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Q8BVI5

- STX16_MOUSE

UniProt

Q8BVI5 - STX16_MOUSE

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Protein
Syntaxin-16
Gene
Stx16
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. intra-Golgi vesicle-mediated transport Source: InterPro
  2. intracellular protein transport Source: InterPro
  3. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-16
Gene namesi
Name:Stx16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1923396. Stx16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 302302Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei303 – 32321Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST
Topological domaini324 – 3263Vesicular Reviewed prediction

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. Golgi membrane Source: UniProtKB-SubCell
  3. SNARE complex Source: InterPro
  4. integral component of membrane Source: UniProtKB-KW
  5. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Syntaxin-16
PRO_0000210227Add
BLAST

Proteomic databases

PaxDbiQ8BVI5.
PRIDEiQ8BVI5.

PTM databases

PhosphoSiteiQ8BVI5.

Expressioni

Gene expression databases

BgeeiQ8BVI5.
CleanExiMM_STX16.
GenevestigatoriQ8BVI5.

Interactioni

Subunit structurei

Interacts with GCC2 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Vps45O087006EBI-3871057,EBI-7849203From a different organism.

Protein-protein interaction databases

IntActiQ8BVI5. 4 interactions.
MINTiMINT-1859484.

Structurei

3D structure databases

ProteinModelPortaliQ8BVI5.
SMRiQ8BVI5. Positions 77-293.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini231 – 29363t-SNARE coiled-coil homology
Add
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5325.
GeneTreeiENSGT00550000075126.
HOGENOMiHOG000190358.
HOVERGENiHBG057612.
InParanoidiQ8BVI5.
KOiK08489.
PhylomeDBiQ8BVI5.
TreeFamiTF314090.

Family and domain databases

InterProiIPR028673. STX16.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF79. PTHR19957:SF79. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BVI5-1 [UniParc]FASTAAdd to Basket

« Hide

MATRRLTDAF LLLRNNSIQT RQLLAEQVSS HTTSSPLHSR SIAAELDELA    50
DDRMALVSGI SLDPEAAIGV TKRSPPKWVD GVDEIQYDVG RIKQKMKELA 100
SLHDKHLNRP TLDDSSEEEH AIEITTQEVT QLFHRCQRAV QALPSRARRA 150
CSEQEERLLR NVVASLAQAL QELSTSFRHA QSDYLKRMKN REERSQHFFD 200
TPVPLMDDGD DATLYGQGFT DDQLVLVEQN TLMVEERERE IRQIVQSISD 250
LNEIFRDLGA MIVEQGTVLD RIDYNVEQSC VKTEDGLKQL HKAEQYQKKN 300
RKMLVIVILV AVIIVLLVAL VAVKSR 326
Length:326
Mass (Da):37,080
Last modified:July 27, 2011 - v3
Checksum:iE1042EA1A15372B6
GO

Sequence cautioni

The sequence BAC37129.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → T in BAC37129. 1 Publication
Sequence conflicti45 – 462EL → DV in BAC37129. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK078110 mRNA. Translation: BAC37129.1. Different initiation.
AL669896 Genomic DNA. Translation: CAM25416.2.
CCDSiCCDS17147.2.
RefSeqiNP_766263.2. NM_172675.4.
UniGeneiMm.277977.

Genome annotation databases

EnsembliENSMUST00000087908; ENSMUSP00000085218; ENSMUSG00000027522.
GeneIDi228960.
KEGGimmu:228960.
UCSCiuc008oej.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK078110 mRNA. Translation: BAC37129.1 . Different initiation.
AL669896 Genomic DNA. Translation: CAM25416.2 .
CCDSi CCDS17147.2.
RefSeqi NP_766263.2. NM_172675.4.
UniGenei Mm.277977.

3D structure databases

ProteinModelPortali Q8BVI5.
SMRi Q8BVI5. Positions 77-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BVI5. 4 interactions.
MINTi MINT-1859484.

PTM databases

PhosphoSitei Q8BVI5.

Proteomic databases

PaxDbi Q8BVI5.
PRIDEi Q8BVI5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087908 ; ENSMUSP00000085218 ; ENSMUSG00000027522 .
GeneIDi 228960.
KEGGi mmu:228960.
UCSCi uc008oej.1. mouse.

Organism-specific databases

CTDi 8675.
MGIi MGI:1923396. Stx16.

Phylogenomic databases

eggNOGi COG5325.
GeneTreei ENSGT00550000075126.
HOGENOMi HOG000190358.
HOVERGENi HBG057612.
InParanoidi Q8BVI5.
KOi K08489.
PhylomeDBi Q8BVI5.
TreeFami TF314090.

Miscellaneous databases

ChiTaRSi STX16. mouse.
NextBioi 379259.
PROi Q8BVI5.
SOURCEi Search...

Gene expression databases

Bgeei Q8BVI5.
CleanExi MM_STX16.
Genevestigatori Q8BVI5.

Family and domain databases

InterProi IPR028673. STX16.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
PANTHERi PTHR19957:SF79. PTHR19957:SF79. 1 hit.
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Medulla oblongata.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTX16_MOUSE
AccessioniPrimary (citable) accession number: Q8BVI5
Secondary accession number(s): A2ACM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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