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Q8BVN4

- MTEF4_MOUSE

UniProt

Q8BVN4 - MTEF4_MOUSE

Protein

Transcription termination factor 4, mitochondrial

Gene

Mterf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S By similarity. Targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit.By similarity1 Publication

    GO - Molecular functioni

    1. rRNA binding Source: MGI

    GO - Biological processi

    1. camera-type eye development Source: MGI
    2. heart development Source: MGI
    3. protein targeting to mitochondrion Source: MGI
    4. ribosome assembly Source: MGI
    5. rRNA processing Source: UniProtKB-KW
    6. transcription from mitochondrial promoter Source: MGI

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription termination factor 4, mitochondrial
    Alternative name(s):
    Mitochondrial transcription termination factor 4
    Short name:
    MTERF4
    mTERF domain-containing protein 2
    Gene namesi
    Name:Mterf4
    Synonyms:Mterfd2
    Ordered Locus Names:HSPC096
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1918355. Mterfd2.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: MGI
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Disruption phenotypei

    Ablation of the gene is not viable. At 8.5 dpc, mutant homozygous embryos exhibit much reduced size, lack of heart and no optic disks. Conditional knockout in heart leads to severe mitochondrial cardiomyopathy. Premature death occurs at about 21 weeks and decreased body weight is observed from 15 weeks until death.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4242MitochondrionBy similarityAdd
    BLAST
    Chaini43 – 346304Transcription termination factor 4, mitochondrialPRO_0000255462Add
    BLAST

    Proteomic databases

    PaxDbiQ8BVN4.
    PRIDEiQ8BVN4.

    PTM databases

    PhosphoSiteiQ8BVN4.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest levels in liver, followed by testis, kidney and brain.1 Publication

    Gene expression databases

    ArrayExpressiQ8BVN4.
    BgeeiQ8BVN4.
    CleanExiMM_MTERFD2.
    GenevestigatoriQ8BVN4.

    Interactioni

    Subunit structurei

    Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000027492.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BVN4.
    SMRiQ8BVN4. Positions 89-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati142 – 17231MTERF 1Add
    BLAST
    Repeati177 – 20428MTERF 2Add
    BLAST
    Repeati209 – 23931MTERF 3Add
    BLAST
    Repeati245 – 27026MTERF 4Add
    BLAST
    Repeati290 – 31829MTERF 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni310 – 32718Dimerization with NSUN4By similarityAdd
    BLAST

    Domaini

    The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction.By similarity

    Sequence similaritiesi

    Belongs to the mTERF family.Curated

    Keywords - Domaini

    Repeat, Transit peptide

    Phylogenomic databases

    eggNOGiNOG44738.
    GeneTreeiENSGT00460000041648.
    HOGENOMiHOG000069984.
    HOVERGENiHBG081990.
    InParanoidiQ8BVN4.
    KOiK15032.
    OMAiTEILHRC.
    PhylomeDBiQ8BVN4.
    TreeFamiTF329452.

    Family and domain databases

    InterProiIPR003690. Mit_transcrip_term-rel.
    [Graphical view]
    PfamiPF02536. mTERF. 1 hit.
    [Graphical view]
    SMARTiSM00733. Mterf. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BVN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASLGRQVPE WHRLLALSWA CLVRQTPHLR EQKQMSPSLS CKLTTVPGRG    50
    SFQEFSSITP QKYMQEPENR TRLVQCLHEE QKPCVDPESL EPEKVIRSLQ 100
    DMGFAEAHIH SLFSIQPSVH PQQLLGIVSE LLLLGLNPEP VFNALKKNPQ 150
    LLKLSSMQMK RRSSYLRKLG LGEGKLKRVL SVCPEVFTMH QRDIDRVVKV 200
    LREKCLFTAQ HITDVLHRCP TVLQEDPNEL EYKFQYAYFR MGLTHLDIVR 250
    TNFLQYSITK IKQRHIYLER LGRYQTPDKK GQTQIPNPSL RNILRVSEAE 300
    FLARTACSSV EEFQVFKKLL DQEEEEESES HASEEEEEEE EEEELL 346
    Length:346
    Mass (Da):40,249
    Last modified:March 1, 2003 - v1
    Checksum:iEA34F8129804CC07
    GO

    Sequence cautioni

    The sequence AAH02280.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH55877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561S → N in AAH02280. (PubMed:15489334)Curated
    Sequence conflicti156 – 1561S → N in AAH55877. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK077142 mRNA. Translation: BAC36640.1.
    BC002280 mRNA. Translation: AAH02280.1. Different initiation.
    BC055877 mRNA. Translation: AAH55877.1. Different initiation.
    BC064709 mRNA. Translation: AAH64709.1.
    CCDSiCCDS35671.1.
    RefSeqiNP_835152.1. NM_178051.3.
    UniGeneiMm.52809.

    Genome annotation databases

    EnsembliENSMUST00000027492; ENSMUSP00000027492; ENSMUSG00000026273.
    GeneIDi69821.
    KEGGimmu:69821.
    UCSCiuc007cdo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK077142 mRNA. Translation: BAC36640.1 .
    BC002280 mRNA. Translation: AAH02280.1 . Different initiation.
    BC055877 mRNA. Translation: AAH55877.1 . Different initiation.
    BC064709 mRNA. Translation: AAH64709.1 .
    CCDSi CCDS35671.1.
    RefSeqi NP_835152.1. NM_178051.3.
    UniGenei Mm.52809.

    3D structure databases

    ProteinModelPortali Q8BVN4.
    SMRi Q8BVN4. Positions 89-326.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000027492.

    PTM databases

    PhosphoSitei Q8BVN4.

    Proteomic databases

    PaxDbi Q8BVN4.
    PRIDEi Q8BVN4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027492 ; ENSMUSP00000027492 ; ENSMUSG00000026273 .
    GeneIDi 69821.
    KEGGi mmu:69821.
    UCSCi uc007cdo.1. mouse.

    Organism-specific databases

    CTDi 69821.
    MGIi MGI:1918355. Mterfd2.

    Phylogenomic databases

    eggNOGi NOG44738.
    GeneTreei ENSGT00460000041648.
    HOGENOMi HOG000069984.
    HOVERGENi HBG081990.
    InParanoidi Q8BVN4.
    KOi K15032.
    OMAi TEILHRC.
    PhylomeDBi Q8BVN4.
    TreeFami TF329452.

    Miscellaneous databases

    NextBioi 330419.
    PROi Q8BVN4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BVN4.
    Bgeei Q8BVN4.
    CleanExi MM_MTERFD2.
    Genevestigatori Q8BVN4.

    Family and domain databases

    InterProi IPR003690. Mit_transcrip_term-rel.
    [Graphical view ]
    Pfami PF02536. mTERF. 1 hit.
    [Graphical view ]
    SMARTi SM00733. Mterf. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney and Mammary tumor.
    3. Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, CONDITIONAL KNOCKOUT.

    Entry informationi

    Entry nameiMTEF4_MOUSE
    AccessioniPrimary (citable) accession number: Q8BVN4
    Secondary accession number(s): Q99LQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3