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Protein

Phosducin-like protein 3

Gene

Pdcl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAngiogenesis, Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein 3
Alternative name(s):
Viral IAP-associated factor 1
Short name:
VIAF-1
Gene namesi
Name:Pdcl3
Synonyms:Viaf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1916083 Pdcl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001637591 – 240Phosducin-like protein 3Add BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1
Modified residuei65PhosphoserineCombined sources1
Modified residuei235PhosphoserineBy similarity1
Modified residuei237PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BVF2
MaxQBiQ8BVF2
PaxDbiQ8BVF2
PeptideAtlasiQ8BVF2
PRIDEiQ8BVF2

PTM databases

iPTMnetiQ8BVF2
PhosphoSitePlusiQ8BVF2

Expressioni

Gene expression databases

BgeeiENSMUSG00000026078
CleanExiMM_PDCL3
ExpressionAtlasiQ8BVF2 baseline and differential
GenevisibleiQ8BVF2 MM

Interactioni

Subunit structurei

Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BVF2, 2 interactors
MINTiQ8BVF2
STRINGi10090.ENSMUSP00000027247

Structurei

3D structure databases

ProteinModelPortaliQ8BVF2
SMRiQ8BVF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni92 – 240Thioredoxin foldBy similarityAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 73Glu-richAdd BLAST50

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3170 Eukaryota
ENOG4111H24 LUCA
GeneTreeiENSGT00910000144176
HOGENOMiHOG000184445
HOVERGENiHBG108238
InParanoidiQ8BVF2
OMAiIKFCEIR
OrthoDBiEOG091G0QP8
PhylomeDBiQ8BVF2
TreeFamiTF315179

Family and domain databases

InterProiView protein in InterPro
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BVF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDPNADTEW NDILRKKGIL PPKESLKELE EEEAEKEEQL LQQSVVKTYE
60 70 80 90 100
DMTLEELEEN EDEFSEEDER AIEMYRQQRL AEWKATQLKN KFGEVLEISG
110 120 130 140 150
KDYVQEVTKA GEGLWVILHL YKQGIPLCSL INHHLSGLAR KFPDVKFIKA
160 170 180 190 200
ISTTCIPNYP DRNLPTVFVY REGDIKAQFI GPLVFGGMNL TIDELEWKLS
210 220 230 240
ESGAIKTALE ENPKKPIQDL LLSSVRGPVP MRRDSDSEDD
Length:240
Mass (Da):27,581
Last modified:March 1, 2003 - v1
Checksum:i446AB65099164E09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59Missing in BAB23267 (PubMed:16141072).Curated1
Sequence conflicti216P → L in AAH05601 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110512 mRNA Translation: AAG21888.1
AK004334 mRNA Translation: BAB23267.1
AK078372 mRNA Translation: BAC37242.1
AK168509 mRNA Translation: BAE40392.1
BC005601 mRNA Translation: AAH05601.1
CCDSiCCDS14903.1
RefSeqiNP_081126.2, NM_026850.4
UniGeneiMm.28121

Genome annotation databases

EnsembliENSMUST00000027247; ENSMUSP00000027247; ENSMUSG00000026078
GeneIDi68833
KEGGimmu:68833
UCSCiuc007atc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPDCL3_MOUSE
AccessioniPrimary (citable) accession number: Q8BVF2
Secondary accession number(s): Q3TH06, Q99JX2, Q9D0W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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