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Protein

Janus kinase and microtubule-interacting protein 1

Gene

Jakmip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.1 Publication

GO - Molecular functioni

  • GABA receptor binding Source: MGI
  • kinesin binding Source: MGI
  • RNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Janus kinase and microtubule-interacting protein 1
Alternative name(s):
GABA-B receptor-binding protein
Multiple alpha-helices and RNA-linker protein 1
Short name:
Marlin-1
Gene namesi
Name:Jakmip1
Synonyms:Gababrbp, Marlin1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1923321. Jakmip1.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Membrane By similarity; Peripheral membrane protein By similarity

  • Note: Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Janus kinase and microtubule-interacting protein 1PRO_0000323009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei382 – 3821PhosphoserineCombined sources
Modified residuei470 – 4701PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BVL9.
MaxQBiQ8BVL9.
PaxDbiQ8BVL9.
PRIDEiQ8BVL9.

PTM databases

iPTMnetiQ8BVL9.
PhosphoSiteiQ8BVL9.

Expressioni

Gene expression databases

BgeeiQ8BVL9.
ExpressionAtlasiQ8BVL9. baseline and differential.
GenevisibleiQ8BVL9. MM.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with JAK1 and TYK2 (By similarity). Forms a complex with GABBR1 and KIF5B/kinesin-1.By similarity2 Publications

GO - Molecular functioni

  • GABA receptor binding Source: MGI
  • kinesin binding Source: MGI

Protein-protein interaction databases

BioGridi217944. 3 interactions.
STRINGi10090.ENSMUSP00000038504.

Structurei

3D structure databases

ProteinModelPortaliQ8BVL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 365365Mediates association with microtubulesBy similarityAdd
BLAST
Regioni365 – 626262Mediates interaction with TYK2 and GABBR1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili13 – 255243Sequence analysisAdd
BLAST
Coiled coili284 – 413130Sequence analysisAdd
BLAST
Coiled coili490 – 604115Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the JAKMIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II6X. Eukaryota.
ENOG4110F4A. LUCA.
GeneTreeiENSGT00390000002812.
HOGENOMiHOG000060161.
HOVERGENiHBG054249.
InParanoidiQ8BVL9.
OrthoDBiEOG7HHWRJ.
TreeFamiTF331900.

Family and domain databases

InterProiIPR024836. JAKMIP.
IPR031994. JAKMIP_C.
[Graphical view]
PANTHERiPTHR18935. PTHR18935. 1 hit.
PfamiPF16034. JAKMIP_CC3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BVL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKGRSKGD KPEAETDSVQ MANEELRAKL TNIQIEFQQE KSKVGKLRER
60 70 80 90 100
LQEAKLEREQ EQRRHTAYIS ELKAKLHEEK TKELQALREA LIRQHEQEAA
110 120 130 140 150
RTAKIKEGEL QRLQATLNVL RDGAADKVKT ALLADAREEA RRTFDGERQR
160 170 180 190 200
LQQEILELKA ARKQAEEALS NCMQADKAKA ADLRAAYQAH QDEVHRIKRE
210 220 230 240 250
CERDIRRLMD EIKGKERVIL ALEKELGVQT GQTQRLLLQK EALDEQLVQV
260 270 280 290 300
KEAERHHSSP KRELPPGIGD MAELMGGQDQ HMDERDVRRF QLKIAELNSV
310 320 330 340 350
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEELLHSI
360 370 380 390 400
QRMEEKLKSL TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL
410 420 430 440 450
QVLEQQHVID DLSLERERLL RSKRHRGKSL KPPKKHVVET FFGFDEESVD
460 470 480 490 500
SETLSETSYN TDRTDRTPAT PEEDLDETTT REEADLRFCQ LTREYQALQR
510 520 530 540 550
AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE KLLVEKGQDA
560 570 580 590 600
AWVEEKQVLM RTNQDLLEKI YRLEMEENQL KSEMQDAKDQ NELLEFRVLE
610 620
LEVRDSICCK LSNGADILFE PKLKFM
Length:626
Mass (Da):73,139
Last modified:July 27, 2011 - v2
Checksum:iEDE98EDF83AF486A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti207 – 2071R → G in BAC36736 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077298 mRNA. Translation: BAC36736.1.
BC138646 mRNA. Translation: AAI38647.1.
BC138649 mRNA. Translation: AAI38650.1.
CCDSiCCDS19246.1.
RefSeqiNP_848481.2. NM_178394.4.
UniGeneiMm.85280.

Genome annotation databases

EnsembliENSMUST00000043794; ENSMUSP00000038504; ENSMUSG00000063646.
GeneIDi76071.
KEGGimmu:76071.
UCSCiuc008xfh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077298 mRNA. Translation: BAC36736.1.
BC138646 mRNA. Translation: AAI38647.1.
BC138649 mRNA. Translation: AAI38650.1.
CCDSiCCDS19246.1.
RefSeqiNP_848481.2. NM_178394.4.
UniGeneiMm.85280.

3D structure databases

ProteinModelPortaliQ8BVL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217944. 3 interactions.
STRINGi10090.ENSMUSP00000038504.

PTM databases

iPTMnetiQ8BVL9.
PhosphoSiteiQ8BVL9.

Proteomic databases

EPDiQ8BVL9.
MaxQBiQ8BVL9.
PaxDbiQ8BVL9.
PRIDEiQ8BVL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043794; ENSMUSP00000038504; ENSMUSG00000063646.
GeneIDi76071.
KEGGimmu:76071.
UCSCiuc008xfh.1. mouse.

Organism-specific databases

CTDi152789.
MGIiMGI:1923321. Jakmip1.

Phylogenomic databases

eggNOGiENOG410II6X. Eukaryota.
ENOG4110F4A. LUCA.
GeneTreeiENSGT00390000002812.
HOGENOMiHOG000060161.
HOVERGENiHBG054249.
InParanoidiQ8BVL9.
OrthoDBiEOG7HHWRJ.
TreeFamiTF331900.

Miscellaneous databases

ChiTaRSiJakmip1. mouse.
PROiQ8BVL9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BVL9.
ExpressionAtlasiQ8BVL9. baseline and differential.
GenevisibleiQ8BVL9. MM.

Family and domain databases

InterProiIPR024836. JAKMIP.
IPR031994. JAKMIP_C.
[Graphical view]
PANTHERiPTHR18935. PTHR18935. 1 hit.
PfamiPF16034. JAKMIP_CC3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: INTERACTION WITH GABBR1.
  4. "Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport."
    Vidal R.L., Ramirez O.A., Sandoval L., Koenig-Robert R., Haertel S., Couve A.
    Mol. Cell. Neurosci. 35:501-512(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KIF5B.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Lung, Spleen and Testis.

Entry informationi

Entry nameiJKIP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BVL9
Secondary accession number(s): B2RS01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.