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Q8BVN4

- MTEF4_MOUSE

UniProt

Q8BVN4 - MTEF4_MOUSE

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Protein
Transcription termination factor 4, mitochondrial
Gene
Mterf4, Mterfd2, HSPC096
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S By similarity. Targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit.1 Publication

GO - Molecular functioni

  1. rRNA binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. camera-type eye development Source: MGI
  2. heart development Source: MGI
  3. protein targeting to mitochondrion Source: MGI
  4. rRNA processing Source: UniProtKB-KW
  5. ribosome assembly Source: MGI
  6. transcription from mitochondrial promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 4, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 4
Short name:
MTERF4
mTERF domain-containing protein 2
Gene namesi
Name:Mterf4
Synonyms:Mterfd2
Ordered Locus Names:HSPC096
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1918355. Mterfd2.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrial large ribosomal subunit Source: MGI
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Ablation of the gene is not viable. At 8.5 dpc, mutant homozygous embryos exhibit much reduced size, lack of heart and no optic disks. Conditional knockout in heart leads to severe mitochondrial cardiomyopathy. Premature death occurs at about 21 weeks and decreased body weight is observed from 15 weeks until death.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242Mitochondrion By similarity
Add
BLAST
Chaini43 – 346304Transcription termination factor 4, mitochondrial
PRO_0000255462Add
BLAST

Proteomic databases

PaxDbiQ8BVN4.
PRIDEiQ8BVN4.

PTM databases

PhosphoSiteiQ8BVN4.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in liver, followed by testis, kidney and brain.1 Publication

Gene expression databases

ArrayExpressiQ8BVN4.
BgeeiQ8BVN4.
CleanExiMM_MTERFD2.
GenevestigatoriQ8BVN4.

Interactioni

Subunit structurei

Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027492.

Structurei

3D structure databases

ProteinModelPortaliQ8BVN4.
SMRiQ8BVN4. Positions 89-326.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati142 – 17231MTERF 1
Add
BLAST
Repeati177 – 20428MTERF 2
Add
BLAST
Repeati209 – 23931MTERF 3
Add
BLAST
Repeati245 – 27026MTERF 4
Add
BLAST
Repeati290 – 31829MTERF 5
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni310 – 32718Dimerization with NSUN4 By similarity
Add
BLAST

Domaini

The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction By similarity.

Sequence similaritiesi

Belongs to the mTERF family.

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiNOG44738.
GeneTreeiENSGT00460000041648.
HOGENOMiHOG000069984.
HOVERGENiHBG081990.
InParanoidiQ8BVN4.
KOiK15032.
OMAiTEILHRC.
PhylomeDBiQ8BVN4.
TreeFamiTF329452.

Family and domain databases

InterProiIPR003690. Mit_transcrip_term-rel.
[Graphical view]
PfamiPF02536. mTERF. 1 hit.
[Graphical view]
SMARTiSM00733. Mterf. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BVN4-1 [UniParc]FASTAAdd to Basket

« Hide

MASLGRQVPE WHRLLALSWA CLVRQTPHLR EQKQMSPSLS CKLTTVPGRG    50
SFQEFSSITP QKYMQEPENR TRLVQCLHEE QKPCVDPESL EPEKVIRSLQ 100
DMGFAEAHIH SLFSIQPSVH PQQLLGIVSE LLLLGLNPEP VFNALKKNPQ 150
LLKLSSMQMK RRSSYLRKLG LGEGKLKRVL SVCPEVFTMH QRDIDRVVKV 200
LREKCLFTAQ HITDVLHRCP TVLQEDPNEL EYKFQYAYFR MGLTHLDIVR 250
TNFLQYSITK IKQRHIYLER LGRYQTPDKK GQTQIPNPSL RNILRVSEAE 300
FLARTACSSV EEFQVFKKLL DQEEEEESES HASEEEEEEE EEEELL 346
Length:346
Mass (Da):40,249
Last modified:March 1, 2003 - v1
Checksum:iEA34F8129804CC07
GO

Sequence cautioni

The sequence AAH02280.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH55877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561S → N in AAH02280. 1 Publication
Sequence conflicti156 – 1561S → N in AAH55877. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK077142 mRNA. Translation: BAC36640.1.
BC002280 mRNA. Translation: AAH02280.1. Different initiation.
BC055877 mRNA. Translation: AAH55877.1. Different initiation.
BC064709 mRNA. Translation: AAH64709.1.
CCDSiCCDS35671.1.
RefSeqiNP_835152.1. NM_178051.3.
UniGeneiMm.52809.

Genome annotation databases

EnsembliENSMUST00000027492; ENSMUSP00000027492; ENSMUSG00000026273.
GeneIDi69821.
KEGGimmu:69821.
UCSCiuc007cdo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK077142 mRNA. Translation: BAC36640.1 .
BC002280 mRNA. Translation: AAH02280.1 . Different initiation.
BC055877 mRNA. Translation: AAH55877.1 . Different initiation.
BC064709 mRNA. Translation: AAH64709.1 .
CCDSi CCDS35671.1.
RefSeqi NP_835152.1. NM_178051.3.
UniGenei Mm.52809.

3D structure databases

ProteinModelPortali Q8BVN4.
SMRi Q8BVN4. Positions 89-326.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000027492.

PTM databases

PhosphoSitei Q8BVN4.

Proteomic databases

PaxDbi Q8BVN4.
PRIDEi Q8BVN4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027492 ; ENSMUSP00000027492 ; ENSMUSG00000026273 .
GeneIDi 69821.
KEGGi mmu:69821.
UCSCi uc007cdo.1. mouse.

Organism-specific databases

CTDi 130916.
MGIi MGI:1918355. Mterfd2.

Phylogenomic databases

eggNOGi NOG44738.
GeneTreei ENSGT00460000041648.
HOGENOMi HOG000069984.
HOVERGENi HBG081990.
InParanoidi Q8BVN4.
KOi K15032.
OMAi TEILHRC.
PhylomeDBi Q8BVN4.
TreeFami TF329452.

Miscellaneous databases

NextBioi 330419.
PROi Q8BVN4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BVN4.
Bgeei Q8BVN4.
CleanExi MM_MTERFD2.
Genevestigatori Q8BVN4.

Family and domain databases

InterProi IPR003690. Mit_transcrip_term-rel.
[Graphical view ]
Pfami PF02536. mTERF. 1 hit.
[Graphical view ]
SMARTi SM00733. Mterf. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney and Mammary tumor.
  3. Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, CONDITIONAL KNOCKOUT.

Entry informationi

Entry nameiMTEF4_MOUSE
AccessioniPrimary (citable) accession number: Q8BVN4
Secondary accession number(s): Q99LQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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