylogenomic databases

eggNOGiCOG1501.
HOVERGENiHBG051683.
InParanoidiQ8BVW0.
KOiK12317.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 2 hits.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BVW0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAAEKEEIS VEDEAVDKTI FKDCGKIAFY RRQKQQLTKT TTYQALLGSV
60 70 80 90 100
DTEQDSTRFQ IISEATKIPL VAEVYGIEKD IFRLKINEET PLKPRLVCSG
110 120 130 140 150
DTGSLILTNR KGDLKCHVSA NPFKIDLLSK NEAVISINSL GQLYFEHLQV
160 170 180 190 200
PHKQRATKGN GQNTPAATSQ ENQEDLGLWE EKFGKFVDVK ANGPSSVGLD
210 220 230 240 250
FSLHGFEHLY GIPQHAESHQ LKNTRDGDAY RLYNLDVYGY QVHDKMGIYG
260 270 280 290 300
SVPYLLAHKQ GRTVGIFWLN ASETLVEINT EPAVEYTLTQ MGPAAAKPKV
310 320 330 340 350
RCRTDVHWMS ESGIIDVFLL TGPTPADVFK QYSYITGTQA MPPLFSLGYH
360 370 380 390 400
QCRWNYEDEQ DVKAVDAGFD EHDIPYDVMW LDIEHTEDKK YFTWDKKRFA
410 420 430 440 450
NPKRMQELLR SKKRKLVVIS DPHIKVDPDY TVYAQAKEQG FFVKNPEGGD
460 470 480 490 500
FEGVCWPGLS SYLDFTNPKV REWYSSLFAF PVYQGSTDIL FLWNDMNEPS
510 520 530 540 550
VFRGPELTMH KSAVHYGDWE HRELHNIYGF YQQMATAEGL IQRSKGKERP
560 570 580 590 600
FVLSRSFFAG SQKYGAVWTG DNKAEWSYLK ISIPMLLTLS VSGISFCGAD
610 620 630 640 650
VGGFIGNPEA ELLVRWYQAG AYQPFFRGHA TMNTKRREPW LFGEEYTQLI
660 670 680 690 700
REAIRQRYAL LPYLYSLFYH THVSSQPVMR PLWVEYPDDL ETFAVEDEYM
710 720 730 740 750
LGSALLVHPV TDPQTATIDV FLPGSDEVWY DSKTFAYWKG GCTVKIPVTL
760 770 780 790 800
DTIPVFQRGG SVVPVKTTVG TSTGWMADSP YELRVALSTQ GSAVGELYLD
810 820 830 840 850
DGHSFQYLHQ NQFLYRKFLF CSSVLTNRCA NEKGHYPSKC IVEQILVLGL
860 870 880 890
KKKPSSVTTH LSDGRAQPAA FTYCAETSAL RLEKLSLRIG EDWEVRVG
Length:898
Mass (Da):102,008
Last modified:June 7, 2004 - v2
Checksum:i6AE5A1EBADBA52C0
GO
Isoform 2 (identifier: Q8BVW0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-95: R → RYEVPDVINSKLGTVR
     154-199: QRATKGNGQN...KANGPSSVGL → LYTLLALKIY...SFLPFPPTRL
     200-898: Missing.

Note: No experimental confirmation available. May be due to an intron retention.

Show »
Length:214
Mass (Da):24,335
Checksum:i369B89CE2AFD9565
GO

Sequence cautioni

The sequence BAC36303.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei95 – 951R → RYEVPDVINSKLGTVR in isoform 2. 1 PublicationVSP_010619
Alternative sequencei154 – 19946QRATK…SSVGL → LYTLLALKIYLNGACLEYQL PWTRVFTLAQQMPYCLSFLP FPPTRL in isoform 2. 1 PublicationVSP_010620Add
BLAST
Alternative sequencei200 – 898699Missing in isoform 2. 1 PublicationVSP_010621Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK034155 mRNA. Translation: BAC28611.1.
AK036238 mRNA. Translation: BAC29357.1.
AK076333 mRNA. Translation: BAC36303.1. Different initiation.
RefSeqiNP_766260.2. NM_172672.2.
UniGeneiMm.38851.

Genome annotation databases

GeneIDi76051.
KEGGimmu:76051.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK034155 mRNA. Translation: BAC28611.1 .
AK036238 mRNA. Translation: BAC29357.1 .
AK076333 mRNA. Translation: BAC36303.1 . Different initiation.
RefSeqi NP_766260.2. NM_172672.2.
UniGenei Mm.38851.

3D structure databases

ProteinModelPortali Q8BVW0.
SMRi Q8BVW0. Positions 208-896.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BVW0. 1 interaction.
MINTi MINT-4095605.
STRINGi 10090.ENSMUSP00000116898.

Chemistry

BindingDBi Q8BVW0.
ChEMBLi CHEMBL3635.

Protein family/group databases

CAZyi GH31. Glycoside Hydrolase Family 31.

PTM databases

PhosphoSitei Q8BVW0.

Proteomic databases

MaxQBi Q8BVW0.
PaxDbi Q8BVW0.
PRIDEi Q8BVW0.

Protocols and materials databases

DNASUi 76051.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 76051.
KEGGi mmu:76051.

Organism-specific databases

CTDi 2595.
MGIi MGI:1923301. Ganc.

Phylogenomic databases

eggNOGi COG1501.
HOVERGENi HBG051683.
InParanoidi Q8BVW0.
KOi K12317.

Miscellaneous databases

NextBioi 344511.
PROi Q8BVW0.
SOURCEi Search...

Gene expression databases

CleanExi MM_GANC.
Genevestigatori Q8BVW0.

Family and domain databases

InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 2 hits.
PROSITEi PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Diencephalon and Skin.

Entry informationi

Entry nameiGANC_MOUSE
AccessioniPrimary (citable) accession number: Q8BVW0
Secondary accession number(s): Q8BH03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3