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Q8BVK9 (SP110_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sp110 nuclear body protein
Alternative name(s):
Intracellular pathogen resistance protein 1
Gene names
Name:Sp110
Synonyms:Ifi75, Ipr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells. Ref.1

Subcellular location

Nucleus By similarity.

Tissue specificity

Detected in lung and macrophages. Ref.1

Induction

Up-regulated after infection with M.tuberculosis. Ref.1

Involvement in disease

Defects in Sp110 are a cause of severely impaired resistance to infection by M.tuberculosis. Ref.1

Sequence similarities

Contains 1 HSR domain.

Contains 1 SAND domain.

Sequence caution

The sequence AAH18413.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Sp110 nuclear body protein
PRO_0000247960

Regions

Domain1 – 108108HSR
Domain353 – 43381SAND
Motif251 – 26616Nuclear localization signal Potential

Amino acid modifications

Modified residue1751Phosphoserine Ref.4
Modified residue1771Phosphoserine Ref.4
Modified residue2261Phosphoserine By similarity

Experimental info

Sequence conflict1541P → L in AAH18413. Ref.3
Sequence conflict1541P → L in AAH39938. Ref.3
Sequence conflict1841L → P in AAH18413. Ref.3
Sequence conflict1841L → P in AAH39938. Ref.3
Sequence conflict2471A → G in AAH39938. Ref.3
Sequence conflict2521R → H in AAH39938. Ref.3
Sequence conflict2731M → MA in AAH39938. Ref.3
Sequence conflict3101Q → L in AAH39938. Ref.3
Sequence conflict3121T → A in AAH39938. Ref.3
Sequence conflict3241E → G in BAE29505. Ref.2
Sequence conflict4051G → R in AAH39938. Ref.3
Sequence conflict4171R → C in AAH39938. Ref.3
Sequence conflict434 – 4352FT → CI in AAH39938. Ref.3

Secondary structure

............. 445
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8BVK9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: A2F442C9ABFB3C5B

FASTA44550,140
        10         20         30         40         50         60 
MFTLTKALEK ALLQHFIYMK VNIAYAINKP FPFFEALRDN SFITERMYKE SLEACQNLVP 

        70         80         90        100        110        120 
LSKVVHNILT SLEQTFHPSV LLTLFSKVNL REYPSLVAIF RSFRNVGYTY EEKNRPPLTL 

       130        140        150        160        170        180 
LEDLANPAEG CSLQTLLPPP RPQISLPSHL SSAPRVCDPR ATAQPIIEIL DEQPSPSPRA 

       190        200        210        220        230        240 
VPLLGCIQEG KTTPVSSRDH QRKDKEDSRE MPHSPSGPES VVKDDSPAAN DLEMAREVPC 

       250        260        270        280        290        300 
TPANKKARRK KRPNWSNSKR RRQKKKPRQD EMMGVASPGH GVQEKLKAVS RRTLWKDDSS 

       310        320        330        340        350        360 
TNVKEVTKTQ RTRMRRAQTS NSQEISKEAS KTSGRKRPST ARRTTQVPEK TKNDAVDFSP 

       370        380        390        400        410        420 
TLPVTCGKAK GTLFQEKLKQ GASKKCIQNE AGDWLTVKEF LNEGGRATSK DWKGVIRCNG 

       430        440 
ETLRHLEQKG LLFFTSKSKP QKKGA 

« Hide

References

« Hide 'large scale' references
[1]"Ipr1 gene mediates innate immunity to tuberculosis."
Pan H., Yan B.-S., Rojas M., Shebzukhov Y.V., Zhou H., Kobzik L., Higgins D.E., Daly M.J., Bloom B.R., Kramnik I.
Nature 434:767-772(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISEASE, INDUCTION, TISSUE SPECIFICITY.
Strain: C3Heb/FeJ.
Tissue: Lung.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II and NMRI.
Tissue: Mammary tumor.
[4]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175 AND SER-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Solution structure of the SAND domain of the putative nuclear protein homolog (5830484A20RIK)."
RIKEN structural genomics initiative (RSGI)
Submitted (JUN-2004) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 353-433.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY845948 mRNA. Translation: AAW32543.1.
AK077800 mRNA. Translation: BAC37018.1.
AK150373 mRNA. Translation: BAE29505.1.
BC018413 mRNA. Translation: AAH18413.1. Sequence problems.
BC039938 mRNA. Translation: AAH39938.1.
BC094500 mRNA. Translation: AAH94500.1.
RefSeqNP_084470.1. NM_030194.1.
NP_780606.3. NM_175397.4.
UniGeneMm.335802.
Mm.461913.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UFNNMR-A353-433[»]
ProteinModelPortalQ8BVK9.
SMRQ8BVK9. Positions 353-433.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid224528. 1 interaction.
STRING10090.ENSMUSP00000091226.

PTM databases

PhosphoSiteQ8BVK9.

Proteomic databases

PaxDbQ8BVK9.
PRIDEQ8BVK9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000093508; ENSMUSP00000091226; ENSMUSG00000070034.
GeneID109032.
KEGGmmu:109032.
UCSCuc007btz.2. mouse.

Organism-specific databases

CTD3431.
MGIMGI:1923364. Sp110.

Phylogenomic databases

eggNOGNOG306672.
GeneTreeENSGT00510000046835.
HOGENOMHOG000089984.
HOVERGENHBG006294.
InParanoidQ8BVK9.
OMACARRCES.
OrthoDBEOG7SR4MV.
PhylomeDBQ8BVK9.
TreeFamTF335091.

Gene expression databases

BgeeQ8BVK9.
CleanExMM_SP110.
GenevestigatorQ8BVK9.

Family and domain databases

Gene3D3.10.390.10. 1 hit.
InterProIPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR004865. Sp100.
[Graphical view]
PfamPF01342. SAND. 1 hit.
PF03172. Sp100. 1 hit.
[Graphical view]
SMARTSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMSSF63763. SSF63763. 1 hit.
PROSITEPS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8BVK9.
NextBio361588.
PROQ8BVK9.
SOURCESearch...

Entry information

Entry nameSP110_MOUSE
AccessionPrimary (citable) accession number: Q8BVK9
Secondary accession number(s): Q05D41, Q3UCV7, Q80V00
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot