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Q8BVE8

- NSD2_MOUSE

UniProt

Q8BVE8 - NSD2_MOUSE

Protein

Histone-lysine N-methyltransferase NSD2

Gene

Whsc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity.1 Publication

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi453 – 52169HMG boxPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri667 – 71347PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri714 – 77057PHD-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri831 – 87545PHD-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1239 – 128648PHD-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: UniProtKB-KW
    3. histone-lysine N-methyltransferase activity Source: MGI
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. atrial septum primum morphogenesis Source: MGI
    2. atrial septum secundum morphogenesis Source: MGI
    3. bone development Source: MGI
    4. chromatin modification Source: MGI
    5. histone lysine methylation Source: GOC
    6. membranous septum morphogenesis Source: MGI
    7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase NSD2 (EC:2.1.1.43)
    Alternative name(s):
    Multiple myeloma SET domain-containing protein
    Short name:
    MMSET
    Nuclear SET domain-containing protein 2
    Short name:
    NSD2
    Wolf-Hirschhorn syndrome candidate 1 protein homolog
    Short name:
    WHSC1
    Gene namesi
    Name:Whsc1
    Synonyms:Kiaa1090, Nsd2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1276574. Whsc1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nuclear membrane Source: Ensembl
    3. nucleolus Source: Ensembl
    4. nucleus Source: MGI

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1138 – 11381R → A: No methyltransferase activity. 1 Publication
    Mutagenesisi1144 – 11441C → A: No methyltransferase activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13651365Histone-lysine N-methyltransferase NSD2PRO_0000259520Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei110 – 1101PhosphothreonineBy similarity
    Modified residuei114 – 1141PhosphothreonineBy similarity
    Modified residuei121 – 1211PhosphoserineBy similarity
    Modified residuei376 – 3761PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8BVE8.
    PaxDbiQ8BVE8.
    PRIDEiQ8BVE8.

    PTM databases

    PhosphoSiteiQ8BVE8.

    Expressioni

    Tissue specificityi

    Expressed preferentially in rapidly growing embryonic tissues.1 Publication

    Developmental stagei

    Ubiquitously expressed in early development.1 Publication

    Gene expression databases

    ArrayExpressiQ8BVE8.
    BgeeiQ8BVE8.
    CleanExiMM_WHSC1.
    GenevestigatoriQ8BVE8.

    Interactioni

    Protein-protein interaction databases

    BioGridi223605. 13 interactions.
    DIPiDIP-60452N.
    IntActiQ8BVE8. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BVE8.
    SMRiQ8BVE8. Positions 217-285, 667-712, 716-763, 833-873, 877-973, 976-1203, 1239-1327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini222 – 28665PWWP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini880 – 94263PWWP 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1011 – 106151AWSPROSITE-ProRule annotationAdd
    BLAST
    Domaini1063 – 1180118SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini1187 – 120317Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
    Contains 1 AWS domain.PROSITE-ProRule annotation
    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation
    Contains 4 PHD-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 2 PWWP domains.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri667 – 71347PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri714 – 77057PHD-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri831 – 87545PHD-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1239 – 128648PHD-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2940.
    GeneTreeiENSGT00740000114921.
    HOGENOMiHOG000230893.
    HOVERGENiHBG079979.
    KOiK11424.
    OMAiPSKGKMM.
    OrthoDBiEOG7Z69BG.
    PhylomeDBiQ8BVE8.
    TreeFamiTF329088.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    3.30.40.10. 3 hits.
    InterProiIPR006560. AWS.
    IPR009071. HMG_box_dom.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF00628. PHD. 1 hit.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00398. HMG. 1 hit.
    SM00249. PHD. 4 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    SSF57903. SSF57903. 3 hits.
    PROSITEiPS51215. AWS. 1 hit.
    PS50118. HMG_BOX_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BVE8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEFSIRKSPL SVQKVVKCMK MKQTPEILGS ANGKTQNCEV NHECSVFLSK     50
    AQLSNSLQEG VMQKFNGHDA LPFLPAEKLK DLTSCVFNGE PGAHDTKLCF 100
    EAQEVKGIGT PPNTTPIKNG SPEIKLKITK TYMNGKPLFE SSICGDGAAD 150
    VSQSEENEQK SDNKTRRNRK RSIKYDSLLE QGLVEAALVS KISSPADKKI 200
    PVKKESCPNT GRDRDLLLKY NVGDLVWSKV SGYPWWPCMV SADPLLHNHT 250
    KLKGQKKSAR QYHVQFFGDA PERAWIFEKS LVAFEGEEQF EKLCQESAKQ 300
    APTKAEKIKL LKPISGRLRA QWEMGIVQAE EAASMSIEER KAKFTFLYVG 350
    DQLHLNPQVA KEAGIVTEPL GEMVDSSGAS EEAAVDPGSV REEDIPTKRR 400
    RRTKRSSSAE NQEGDPGTDK STPPKMAEAE PKRGVGSPAG RKKSTGSAPR 450
    SRKGDSAAQF LVFCQKHRDE VVAEHPDASG EEIEELLGSQ WSMLNEKQKA 500
    RYNTKFSLMI SAQSEEDSGN GNGKKRSHTK RADDPAEDVD VEDAPRKRLR 550
    ADKHSLRKRE TITDKTARTS SYKAIEAASS LKSQAATKNL SDACKPLKKR 600
    NRASATASSA LGFNKSSSPS ASLTEHEVSD SPGDEPSESP YESADETQTE 650
    ASVSSKKSER GMAAKKEYVC QLCEKTGSLL LCEGPCCGAF HLACLGLSRR 700
    PEGRFTCTEC ASGIHSCFVC KESKMEVKRC VVNQCGKFYH EACVKKYPLT 750
    VFESRGFRCP LHSCMSCHAS NPSNPRPSKG KMMRCVRCPV AYHGGDACLA 800
    AGCSVIASNS IICTGHFTAR KGKRHHTHVN VSWCFVCSKG GSLLCCEACP 850
    AAFHPDCLNI EMPDGSWFCN DCRAGKKLHF QDIIWVKLGN YRWWPAEVCH 900
    PKNVPPNIQK MKHEIGEFPV FFFGSKDYYW THQARVFPYM EGDRGSRYQG 950
    VRGIGRVFKN ALQEAEARFN EVKLQREARE TQESERKPPP YKHIKVNKPY 1000
    GKVQIYTADI SEIPKCNCKP TDENPCGSDS ECLNRMLMFE CHPQVCPAGE 1050
    YCQNQCFTKR QYPETKIIKT DGKGWGLVAK RDIRKGEFVN EYVGELIDEE 1100
    ECMARIKYAH ENDITHFYML TIDKDRIIDA GPKGNYSRFM NHSCQPNCET 1150
    LKWTVNGDTR VGLFAVCDIP AGTELTFNYN LDCLGNEKTV CRCGASNCSG 1200
    FLGDRPKTSA SLSSEEKGKK AKKKTRRRRA KGEGKRQSED ECFRCGDGGQ 1250
    LVLCDRKFCT KAYHLSCLGL GKRPFGKWEC PWHHCDVCGK PSTSFCHLCP 1300
    NSFCKEHQDG TAFRSTQDGQ SYCCEHDLRA DSSSSTKTEK PFPESLKSKG 1350
    KRKKRRCWRR VTDGK 1365
    Length:1,365
    Mass (Da):152,253
    Last modified:October 31, 2006 - v2
    Checksum:iD8DC3F687D3EA2C2
    GO
    Isoform 2 (identifier: Q8BVE8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         558-558: K → KQ

    Show »
    Length:1,366
    Mass (Da):152,381
    Checksum:i28858A53E6156DEF
    GO
    Isoform 3 (identifier: Q8BVE8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-519: Missing.
         520-522: NGN → MGM
         558-558: K → KQ

    Note: No experimental confirmation available.

    Show »
    Length:847
    Mass (Da):95,042
    Checksum:iEE0EF9742565F18D
    GO
    Isoform RE-IIBP (identifier: Q8BVE8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-661: Missing.

    Show »
    Length:704
    Mass (Da):79,633
    Checksum:iDFB1AC7E5D1E7E4F
    GO

    Sequence cautioni

    The sequence ACE75882.1 differs from that shown. Reason: Incorrectly indicated as originating from human.
    The sequence BAC37342.1 differs from that shown. Reason: Frameshift at positions 649 and 759.
    The sequence BAC98097.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti757 – 7571F → L in BAC37342. (PubMed:16141072)Curated
    Sequence conflicti1019 – 10191K → T in ACE75882. (PubMed:18172012)Curated
    Sequence conflicti1345 – 13451S → L in AAH53454. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 661661Missing in isoform RE-IIBP. 1 PublicationVSP_044420Add
    BLAST
    Alternative sequencei1 – 519519Missing in isoform 3. 1 PublicationVSP_021424Add
    BLAST
    Alternative sequencei520 – 5223NGN → MGM in isoform 3. 1 PublicationVSP_021425
    Alternative sequencei558 – 5581K → KQ in isoform 2 and isoform 3. 2 PublicationsVSP_021426

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU733655 mRNA. Translation: ACE75882.1. Sequence problems.
    AK129287 mRNA. Translation: BAC98097.1. Different initiation.
    AC163329 Genomic DNA. No translation available.
    AK078622 mRNA. Translation: BAC37342.1. Frameshift.
    BC046473 mRNA. Translation: AAH46473.1.
    BC053454 mRNA. Translation: AAH53454.1.
    CCDSiCCDS51467.1. [Q8BVE8-2]
    CCDS51468.1. [Q8BVE8-1]
    RefSeqiNP_001074571.2. NM_001081102.2. [Q8BVE8-2]
    NP_780440.2. NM_175231.2. [Q8BVE8-1]
    XP_006503721.1. XM_006503658.1. [Q8BVE8-2]
    XP_006503722.1. XM_006503659.1. [Q8BVE8-2]
    XP_006503723.1. XM_006503660.1. [Q8BVE8-1]
    UniGeneiMm.19892.
    Mm.332320.
    Mm.491382.

