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Protein

Phosducin-like protein 3

Gene

Pdcl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein 3
Alternative name(s):
Viral IAP-associated factor 1
Short name:
VIAF-1
Gene namesi
Name:Pdcl3
Synonyms:Viaf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1916083. Pdcl3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Phosducin-like protein 3PRO_0000163759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441PhosphoserineBy similarity
Modified residuei65 – 651PhosphoserineCombined sources
Modified residuei235 – 2351PhosphoserineBy similarity
Modified residuei237 – 2371PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BVF2.
MaxQBiQ8BVF2.
PaxDbiQ8BVF2.
PeptideAtlasiQ8BVF2.
PRIDEiQ8BVF2.

PTM databases

iPTMnetiQ8BVF2.
PhosphoSiteiQ8BVF2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026078.
CleanExiMM_PDCL3.
ExpressionAtlasiQ8BVF2. baseline and differential.
GenevisibleiQ8BVF2. MM.

Interactioni

Subunit structurei

Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BVF2. 2 interactions.
MINTiMINT-4604227.
STRINGi10090.ENSMUSP00000027247.

Structurei

3D structure databases

ProteinModelPortaliQ8BVF2.
SMRiQ8BVF2. Positions 20-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni92 – 240149Thioredoxin foldBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 7350Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3170. Eukaryota.
ENOG4111H24. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ8BVF2.
OMAiPLCSLIN.
OrthoDBiEOG091G0QP8.
PhylomeDBiQ8BVF2.
TreeFamiTF315179.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006442. Antitoxin_Phd/YefM.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01552. phd_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BVF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDPNADTEW NDILRKKGIL PPKESLKELE EEEAEKEEQL LQQSVVKTYE
60 70 80 90 100
DMTLEELEEN EDEFSEEDER AIEMYRQQRL AEWKATQLKN KFGEVLEISG
110 120 130 140 150
KDYVQEVTKA GEGLWVILHL YKQGIPLCSL INHHLSGLAR KFPDVKFIKA
160 170 180 190 200
ISTTCIPNYP DRNLPTVFVY REGDIKAQFI GPLVFGGMNL TIDELEWKLS
210 220 230 240
ESGAIKTALE ENPKKPIQDL LLSSVRGPVP MRRDSDSEDD
Length:240
Mass (Da):27,581
Last modified:March 1, 2003 - v1
Checksum:i446AB65099164E09
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591Missing in BAB23267 (PubMed:16141072).Curated
Sequence conflicti216 – 2161P → L in AAH05601 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110512 mRNA. Translation: AAG21888.1.
AK004334 mRNA. Translation: BAB23267.1.
AK078372 mRNA. Translation: BAC37242.1.
AK168509 mRNA. Translation: BAE40392.1.
BC005601 mRNA. Translation: AAH05601.1.
CCDSiCCDS14903.1.
RefSeqiNP_081126.2. NM_026850.4.
UniGeneiMm.28121.

Genome annotation databases

EnsembliENSMUST00000027247; ENSMUSP00000027247; ENSMUSG00000026078.
GeneIDi68833.
KEGGimmu:68833.
UCSCiuc007atc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110512 mRNA. Translation: AAG21888.1.
AK004334 mRNA. Translation: BAB23267.1.
AK078372 mRNA. Translation: BAC37242.1.
AK168509 mRNA. Translation: BAE40392.1.
BC005601 mRNA. Translation: AAH05601.1.
CCDSiCCDS14903.1.
RefSeqiNP_081126.2. NM_026850.4.
UniGeneiMm.28121.

3D structure databases

ProteinModelPortaliQ8BVF2.
SMRiQ8BVF2. Positions 20-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BVF2. 2 interactions.
MINTiMINT-4604227.
STRINGi10090.ENSMUSP00000027247.

PTM databases

iPTMnetiQ8BVF2.
PhosphoSiteiQ8BVF2.

Proteomic databases

EPDiQ8BVF2.
MaxQBiQ8BVF2.
PaxDbiQ8BVF2.
PeptideAtlasiQ8BVF2.
PRIDEiQ8BVF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027247; ENSMUSP00000027247; ENSMUSG00000026078.
GeneIDi68833.
KEGGimmu:68833.
UCSCiuc007atc.1. mouse.

Organism-specific databases

CTDi79031.
MGIiMGI:1916083. Pdcl3.

Phylogenomic databases

eggNOGiKOG3170. Eukaryota.
ENOG4111H24. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ8BVF2.
OMAiPLCSLIN.
OrthoDBiEOG091G0QP8.
PhylomeDBiQ8BVF2.
TreeFamiTF315179.

Miscellaneous databases

PROiQ8BVF2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026078.
CleanExiMM_PDCL3.
ExpressionAtlasiQ8BVF2. baseline and differential.
GenevisibleiQ8BVF2. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006442. Antitoxin_Phd/YefM.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01552. phd_fam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDCL3_MOUSE
AccessioniPrimary (citable) accession number: Q8BVF2
Secondary accession number(s): Q3TH06, Q99JX2, Q9D0W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.