Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8BVN4 (MTER2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
mTERF domain-containing protein 2
Alternative name(s):
Mitochondrial transcription termination factor 4
Short name=MTERF4
Gene names
Name:Mterfd2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the targeting of the methyltransferase NSUN4 to mitochondrial large ribosomal subunit and efficient rRNA methylation. Ref.3

Subunit structure

Heterodimer with NSUN4. Ref.3

Subcellular location

Mitochondrion Ref.3.

Domain

The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction By similarity.

Disruption phenotype

Leads to defective ribosomal assembly and a drastic reduction in translation. Ref.3

Sequence similarities

Belongs to the mTERF family.

Sequence caution

The sequence AAH02280.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH55877.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346mTERF domain-containing protein 2
PRO_0000255462

Regions

Repeat142 – 17231MTERF 1
Repeat177 – 20428MTERF 2
Repeat209 – 23931MTERF 3
Repeat245 – 27026MTERF 4
Repeat290 – 31829MTERF 5
Region310 – 32718Dimerization with NSUN4 By similarity

Experimental info

Sequence conflict1561S → N in AAH02280. Ref.2
Sequence conflict1561S → N in AAH55877. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8BVN4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: EA34F8129804CC07

FASTA34640,249
        10         20         30         40         50         60 
MASLGRQVPE WHRLLALSWA CLVRQTPHLR EQKQMSPSLS CKLTTVPGRG SFQEFSSITP 

        70         80         90        100        110        120 
QKYMQEPENR TRLVQCLHEE QKPCVDPESL EPEKVIRSLQ DMGFAEAHIH SLFSIQPSVH 

       130        140        150        160        170        180 
PQQLLGIVSE LLLLGLNPEP VFNALKKNPQ LLKLSSMQMK RRSSYLRKLG LGEGKLKRVL 

       190        200        210        220        230        240 
SVCPEVFTMH QRDIDRVVKV LREKCLFTAQ HITDVLHRCP TVLQEDPNEL EYKFQYAYFR 

       250        260        270        280        290        300 
MGLTHLDIVR TNFLQYSITK IKQRHIYLER LGRYQTPDKK GQTQIPNPSL RNILRVSEAE 

       310        320        330        340 
FLARTACSSV EEFQVFKKLL DQEEEEESES HASEEEEEEE EEEELL

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney and Mammary tumor.
[3]"MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome."
Camara Y., Asin-Cayuela J., Park C.B., Metodiev M.D., Shi Y., Ruzzenente B., Kukat C., Habermann B., Wibom R., Hultenby K., Franz T., Erdjument-Bromage H., Tempst P., Hallberg B.M., Gustafsson C.M., Larsson N.G.
Cell Metab. 13:527-539(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK077142 mRNA. Translation: BAC36640.1.
BC002280 mRNA. Translation: AAH02280.1. Different initiation.
BC055877 mRNA. Translation: AAH55877.1. Different initiation.
BC064709 mRNA. Translation: AAH64709.1.
IPIIPI00225936.
RefSeqNP_835152.1. NM_178051.3.
UniGeneMm.52809.

3D structure databases

ProteinModelPortalQ8BVN4.
SMRQ8BVN4. Positions 89-326.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000027492.

PTM databases

PhosphoSiteQ8BVN4.

Proteomic databases

PaxDbQ8BVN4.
PRIDEQ8BVN4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027492; ENSMUSP00000027492; ENSMUSG00000026273.
GeneID69821.
KEGGmmu:69821.
UCSCuc007cdo.1. mouse.

Organism-specific databases

CTD130916.
MGIMGI:1918355. Mterfd2.

Phylogenomic databases

eggNOGNOG44738.
GeneTreeENSGT00460000041648.
HOGENOMHOG000069984.
HOVERGENHBG081990.
InParanoidQ8BVN4.
KOK15032.
OMATEILHRC.
OrthoDBEOG4MKNGP.

Gene expression databases

ArrayExpressQ8BVN4.
BgeeQ8BVN4.
CleanExMM_MTERFD2.
GenevestigatorQ8BVN4.
GermOnlineENSMUSG00000026273. Mus musculus.

Family and domain databases

InterProIPR003690. Mit_transcrip_term-rel.
[Graphical view]
PfamPF02536. mTERF. 1 hit.
[Graphical view]
SMARTSM00733. Mterf. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio330419.
SOURCESearch...

Entry information

Entry nameMTER2_MOUSE
AccessionPrimary (citable) accession number: Q8BVN4
Secondary accession number(s): Q99LQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents