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Q8BV96

- Q8BV96_MOUSE

UniProt

Q8BV96 - Q8BV96_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Hmgcr

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: MGI
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. cholesterol biosynthetic process Source: MGI
    2. coenzyme A metabolic process Source: InterPro
    3. isoprenoid biosynthetic process Source: InterPro
    4. negative regulation of MAP kinase activity Source: MGI
    5. visual learning Source: MGI

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:HmgcrImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96159. Hmgcr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro

    Expressioni

    Gene expression databases

    GenevestigatoriQ8BV96.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BV96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMG-CoA reductase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG103243.
    InParanoidiQ8BV96.
    KOiK00021.

    Family and domain databases

    Gene3Di3.30.70.420. 1 hit.
    3.90.770.10. 2 hits.
    InterProiIPR002202. HMG_CoA_Rdtase.
    IPR023074. HMG_CoA_Rdtase_cat.
    IPR023076. HMG_CoA_Rdtase_CS.
    IPR004554. HMG_CoA_Rdtase_eu_arc.
    IPR009023. HMG_CoA_Rdtase_NAD(P)-bd_dom.
    IPR009029. HMG_CoA_Rdtase_sub-bd_dom.
    [Graphical view]
    PANTHERiPTHR10572. PTHR10572. 1 hit.
    PfamiPF00368. HMG-CoA_red. 1 hit.
    [Graphical view]
    PRINTSiPR00071. HMGCOARDTASE.
    SUPFAMiSSF55035. SSF55035. 1 hit.
    SSF56542. SSF56542. 2 hits.
    TIGRFAMsiTIGR00533. HMG_CoA_R_NADP. 1 hit.
    PROSITEiPS00066. HMG_COA_REDUCTASE_1. 1 hit.
    PS00318. HMG_COA_REDUCTASE_2. 1 hit.
    PS01192. HMG_COA_REDUCTASE_3. 1 hit.
    PS50065. HMG_COA_REDUCTASE_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8BV96-1 [UniParc]FASTAAdd to Basket

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    VPMATTEGCL VASTNRGCRA ISLGGGASSR VLADGMTRGP VVRLPRACDS    50
    AEVKTWLETP EGFAVIKEAF DSTSRFARLQ KLHVTMAGRN LYIRFQSRTG 100
    DAMGMNMISK GTEKALLKLQ EFFPDMQILA VSGNYCTDKK PAAINWIEGR 150
    GKTVVCEAVI PAKVVREVLK TTTEAMVDVN INKNLVGSAM AGSIGGYNAH 200
    AANIVTAIYI ACGQDAAQNV GSSKCITLME ASGPTNEDLY ISCTMPSIEI 250
    GTVGGGTNLL PQQACLQMLG VQGACKDNPG ENARQLARIV CGTVMAGELS 300
    LMAALAAGHL VRSHMVHNRS KINLQDLQGT CTKKAA 336
    Length:336
    Mass (Da):35,497
    Last modified:March 1, 2003 - v1
    Checksum:iB6C9DF1BDF08F9BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK079302 mRNA. Translation: BAC37602.1.
    RefSeqiNP_032281.2. NM_008255.2.
    UniGeneiMm.316652.

    Genome annotation databases

    GeneIDi15357.
    KEGGimmu:15357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK079302 mRNA. Translation: BAC37602.1 .
    RefSeqi NP_032281.2. NM_008255.2.
    UniGenei Mm.316652.

    3D structure databases

    ProteinModelPortali Q8BV96.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 15357.
    KEGGi mmu:15357.

    Organism-specific databases

    CTDi 3156.
    MGIi MGI:96159. Hmgcr.

    Phylogenomic databases

    HOVERGENi HBG103243.
    InParanoidi Q8BV96.
    KOi K00021.

    Miscellaneous databases

    ChiTaRSi Hmgcr. mouse.
    NextBioi 287972.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8BV96.

    Family and domain databases

    Gene3Di 3.30.70.420. 1 hit.
    3.90.770.10. 2 hits.
    InterProi IPR002202. HMG_CoA_Rdtase.
    IPR023074. HMG_CoA_Rdtase_cat.
    IPR023076. HMG_CoA_Rdtase_CS.
    IPR004554. HMG_CoA_Rdtase_eu_arc.
    IPR009023. HMG_CoA_Rdtase_NAD(P)-bd_dom.
    IPR009029. HMG_CoA_Rdtase_sub-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10572. PTHR10572. 1 hit.
    Pfami PF00368. HMG-CoA_red. 1 hit.
    [Graphical view ]
    PRINTSi PR00071. HMGCOARDTASE.
    SUPFAMi SSF55035. SSF55035. 1 hit.
    SSF56542. SSF56542. 2 hits.
    TIGRFAMsi TIGR00533. HMG_CoA_R_NADP. 1 hit.
    PROSITEi PS00066. HMG_COA_REDUCTASE_1. 1 hit.
    PS00318. HMG_COA_REDUCTASE_2. 1 hit.
    PS01192. HMG_COA_REDUCTASE_3. 1 hit.
    PS50065. HMG_COA_REDUCTASE_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Urinary bladderImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Urinary bladderImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Urinary bladderImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Urinary bladderImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Urinary bladderImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Urinary bladderImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Urinary bladderImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Urinary bladderImported.

    Entry informationi

    Entry nameiQ8BV96_MOUSE
    AccessioniPrimary (citable) accession number: Q8BV96
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)