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Q8BVL3

- SNX17_MOUSE

UniProt

Q8BVL3 - SNX17_MOUSE

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Protein
Sorting nexin-17
Gene
Snx17
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Phosphatidylinositol 3-phosphate By similarity
Binding sitei38 – 381Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei62 – 621Phosphatidylinositol 3-phosphate By similarity
Binding sitei75 – 751Phosphatidylinositol 3-phosphate By similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: UniProtKB
  2. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. receptor-mediated endocytosis Source: MGI
  3. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-17
Gene namesi
Name:Snx17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2387801. Snx17.

Subcellular locationi

Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity 3 Publications

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. cytoplasm Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: UniProtKB
  4. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  5. cytosol Source: UniProtKB
  6. early endosome Source: UniProtKB-SubCell
  7. endosome Source: MGI
  8. endosome membrane Source: MGI
  9. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Sorting nexin-17
PRO_0000236205Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei407 – 4071Phosphoserine By similarity
Modified residuei409 – 4091Phosphoserine1 Publication
Modified residuei415 – 4151Phosphoserine By similarity
Modified residuei421 – 4211Phosphoserine1 Publication
Modified residuei437 – 4371Phosphoserine By similarity
Modified residuei440 – 4401Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BVL3.
PaxDbiQ8BVL3.
PRIDEiQ8BVL3.

Expressioni

Tissue specificityi

Detected in brain neurons (at protein level). Broadly expressed, with highest levels in brain and placenta, and lowest levels in colon, intestine and liver.2 Publications

Gene expression databases

ArrayExpressiQ8BVL3.
BgeeiQ8BVL3.
CleanExiMM_SNX17.
GenevestigatoriQ8BVL3.

Interactioni

Subunit structurei

Monomer. Interacts with HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif). Interacts with KRIT1 (via N-terminus) By similarity. Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B.4 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031029.

Structurei

3D structure databases

ProteinModelPortaliQ8BVL3.
SMRiQ8BVL3. Positions 1-109, 112-388.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 109109PX
Add
BLAST
Domaini115 – 20692Ras-associating
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 432318FERM-like By similarity
Add
BLAST
Regioni270 – 432163PTB-like F3 module By similarity
Add
BLAST

Domaini

The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes By similarity.
The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS By similarity.

Sequence similaritiesi

Belongs to the sorting nexin family.

Phylogenomic databases

eggNOGiNOG290558.
GeneTreeiENSGT00530000063147.
HOGENOMiHOG000007722.
HOVERGENiHBG061207.
InParanoidiQ8BVL3.
KOiK17929.
OMAiKKIFTLT.
OrthoDBiEOG70CR71.
PhylomeDBiQ8BVL3.
TreeFamiTF318398.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR001683. Phox.
IPR000159. Ras-assoc.
IPR028666. SNX17.
[Graphical view]
PANTHERiPTHR12431:SF16. PTHR12431:SF16. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BVL3-1 [UniParc]FASTAAdd to Basket

« Hide

MHFSIPETES RSGDSGGSAY VAYNIHVNGV LHCRVRYSQL LGLHEQLRKE    50
YGANVVPAFP PKKLFSLTPA EVEQRREQLE KYMQAVRQDP LLGSSETFNS 100
FLRRAQQETQ QVPTEEVSLE VLLSNGQKVL VTVLTSDQTE DVLEAVAAKL 150
DLPDDLIGYF SLFLVREKED GAFSFVRKLQ EFELPYVSVT SLRSQEYKIV 200
LRKSYWDSAY DDDVMENRVG LNLLYAQTVS DIEHGWILVT KEQHRQLKSL 250
QEKVSKKEFL RLAQTLRHYG YLRFDACVAD FPEKDCPVVV SAGNSELSLQ 300
LRLPGQQLRE GSFRVTRMRC WRVTSSVPLP SGGTSSPSRG RGEVRLELAF 350
EYLMSKDRLQ WVTITSPQAI MMSICLQSMV DELMVKKSGG SIRKMLRRRV 400
GGTLRRSDSQ QAVKSPPLLE SPDASRESMV KLSSKLSAVS LRGIGSPSTD 450
ASASAVHGNF AFEGIGDEDL 470
Length:470
Mass (Da):52,797
Last modified:May 30, 2006 - v2
Checksum:i3023B5FAEF38BB42
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981K → E in BAC37004. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK077650 mRNA. Translation: BAC36927.1.
AK077780 mRNA. Translation: BAC37004.1.
AK156299 mRNA. Translation: BAE33663.1.
BC026571 mRNA. Translation: AAH26571.1.
BC023732 mRNA. Translation: AAH23732.1.
CCDSiCCDS19177.1.
RefSeqiNP_710147.1. NM_153680.2.
UniGeneiMm.6118.

