Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8BVI5

- STX16_MOUSE

UniProt

Q8BVI5 - STX16_MOUSE

Protein

Syntaxin-16

Gene

Stx16

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. intra-Golgi vesicle-mediated transport Source: InterPro
    3. retrograde transport, endosome to Golgi Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-16
    Gene namesi
    Name:Stx16
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1923396. Stx16.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: MGI
    2. Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. nucleolus Source: Ensembl
    5. SNARE complex Source: InterPro

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Syntaxin-16PRO_0000210227Add
    BLAST

    Proteomic databases

    PaxDbiQ8BVI5.
    PRIDEiQ8BVI5.

    PTM databases

    PhosphoSiteiQ8BVI5.

    Expressioni

    Gene expression databases

    BgeeiQ8BVI5.
    CleanExiMM_STX16.
    GenevestigatoriQ8BVI5.

    Interactioni

    Subunit structurei

    Interacts with GCC2.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Vps45O087006EBI-3871057,EBI-7849203From a different organism.

    Protein-protein interaction databases

    IntActiQ8BVI5. 4 interactions.
    MINTiMINT-1859484.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BVI5.
    SMRiQ8BVI5. Positions 77-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 302302CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini324 – 3263VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei303 – 32321Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini231 – 29363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5325.
    GeneTreeiENSGT00550000075126.
    HOGENOMiHOG000190358.
    HOVERGENiHBG057612.
    InParanoidiQ8BVI5.
    KOiK08489.
    PhylomeDBiQ8BVI5.
    TreeFamiTF314090.

    Family and domain databases

    InterProiIPR028673. STX16.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PANTHERiPTHR19957:SF79. PTHR19957:SF79. 1 hit.
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BVI5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATRRLTDAF LLLRNNSIQT RQLLAEQVSS HTTSSPLHSR SIAAELDELA    50
    DDRMALVSGI SLDPEAAIGV TKRSPPKWVD GVDEIQYDVG RIKQKMKELA 100
    SLHDKHLNRP TLDDSSEEEH AIEITTQEVT QLFHRCQRAV QALPSRARRA 150
    CSEQEERLLR NVVASLAQAL QELSTSFRHA QSDYLKRMKN REERSQHFFD 200
    TPVPLMDDGD DATLYGQGFT DDQLVLVEQN TLMVEERERE IRQIVQSISD 250
    LNEIFRDLGA MIVEQGTVLD RIDYNVEQSC VKTEDGLKQL HKAEQYQKKN 300
    RKMLVIVILV AVIIVLLVAL VAVKSR 326
    Length:326
    Mass (Da):37,080
    Last modified:July 27, 2011 - v3
    Checksum:iE1042EA1A15372B6
    GO

    Sequence cautioni

    The sequence BAC37129.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → T in BAC37129. (PubMed:16141072)Curated
    Sequence conflicti45 – 462EL → DV in BAC37129. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK078110 mRNA. Translation: BAC37129.1. Different initiation.
    AL669896 Genomic DNA. Translation: CAM25416.2.
    CCDSiCCDS17147.2.
    RefSeqiNP_766263.2. NM_172675.4.
    UniGeneiMm.277977.

    Genome annotation databases

    EnsembliENSMUST00000087908; ENSMUSP00000085218; ENSMUSG00000027522.
    GeneIDi228960.
    KEGGimmu:228960.
    UCSCiuc008oej.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK078110 mRNA. Translation: BAC37129.1 . Different initiation.
    AL669896 Genomic DNA. Translation: CAM25416.2 .
    CCDSi CCDS17147.2.
    RefSeqi NP_766263.2. NM_172675.4.
    UniGenei Mm.277977.

    3D structure databases

    ProteinModelPortali Q8BVI5.
    SMRi Q8BVI5. Positions 77-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BVI5. 4 interactions.
    MINTi MINT-1859484.

    PTM databases

    PhosphoSitei Q8BVI5.

    Proteomic databases

    PaxDbi Q8BVI5.
    PRIDEi Q8BVI5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087908 ; ENSMUSP00000085218 ; ENSMUSG00000027522 .
    GeneIDi 228960.
    KEGGi mmu:228960.
    UCSCi uc008oej.1. mouse.

    Organism-specific databases

    CTDi 8675.
    MGIi MGI:1923396. Stx16.

    Phylogenomic databases

    eggNOGi COG5325.
    GeneTreei ENSGT00550000075126.
    HOGENOMi HOG000190358.
    HOVERGENi HBG057612.
    InParanoidi Q8BVI5.
    KOi K08489.
    PhylomeDBi Q8BVI5.
    TreeFami TF314090.

    Miscellaneous databases

    ChiTaRSi STX16. mouse.
    NextBioi 379259.
    PROi Q8BVI5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BVI5.
    CleanExi MM_STX16.
    Genevestigatori Q8BVI5.

    Family and domain databases

    InterProi IPR028673. STX16.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    PANTHERi PTHR19957:SF79. PTHR19957:SF79. 1 hit.
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Medulla oblongata.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSTX16_MOUSE
    AccessioniPrimary (citable) accession number: Q8BVI5
    Secondary accession number(s): A2ACM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 92 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3