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Protein

Dipeptidyl peptidase 9

Gene

Dpp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Enzyme regulationi

Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei729Charge relay systemBy similarity1
Active sitei807Charge relay systemBy similarity1
Active sitei839Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERimouse-dpp9 DPP4N_Peptidase_S9
MEROPSiS09.019

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 9 (EC:3.4.14.5)
Short name:
DP9
Alternative name(s):
Dipeptidyl peptidase IX
Short name:
DPP IX
Dipeptidyl peptidase-like protein 9
Short name:
DPLP9
Gene namesi
Name:Dpp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2443967 Dpp9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3259484

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224161 – 862Dipeptidyl peptidase 9Add BLAST862

Proteomic databases

EPDiQ8BVG4
PaxDbiQ8BVG4
PeptideAtlasiQ8BVG4
PRIDEiQ8BVG4

PTM databases

iPTMnetiQ8BVG4
PhosphoSitePlusiQ8BVG4

Expressioni

Gene expression databases

BgeeiENSMUSG00000001229
CleanExiMM_DPP9
GenevisibleiQ8BVG4 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BVG4, 2 interactors
MINTiQ8BVG4
STRINGi10090.ENSMUSP00000046604

Structurei

3D structure databases

ProteinModelPortaliQ8BVG4
SMRiQ8BVG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family. DPPIV subfamily.Curated

Phylogenomic databases

eggNOGiKOG2281 Eukaryota
COG1506 LUCA
GeneTreeiENSGT00760000119233
HOGENOMiHOG000006870
HOVERGENiHBG061620
InParanoidiQ8BVG4
KOiK08656
OMAiWASMMEA
OrthoDBiEOG091G05F9
PhylomeDBiQ8BVG4
TreeFamiTF313309

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BVG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCSGVSPVEQ VAAGDMDDTA ARFCVQKHSW DGLRSIIHGS RKSSGLIVSK
60 70 80 90 100
APHDFQFVQK PDESGPHSHR LYYLGMPYGS RENSLLYSEI PKKVRKEALL
110 120 130 140 150
LLSWKQMLDH FQATPHHGVY SREEELLRER KRLGVFGITS YDFHSESGLF
160 170 180 190 200
LFQASNSLFH CRDGGKNGFM VSPMKPLEIK TQCSGPRMDP KICPADPAFF
210 220 230 240 250
SFINNSDLWV ANIETGEERR LTFCHQGSAG VLDNPKSAGV ATFVIQEEFD
260 270 280 290 300
RFTGCWWCPT ASWEGSEGLK TLRILYEEVD ESEVEVIHVP SPALEERKTD
310 320 330 340 350
SYRYPRTGSK NPKIALKLAE LQTDHQGKIV SSCEKELVQP FSSLFPKVEY
360 370 380 390 400
IARAGWTRDG KYAWAMFLDR PQQRLQLVLL PPALFIPAVE SEAQRQAAAR
410 420 430 440 450
AVPKNVQPFV IYEEVTNVWI NVHDIFHPFP QAEGQQDFCF LRANECKTGF
460 470 480 490 500
CHLYRVTVEL KTKDYDWTEP LSPTEDEFKC PIKEEVALTS GEWEVLSRHG
510 520 530 540 550
SKIWVNEQTK LVYFQGTKDT PLEHHLYVVS YESAGEIVRL TTLGFSHSCS
560 570 580 590 600
MSQSFDMFVS HYSSVSTPPC VHVYKLSGPD DDPLHKQPRF WASMMEAANC
610 620 630 640 650
PPDYVPPEIF HFHTRADVQL YGMIYKPHTL QPGRKHPTVL FVYGGPQVQL
660 670 680 690 700
VNNSFKGIKY LRLNTLASLG YAVVVIDGRG SCQRGLHFEG ALKNQMGQVE
710 720 730 740 750
IEDQVEGLQY VAEKYGFIDL SRVAIHGWSY GGFLSLMGLI HKPQVFKVAI
760 770 780 790 800
AGAPVTVWMA YDTGYTERYM DVPENNQQGY EAGSVALHVE KLPNEPNRLL
810 820 830 840 850
ILHGFLDENV HFFHTNFLVS QLIRAGKPYQ LQIYPNERHS IRCRESGEHY
860
EVTLLHFLQE HL
Length:862
Mass (Da):98,001
Last modified:June 7, 2005 - v2
Checksum:iB1D566E824A834E8
GO
Isoform 2 (identifier: Q8BVG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     748-787: VAIAGAPVTV...QGYEAGSVAL → PPHEAESPSS...PGTPASEGQR
     788-862: Missing.

Show »
Length:712
Mass (Da):80,596
Checksum:i658A3A4569A5F283
GO

Sequence cautioni

The sequence BAD21428 differs from that shown. Reason: Frameshift at position 745.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti369D → Y in BAC37211 (PubMed:16141072).Curated1
Sequence conflicti546S → F in BAD21428 (PubMed:15449545).Curated1
Sequence conflicti777Q → K in BAC37211 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0138701 – 75Missing in isoform 2. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_013871748 – 787VAIAG…GSVAL → PPHEAESPSSLPATTDPRMA SASSSMWEAKPGTPASEGQR in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_013872788 – 862Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050021 mRNA Translation: BAC34034.1
AK078301 mRNA Translation: BAC37211.1
AK131178 mRNA Translation: BAD21428.1 Sequence problems.
BC057631 mRNA Translation: AAH57631.1
CCDSiCCDS37663.1 [Q8BVG4-1]
RefSeqiNP_766212.2, NM_172624.3 [Q8BVG4-1]
XP_006524218.1, XM_006524155.3 [Q8BVG4-1]
UniGeneiMm.205535

Genome annotation databases

EnsembliENSMUST00000038794; ENSMUSP00000046604; ENSMUSG00000001229 [Q8BVG4-1]
GeneIDi224897
KEGGimmu:224897
UCSCiuc008dbh.2 mouse [Q8BVG4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDPP9_MOUSE
AccessioniPrimary (citable) accession number: Q8BVG4
Secondary accession number(s): Q6KAM9, Q8BWT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health