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Protein

3-hydroxy-3-methylglutaryl coenzyme A reductase

Gene

Hmgcr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.UniRule annotationSAAS annotation

Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs1), 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs1), Hydroxymethylglutaryl-CoA synthase, cytoplasmic (Hmgcs1), 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs1), Hydroxymethylglutaryl-CoA synthase, mitochondrial (Hmgcs2), 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs1), 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs2), 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs1)
  3. 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgcr), 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgcr), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgcr)
This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandNADPUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00058; UER00103

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxy-3-methylglutaryl coenzyme A reductaseUniRule annotation (EC:1.1.1.34UniRule annotation)
Short name:
HMG-CoA reductaseUniRule annotation
Gene namesi
Name:HmgcrImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96159 Hmgcr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiQ8BV96

Expressioni

Gene expression databases

GenevisibleiQ8BV96 MM

Structurei

3D structure databases

ProteinModelPortaliQ8BV96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA reductase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2480 Eukaryota
COG1257 LUCA
HOVERGENiHBG103243
KOiK00021

Family and domain databases

CDDicd00643 HMG-CoA_reductase_classI, 1 hit
Gene3Di3.30.70.420, 1 hit
3.90.770.10, 2 hits
InterProiView protein in InterPro
IPR002202 HMG_CoA_Rdtase
IPR023074 HMG_CoA_Rdtase_cat_sf
IPR023076 HMG_CoA_Rdtase_CS
IPR004554 HMG_CoA_Rdtase_eu_arc
IPR009023 HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029 HMG_CoA_Rdtase_sub-bd_dom_sf
PANTHERiPTHR10572 PTHR10572, 1 hit
PfamiView protein in Pfam
PF00368 HMG-CoA_red, 1 hit
PRINTSiPR00071 HMGCOARDTASE
SUPFAMiSSF55035 SSF55035, 1 hit
SSF56542 SSF56542, 2 hits
TIGRFAMsiTIGR00533 HMG_CoA_R_NADP, 1 hit
PROSITEiView protein in PROSITE
PS00066 HMG_COA_REDUCTASE_1, 1 hit
PS00318 HMG_COA_REDUCTASE_2, 1 hit
PS01192 HMG_COA_REDUCTASE_3, 1 hit
PS50065 HMG_COA_REDUCTASE_4, 1 hit

Sequencei

Sequence statusi: Fragment.

Q8BV96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VPMATTEGCL VASTNRGCRA ISLGGGASSR VLADGMTRGP VVRLPRACDS
60 70 80 90 100
AEVKTWLETP EGFAVIKEAF DSTSRFARLQ KLHVTMAGRN LYIRFQSRTG
110 120 130 140 150
DAMGMNMISK GTEKALLKLQ EFFPDMQILA VSGNYCTDKK PAAINWIEGR
160 170 180 190 200
GKTVVCEAVI PAKVVREVLK TTTEAMVDVN INKNLVGSAM AGSIGGYNAH
210 220 230 240 250
AANIVTAIYI ACGQDAAQNV GSSKCITLME ASGPTNEDLY ISCTMPSIEI
260 270 280 290 300
GTVGGGTNLL PQQACLQMLG VQGACKDNPG ENARQLARIV CGTVMAGELS
310 320 330
LMAALAAGHL VRSHMVHNRS KINLQDLQGT CTKKAA
Length:336
Mass (Da):35,497
Last modified:March 1, 2003 - v1
Checksum:iB6C9DF1BDF08F9BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079302 mRNA Translation: BAC37602.1
RefSeqiNP_032281.2, NM_008255.2
UniGeneiMm.316652

Genome annotation databases

GeneIDi15357
KEGGimmu:15357

Similar proteinsi

Entry informationi

Entry nameiQ8BV96_MOUSE
AccessioniPrimary (citable) accession number: Q8BV96
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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