    Genome annotation databases

    EnsembliENSMUST00000058096; ENSMUSP00000058940; ENSMUSG00000057406. [Q8BVE8-1]
    ENSMUST00000066854; ENSMUSP00000067205; ENSMUSG00000057406. [Q8BVE8-2]
    ENSMUST00000075812; ENSMUSP00000075210; ENSMUSG00000057406. [Q8BVE8-2]
    GeneIDi107823.
    KEGGimmu:107823.
    UCSCiuc008xbm.2. mouse. [Q8BVE8-1]
    uc012duw.1. mouse. [Q8BVE8-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU733655 mRNA. Translation: ACE75882.1 . Sequence problems.
    AK129287 mRNA. Translation: BAC98097.1 . Different initiation.
    AC163329 Genomic DNA. No translation available.
    AK078622 mRNA. Translation: BAC37342.1 . Frameshift.
    BC046473 mRNA. Translation: AAH46473.1 .
    BC053454 mRNA. Translation: AAH53454.1 .
    CCDSi CCDS51467.1. [Q8BVE8-2 ]
    CCDS51468.1. [Q8BVE8-1 ]
    RefSeqi NP_001074571.2. NM_001081102.2. [Q8BVE8-2 ]
    NP_780440.2. NM_175231.2. [Q8BVE8-1 ]
    XP_006503721.1. XM_006503658.1. [Q8BVE8-2 ]
    XP_006503722.1. XM_006503659.1. [Q8BVE8-2 ]
    XP_006503723.1. XM_006503660.1. [Q8BVE8-1 ]
    UniGenei Mm.19892.
    Mm.332320.
    Mm.491382.

    3D structure databases

    ProteinModelPortali Q8BVE8.
    SMRi Q8BVE8. Positions 217-285, 667-712, 716-763, 833-873, 877-973, 976-1203, 1239-1327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 223605. 13 interactions.
    DIPi DIP-60452N.
    IntActi Q8BVE8. 3 interactions.

    PTM databases

    PhosphoSitei Q8BVE8.

    Proteomic databases

    MaxQBi Q8BVE8.
    PaxDbi Q8BVE8.
    PRIDEi Q8BVE8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000058096 ; ENSMUSP00000058940 ; ENSMUSG00000057406 . [Q8BVE8-1 ]
    ENSMUST00000066854 ; ENSMUSP00000067205 ; ENSMUSG00000057406 . [Q8BVE8-2 ]
    ENSMUST00000075812 ; ENSMUSP00000075210 ; ENSMUSG00000057406 . [Q8BVE8-2 ]
    GeneIDi 107823.
    KEGGi mmu:107823.
    UCSCi uc008xbm.2. mouse. [Q8BVE8-1 ]
    uc012duw.1. mouse. [Q8BVE8-2 ]

    Organism-specific databases

    CTDi 7468.
    MGIi MGI:1276574. Whsc1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG2940.
    GeneTreei ENSGT00740000114921.
    HOGENOMi HOG000230893.
    HOVERGENi HBG079979.
    KOi K11424.
    OMAi PSKGKMM.
    OrthoDBi EOG7Z69BG.
    PhylomeDBi Q8BVE8.
    TreeFami TF329088.

    Miscellaneous databases

    ChiTaRSi WHSC1. human.
    NextBioi 35470773.
    PROi Q8BVE8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BVE8.
    Bgeei Q8BVE8.
    CleanExi MM_WHSC1.
    Genevestigatori Q8BVE8.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    3.30.40.10. 3 hits.
    InterProi IPR006560. AWS.
    IPR009071. HMG_box_dom.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF00628. PHD. 1 hit.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00398. HMG. 1 hit.
    SM00249. PHD. 4 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    SSF57903. SSF57903. 3 hits.
    PROSITEi PS51215. AWS. 1 hit.
    PS50118. HMG_BOX_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity."
      Kim J.Y., Kee H.J., Choe N.W., Kim S.M., Eom G.H., Baek H.J., Kook H., Kook H., Seo S.B.
      Mol. Cell. Biol. 28:2023-2034(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RE-IIBP), FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF ARG-1138 AND CYS-1144.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Embryonic tail.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 446-1365 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Adrenal gland.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 516-1365 (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Limb and Mammary tumor.
    6. "WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma."
      Stec I., Wright T.J., van Ommen G.-J.B., de Boer P.A., van Haeringen A., Moorman A.F.M., Altherr M.R., den Dunnen J.T.
      Hum. Mol. Genet. 7:1071-1082(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiNSD2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BVE8
    Secondary accession number(s): B3VCH6
    , Q6ZPY1, Q7TSF5, Q811F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3