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Protein

Dipeptidyl peptidase 9

Gene

Dpp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Enzyme regulationi

Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei729 – 7291Charge relay systemBy similarity
Active sitei807 – 8071Charge relay systemBy similarity
Active sitei839 – 8391Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. identical protein binding Source: MGI
  3. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.019.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 9 (EC:3.4.14.5)
Short name:
DP9
Alternative name(s):
Dipeptidyl peptidase IX
Short name:
DPP IX
Dipeptidyl peptidase-like protein 9
Short name:
DPLP9
Gene namesi
Name:Dpp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2443967. Dpp9.

Subcellular locationi

  1. Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: UniProtKB-SubCell
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Dipeptidyl peptidase 9PRO_0000122416Add
BLAST

Proteomic databases

MaxQBiQ8BVG4.
PaxDbiQ8BVG4.
PRIDEiQ8BVG4.

PTM databases

PhosphoSiteiQ8BVG4.

Expressioni

Gene expression databases

BgeeiQ8BVG4.
CleanExiMM_DPP9.
GenevestigatoriQ8BVG4.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ8BVG4. 2 interactions.
MINTiMINT-4997661.
STRINGi10090.ENSMUSP00000046604.

Structurei

3D structure databases

ProteinModelPortaliQ8BVG4.
SMRiQ8BVG4. Positions 621-860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family. DPPIV subfamily.Curated

Phylogenomic databases

eggNOGiCOG1506.
GeneTreeiENSGT00760000119233.
HOGENOMiHOG000006870.
HOVERGENiHBG061620.
InParanoidiQ8BVG4.
KOiK08656.
OMAiDGRARCY.
OrthoDBiEOG7XWPN8.
PhylomeDBiQ8BVG4.
TreeFamiTF313309.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BVG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCSGVSPVEQ VAAGDMDDTA ARFCVQKHSW DGLRSIIHGS RKSSGLIVSK
60 70 80 90 100
APHDFQFVQK PDESGPHSHR LYYLGMPYGS RENSLLYSEI PKKVRKEALL
110 120 130 140 150
LLSWKQMLDH FQATPHHGVY SREEELLRER KRLGVFGITS YDFHSESGLF
160 170 180 190 200
LFQASNSLFH CRDGGKNGFM VSPMKPLEIK TQCSGPRMDP KICPADPAFF
210 220 230 240 250
SFINNSDLWV ANIETGEERR LTFCHQGSAG VLDNPKSAGV ATFVIQEEFD
260 270 280 290 300
RFTGCWWCPT ASWEGSEGLK TLRILYEEVD ESEVEVIHVP SPALEERKTD
310 320 330 340 350
SYRYPRTGSK NPKIALKLAE LQTDHQGKIV SSCEKELVQP FSSLFPKVEY
360 370 380 390 400
IARAGWTRDG KYAWAMFLDR PQQRLQLVLL PPALFIPAVE SEAQRQAAAR
410 420 430 440 450
AVPKNVQPFV IYEEVTNVWI NVHDIFHPFP QAEGQQDFCF LRANECKTGF
460 470 480 490 500
CHLYRVTVEL KTKDYDWTEP LSPTEDEFKC PIKEEVALTS GEWEVLSRHG
510 520 530 540 550
SKIWVNEQTK LVYFQGTKDT PLEHHLYVVS YESAGEIVRL TTLGFSHSCS
560 570 580 590 600
MSQSFDMFVS HYSSVSTPPC VHVYKLSGPD DDPLHKQPRF WASMMEAANC
610 620 630 640 650
PPDYVPPEIF HFHTRADVQL YGMIYKPHTL QPGRKHPTVL FVYGGPQVQL
660 670 680 690 700
VNNSFKGIKY LRLNTLASLG YAVVVIDGRG SCQRGLHFEG ALKNQMGQVE
710 720 730 740 750
IEDQVEGLQY VAEKYGFIDL SRVAIHGWSY GGFLSLMGLI HKPQVFKVAI
760 770 780 790 800
AGAPVTVWMA YDTGYTERYM DVPENNQQGY EAGSVALHVE KLPNEPNRLL
810 820 830 840 850
ILHGFLDENV HFFHTNFLVS QLIRAGKPYQ LQIYPNERHS IRCRESGEHY
860
EVTLLHFLQE HL
Length:862
Mass (Da):98,001
Last modified:June 7, 2005 - v2
Checksum:iB1D566E824A834E8
GO
Isoform 2 (identifier: Q8BVG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     748-787: VAIAGAPVTV...QGYEAGSVAL → PPHEAESPSS...PGTPASEGQR
     788-862: Missing.

