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Protein

Syntaxin-16

Gene

Stx16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-16
Gene namesi
Name:Stx16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923396. Stx16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 302CytoplasmicSequence analysisAdd BLAST302
Transmembranei303 – 323Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini324 – 326VesicularSequence analysis3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102271 – 326Syntaxin-16Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BVI5.
MaxQBiQ8BVI5.
PaxDbiQ8BVI5.
PeptideAtlasiQ8BVI5.
PRIDEiQ8BVI5.

PTM databases

iPTMnetiQ8BVI5.
PhosphoSitePlusiQ8BVI5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027522.
CleanExiMM_STX16.
ExpressionAtlasiQ8BVI5. baseline and differential.
GenevisibleiQ8BVI5. MM.

Interactioni

Subunit structurei

Interacts with GCC2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Vps45O087006EBI-3871057,EBI-7849203From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BVI5. 4 interactors.
MINTiMINT-1859484.
STRINGi10090.ENSMUSP00000085218.

Structurei

3D structure databases

ProteinModelPortaliQ8BVI5.
SMRiQ8BVI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini231 – 293t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0809. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00550000075126.
HOGENOMiHOG000190358.
HOVERGENiHBG057612.
InParanoidiQ8BVI5.
KOiK08489.
PhylomeDBiQ8BVI5.
TreeFamiTF314090.

Family and domain databases

InterProiIPR028673. STX16.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF83. PTHR19957:SF83. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BVI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRRLTDAF LLLRNNSIQT RQLLAEQVSS HTTSSPLHSR SIAAELDELA
60 70 80 90 100
DDRMALVSGI SLDPEAAIGV TKRSPPKWVD GVDEIQYDVG RIKQKMKELA
110 120 130 140 150
SLHDKHLNRP TLDDSSEEEH AIEITTQEVT QLFHRCQRAV QALPSRARRA
160 170 180 190 200
CSEQEERLLR NVVASLAQAL QELSTSFRHA QSDYLKRMKN REERSQHFFD
210 220 230 240 250
TPVPLMDDGD DATLYGQGFT DDQLVLVEQN TLMVEERERE IRQIVQSISD
260 270 280 290 300
LNEIFRDLGA MIVEQGTVLD RIDYNVEQSC VKTEDGLKQL HKAEQYQKKN
310 320
RKMLVIVILV AVIIVLLVAL VAVKSR
Length:326
Mass (Da):37,080
Last modified:July 27, 2011 - v3
Checksum:iE1042EA1A15372B6
GO

Sequence cautioni

The sequence BAC37129 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → T in BAC37129 (PubMed:16141072).Curated1
Sequence conflicti45 – 46EL → DV in BAC37129 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078110 mRNA. Translation: BAC37129.1. Different initiation.
AL669896 Genomic DNA. Translation: CAM25416.2.
CCDSiCCDS17147.2.
RefSeqiNP_766263.2. NM_172675.4.
UniGeneiMm.277977.

Genome annotation databases

EnsembliENSMUST00000087908; ENSMUSP00000085218; ENSMUSG00000027522.
GeneIDi228960.
KEGGimmu:228960.
UCSCiuc008oej.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078110 mRNA. Translation: BAC37129.1. Different initiation.
AL669896 Genomic DNA. Translation: CAM25416.2.
CCDSiCCDS17147.2.
RefSeqiNP_766263.2. NM_172675.4.
UniGeneiMm.277977.

3D structure databases

ProteinModelPortaliQ8BVI5.
SMRiQ8BVI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BVI5. 4 interactors.
MINTiMINT-1859484.
STRINGi10090.ENSMUSP00000085218.

PTM databases

iPTMnetiQ8BVI5.
PhosphoSitePlusiQ8BVI5.

Proteomic databases

EPDiQ8BVI5.
MaxQBiQ8BVI5.
PaxDbiQ8BVI5.
PeptideAtlasiQ8BVI5.
PRIDEiQ8BVI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087908; ENSMUSP00000085218; ENSMUSG00000027522.
GeneIDi228960.
KEGGimmu:228960.
UCSCiuc008oej.1. mouse.

Organism-specific databases

CTDi8675.
MGIiMGI:1923396. Stx16.

Phylogenomic databases

eggNOGiKOG0809. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00550000075126.
HOGENOMiHOG000190358.
HOVERGENiHBG057612.
InParanoidiQ8BVI5.
KOiK08489.
PhylomeDBiQ8BVI5.
TreeFamiTF314090.

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

ChiTaRSiStx16. mouse.
PROiQ8BVI5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027522.
CleanExiMM_STX16.
ExpressionAtlasiQ8BVI5. baseline and differential.
GenevisibleiQ8BVI5. MM.

Family and domain databases

InterProiIPR028673. STX16.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF83. PTHR19957:SF83. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX16_MOUSE
AccessioniPrimary (citable) accession number: Q8BVI5
Secondary accession number(s): A2ACM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.