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Protein

Sp110 nuclear body protein

Gene

Sp110

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Immunity, Innate immunity, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sp110 nuclear body protein
Alternative name(s):
Intracellular pathogen resistance protein 1
Gene namesi
Name:Sp110
Synonyms:Ifi75, Ipr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1923364. Sp110.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Sp110 are a cause of severely impaired resistance to infection by M.tuberculosis.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002479601 – 445Sp110 nuclear body proteinAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineCombined sources1
Modified residuei177PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei277PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BVK9.
MaxQBiQ8BVK9.
PaxDbiQ8BVK9.
PeptideAtlasiQ8BVK9.
PRIDEiQ8BVK9.

PTM databases

iPTMnetiQ8BVK9.
PhosphoSitePlusiQ8BVK9.

Expressioni

Tissue specificityi

Detected in lung and macrophages.1 Publication

Inductioni

Up-regulated after infection with M.tuberculosis.1 Publication

Gene expression databases

BgeeiENSMUSG00000070034.
CleanExiMM_SP110.

Interactioni

Protein-protein interaction databases

BioGridi224528. 1 interactor.
STRINGi10090.ENSMUSP00000091226.

Structurei

Secondary structure

1445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi355 – 358Combined sources4
Beta strandi359 – 366Combined sources8
Beta strandi369 – 374Combined sources6
Helixi375 – 379Combined sources5
Helixi397 – 404Combined sources8
Helixi412 – 415Combined sources4
Helixi423 – 428Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UFNNMR-A353-433[»]
ProteinModelPortaliQ8BVK9.
SMRiQ8BVK9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8BVK9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 108HSRPROSITE-ProRule annotationAdd BLAST108
Domaini353 – 433SANDPROSITE-ProRule annotationAdd BLAST81

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi251 – 266Nuclear localization signalSequence analysisAdd BLAST16

Sequence similaritiesi

Contains 1 HSR domain.PROSITE-ProRule annotation
Contains 1 SAND domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00510000046835.
HOGENOMiHOG000089984.
HOVERGENiHBG006294.
InParanoidiQ8BVK9.
OMAiNERARYP.
OrthoDBiEOG091G0KIE.
PhylomeDBiQ8BVK9.
TreeFamiTF335091.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
InterProiIPR004865. HSR_dom.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
[Graphical view]
PfamiPF03172. HSR. 1 hit.
PF01342. SAND. 1 hit.
[Graphical view]
SMARTiSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF63763. SSF63763. 1 hit.
PROSITEiPS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BVK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTLTKALEK ALLQHFIYMK VNIAYAINKP FPFFEALRDN SFITERMYKE
60 70 80 90 100
SLEACQNLVP LSKVVHNILT SLEQTFHPSV LLTLFSKVNL REYPSLVAIF
110 120 130 140 150
RSFRNVGYTY EEKNRPPLTL LEDLANPAEG CSLQTLLPPP RPQISLPSHL
160 170 180 190 200
SSAPRVCDPR ATAQPIIEIL DEQPSPSPRA VPLLGCIQEG KTTPVSSRDH
210 220 230 240 250
QRKDKEDSRE MPHSPSGPES VVKDDSPAAN DLEMAREVPC TPANKKARRK
260 270 280 290 300
KRPNWSNSKR RRQKKKPRQD EMMGVASPGH GVQEKLKAVS RRTLWKDDSS
310 320 330 340 350
TNVKEVTKTQ RTRMRRAQTS NSQEISKEAS KTSGRKRPST ARRTTQVPEK
360 370 380 390 400
TKNDAVDFSP TLPVTCGKAK GTLFQEKLKQ GASKKCIQNE AGDWLTVKEF
410 420 430 440
LNEGGRATSK DWKGVIRCNG ETLRHLEQKG LLFFTSKSKP QKKGA
Length:445
Mass (Da):50,140
Last modified:March 1, 2003 - v1
Checksum:iA2F442C9ABFB3C5B
GO

