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Q8BVK9

- SP110_MOUSE

UniProt

Q8BVK9 - SP110_MOUSE

Protein

Sp110 nuclear body protein

Gene

Sp110

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW
    3. positive regulation of apoptotic process Source: MGI
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. response to bacterium Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Immunity, Innate immunity, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sp110 nuclear body protein
    Alternative name(s):
    Intracellular pathogen resistance protein 1
    Gene namesi
    Name:Sp110
    Synonyms:Ifi75, Ipr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1923364. Sp110.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Sp110 are a cause of severely impaired resistance to infection by M.tuberculosis.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Sp110 nuclear body proteinPRO_0000247960Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei175 – 1751Phosphoserine1 Publication
    Modified residuei177 – 1771Phosphoserine1 Publication
    Modified residuei226 – 2261PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8BVK9.
    PRIDEiQ8BVK9.

    PTM databases

    PhosphoSiteiQ8BVK9.

    Expressioni

    Tissue specificityi

    Detected in lung and macrophages.1 Publication

    Inductioni

    Up-regulated after infection with M.tuberculosis.1 Publication

    Gene expression databases

    BgeeiQ8BVK9.
    CleanExiMM_SP110.
    GenevestigatoriQ8BVK9.

    Interactioni

    Protein-protein interaction databases

    BioGridi224528. 1 interaction.
    STRINGi10090.ENSMUSP00000091226.

    Structurei

    Secondary structure

    1
    445
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi355 – 3584
    Beta strandi359 – 3668
    Beta strandi369 – 3746
    Helixi375 – 3795
    Helixi397 – 4048
    Helixi412 – 4154
    Helixi423 – 4286

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UFNNMR-A353-433[»]
    ProteinModelPortaliQ8BVK9.
    SMRiQ8BVK9. Positions 353-433.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8BVK9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 108108HSRPROSITE-ProRule annotationAdd
    BLAST
    Domaini353 – 43381SANDPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi251 – 26616Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HSR domain.PROSITE-ProRule annotation
    Contains 1 SAND domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG306672.
    GeneTreeiENSGT00510000046835.
    HOGENOMiHOG000089984.
    HOVERGENiHBG006294.
    InParanoidiQ8BVK9.
    OMAiCARRCES.
    OrthoDBiEOG7SR4MV.
    PhylomeDBiQ8BVK9.
    TreeFamiTF335091.

    Family and domain databases

    Gene3Di3.10.390.10. 1 hit.
    InterProiIPR000770. SAND_dom.
    IPR010919. SAND_dom-like.
    IPR004865. Sp100.
    [Graphical view]
    PfamiPF01342. SAND. 1 hit.
    PF03172. Sp100. 1 hit.
    [Graphical view]
    SMARTiSM00258. SAND. 1 hit.
    [Graphical view]
    SUPFAMiSSF63763. SSF63763. 1 hit.
    PROSITEiPS51414. HSR. 1 hit.
    PS50864. SAND. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BVK9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTLTKALEK ALLQHFIYMK VNIAYAINKP FPFFEALRDN SFITERMYKE    50
    SLEACQNLVP LSKVVHNILT SLEQTFHPSV LLTLFSKVNL REYPSLVAIF 100
    RSFRNVGYTY EEKNRPPLTL LEDLANPAEG CSLQTLLPPP RPQISLPSHL 150
    SSAPRVCDPR ATAQPIIEIL DEQPSPSPRA VPLLGCIQEG KTTPVSSRDH 200
    QRKDKEDSRE MPHSPSGPES VVKDDSPAAN DLEMAREVPC TPANKKARRK 250
    KRPNWSNSKR RRQKKKPRQD EMMGVASPGH GVQEKLKAVS RRTLWKDDSS 300
    TNVKEVTKTQ RTRMRRAQTS NSQEISKEAS KTSGRKRPST ARRTTQVPEK 350
    TKNDAVDFSP TLPVTCGKAK GTLFQEKLKQ GASKKCIQNE AGDWLTVKEF 400
    LNEGGRATSK DWKGVIRCNG ETLRHLEQKG LLFFTSKSKP QKKGA 445
    Length:445
    Mass (Da):50,140
    Last modified:March 1, 2003 - v1
    Checksum:iA2F442C9ABFB3C5B
    GO

