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Protein

Syntaxin-16

Gene

Stx16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-16
Gene namesi
Name:Stx16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923396 Stx16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 302CytoplasmicSequence analysisAdd BLAST302
Transmembranei303 – 323Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini324 – 326VesicularSequence analysis3

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102271 – 326Syntaxin-16Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BVI5
MaxQBiQ8BVI5
PaxDbiQ8BVI5
PeptideAtlasiQ8BVI5
PRIDEiQ8BVI5

PTM databases

iPTMnetiQ8BVI5
PhosphoSitePlusiQ8BVI5

Expressioni

Gene expression databases

BgeeiENSMUSG00000027522
CleanExiMM_STX16
ExpressionAtlasiQ8BVI5 baseline and differential
GenevisibleiQ8BVI5 MM

Interactioni

Subunit structurei

Interacts with GCC2 (By similarity). Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Vps45O087006EBI-3871057,EBI-7849203From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BVI5, 4 interactors
MINTiQ8BVI5
STRINGi10090.ENSMUSP00000085218

Structurei

3D structure databases

ProteinModelPortaliQ8BVI5
SMRiQ8BVI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini231 – 293t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0809 Eukaryota
COG5325 LUCA
GeneTreeiENSGT00880000138049
HOGENOMiHOG000190358
HOVERGENiHBG057612
InParanoidiQ8BVI5
KOiK08489
PhylomeDBiQ8BVI5
TreeFamiTF314090

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR028673 STX16
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF141 PTHR19957:SF141, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BVI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRRLTDAF LLLRNNSIQT RQLLAEQVSS HTTSSPLHSR SIAAELDELA
60 70 80 90 100
DDRMALVSGI SLDPEAAIGV TKRSPPKWVD GVDEIQYDVG RIKQKMKELA
110 120 130 140 150
SLHDKHLNRP TLDDSSEEEH AIEITTQEVT QLFHRCQRAV QALPSRARRA
160 170 180 190 200
CSEQEERLLR NVVASLAQAL QELSTSFRHA QSDYLKRMKN REERSQHFFD
210 220 230 240 250
TPVPLMDDGD DATLYGQGFT DDQLVLVEQN TLMVEERERE IRQIVQSISD
260 270 280 290 300
LNEIFRDLGA MIVEQGTVLD RIDYNVEQSC VKTEDGLKQL HKAEQYQKKN
310 320
RKMLVIVILV AVIIVLLVAL VAVKSR
Length:326
Mass (Da):37,080
Last modified:July 27, 2011 - v3
Checksum:iE1042EA1A15372B6
GO

Sequence cautioni

The sequence BAC37129 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → T in BAC37129 (PubMed:16141072).Curated1
Sequence conflicti45 – 46EL → DV in BAC37129 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078110 mRNA Translation: BAC37129.1 Different initiation.
AL669896 Genomic DNA No translation available.
CCDSiCCDS17147.2
RefSeqiNP_766263.2, NM_172675.4
UniGeneiMm.277977

Genome annotation databases

EnsembliENSMUST00000087908; ENSMUSP00000085218; ENSMUSG00000027522
GeneIDi228960
KEGGimmu:228960
UCSCiuc008oej.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSTX16_MOUSE
AccessioniPrimary (citable) accession number: Q8BVI5
Secondary accession number(s): A2ACM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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