Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8BVL3

- SNX17_MOUSE

UniProt

Q8BVL3 - SNX17_MOUSE

Protein

Sorting nexin-17

Gene

Snx17

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (30 May 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei38 – 381Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei62 – 621Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei75 – 751Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: UniProtKB
    2. protein binding Source: MGI

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. receptor-mediated endocytosis Source: MGI
    3. signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-17
    Gene namesi
    Name:Snx17
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2387801. Snx17.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytoplasmic membrane-bounded vesicle Source: UniProtKB
    3. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    4. cytosol Source: UniProtKB
    5. early endosome Source: UniProtKB-SubCell
    6. endosome Source: MGI
    7. endosome membrane Source: MGI
    8. Golgi apparatus Source: Ensembl
    9. protein complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Sorting nexin-17PRO_0000236205Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei407 – 4071PhosphoserineBy similarity
    Modified residuei409 – 4091Phosphoserine1 Publication
    Modified residuei415 – 4151PhosphoserineBy similarity
    Modified residuei421 – 4211Phosphoserine1 Publication
    Modified residuei437 – 4371PhosphoserineBy similarity
    Modified residuei440 – 4401PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8BVL3.
    PaxDbiQ8BVL3.
    PRIDEiQ8BVL3.

    Expressioni

    Tissue specificityi

    Detected in brain neurons (at protein level). Broadly expressed, with highest levels in brain and placenta, and lowest levels in colon, intestine and liver.2 Publications

    Gene expression databases

    ArrayExpressiQ8BVL3.
    BgeeiQ8BVL3.
    CleanExiMM_SNX17.
    GenevestigatoriQ8BVL3.

    Interactioni

    Subunit structurei

    Monomer. Interacts with HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif). Interacts with KRIT1 (via N-terminus) By similarity. Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B.By similarity4 Publications

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000031029.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BVL3.
    SMRiQ8BVL3. Positions 1-109, 112-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 109109PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini115 – 20692Ras-associatingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni115 – 432318FERM-likeBy similarityAdd
    BLAST
    Regioni270 – 432163PTB-like F3 moduleBy similarityAdd
    BLAST

    Domaini

    The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes By similarity.By similarity
    The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.By similarity

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
    Contains 1 Ras-associating domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG290558.
    GeneTreeiENSGT00530000063147.
    HOGENOMiHOG000007722.
    HOVERGENiHBG061207.
    InParanoidiQ8BVL3.
    KOiK17929.
    OMAiKKIFTLT.
    OrthoDBiEOG70CR71.
    PhylomeDBiQ8BVL3.
    TreeFamiTF318398.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR001683. Phox.
    IPR000159. Ras-assoc.
    IPR028666. SNX17.
    [Graphical view]
    PANTHERiPTHR12431:SF16. PTHR12431:SF16. 1 hit.
    PfamiPF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00295. B41. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    PS50200. RA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BVL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHFSIPETES RSGDSGGSAY VAYNIHVNGV LHCRVRYSQL LGLHEQLRKE    50
    YGANVVPAFP PKKLFSLTPA EVEQRREQLE KYMQAVRQDP LLGSSETFNS 100
    FLRRAQQETQ QVPTEEVSLE VLLSNGQKVL VTVLTSDQTE DVLEAVAAKL 150
    DLPDDLIGYF SLFLVREKED GAFSFVRKLQ EFELPYVSVT SLRSQEYKIV 200
    LRKSYWDSAY DDDVMENRVG LNLLYAQTVS DIEHGWILVT KEQHRQLKSL 250
    QEKVSKKEFL RLAQTLRHYG YLRFDACVAD FPEKDCPVVV SAGNSELSLQ 300
    LRLPGQQLRE GSFRVTRMRC WRVTSSVPLP SGGTSSPSRG RGEVRLELAF 350
    EYLMSKDRLQ WVTITSPQAI MMSICLQSMV DELMVKKSGG SIRKMLRRRV 400
    GGTLRRSDSQ QAVKSPPLLE SPDASRESMV KLSSKLSAVS LRGIGSPSTD 450
    ASASAVHGNF AFEGIGDEDL 470
    Length:470
    Mass (Da):52,797
    Last modified:May 30, 2006 - v2
    Checksum:i3023B5FAEF38BB42
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti198 – 1981K → E in BAC37004. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK077650 mRNA. Translation: BAC36927.1.
    AK077780 mRNA. Translation: BAC37004.1.
    AK156299 mRNA. Translation: BAE33663.1.
    BC026571 mRNA. Translation: AAH26571.1.
    BC023732 mRNA. Translation: AAH23732.1.
    CCDSiCCDS19177.1.
    RefSeqiNP_710147.1. NM_153680.2.
    UniGeneiMm.6118.