    Sequence cautioni

    The sequence AAH18413.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541P → L in AAH18413. (PubMed:15489334)Curated
    Sequence conflicti154 – 1541P → L in AAH39938. (PubMed:15489334)Curated
    Sequence conflicti184 – 1841L → P in AAH18413. (PubMed:15489334)Curated
    Sequence conflicti184 – 1841L → P in AAH39938. (PubMed:15489334)Curated
    Sequence conflicti247 – 2471A → G in AAH39938. (PubMed:15489334)Curated
    Sequence conflicti252 – 2521R → H in AAH39938. (PubMed:15489334)Curated
    Sequence conflicti273 – 2731M → MA in AAH39938. (PubMed:15489334)Curated
    Sequence conflicti310 – 3101Q → L in AAH39938. (PubMed:15489334)Curated
    Sequence conflicti312 – 3121T → A in AAH39938. (PubMed:15489334)Curated
    Sequence conflicti324 – 3241E → G in BAE29505. (PubMed:16141072)Curated
    Sequence conflicti405 – 4051G → R in AAH39938. (PubMed:15489334)Curated
    Sequence conflicti417 – 4171R → C in AAH39938. (PubMed:15489334)Curated
    Sequence conflicti434 – 4352FT → CI in AAH39938. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY845948 mRNA. Translation: AAW32543.1.
    AK077800 mRNA. Translation: BAC37018.1.
    AK150373 mRNA. Translation: BAE29505.1.
    BC018413 mRNA. Translation: AAH18413.1. Sequence problems.
    BC039938 mRNA. Translation: AAH39938.1.
    BC094500 mRNA. Translation: AAH94500.1.
    CCDSiCCDS35637.1.
    RefSeqiNP_084470.1. NM_030194.1.
    NP_780606.3. NM_175397.4.
    UniGeneiMm.335802.
    Mm.461913.

    Genome annotation databases

    EnsembliENSMUST00000093508; ENSMUSP00000091226; ENSMUSG00000070034.
    GeneIDi109032.
    KEGGimmu:109032.
    UCSCiuc007btz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY845948 mRNA. Translation: AAW32543.1 .
    AK077800 mRNA. Translation: BAC37018.1 .
    AK150373 mRNA. Translation: BAE29505.1 .
    BC018413 mRNA. Translation: AAH18413.1 . Sequence problems.
    BC039938 mRNA. Translation: AAH39938.1 .
    BC094500 mRNA. Translation: AAH94500.1 .
    CCDSi CCDS35637.1.
    RefSeqi NP_084470.1. NM_030194.1.
    NP_780606.3. NM_175397.4.
    UniGenei Mm.335802.
    Mm.461913.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UFN NMR - A 353-433 [» ]
    ProteinModelPortali Q8BVK9.
    SMRi Q8BVK9. Positions 353-433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 224528. 1 interaction.
    STRINGi 10090.ENSMUSP00000091226.

    PTM databases

    PhosphoSitei Q8BVK9.

    Proteomic databases

    PaxDbi Q8BVK9.
    PRIDEi Q8BVK9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000093508 ; ENSMUSP00000091226 ; ENSMUSG00000070034 .
    GeneIDi 109032.
    KEGGi mmu:109032.
    UCSCi uc007btz.2. mouse.

    Organism-specific databases

    CTDi 3431.
    MGIi MGI:1923364. Sp110.

    Phylogenomic databases

    eggNOGi NOG306672.
    GeneTreei ENSGT00510000046835.
    HOGENOMi HOG000089984.
    HOVERGENi HBG006294.
    InParanoidi Q8BVK9.
    OMAi CARRCES.
    OrthoDBi EOG7SR4MV.
    PhylomeDBi Q8BVK9.
    TreeFami TF335091.

    Miscellaneous databases

    EvolutionaryTracei Q8BVK9.
    NextBioi 361588.
    PROi Q8BVK9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BVK9.
    CleanExi MM_SP110.
    Genevestigatori Q8BVK9.

    Family and domain databases

    Gene3Di 3.10.390.10. 1 hit.
    InterProi IPR000770. SAND_dom.
    IPR010919. SAND_dom-like.
    IPR004865. Sp100.
    [Graphical view ]
    Pfami PF01342. SAND. 1 hit.
    PF03172. Sp100. 1 hit.
    [Graphical view ]
    SMARTi SM00258. SAND. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63763. SSF63763. 1 hit.
    PROSITEi PS51414. HSR. 1 hit.
    PS50864. SAND. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISEASE, INDUCTION, TISSUE SPECIFICITY.
      Strain: C3Heb/FeJ.
      Tissue: Lung.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II and NMRI.
      Tissue: Mammary tumor.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175 AND SER-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Solution structure of the SAND domain of the putative nuclear protein homolog (5830484A20RIK)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 353-433.

    Entry informationi

    Entry nameiSP110_MOUSE
    AccessioniPrimary (citable) accession number: Q8BVK9
    Secondary accession number(s): Q05D41, Q3UCV7, Q80V00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3