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Protein

Janus kinase and microtubule-interacting protein 1

Gene

Jakmip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.1 Publication

GO - Molecular functioni

  • GABA receptor binding Source: MGI
  • kinase binding Source: InterPro
  • kinesin binding Source: MGI
  • microtubule binding Source: InterPro
  • RNA binding Source: MGI

GO - Biological processi

  • cognition Source: MGI
  • positive regulation of cytoplasmic translation Source: GOC-OWL
  • protein transport Source: UniProtKB-KW
  • striatum development Source: GOC-OWL

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Janus kinase and microtubule-interacting protein 1
Alternative name(s):
GABA-B receptor-binding protein
Multiple alpha-helices and RNA-linker protein 1
Short name:
Marlin-1
Gene namesi
Name:Jakmip1
Synonyms:Gababrbp, Marlin1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1923321 Jakmip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003230091 – 626Janus kinase and microtubule-interacting protein 1Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei382PhosphoserineCombined sources1
Modified residuei470PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BVL9
MaxQBiQ8BVL9
PaxDbiQ8BVL9
PRIDEiQ8BVL9

PTM databases

iPTMnetiQ8BVL9
PhosphoSitePlusiQ8BVL9

Expressioni

Gene expression databases

BgeeiENSMUSG00000063646
ExpressionAtlasiQ8BVL9 baseline and differential
GenevisibleiQ8BVL9 MM

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with JAK1 and TYK2 (By similarity). Forms a complex with GABBR1 and KIF5B/kinesin-1.By similarity2 Publications

GO - Molecular functioni

  • GABA receptor binding Source: MGI
  • kinase binding Source: InterPro
  • kinesin binding Source: MGI
  • microtubule binding Source: InterPro

Protein-protein interaction databases

BioGridi217944, 4 interactors
IntActiQ8BVL9, 1 interactor
STRINGi10090.ENSMUSP00000038504

Structurei

3D structure databases

ProteinModelPortaliQ8BVL9
SMRiQ8BVL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 365Mediates association with microtubulesBy similarityAdd BLAST365
Regioni365 – 626Mediates interaction with TYK2 and GABBR1By similarityAdd BLAST262

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 255Sequence analysisAdd BLAST243
Coiled coili284 – 413Sequence analysisAdd BLAST130
Coiled coili490 – 604Sequence analysisAdd BLAST115

Sequence similaritiesi

Belongs to the JAKMIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II6X Eukaryota
ENOG4110F4A LUCA
GeneTreeiENSGT00390000002812
HOGENOMiHOG000060161
HOVERGENiHBG054249
InParanoidiQ8BVL9
TreeFamiTF331900

Family and domain databases

InterProiView protein in InterPro
IPR024836 JAKMIP
IPR031994 JAKMIP_C
PANTHERiPTHR18935 PTHR18935, 1 hit
PfamiView protein in Pfam
PF16034 JAKMIP_CC3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BVL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKGRSKGD KPEAETDSVQ MANEELRAKL TNIQIEFQQE KSKVGKLRER
60 70 80 90 100
LQEAKLEREQ EQRRHTAYIS ELKAKLHEEK TKELQALREA LIRQHEQEAA
110 120 130 140 150
RTAKIKEGEL QRLQATLNVL RDGAADKVKT ALLADAREEA RRTFDGERQR
160 170 180 190 200
LQQEILELKA ARKQAEEALS NCMQADKAKA ADLRAAYQAH QDEVHRIKRE
210 220 230 240 250
CERDIRRLMD EIKGKERVIL ALEKELGVQT GQTQRLLLQK EALDEQLVQV
260 270 280 290 300
KEAERHHSSP KRELPPGIGD MAELMGGQDQ HMDERDVRRF QLKIAELNSV
310 320 330 340 350
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEELLHSI
360 370 380 390 400
QRMEEKLKSL TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL
410 420 430 440 450
QVLEQQHVID DLSLERERLL RSKRHRGKSL KPPKKHVVET FFGFDEESVD
460 470 480 490 500
SETLSETSYN TDRTDRTPAT PEEDLDETTT REEADLRFCQ LTREYQALQR
510 520 530 540 550
AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE KLLVEKGQDA
560 570 580 590 600
AWVEEKQVLM RTNQDLLEKI YRLEMEENQL KSEMQDAKDQ NELLEFRVLE
610 620
LEVRDSICCK LSNGADILFE PKLKFM
Length:626
Mass (Da):73,139
Last modified:July 27, 2011 - v2
Checksum:iEDE98EDF83AF486A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207R → G in BAC36736 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077298 mRNA Translation: BAC36736.1
BC138646 mRNA Translation: AAI38647.1
BC138649 mRNA Translation: AAI38650.1
CCDSiCCDS19246.1
RefSeqiNP_848481.2, NM_178394.4
XP_017176628.1, XM_017321139.1
UniGeneiMm.85280

Genome annotation databases

EnsembliENSMUST00000043794; ENSMUSP00000038504; ENSMUSG00000063646
GeneIDi76071
KEGGimmu:76071
UCSCiuc008xfh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiJKIP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BVL9
Secondary accession number(s): B2RS01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health