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Q8BVG4

- DPP9_MOUSE

UniProt

Q8BVG4 - DPP9_MOUSE

Protein

Dipeptidyl peptidase 9

Gene

Dpp9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Enzyme regulationi

    Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei729 – 7291Charge relay systemBy similarity
    Active sitei807 – 8071Charge relay systemBy similarity
    Active sitei839 – 8391Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.019.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidyl peptidase 9 (EC:3.4.14.5)
    Short name:
    DP9
    Alternative name(s):
    Dipeptidyl peptidase IX
    Short name:
    DPP IX
    Dipeptidyl peptidase-like protein 9
    Short name:
    DPLP9
    Gene namesi
    Name:Dpp9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2443967. Dpp9.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 862862Dipeptidyl peptidase 9PRO_0000122416Add
    BLAST

    Proteomic databases

    MaxQBiQ8BVG4.
    PaxDbiQ8BVG4.
    PRIDEiQ8BVG4.

    PTM databases

    PhosphoSiteiQ8BVG4.

    Expressioni

    Gene expression databases

    BgeeiQ8BVG4.
    CleanExiMM_DPP9.
    GenevestigatoriQ8BVG4.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ8BVG4. 2 interactions.
    MINTiMINT-4997661.
    STRINGi10090.ENSMUSP00000046604.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BVG4.
    SMRiQ8BVG4. Positions 621-860.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family. DPPIV subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG1506.
    GeneTreeiENSGT00740000115073.
    HOGENOMiHOG000006870.
    HOVERGENiHBG061620.
    InParanoidiQ8BVG4.
    KOiK08656.
    OMAiFPRVEYI.
    OrthoDBiEOG7XWPN8.
    PhylomeDBiQ8BVG4.
    TreeFamiTF313309.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BVG4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCSGVSPVEQ VAAGDMDDTA ARFCVQKHSW DGLRSIIHGS RKSSGLIVSK    50
    APHDFQFVQK PDESGPHSHR LYYLGMPYGS RENSLLYSEI PKKVRKEALL 100
    LLSWKQMLDH FQATPHHGVY SREEELLRER KRLGVFGITS YDFHSESGLF 150
    LFQASNSLFH CRDGGKNGFM VSPMKPLEIK TQCSGPRMDP KICPADPAFF 200
    SFINNSDLWV ANIETGEERR LTFCHQGSAG VLDNPKSAGV ATFVIQEEFD 250
    RFTGCWWCPT ASWEGSEGLK TLRILYEEVD ESEVEVIHVP SPALEERKTD 300
    SYRYPRTGSK NPKIALKLAE LQTDHQGKIV SSCEKELVQP FSSLFPKVEY 350
    IARAGWTRDG KYAWAMFLDR PQQRLQLVLL PPALFIPAVE SEAQRQAAAR 400
    AVPKNVQPFV IYEEVTNVWI NVHDIFHPFP QAEGQQDFCF LRANECKTGF 450
    CHLYRVTVEL KTKDYDWTEP LSPTEDEFKC PIKEEVALTS GEWEVLSRHG 500
    SKIWVNEQTK LVYFQGTKDT PLEHHLYVVS YESAGEIVRL TTLGFSHSCS 550
    MSQSFDMFVS HYSSVSTPPC VHVYKLSGPD DDPLHKQPRF WASMMEAANC 600
    PPDYVPPEIF HFHTRADVQL YGMIYKPHTL QPGRKHPTVL FVYGGPQVQL 650
    VNNSFKGIKY LRLNTLASLG YAVVVIDGRG SCQRGLHFEG ALKNQMGQVE 700
    IEDQVEGLQY VAEKYGFIDL SRVAIHGWSY GGFLSLMGLI HKPQVFKVAI 750
    AGAPVTVWMA YDTGYTERYM DVPENNQQGY EAGSVALHVE KLPNEPNRLL 800
    ILHGFLDENV HFFHTNFLVS QLIRAGKPYQ LQIYPNERHS IRCRESGEHY 850
    EVTLLHFLQE HL 862
    Length:862
    Mass (Da):98,001
    Last modified:June 7, 2005 - v2
    Checksum:iB1D566E824A834E8
    GO
    Isoform 2 (identifier: Q8BVG4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-75: Missing.
         748-787: VAIAGAPVTV...QGYEAGSVAL → PPHEAESPSS...PGTPASEGQR
         788-862: Missing.

    Show »
    Length:712
    Mass (Da):80,596
    Checksum:i658A3A4569A5F283
    GO

    Sequence cautioni

    The sequence BAD21428.1 differs from that shown. Reason: Frameshift at position 745.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti369 – 3691D → Y in BAC37211. (PubMed:16141072)Curated
    Sequence conflicti546 – 5461S → F in BAD21428. (PubMed:15449545)Curated
    Sequence conflicti777 – 7771Q → K in BAC37211. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7575Missing in isoform 2. 1 PublicationVSP_013870Add
    BLAST
    Alternative sequencei748 – 78740VAIAG…GSVAL → PPHEAESPSSLPATTDPRMA SASSSMWEAKPGTPASEGQR in isoform 2. 1 PublicationVSP_013871Add
    BLAST
    Alternative sequencei788 – 86275Missing in isoform 2. 1 PublicationVSP_013872Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050021 mRNA. Translation: BAC34034.1.
    AK078301 mRNA. Translation: BAC37211.1.
    AK131178 mRNA. Translation: BAD21428.1. Sequence problems.
    BC057631 mRNA. Translation: AAH57631.1.
    CCDSiCCDS37663.1. [Q8BVG4-1]
    RefSeqiNP_766212.2. NM_172624.3. [Q8BVG4-1]
    XP_006524218.1. XM_006524155.1. [Q8BVG4-1]
    UniGeneiMm.205535.

    Genome annotation databases

    EnsembliENSMUST00000038794; ENSMUSP00000046604; ENSMUSG00000001229. [Q8BVG4-1]
    GeneIDi224897.
    KEGGimmu:224897.
    UCSCiuc008dbh.2. mouse. [Q8BVG4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050021 mRNA. Translation: BAC34034.1 .
    AK078301 mRNA. Translation: BAC37211.1 .
    AK131178 mRNA. Translation: BAD21428.1 . Sequence problems.
    BC057631 mRNA. Translation: AAH57631.1 .
    CCDSi CCDS37663.1. [Q8BVG4-1 ]
    RefSeqi NP_766212.2. NM_172624.3. [Q8BVG4-1 ]
    XP_006524218.1. XM_006524155.1. [Q8BVG4-1 ]
    UniGenei Mm.205535.

    3D structure databases

    ProteinModelPortali Q8BVG4.
    SMRi Q8BVG4. Positions 621-860.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BVG4. 2 interactions.
    MINTi MINT-4997661.
    STRINGi 10090.ENSMUSP00000046604.

    Protein family/group databases

    MEROPSi S09.019.

    PTM databases

    PhosphoSitei Q8BVG4.

    Proteomic databases

    MaxQBi Q8BVG4.
    PaxDbi Q8BVG4.
    PRIDEi Q8BVG4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038794 ; ENSMUSP00000046604 ; ENSMUSG00000001229 . [Q8BVG4-1 ]
    GeneIDi 224897.
    KEGGi mmu:224897.
    UCSCi uc008dbh.2. mouse. [Q8BVG4-1 ]

    Organism-specific databases

    CTDi 91039.
    MGIi MGI:2443967. Dpp9.

    Phylogenomic databases

    eggNOGi COG1506.
    GeneTreei ENSGT00740000115073.
    HOGENOMi HOG000006870.
    HOVERGENi HBG061620.
    InParanoidi Q8BVG4.
    KOi K08656.
    OMAi FPRVEYI.
    OrthoDBi EOG7XWPN8.
    PhylomeDBi Q8BVG4.
    TreeFami TF313309.

    Miscellaneous databases

    ChiTaRSi DPP9. mouse.
    NextBioi 377440.
    PROi Q8BVG4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BVG4.
    CleanExi MM_DPP9.
    Genevestigatori Q8BVG4.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Liver and Olfactory bulb.
    2. "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
      DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiDPP9_MOUSE
    AccessioniPrimary (citable) accession number: Q8BVG4
    Secondary accession number(s): Q6KAM9, Q8BWT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3