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Q8BVK9

- SP110_MOUSE

UniProt

Q8BVK9 - SP110_MOUSE

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Protein
Sp110 nuclear body protein
Gene
Sp110, Ifi75, Ipr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. innate immune response Source: UniProtKB-KW
  3. positive regulation of apoptotic process Source: MGI
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. response to bacterium Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Immunity, Innate immunity, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sp110 nuclear body protein
Alternative name(s):
Intracellular pathogen resistance protein 1
Gene namesi
Name:Sp110
Synonyms:Ifi75, Ipr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1923364. Sp110.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Sp110 are a cause of severely impaired resistance to infection by M.tuberculosis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Sp110 nuclear body protein
PRO_0000247960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751Phosphoserine1 Publication
Modified residuei177 – 1771Phosphoserine1 Publication
Modified residuei226 – 2261Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BVK9.
PRIDEiQ8BVK9.

PTM databases

PhosphoSiteiQ8BVK9.

Expressioni

Tissue specificityi

Detected in lung and macrophages.1 Publication

Inductioni

Up-regulated after infection with M.tuberculosis.1 Publication

Gene expression databases

BgeeiQ8BVK9.
CleanExiMM_SP110.
GenevestigatoriQ8BVK9.

Interactioni

Protein-protein interaction databases

BioGridi224528. 1 interaction.
STRINGi10090.ENSMUSP00000091226.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi355 – 3584
Beta strandi359 – 3668
Beta strandi369 – 3746
Helixi375 – 3795
Helixi397 – 4048
Helixi412 – 4154
Helixi423 – 4286

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UFNNMR-A353-433[»]
ProteinModelPortaliQ8BVK9.
SMRiQ8BVK9. Positions 353-433.

Miscellaneous databases

EvolutionaryTraceiQ8BVK9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 108108HSR
Add
BLAST
Domaini353 – 43381SAND
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi251 – 26616Nuclear localization signal Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 HSR domain.
Contains 1 SAND domain.

Phylogenomic databases

eggNOGiNOG306672.
GeneTreeiENSGT00510000046835.
HOGENOMiHOG000089984.
HOVERGENiHBG006294.
InParanoidiQ8BVK9.
OMAiCARRCES.
OrthoDBiEOG7SR4MV.
PhylomeDBiQ8BVK9.
TreeFamiTF335091.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
InterProiIPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR004865. Sp100.
[Graphical view]
PfamiPF01342. SAND. 1 hit.
PF03172. Sp100. 1 hit.
[Graphical view]
SMARTiSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF63763. SSF63763. 1 hit.
PROSITEiPS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BVK9-1 [UniParc]FASTAAdd to Basket

« Hide

MFTLTKALEK ALLQHFIYMK VNIAYAINKP FPFFEALRDN SFITERMYKE    50
SLEACQNLVP LSKVVHNILT SLEQTFHPSV LLTLFSKVNL REYPSLVAIF 100
RSFRNVGYTY EEKNRPPLTL LEDLANPAEG CSLQTLLPPP RPQISLPSHL 150
SSAPRVCDPR ATAQPIIEIL DEQPSPSPRA VPLLGCIQEG KTTPVSSRDH 200
QRKDKEDSRE MPHSPSGPES VVKDDSPAAN DLEMAREVPC TPANKKARRK 250
KRPNWSNSKR RRQKKKPRQD EMMGVASPGH GVQEKLKAVS RRTLWKDDSS 300
TNVKEVTKTQ RTRMRRAQTS NSQEISKEAS KTSGRKRPST ARRTTQVPEK 350
TKNDAVDFSP TLPVTCGKAK GTLFQEKLKQ GASKKCIQNE AGDWLTVKEF 400
LNEGGRATSK DWKGVIRCNG ETLRHLEQKG LLFFTSKSKP QKKGA 445
Length:445
Mass (Da):50,140
Last modified:March 1, 2003 - v1
Checksum:iA2F442C9ABFB3C5B
GO

Sequence cautioni

The sequence AAH18413.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541P → L in AAH18413. 1 Publication
Sequence conflicti154 – 1541P → L in AAH39938. 1 Publication
Sequence conflicti184 – 1841L → P in AAH18413. 1 Publication
Sequence conflicti184 – 1841L → P in AAH39938. 1 Publication
Sequence conflicti247 – 2471A → G in AAH39938. 1 Publication
Sequence conflicti252 – 2521R → H in AAH39938. 1 Publication
Sequence conflicti273 – 2731M → MA in AAH39938. 1 Publication
Sequence conflicti310 – 3101Q → L in AAH39938. 1 Publication
Sequence conflicti312 – 3121T → A in AAH39938. 1 Publication
Sequence conflicti324 – 3241E → G in BAE29505. 1 Publication
Sequence conflicti405 – 4051G → R in AAH39938. 1 Publication
Sequence conflicti417 – 4171R → C in AAH39938. 1 Publication
Sequence conflicti434 – 4352FT → CI in AAH39938. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY845948 mRNA. Translation: AAW32543.1.
AK077800 mRNA. Translation: BAC37018.1.
AK150373 mRNA. Translation: BAE29505.1.
BC018413 mRNA. Translation: AAH18413.1. Sequence problems.
BC039938 mRNA. Translation: AAH39938.1.
BC094500 mRNA. Translation: AAH94500.1.
CCDSiCCDS35637.1.
RefSeqiNP_084470.1. NM_030194.1.
NP_780606.3. NM_175397.4.
UniGeneiMm.335802.
Mm.461913.

Genome annotation databases

EnsembliENSMUST00000093508; ENSMUSP00000091226; ENSMUSG00000070034.
GeneIDi109032.
KEGGimmu:109032.
UCSCiuc007btz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY845948 mRNA. Translation: AAW32543.1 .
AK077800 mRNA. Translation: BAC37018.1 .
AK150373 mRNA. Translation: BAE29505.1 .
BC018413 mRNA. Translation: AAH18413.1 . Sequence problems.
BC039938 mRNA. Translation: AAH39938.1 .
BC094500 mRNA. Translation: AAH94500.1 .
CCDSi CCDS35637.1.
RefSeqi NP_084470.1. NM_030194.1.
NP_780606.3. NM_175397.4.
UniGenei Mm.335802.
Mm.461913.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UFN NMR - A 353-433 [» ]
ProteinModelPortali Q8BVK9.
SMRi Q8BVK9. Positions 353-433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 224528. 1 interaction.
STRINGi 10090.ENSMUSP00000091226.

PTM databases

PhosphoSitei Q8BVK9.

Proteomic databases

PaxDbi Q8BVK9.
PRIDEi Q8BVK9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000093508 ; ENSMUSP00000091226 ; ENSMUSG00000070034 .
GeneIDi 109032.
KEGGi mmu:109032.
UCSCi uc007btz.2. mouse.

Organism-specific databases

CTDi 3431.
MGIi MGI:1923364. Sp110.

Phylogenomic databases

eggNOGi NOG306672.
GeneTreei ENSGT00510000046835.
HOGENOMi HOG000089984.
HOVERGENi HBG006294.
InParanoidi Q8BVK9.
OMAi CARRCES.
OrthoDBi EOG7SR4MV.
PhylomeDBi Q8BVK9.
TreeFami TF335091.

Miscellaneous databases

EvolutionaryTracei Q8BVK9.
NextBioi 361588.
PROi Q8BVK9.
SOURCEi Search...

Gene expression databases

Bgeei Q8BVK9.
CleanExi MM_SP110.
Genevestigatori Q8BVK9.

Family and domain databases

Gene3Di 3.10.390.10. 1 hit.
InterProi IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR004865. Sp100.
[Graphical view ]
Pfami PF01342. SAND. 1 hit.
PF03172. Sp100. 1 hit.
[Graphical view ]
SMARTi SM00258. SAND. 1 hit.
[Graphical view ]
SUPFAMi SSF63763. SSF63763. 1 hit.
PROSITEi PS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISEASE, INDUCTION, TISSUE SPECIFICITY.
    Strain: C3Heb/FeJ.
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and NMRI.
    Tissue: Mammary tumor.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175 AND SER-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Solution structure of the SAND domain of the putative nuclear protein homolog (5830484A20RIK)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 353-433.

Entry informationi

Entry nameiSP110_MOUSE
AccessioniPrimary (citable) accession number: Q8BVK9
Secondary accession number(s): Q05D41, Q3UCV7, Q80V00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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