Show »
Length:712
Mass (Da):80,596
Checksum:i658A3A4569A5F283
GO

Sequence cautioni

The sequence BAD21428.1 differs from that shown. Reason: Frameshift at position 745. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691D → Y in BAC37211 (PubMed:16141072).Curated
Sequence conflicti546 – 5461S → F in BAD21428 (PubMed:15449545).Curated
Sequence conflicti777 – 7771Q → K in BAC37211 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7575Missing in isoform 2. 1 PublicationVSP_013870Add
BLAST
Alternative sequencei748 – 78740VAIAG…GSVAL → PPHEAESPSSLPATTDPRMA SASSSMWEAKPGTPASEGQR in isoform 2. 1 PublicationVSP_013871Add
BLAST
Alternative sequencei788 – 86275Missing in isoform 2. 1 PublicationVSP_013872Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050021 mRNA. Translation: BAC34034.1.
AK078301 mRNA. Translation: BAC37211.1.
AK131178 mRNA. Translation: BAD21428.1. Sequence problems.
BC057631 mRNA. Translation: AAH57631.1.
CCDSiCCDS37663.1. [Q8BVG4-1]
RefSeqiNP_766212.2. NM_172624.3. [Q8BVG4-1]
XP_006524218.1. XM_006524155.2. [Q8BVG4-1]
UniGeneiMm.205535.

Genome annotation databases

EnsembliENSMUST00000038794; ENSMUSP00000046604; ENSMUSG00000001229. [Q8BVG4-1]
GeneIDi224897.
KEGGimmu:224897.
UCSCiuc008dbh.2. mouse. [Q8BVG4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050021 mRNA. Translation: BAC34034.1.
AK078301 mRNA. Translation: BAC37211.1.
AK131178 mRNA. Translation: BAD21428.1. Sequence problems.
BC057631 mRNA. Translation: AAH57631.1.
CCDSiCCDS37663.1. [Q8BVG4-1]
RefSeqiNP_766212.2. NM_172624.3. [Q8BVG4-1]
XP_006524218.1. XM_006524155.2. [Q8BVG4-1]
UniGeneiMm.205535.

3D structure databases

ProteinModelPortaliQ8BVG4.
SMRiQ8BVG4. Positions 621-860.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BVG4. 2 interactions.
MINTiMINT-4997661.
STRINGi10090.ENSMUSP00000046604.

Chemistry

ChEMBLiCHEMBL3259484.

Protein family/group databases

MEROPSiS09.019.

PTM databases

PhosphoSiteiQ8BVG4.

Proteomic databases

MaxQBiQ8BVG4.
PaxDbiQ8BVG4.
PRIDEiQ8BVG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038794; ENSMUSP00000046604; ENSMUSG00000001229. [Q8BVG4-1]
GeneIDi224897.
KEGGimmu:224897.
UCSCiuc008dbh.2. mouse. [Q8BVG4-1]

Organism-specific databases

CTDi91039.
MGIiMGI:2443967. Dpp9.

Phylogenomic databases

eggNOGiCOG1506.
GeneTreeiENSGT00760000119233.
HOGENOMiHOG000006870.
HOVERGENiHBG061620.
InParanoidiQ8BVG4.
KOiK08656.
OMAiDGRARCY.
OrthoDBiEOG7XWPN8.
PhylomeDBiQ8BVG4.
TreeFamiTF313309.

Miscellaneous databases

ChiTaRSiDpp9. mouse.
NextBioi377440.
PROiQ8BVG4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BVG4.
CleanExiMM_DPP9.
GenevestigatoriQ8BVG4.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Liver and Olfactory bulb.
  2. "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
    DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiDPP9_MOUSE
AccessioniPrimary (citable) accession number: Q8BVG4
Secondary accession number(s): Q6KAM9, Q8BWT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: April 1, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.