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Protein

Sorting nexin-17

Gene

Snx17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei38Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei62Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei75Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • aorta development Source: MGI
  • cardiac septum development Source: MGI
  • coronary vasculature development Source: MGI
  • intracellular protein transport Source: GO_Central
  • receptor-mediated endocytosis Source: MGI
  • retrograde transport, endosome to plasma membrane Source: GO_Central
  • signal transduction Source: InterPro

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-17
Gene namesi
Name:Snx17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2387801 Snx17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002362051 – 470Sorting nexin-17Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineBy similarity1
Modified residuei407PhosphoserineBy similarity1
Modified residuei409PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei437PhosphoserineBy similarity1
Modified residuei440PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BVL3
MaxQBiQ8BVL3
PaxDbiQ8BVL3
PeptideAtlasiQ8BVL3
PRIDEiQ8BVL3

PTM databases

iPTMnetiQ8BVL3
PhosphoSitePlusiQ8BVL3

Expressioni

Tissue specificityi

Detected in brain neurons (at protein level). Broadly expressed, with highest levels in brain and placenta, and lowest levels in colon, intestine and liver.2 Publications

Gene expression databases

BgeeiENSMUSG00000029146
CleanExiMM_SNX17
ExpressionAtlasiQ8BVL3 baseline and differential
GenevisibleiQ8BVL3 MM

Interactioni

Subunit structurei

Monomer. Interacts with HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif). Interacts with KRIT1 (via N-terminus) (By similarity). Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B.By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031029

Structurei

3D structure databases

ProteinModelPortaliQ8BVL3
SMRiQ8BVL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 109PXPROSITE-ProRule annotationAdd BLAST109
Domaini115 – 206Ras-associatingPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 432FERM-likeBy similarityAdd BLAST318
Regioni270 – 432PTB-like F3 moduleBy similarityAdd BLAST163

Domaini

The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes (By similarity).By similarity
The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG3784 Eukaryota
ENOG410XT9I LUCA
GeneTreeiENSGT00530000063147
HOGENOMiHOG000007722
HOVERGENiHBG061207
InParanoidiQ8BVL3
KOiK17929
OMAiSVCLQAM
OrthoDBiEOG091G0BES
PhylomeDBiQ8BVL3
TreeFamiTF318398

Family and domain databases

CDDicd13337 FERM-like_C_SNX17, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR000159 RA_dom
IPR028666 SNX17
IPR037831 SNX17/27/31
IPR037836 SNX17_FERM-like_dom
PANTHERiPTHR12431 PTHR12431, 1 hit
PTHR12431:SF16 PTHR12431:SF16, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50200 RA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BVL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFSIPETES RSGDSGGSAY VAYNIHVNGV LHCRVRYSQL LGLHEQLRKE
60 70 80 90 100
YGANVVPAFP PKKLFSLTPA EVEQRREQLE KYMQAVRQDP LLGSSETFNS
110 120 130 140 150
FLRRAQQETQ QVPTEEVSLE VLLSNGQKVL VTVLTSDQTE DVLEAVAAKL
160 170 180 190 200
DLPDDLIGYF SLFLVREKED GAFSFVRKLQ EFELPYVSVT SLRSQEYKIV
210 220 230 240 250
LRKSYWDSAY DDDVMENRVG LNLLYAQTVS DIEHGWILVT KEQHRQLKSL
260 270 280 290 300
QEKVSKKEFL RLAQTLRHYG YLRFDACVAD FPEKDCPVVV SAGNSELSLQ
310 320 330 340 350
LRLPGQQLRE GSFRVTRMRC WRVTSSVPLP SGGTSSPSRG RGEVRLELAF
360 370 380 390 400
EYLMSKDRLQ WVTITSPQAI MMSICLQSMV DELMVKKSGG SIRKMLRRRV
410 420 430 440 450
GGTLRRSDSQ QAVKSPPLLE SPDASRESMV KLSSKLSAVS LRGIGSPSTD
460 470
ASASAVHGNF AFEGIGDEDL
Length:470
Mass (Da):52,797
Last modified:May 30, 2006 - v2
Checksum:i3023B5FAEF38BB42
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198K → E in BAC37004 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077650 mRNA Translation: BAC36927.1
AK077780 mRNA Translation: BAC37004.1
AK156299 mRNA Translation: BAE33663.1
BC026571 mRNA Translation: AAH26571.1
BC023732 mRNA Translation: AAH23732.1
CCDSiCCDS19177.1
RefSeqiNP_710147.1, NM_153680.2
UniGeneiMm.6118

Genome annotation databases

EnsembliENSMUST00000031029; ENSMUSP00000031029; ENSMUSG00000029146
GeneIDi266781
KEGGimmu:266781
UCSCiuc008wxm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSNX17_MOUSE
AccessioniPrimary (citable) accession number: Q8BVL3
Secondary accession number(s): Q8R0N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: April 25, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health