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Q8BVW0 (GANC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neutral alpha-glucosidase C

EC=3.2.1.-
Gene names
Name:Ganc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length898 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has alpha-glucosidase activity By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing 1,4-linked D-glucose residues with release of D-glucose.

Sequence similarities

Belongs to the glycosyl hydrolase 31 family.

Sequence caution

The sequence BAC36303.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglucose metabolic process

Inferred by curator PubMed 1914521. Source: MGI

   Molecular_functionalpha-glucosidase activity

Inferred from direct assay PubMed 1914521. Source: MGI

carbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BVW0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BVW0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     95-95: R → RYEVPDVINSKLGTVR
     154-199: QRATKGNGQN...KANGPSSVGL → LYTLLALKIY...SFLPFPPTRL
     200-898: Missing.
Note: No experimental confirmation available. May be due to an intron retention.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 898898Neutral alpha-glucosidase C
PRO_0000185366

Sites

Active site4951Nucleophile By similarity
Active site4981 By similarity
Active site5711Proton donor By similarity

Natural variations

Alternative sequence951R → RYEVPDVINSKLGTVR in isoform 2.
VSP_010619
Alternative sequence154 – 19946QRATK…SSVGL → LYTLLALKIYLNGACLEYQL PWTRVFTLAQQMPYCLSFLP FPPTRL in isoform 2.
VSP_010620
Alternative sequence200 – 898699Missing in isoform 2.
VSP_010621

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 7, 2004. Version 2.
Checksum: 6AE5A1EBADBA52C0

FASTA898102,008
        10         20         30         40         50         60 
MEAAEKEEIS VEDEAVDKTI FKDCGKIAFY RRQKQQLTKT TTYQALLGSV DTEQDSTRFQ 

        70         80         90        100        110        120 
IISEATKIPL VAEVYGIEKD IFRLKINEET PLKPRLVCSG DTGSLILTNR KGDLKCHVSA 

       130        140        150        160        170        180 
NPFKIDLLSK NEAVISINSL GQLYFEHLQV PHKQRATKGN GQNTPAATSQ ENQEDLGLWE 

       190        200        210        220        230        240 
EKFGKFVDVK ANGPSSVGLD FSLHGFEHLY GIPQHAESHQ LKNTRDGDAY RLYNLDVYGY 

       250        260        270        280        290        300 
QVHDKMGIYG SVPYLLAHKQ GRTVGIFWLN ASETLVEINT EPAVEYTLTQ MGPAAAKPKV 

       310        320        330        340        350        360 
RCRTDVHWMS ESGIIDVFLL TGPTPADVFK QYSYITGTQA MPPLFSLGYH QCRWNYEDEQ 

       370        380        390        400        410        420 
DVKAVDAGFD EHDIPYDVMW LDIEHTEDKK YFTWDKKRFA NPKRMQELLR SKKRKLVVIS 

       430        440        450        460        470        480 
DPHIKVDPDY TVYAQAKEQG FFVKNPEGGD FEGVCWPGLS SYLDFTNPKV REWYSSLFAF 

       490        500        510        520        530        540 
PVYQGSTDIL FLWNDMNEPS VFRGPELTMH KSAVHYGDWE HRELHNIYGF YQQMATAEGL 

       550        560        570        580        590        600 
IQRSKGKERP FVLSRSFFAG SQKYGAVWTG DNKAEWSYLK ISIPMLLTLS VSGISFCGAD 

       610        620        630        640        650        660 
VGGFIGNPEA ELLVRWYQAG AYQPFFRGHA TMNTKRREPW LFGEEYTQLI REAIRQRYAL 

       670        680        690        700        710        720 
LPYLYSLFYH THVSSQPVMR PLWVEYPDDL ETFAVEDEYM LGSALLVHPV TDPQTATIDV 

       730        740        750        760        770        780 
FLPGSDEVWY DSKTFAYWKG GCTVKIPVTL DTIPVFQRGG SVVPVKTTVG TSTGWMADSP 

       790        800        810        820        830        840 
YELRVALSTQ GSAVGELYLD DGHSFQYLHQ NQFLYRKFLF CSSVLTNRCA NEKGHYPSKC 

       850        860        870        880        890 
IVEQILVLGL KKKPSSVTTH LSDGRAQPAA FTYCAETSAL RLEKLSLRIG EDWEVRVG 

« Hide

Isoform 2 [UniParc].

Checksum: 369B89CE2AFD9565
Show »

FASTA21424,335

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Cerebellum, Diencephalon and Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK034155 mRNA. Translation: BAC28611.1.
AK036238 mRNA. Translation: BAC29357.1.
AK076333 mRNA. Translation: BAC36303.1. Different initiation.
RefSeqNP_766260.2. NM_172672.2.
UniGeneMm.38851.

3D structure databases

ProteinModelPortalQ8BVW0.
SMRQ8BVW0. Positions 208-896.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8BVW0. 1 interaction.
MINTMINT-4095605.
STRING10090.ENSMUSP00000116898.

Chemistry

BindingDBQ8BVW0.
ChEMBLCHEMBL3635.

Protein family/group databases

CAZyGH31. Glycoside Hydrolase Family 31.

PTM databases

PhosphoSiteQ8BVW0.

Proteomic databases

MaxQBQ8BVW0.
PaxDbQ8BVW0.
PRIDEQ8BVW0.

Protocols and materials databases

DNASU76051.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID76051.
KEGGmmu:76051.

Organism-specific databases

CTD2595.
MGIMGI:1923301. Ganc.

Phylogenomic databases

eggNOGCOG1501.
HOVERGENHBG051683.
InParanoidQ8BVW0.
KOK12317.

Gene expression databases

CleanExMM_GANC.
GenevestigatorQ8BVW0.

Family and domain databases

InterProIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 2 hits.
PROSITEPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio344511.
PROQ8BVW0.
SOURCESearch...

Entry information

Entry nameGANC_MOUSE
AccessionPrimary (citable) accession number: Q8BVW0
Secondary accession number(s): Q8BH03
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 11, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries