Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8BVG4 (DPP9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dipeptidyl peptidase 9

Short name=DP9
EC=3.4.14.5
Alternative name(s):
Dipeptidyl peptidase IX
Short name=DPP IX
Dipeptidyl peptidase-like protein 9
Short name=DPLP9
Gene names
Name:Dpp9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length862 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Enzyme regulation

Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasmcytosol By similarity.

Sequence similarities

Belongs to the peptidase S9B family. DPPIV subfamily.

Sequence caution

The sequence BAD21428.1 differs from that shown. Reason: Frameshift at position 745.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BVG4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BVG4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     748-787: VAIAGAPVTV...QGYEAGSVAL → PPHEAESPSS...PGTPASEGQR
     788-862: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 862862Dipeptidyl peptidase 9
PRO_0000122416

Sites

Active site7291Charge relay system By similarity
Active site8071Charge relay system By similarity
Active site8391Charge relay system By similarity

Natural variations

Alternative sequence1 – 7575Missing in isoform 2.
VSP_013870
Alternative sequence748 – 78740VAIAG…GSVAL → PPHEAESPSSLPATTDPRMA SASSSMWEAKPGTPASEGQR in isoform 2.
VSP_013871
Alternative sequence788 – 86275Missing in isoform 2.
VSP_013872

Experimental info

Sequence conflict3691D → Y in BAC37211. Ref.1
Sequence conflict5461S → F in BAD21428. Ref.2
Sequence conflict7771Q → K in BAC37211. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: B1D566E824A834E8

FASTA86298,001
        10         20         30         40         50         60 
MCSGVSPVEQ VAAGDMDDTA ARFCVQKHSW DGLRSIIHGS RKSSGLIVSK APHDFQFVQK 

        70         80         90        100        110        120 
PDESGPHSHR LYYLGMPYGS RENSLLYSEI PKKVRKEALL LLSWKQMLDH FQATPHHGVY 

       130        140        150        160        170        180 
SREEELLRER KRLGVFGITS YDFHSESGLF LFQASNSLFH CRDGGKNGFM VSPMKPLEIK 

       190        200        210        220        230        240 
TQCSGPRMDP KICPADPAFF SFINNSDLWV ANIETGEERR LTFCHQGSAG VLDNPKSAGV 

       250        260        270        280        290        300 
ATFVIQEEFD RFTGCWWCPT ASWEGSEGLK TLRILYEEVD ESEVEVIHVP SPALEERKTD 

       310        320        330        340        350        360 
SYRYPRTGSK NPKIALKLAE LQTDHQGKIV SSCEKELVQP FSSLFPKVEY IARAGWTRDG 

       370        380        390        400        410        420 
KYAWAMFLDR PQQRLQLVLL PPALFIPAVE SEAQRQAAAR AVPKNVQPFV IYEEVTNVWI 

       430        440        450        460        470        480 
NVHDIFHPFP QAEGQQDFCF LRANECKTGF CHLYRVTVEL KTKDYDWTEP LSPTEDEFKC 

       490        500        510        520        530        540 
PIKEEVALTS GEWEVLSRHG SKIWVNEQTK LVYFQGTKDT PLEHHLYVVS YESAGEIVRL 

       550        560        570        580        590        600 
TTLGFSHSCS MSQSFDMFVS HYSSVSTPPC VHVYKLSGPD DDPLHKQPRF WASMMEAANC 

       610        620        630        640        650        660 
PPDYVPPEIF HFHTRADVQL YGMIYKPHTL QPGRKHPTVL FVYGGPQVQL VNNSFKGIKY 

       670        680        690        700        710        720 
LRLNTLASLG YAVVVIDGRG SCQRGLHFEG ALKNQMGQVE IEDQVEGLQY VAEKYGFIDL 

       730        740        750        760        770        780 
SRVAIHGWSY GGFLSLMGLI HKPQVFKVAI AGAPVTVWMA YDTGYTERYM DVPENNQQGY 

       790        800        810        820        830        840 
EAGSVALHVE KLPNEPNRLL ILHGFLDENV HFFHTNFLVS QLIRAGKPYQ LQIYPNERHS 

       850        860 
IRCRESGEHY EVTLLHFLQE HL 

« Hide

Isoform 2 [UniParc].

Checksum: 658A3A4569A5F283
Show »

FASTA71280,596

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Liver and Olfactory bulb.
[2]"Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK050021 mRNA. Translation: BAC34034.1.
AK078301 mRNA. Translation: BAC37211.1.
AK131178 mRNA. Translation: BAD21428.1. Sequence problems.
BC057631 mRNA. Translation: AAH57631.1.
CCDSCCDS37663.1. [Q8BVG4-1]
RefSeqNP_766212.2. NM_172624.3. [Q8BVG4-1]
XP_006524218.1. XM_006524155.1. [Q8BVG4-1]
UniGeneMm.205535.

3D structure databases

ProteinModelPortalQ8BVG4.
SMRQ8BVG4. Positions 621-860.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8BVG4. 2 interactions.
MINTMINT-4997661.
STRING10090.ENSMUSP00000046604.

Protein family/group databases

MEROPSS09.019.

PTM databases

PhosphoSiteQ8BVG4.

Proteomic databases

MaxQBQ8BVG4.
PaxDbQ8BVG4.
PRIDEQ8BVG4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038794; ENSMUSP00000046604; ENSMUSG00000001229. [Q8BVG4-1]
GeneID224897.
KEGGmmu:224897.
UCSCuc008dbh.2. mouse. [Q8BVG4-1]

Organism-specific databases

CTD91039.
MGIMGI:2443967. Dpp9.

Phylogenomic databases

eggNOGCOG1506.
GeneTreeENSGT00740000115073.
HOGENOMHOG000006870.
HOVERGENHBG061620.
InParanoidQ8BVG4.
KOK08656.
OMAFPRVEYI.
OrthoDBEOG7XWPN8.
PhylomeDBQ8BVG4.
TreeFamTF313309.

Gene expression databases

BgeeQ8BVG4.
CleanExMM_DPP9.
GenevestigatorQ8BVG4.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

ChiTaRSDPP9. mouse.
NextBio377440.
PROQ8BVG4.
SOURCESearch...

Entry information

Entry nameDPP9_MOUSE
AccessionPrimary (citable) accession number: Q8BVG4
Secondary accession number(s): Q6KAM9, Q8BWT9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot