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Protein

ADP-ribose pyrophosphatase, mitochondrial

Gene

Nudt9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.

Catalytic activityi

ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate.

Cofactori

Protein has several cofactor binding sites:

GO - Molecular functioni

  • adenosine-diphosphatase activity Source: MGI
  • ADP-ribose diphosphatase activity Source: MGI

GO - Biological processi

  • ADP catabolic process Source: MGI
  • IDP catabolic process Source: MGI

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Manganese

Enzyme and pathway databases

ReactomeiR-MMU-2393930 Phosphate bond hydrolysis by NUDT proteins

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribose pyrophosphatase, mitochondrial (EC:3.6.1.13)
Alternative name(s):
ADP-ribose diphosphatase
ADP-ribose phosphohydrolase
Adenosine diphosphoribose pyrophosphatase
Short name:
ADPR-PPase
Nucleoside diphosphate-linked moiety X motif 9
Short name:
Nudix motif 9
Gene namesi
Name:Nudt9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1921417 Nudt9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionSequence analysisAdd BLAST46
ChainiPRO_000001995147 – 350ADP-ribose pyrophosphatase, mitochondrialAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei121PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BVU5
MaxQBiQ8BVU5
PaxDbiQ8BVU5
PeptideAtlasiQ8BVU5
PRIDEiQ8BVU5

PTM databases

iPTMnetiQ8BVU5
PhosphoSitePlusiQ8BVU5

Expressioni

Gene expression databases

BgeeiENSMUSG00000029310
ExpressionAtlasiQ8BVU5 baseline and differential
GenevisibleiQ8BVU5 MM

Interactioni

Subunit structurei

Monomer. Interacts with GLOD4.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031250

Structurei

3D structure databases

ProteinModelPortaliQ8BVU5
SMRiQ8BVU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 334Nudix hydrolasePROSITE-ProRule annotationAdd BLAST157

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi215 – 237Nudix boxAdd BLAST23

Sequence similaritiesi

Belongs to the Nudix hydrolase family. NudF subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4195 Eukaryota
ENOG410XPYY LUCA
GeneTreeiENSGT00390000017405
HOGENOMiHOG000130166
HOVERGENiHBG052693
InParanoidiQ8BVU5
KOiK13988
OMAiDDFRNTD
OrthoDBiEOG091G0H75
PhylomeDBiQ8BVU5
TreeFamiTF106351

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BVU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRSLGQAV ATVSLSVALA SVTVRSSACR AVPAPRNTFP TCGFHLNANI
60 70 80 90 100
MSGSNGAKEN SHNKARTSPY PGSKVERSQV PNEKVGWLVE WQDYNPVEYT
110 120 130 140 150
AVSVLAGPQW ADPQISESNF SPKFNEKDGH VERKSQNGLY EIENGRPRNP
160 170 180 190 200
AGRTGLVGRG LLGRWGPNHA ADPIITRWKR DESGNKITHP VSGKCILQFV
210 220 230 240 250
AIKRKDCGEW AIPGGMVDPG EKISATLKRE FGEEALNSLQ KSSAEKREIE
260 270 280 290 300
EKLHALFSQE HLVIYKGYVD DPRNTDNAWM ETEAVNYHDE TGETMDNLTL
310 320 330 340 350
EAGDDAGKVK WVDISDQLKL YASHSQFIKL VAEKRDAHWS EDHAADSRGL
Length:350
Mass (Da):38,604
Last modified:March 1, 2003 - v1
Checksum:iEDD9371307AB3373
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti343H → R in AAH33921 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076500 mRNA Translation: BAC36366.1
AK158058 mRNA Translation: BAE34342.1
AL714024 Genomic DNA No translation available.
BC033921 mRNA Translation: AAH33921.1
CCDSiCCDS19482.1
RefSeqiNP_083070.2, NM_028794.4
UniGeneiMm.241484

Genome annotation databases

EnsembliENSMUST00000031250; ENSMUSP00000031250; ENSMUSG00000029310
GeneIDi74167
KEGGimmu:74167
UCSCiuc008yka.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNUDT9_MOUSE
AccessioniPrimary (citable) accession number: Q8BVU5
Secondary accession number(s): A2AH31, Q3TZ68, Q8K1J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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