    Genome annotation databases

    EnsembliENSMUST00000031029; ENSMUSP00000031029; ENSMUSG00000029146.
    GeneIDi266781.
    KEGGimmu:266781.
    UCSCiuc008wxm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK077650 mRNA. Translation: BAC36927.1 .
    AK077780 mRNA. Translation: BAC37004.1 .
    AK156299 mRNA. Translation: BAE33663.1 .
    BC026571 mRNA. Translation: AAH26571.1 .
    BC023732 mRNA. Translation: AAH23732.1 .
    CCDSi CCDS19177.1.
    RefSeqi NP_710147.1. NM_153680.2.
    UniGenei Mm.6118.

    3D structure databases

    ProteinModelPortali Q8BVL3.
    SMRi Q8BVL3. Positions 1-109, 112-388.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000031029.

    Proteomic databases

    MaxQBi Q8BVL3.
    PaxDbi Q8BVL3.
    PRIDEi Q8BVL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031029 ; ENSMUSP00000031029 ; ENSMUSG00000029146 .
    GeneIDi 266781.
    KEGGi mmu:266781.
    UCSCi uc008wxm.1. mouse.

    Organism-specific databases

    CTDi 9784.
    MGIi MGI:2387801. Snx17.

    Phylogenomic databases

    eggNOGi NOG290558.
    GeneTreei ENSGT00530000063147.
    HOGENOMi HOG000007722.
    HOVERGENi HBG061207.
    InParanoidi Q8BVL3.
    KOi K17929.
    OMAi KKIFTLT.
    OrthoDBi EOG70CR71.
    PhylomeDBi Q8BVL3.
    TreeFami TF318398.

    Miscellaneous databases

    NextBioi 392194.
    PROi Q8BVL3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BVL3.
    Bgeei Q8BVL3.
    CleanExi MM_SNX17.
    Genevestigatori Q8BVL3.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR001683. Phox.
    IPR000159. Ras-assoc.
    IPR028666. SNX17.
    [Graphical view ]
    PANTHERi PTHR12431:SF16. PTHR12431:SF16. 1 hit.
    Pfami PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00295. B41. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    PS50200. RA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Spleen and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon and Mammary tumor.
    3. "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor."
      Stockinger W., Sailler B., Strasser V., Recheis B., Fasching D., Kahr L., Schneider W.J., Nimpf J.
      EMBO J. 21:4259-4267(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LDLR; VLDLR; LRP1 AND LRP8, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.
    4. Cited for: INTERACTION WITH LRP1, SUBCELLULAR LOCATION, FUNCTION.
    5. "Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes."
      Lee J., Retamal C., Cuitino L., Caruano-Yzermans A., Shin J.E., van Kerkhof P., Marzolo M.P., Bu G.
      J. Biol. Chem. 283:11501-11508(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH APP, TISSUE SPECIFICITY.
    6. "Sorting nexin 17 interacts directly with kinesin superfamily KIF1Bbeta protein."
      Seog D.H., Han J.
      Korean J. Physiol. Pharmacol. 12:199-204(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KIF1B.
    7. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409 AND SER-421, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSNX17_MOUSE
    AccessioniPrimary (citable) accession number: Q8BVL3
    Secondary accession number(s): Q8R0N8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3