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Q8BV96

- Q8BV96_MOUSE

UniProt

Q8BV96 - Q8BV96_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene
Hmgcr
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: MGI
  2. NADP binding Source: InterPro

GO - Biological processi

  1. cholesterol biosynthetic process Source: MGI
  2. coenzyme A metabolic process Source: InterPro
  3. isoprenoid biosynthetic process Source: InterPro
  4. negative regulation of MAP kinase activity Source: MGI
  5. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:HmgcrImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96159. Hmgcr.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8BV96.

Structurei

3D structure databases

ProteinModelPortaliQ8BV96.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA reductase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG103243.
InParanoidiQ8BV96.
KOiK00021.

Family and domain databases

Gene3Di3.30.70.420. 1 hit.
3.90.770.10. 2 hits.
InterProiIPR002202. HMG_CoA_Rdtase.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR004554. HMG_CoA_Rdtase_eu_arc.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd_dom.
IPR009029. HMG_CoA_Rdtase_sub-bd_dom.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PfamiPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSiPR00071. HMGCOARDTASE.
SUPFAMiSSF55035. SSF55035. 1 hit.
SSF56542. SSF56542. 2 hits.
TIGRFAMsiTIGR00533. HMG_CoA_R_NADP. 1 hit.
PROSITEiPS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS00318. HMG_COA_REDUCTASE_2. 1 hit.
PS01192. HMG_COA_REDUCTASE_3. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8BV96-1 [UniParc]FASTAAdd to Basket

« Hide

VPMATTEGCL VASTNRGCRA ISLGGGASSR VLADGMTRGP VVRLPRACDS    50
AEVKTWLETP EGFAVIKEAF DSTSRFARLQ KLHVTMAGRN LYIRFQSRTG 100
DAMGMNMISK GTEKALLKLQ EFFPDMQILA VSGNYCTDKK PAAINWIEGR 150
GKTVVCEAVI PAKVVREVLK TTTEAMVDVN INKNLVGSAM AGSIGGYNAH 200
AANIVTAIYI ACGQDAAQNV GSSKCITLME ASGPTNEDLY ISCTMPSIEI 250
GTVGGGTNLL PQQACLQMLG VQGACKDNPG ENARQLARIV CGTVMAGELS 300
LMAALAAGHL VRSHMVHNRS KINLQDLQGT CTKKAA 336
Length:336
Mass (Da):35,497
Last modified:March 1, 2003 - v1
Checksum:iB6C9DF1BDF08F9BC
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK079302 mRNA. Translation: BAC37602.1.
RefSeqiNP_032281.2. NM_008255.2.
UniGeneiMm.316652.

Genome annotation databases

GeneIDi15357.
KEGGimmu:15357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK079302 mRNA. Translation: BAC37602.1 .
RefSeqi NP_032281.2. NM_008255.2.
UniGenei Mm.316652.

3D structure databases

ProteinModelPortali Q8BV96.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15357.
KEGGi mmu:15357.

Organism-specific databases

CTDi 3156.
MGIi MGI:96159. Hmgcr.

Phylogenomic databases

HOVERGENi HBG103243.
InParanoidi Q8BV96.
KOi K00021.

Miscellaneous databases

ChiTaRSi Hmgcr. mouse.
NextBioi 287972.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8BV96.

Family and domain databases

Gene3Di 3.30.70.420. 1 hit.
3.90.770.10. 2 hits.
InterProi IPR002202. HMG_CoA_Rdtase.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR004554. HMG_CoA_Rdtase_eu_arc.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd_dom.
IPR009029. HMG_CoA_Rdtase_sub-bd_dom.
[Graphical view ]
PANTHERi PTHR10572. PTHR10572. 1 hit.
Pfami PF00368. HMG-CoA_red. 1 hit.
[Graphical view ]
PRINTSi PR00071. HMGCOARDTASE.
SUPFAMi SSF55035. SSF55035. 1 hit.
SSF56542. SSF56542. 2 hits.
TIGRFAMsi TIGR00533. HMG_CoA_R_NADP. 1 hit.
PROSITEi PS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS00318. HMG_COA_REDUCTASE_2. 1 hit.
PS01192. HMG_COA_REDUCTASE_3. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.

Entry informationi

Entry nameiQ8BV96_MOUSE
AccessioniPrimary (citable) accession number: Q8BV96
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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