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Q8BVE3

- VATH_MOUSE

UniProt

Q8BVE3 - VATH_MOUSE

Protein

V-type proton ATPase subunit H

Gene

Atp6v1h

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes By similarity.By similarity

    GO - Molecular functioni

    1. proton-transporting ATPase activity, rotational mechanism Source: InterPro

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro
    2. endocytosis Source: Ensembl

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit H
    Short name:
    V-ATPase subunit H
    Alternative name(s):
    Vacuolar proton pump subunit H
    Gene namesi
    Name:Atp6v1h
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1914864. Atp6v1h.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosomal membrane Source: Ensembl
    2. vacuolar proton-transporting V-type ATPase, V1 domain Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483V-type proton ATPase subunit HPRO_0000124194Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei483 – 4831PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8BVE3.
    PaxDbiQ8BVE3.
    PRIDEiQ8BVE3.

    PTM databases

    PhosphoSiteiQ8BVE3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BVE3.
    BgeeiQ8BVE3.
    CleanExiMM_ATP6V1H.
    GenevestigatoriQ8BVE3.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with AP2M1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi224360. 1 interaction.
    IntActiQ8BVE3. 5 interactions.
    MINTiMINT-4112764.
    STRINGi10090.ENSMUSP00000040756.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BVE3.
    SMRiQ8BVE3. Positions 227-465.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase H subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG5231.
    GeneTreeiENSGT00390000003289.
    HOGENOMiHOG000007240.
    HOVERGENiHBG000459.
    InParanoidiQ8BVE3.
    KOiK02144.
    OMAiDTLQENH.
    OrthoDBiEOG7CCBQQ.
    PhylomeDBiQ8BVE3.
    TreeFamiTF313488.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    1.25.40.150. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR004908. ATPase_V1-cplx_hsu.
    IPR011987. ATPase_V1-cplx_hsu_C.
    [Graphical view]
    PANTHERiPTHR10698. PTHR10698. 1 hit.
    PfamiPF11698. V-ATPase_H_C. 1 hit.
    PF03224. V-ATPase_H_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF032184. ATPase_V1_H. 1 hit.
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8BVE3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKMDIRGAV DAAVPTNIIA AKAAEVRANK VNWQSYLQGQ MISAEDCEFI    50
    QRFEMKRSSE DKQEMLQTEG SQCAKTFINL MTHISKEQTV QYILTMVDDM 100
    LQENHQRVSI FFDYAKRSKS TAWPYFLPML NRQDPFTVHM AARIIAKLAA 150
    WGKELMEGSD LNYYFNWIKT QLSSQKLRGS GVAVETGTIS SSDSSQYVQC 200
    VAGCLQLMLR VNEYRFAWVE ADGVNCIMGV LSNKCGFQLQ YQMIFSIWLL 250
    AFSPQMCEHL RRYNIIPVLS DILQESVKEK VTRIILAAFR NFLEKSTERE 300
    TRQEYALAMI QCKVLKQLEN LEQQKYDDED ISEDIKFLLE KLGESVQDLS 350
    SFDEYSSELK SGRLEWSPVH KSEKFWRENA VRLNEKNYEL LKILTKLLEV 400
    SDDPQVLAVA AHDVGEYVRH YPRGKRVIEQ LGGKQLVMNH MHHEDQQVRY 450
    NALLAVQKLM VHNWEYLGKQ LQSEQPQTAA ARS 483
    Length:483
    Mass (Da):55,855
    Last modified:March 1, 2003 - v1
    Checksum:iA976B7DC889B84CD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti247 – 2471I → V in AAH09154. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK078767 mRNA. Translation: BAC37382.1.
    BC009154 mRNA. Translation: AAH09154.1.
    CCDSiCCDS14808.1.
    RefSeqiNP_598587.2. NM_133826.4.
    XP_006495496.1. XM_006495433.1.
    UniGeneiMm.27082.

    Genome annotation databases

    EnsembliENSMUST00000044369; ENSMUSP00000040756; ENSMUSG00000033793.
    GeneIDi108664.
    KEGGimmu:108664.
    UCSCiuc007afn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK078767 mRNA. Translation: BAC37382.1 .
    BC009154 mRNA. Translation: AAH09154.1 .
    CCDSi CCDS14808.1.
    RefSeqi NP_598587.2. NM_133826.4.
    XP_006495496.1. XM_006495433.1.
    UniGenei Mm.27082.

    3D structure databases

    ProteinModelPortali Q8BVE3.
    SMRi Q8BVE3. Positions 227-465.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 224360. 1 interaction.
    IntActi Q8BVE3. 5 interactions.
    MINTi MINT-4112764.
    STRINGi 10090.ENSMUSP00000040756.

    Protein family/group databases

    TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    PTM databases

    PhosphoSitei Q8BVE3.

    Proteomic databases

    MaxQBi Q8BVE3.
    PaxDbi Q8BVE3.
    PRIDEi Q8BVE3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044369 ; ENSMUSP00000040756 ; ENSMUSG00000033793 .
    GeneIDi 108664.
    KEGGi mmu:108664.
    UCSCi uc007afn.1. mouse.

    Organism-specific databases

    CTDi 51606.
    MGIi MGI:1914864. Atp6v1h.

    Phylogenomic databases

    eggNOGi COG5231.
    GeneTreei ENSGT00390000003289.
    HOGENOMi HOG000007240.
    HOVERGENi HBG000459.
    InParanoidi Q8BVE3.
    KOi K02144.
    OMAi DTLQENH.
    OrthoDBi EOG7CCBQQ.
    PhylomeDBi Q8BVE3.
    TreeFami TF313488.

    Enzyme and pathway databases

    Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Miscellaneous databases

    ChiTaRSi ATP6V1H. mouse.
    NextBioi 361187.
    PROi Q8BVE3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BVE3.
    Bgeei Q8BVE3.
    CleanExi MM_ATP6V1H.
    Genevestigatori Q8BVE3.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    1.25.40.150. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR004908. ATPase_V1-cplx_hsu.
    IPR011987. ATPase_V1-cplx_hsu_C.
    [Graphical view ]
    PANTHERi PTHR10698. PTHR10698. 1 hit.
    Pfami PF11698. V-ATPase_H_C. 1 hit.
    PF03224. V-ATPase_H_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF032184. ATPase_V1_H. 1 hit.
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 76-86; 108-116; 263-278; 284-290; 342-360; 397-419 AND 450-458, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiVATH_MOUSE
    AccessioniPrimary (citable) accession number: Q8BVE3
    Secondary accession number(s): Q921X8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3