Genome annotation databases

EnsembliENSMUST00000031029; ENSMUSP00000031029; ENSMUSG00000029146.
GeneIDi266781.
KEGGimmu:266781.
UCSCiuc008wxm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK077650 mRNA. Translation: BAC36927.1 .
AK077780 mRNA. Translation: BAC37004.1 .
AK156299 mRNA. Translation: BAE33663.1 .
BC026571 mRNA. Translation: AAH26571.1 .
BC023732 mRNA. Translation: AAH23732.1 .
CCDSi CCDS19177.1.
RefSeqi NP_710147.1. NM_153680.2.
UniGenei Mm.6118.

3D structure databases

ProteinModelPortali Q8BVL3.
SMRi Q8BVL3. Positions 1-109, 112-388.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000031029.

Proteomic databases

MaxQBi Q8BVL3.
PaxDbi Q8BVL3.
PRIDEi Q8BVL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031029 ; ENSMUSP00000031029 ; ENSMUSG00000029146 .
GeneIDi 266781.
KEGGi mmu:266781.
UCSCi uc008wxm.1. mouse.

Organism-specific databases

CTDi 9784.
MGIi MGI:2387801. Snx17.

Phylogenomic databases

eggNOGi NOG290558.
GeneTreei ENSGT00530000063147.
HOGENOMi HOG000007722.
HOVERGENi HBG061207.
InParanoidi Q8BVL3.
KOi K17929.
OMAi KKIFTLT.
OrthoDBi EOG70CR71.
PhylomeDBi Q8BVL3.
TreeFami TF318398.

Miscellaneous databases

NextBioi 392194.
PROi Q8BVL3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BVL3.
Bgeei Q8BVL3.
CleanExi MM_SNX17.
Genevestigatori Q8BVL3.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR001683. Phox.
IPR000159. Ras-assoc.
IPR028666. SNX17.
[Graphical view ]
PANTHERi PTHR12431:SF16. PTHR12431:SF16. 1 hit.
Pfami PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00295. B41. 1 hit.
SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
PS50200. RA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Spleen and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.
  3. "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor."
    Stockinger W., Sailler B., Strasser V., Recheis B., Fasching D., Kahr L., Schneider W.J., Nimpf J.
    EMBO J. 21:4259-4267(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LDLR; VLDLR; LRP1 AND LRP8, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.
  4. Cited for: INTERACTION WITH LRP1, SUBCELLULAR LOCATION, FUNCTION.
  5. "Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes."
    Lee J., Retamal C., Cuitino L., Caruano-Yzermans A., Shin J.E., van Kerkhof P., Marzolo M.P., Bu G.
    J. Biol. Chem. 283:11501-11508(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH APP, TISSUE SPECIFICITY.
  6. "Sorting nexin 17 interacts directly with kinesin superfamily KIF1Bbeta protein."
    Seog D.H., Han J.
    Korean J. Physiol. Pharmacol. 12:199-204(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIF1B.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409 AND SER-421, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNX17_MOUSE
AccessioniPrimary (citable) accession number: Q8BVL3
Secondary accession number(s): Q8R0N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi