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Protein

Sorting nexin-17

Gene

Snx17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei38Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei62Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei75Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • aorta development Source: MGI
  • cardiac septum development Source: MGI
  • coronary vasculature development Source: MGI
  • intracellular protein transport Source: GO_Central
  • receptor-mediated endocytosis Source: MGI
  • retrograde transport, endosome to plasma membrane Source: GO_Central
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-17
Gene namesi
Name:Snx17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2387801. Snx17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002362051 – 470Sorting nexin-17Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineBy similarity1
Modified residuei407PhosphoserineBy similarity1
Modified residuei409PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei437PhosphoserineBy similarity1
Modified residuei440PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BVL3.
MaxQBiQ8BVL3.
PaxDbiQ8BVL3.
PeptideAtlasiQ8BVL3.
PRIDEiQ8BVL3.

PTM databases

iPTMnetiQ8BVL3.
PhosphoSitePlusiQ8BVL3.

Expressioni

Tissue specificityi

Detected in brain neurons (at protein level). Broadly expressed, with highest levels in brain and placenta, and lowest levels in colon, intestine and liver.2 Publications

Gene expression databases

BgeeiENSMUSG00000029146.
CleanExiMM_SNX17.
ExpressionAtlasiQ8BVL3. baseline and differential.
GenevisibleiQ8BVL3. MM.

Interactioni

Subunit structurei

Monomer. Interacts with HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif). Interacts with KRIT1 (via N-terminus) (By similarity). Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B.By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031029.

Structurei

3D structure databases

ProteinModelPortaliQ8BVL3.
SMRiQ8BVL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 109PXPROSITE-ProRule annotationAdd BLAST109
Domaini115 – 206Ras-associatingPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 432FERM-likeBy similarityAdd BLAST318
Regioni270 – 432PTB-like F3 moduleBy similarityAdd BLAST163

Domaini

The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes (By similarity).By similarity
The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3784. Eukaryota.
ENOG410XT9I. LUCA.
GeneTreeiENSGT00530000063147.
HOGENOMiHOG000007722.
HOVERGENiHBG061207.
InParanoidiQ8BVL3.
KOiK17929.
OMAiAVFFRND.
OrthoDBiEOG091G0BES.
PhylomeDBiQ8BVL3.
TreeFamiTF318398.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR000159. RA_dom.
IPR028666. SNX17.
[Graphical view]
PANTHERiPTHR12431:SF16. PTHR12431:SF16. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BVL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFSIPETES RSGDSGGSAY VAYNIHVNGV LHCRVRYSQL LGLHEQLRKE
60 70 80 90 100
YGANVVPAFP PKKLFSLTPA EVEQRREQLE KYMQAVRQDP LLGSSETFNS
110 120 130 140 150
FLRRAQQETQ QVPTEEVSLE VLLSNGQKVL VTVLTSDQTE DVLEAVAAKL
160 170 180 190 200
DLPDDLIGYF SLFLVREKED GAFSFVRKLQ EFELPYVSVT SLRSQEYKIV
210 220 230 240 250
LRKSYWDSAY DDDVMENRVG LNLLYAQTVS DIEHGWILVT KEQHRQLKSL
260 270 280 290 300
QEKVSKKEFL RLAQTLRHYG YLRFDACVAD FPEKDCPVVV SAGNSELSLQ
310 320 330 340 350
LRLPGQQLRE GSFRVTRMRC WRVTSSVPLP SGGTSSPSRG RGEVRLELAF
360 370 380 390 400
EYLMSKDRLQ WVTITSPQAI MMSICLQSMV DELMVKKSGG SIRKMLRRRV
410 420 430 440 450
GGTLRRSDSQ QAVKSPPLLE SPDASRESMV KLSSKLSAVS LRGIGSPSTD
460 470
ASASAVHGNF AFEGIGDEDL
Length:470
Mass (Da):52,797
Last modified:May 30, 2006 - v2
Checksum:i3023B5FAEF38BB42
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198K → E in BAC37004 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077650 mRNA. Translation: BAC36927.1.
AK077780 mRNA. Translation: BAC37004.1.
AK156299 mRNA. Translation: BAE33663.1.
BC026571 mRNA. Translation: AAH26571.1.
BC023732 mRNA. Translation: AAH23732.1.
CCDSiCCDS19177.1.
RefSeqiNP_710147.1. NM_153680.2.
UniGeneiMm.6118.

Genome annotation databases

EnsembliENSMUST00000031029; ENSMUSP00000031029; ENSMUSG00000029146.
GeneIDi266781.
KEGGimmu:266781.
UCSCiuc008wxm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077650 mRNA. Translation: BAC36927.1.
AK077780 mRNA. Translation: BAC37004.1.
AK156299 mRNA. Translation: BAE33663.1.
BC026571 mRNA. Translation: AAH26571.1.
BC023732 mRNA. Translation: AAH23732.1.
CCDSiCCDS19177.1.
RefSeqiNP_710147.1. NM_153680.2.
UniGeneiMm.6118.

3D structure databases

ProteinModelPortaliQ8BVL3.
SMRiQ8BVL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031029.

PTM databases

iPTMnetiQ8BVL3.
PhosphoSitePlusiQ8BVL3.

Proteomic databases

EPDiQ8BVL3.
MaxQBiQ8BVL3.
PaxDbiQ8BVL3.
PeptideAtlasiQ8BVL3.
PRIDEiQ8BVL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031029; ENSMUSP00000031029; ENSMUSG00000029146.
GeneIDi266781.
KEGGimmu:266781.
UCSCiuc008wxm.1. mouse.

Organism-specific databases

CTDi9784.
MGIiMGI:2387801. Snx17.

Phylogenomic databases

eggNOGiKOG3784. Eukaryota.
ENOG410XT9I. LUCA.
GeneTreeiENSGT00530000063147.
HOGENOMiHOG000007722.
HOVERGENiHBG061207.
InParanoidiQ8BVL3.
KOiK17929.
OMAiAVFFRND.
OrthoDBiEOG091G0BES.
PhylomeDBiQ8BVL3.
TreeFamiTF318398.

Miscellaneous databases

PROiQ8BVL3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029146.
CleanExiMM_SNX17.
ExpressionAtlasiQ8BVL3. baseline and differential.
GenevisibleiQ8BVL3. MM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR000159. RA_dom.
IPR028666. SNX17.
[Graphical view]
PANTHERiPTHR12431:SF16. PTHR12431:SF16. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX17_MOUSE
AccessioniPrimary (citable) accession number: Q8BVL3
Secondary accession number(s): Q8R0N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.