Sequence cautioni

The sequence AAH18413 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154P → L in AAH18413 (PubMed:15489334).Curated1
Sequence conflicti154P → L in AAH39938 (PubMed:15489334).Curated1
Sequence conflicti184L → P in AAH18413 (PubMed:15489334).Curated1
Sequence conflicti184L → P in AAH39938 (PubMed:15489334).Curated1
Sequence conflicti247A → G in AAH39938 (PubMed:15489334).Curated1
Sequence conflicti252R → H in AAH39938 (PubMed:15489334).Curated1
Sequence conflicti273M → MA in AAH39938 (PubMed:15489334).Curated1
Sequence conflicti310Q → L in AAH39938 (PubMed:15489334).Curated1
Sequence conflicti312T → A in AAH39938 (PubMed:15489334).Curated1
Sequence conflicti324E → G in BAE29505 (PubMed:16141072).Curated1
Sequence conflicti405G → R in AAH39938 (PubMed:15489334).Curated1
Sequence conflicti417R → C in AAH39938 (PubMed:15489334).Curated1
Sequence conflicti434 – 435FT → CI in AAH39938 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY845948 mRNA. Translation: AAW32543.1.
AK077800 mRNA. Translation: BAC37018.1.
AK150373 mRNA. Translation: BAE29505.1.
BC018413 mRNA. Translation: AAH18413.1. Sequence problems.
BC039938 mRNA. Translation: AAH39938.1.
BC094500 mRNA. Translation: AAH94500.1.
CCDSiCCDS35637.1.
RefSeqiNP_084470.1. NM_030194.1.
NP_780606.3. NM_175397.4.
UniGeneiMm.335802.
Mm.461913.

Genome annotation databases

EnsembliENSMUST00000093508; ENSMUSP00000091226; ENSMUSG00000070034.
GeneIDi109032.
KEGGimmu:109032.
UCSCiuc007btz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY845948 mRNA. Translation: AAW32543.1.
AK077800 mRNA. Translation: BAC37018.1.
AK150373 mRNA. Translation: BAE29505.1.
BC018413 mRNA. Translation: AAH18413.1. Sequence problems.
BC039938 mRNA. Translation: AAH39938.1.
BC094500 mRNA. Translation: AAH94500.1.
CCDSiCCDS35637.1.
RefSeqiNP_084470.1. NM_030194.1.
NP_780606.3. NM_175397.4.
UniGeneiMm.335802.
Mm.461913.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UFNNMR-A353-433[»]
ProteinModelPortaliQ8BVK9.
SMRiQ8BVK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224528. 1 interactor.
STRINGi10090.ENSMUSP00000091226.

PTM databases

iPTMnetiQ8BVK9.
PhosphoSitePlusiQ8BVK9.

Proteomic databases

EPDiQ8BVK9.
MaxQBiQ8BVK9.
PaxDbiQ8BVK9.
PeptideAtlasiQ8BVK9.
PRIDEiQ8BVK9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093508; ENSMUSP00000091226; ENSMUSG00000070034.
GeneIDi109032.
KEGGimmu:109032.
UCSCiuc007btz.2. mouse.

Organism-specific databases

CTDi3431.
MGIiMGI:1923364. Sp110.

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00510000046835.
HOGENOMiHOG000089984.
HOVERGENiHBG006294.
InParanoidiQ8BVK9.
OMAiNERARYP.
OrthoDBiEOG091G0KIE.
PhylomeDBiQ8BVK9.
TreeFamiTF335091.

Miscellaneous databases

EvolutionaryTraceiQ8BVK9.
PROiQ8BVK9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070034.
CleanExiMM_SP110.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
InterProiIPR004865. HSR_dom.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
[Graphical view]
PfamiPF03172. HSR. 1 hit.
PF01342. SAND. 1 hit.
[Graphical view]
SMARTiSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF63763. SSF63763. 1 hit.
PROSITEiPS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSP110_MOUSE
AccessioniPrimary (citable) accession number: Q8BVK9
Secondary accession number(s): Q05D41, Q3UCV7, Q80V00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.