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Protein

Solute carrier family 25 member 41

Gene

Slc25a41

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 41
Gene namesi
Name:Slc25a41Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2144215. Slc25a41.

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5018Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei88 – 10720Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei131 – 14414Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei182 – 20019Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei219 – 24325Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei279 – 29820Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Solute carrier family 25 member 41PRO_0000319991Add
BLAST

Proteomic databases

MaxQBiQ8BVN7.
PaxDbiQ8BVN7.
PRIDEiQ8BVN7.

PTM databases

PhosphoSiteiQ8BVN7.

Expressioni

Gene expression databases

BgeeiQ8BVN7.
CleanExiMM_SLC25A41.
ExpressionAtlasiQ8BVN7. baseline and differential.
GenevisibleiQ8BVN7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058877.

Structurei

3D structure databases

ProteinModelPortaliQ8BVN7.
SMRiQ8BVN7. Positions 28-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 11387Solcar 1Sequence analysisAdd
BLAST
Repeati121 – 20686Solcar 2Sequence analysisAdd
BLAST
Repeati217 – 30488Solcar 3Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ8BVN7.
KOiK14684.
OMAiYMQVYSS.
OrthoDBiEOG7V7661.
PhylomeDBiQ8BVN7.
TreeFamiTF313492.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q8BVN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVHLEVLDT GEQLMVPVDV LEEENKGTLW KFLLSGAMAG AVSRTGTAPL
60 70 80 90 100
DRARVYMQVY SSKSNFRNLL SGLRSLVQEG GVRSLWRGNG INVLKIAPEY
110 120 130 140 150
AIKFSVCEQS KNFFYGVHSS QLFQERVVAG SLAVAVSQTL INPMEVLKTR
160 170 180 190 200
LTLRFTGQYK GLLDCARQIL ERDGTRALYR GYLPNMLGII PYACTDLAVY
210 220 230 240 250
ELLQCLWQKL GRDMKDPSGL VSLSSVTLST TCGQMASYPL TLVRTRMQAQ
260 270 280 290 300
DTVEGSNPTM QGVFKRILSQ QGWPGLYRGM TPTLLKVLPA GGISYLVYEA
310
MKKTLGVQVL SR
Length:312
Mass (Da):34,505
Last modified:March 1, 2003 - v1
Checksum:iD20226711BA6877C
GO
Isoform 21 Publication (identifier: Q8BVN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:298
Mass (Da):32,982
Checksum:iE445C826A3F13460
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1414Missing in isoform 2. 1 PublicationVSP_052684Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077111 mRNA. Translation: BAC36618.1.
BC115588 mRNA. Translation: AAI15589.1.
BC115589 mRNA. Translation: AAI15590.1.
CCDSiCCDS37668.1. [Q8BVN7-1]
RefSeqiNP_780542.1. NM_175333.3. [Q8BVN7-1]
XP_006523445.1. XM_006523382.1. [Q8BVN7-2]
XP_011244530.1. XM_011246228.1. [Q8BVN7-1]
UniGeneiMm.33647.

Genome annotation databases

EnsembliENSMUST00000058661; ENSMUSP00000058877; ENSMUSG00000011486. [Q8BVN7-1]
ENSMUST00000169012; ENSMUSP00000130857; ENSMUSG00000011486. [Q8BVN7-2]
GeneIDi103775.
KEGGimmu:103775.
UCSCiuc008dds.1. mouse. [Q8BVN7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077111 mRNA. Translation: BAC36618.1.
BC115588 mRNA. Translation: AAI15589.1.
BC115589 mRNA. Translation: AAI15590.1.
CCDSiCCDS37668.1. [Q8BVN7-1]
RefSeqiNP_780542.1. NM_175333.3. [Q8BVN7-1]
XP_006523445.1. XM_006523382.1. [Q8BVN7-2]
XP_011244530.1. XM_011246228.1. [Q8BVN7-1]
UniGeneiMm.33647.

3D structure databases

ProteinModelPortaliQ8BVN7.
SMRiQ8BVN7. Positions 28-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058877.

PTM databases

PhosphoSiteiQ8BVN7.

Proteomic databases

MaxQBiQ8BVN7.
PaxDbiQ8BVN7.
PRIDEiQ8BVN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058661; ENSMUSP00000058877; ENSMUSG00000011486. [Q8BVN7-1]
ENSMUST00000169012; ENSMUSP00000130857; ENSMUSG00000011486. [Q8BVN7-2]
GeneIDi103775.
KEGGimmu:103775.
UCSCiuc008dds.1. mouse. [Q8BVN7-1]

Organism-specific databases

CTDi284427.
MGIiMGI:2144215. Slc25a41.

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ8BVN7.
KOiK14684.
OMAiYMQVYSS.
OrthoDBiEOG7V7661.
PhylomeDBiQ8BVN7.
TreeFamiTF313492.

Miscellaneous databases

NextBioi356117.
PROiQ8BVN7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BVN7.
CleanExiMM_SLC25A41.
ExpressionAtlasiQ8BVN7. baseline and differential.
GenevisibleiQ8BVN7. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiS2541_MOUSE
AccessioniPrimary (citable) accession number: Q8BVN7
Secondary accession number(s): Q14BV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.