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Protein

Interferon-induced protein 44

Gene

Ifi44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

This protein aggregates to form microtubular structures.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced protein 44
Alternative name(s):
Microtubule-associated protein 44
Gene namesi
Name:Ifi44
Synonyms:Mtap44
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2443016. Ifi44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Interferon-induced protein 44PRO_0000337871Add
BLAST

Proteomic databases

MaxQBiQ8BV66.
PaxDbiQ8BV66.
PRIDEiQ8BV66.

PTM databases

PhosphoSiteiQ8BV66.

Expressioni

Gene expression databases

BgeeiQ8BV66.
GenevisibleiQ8BV66. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029671.

Structurei

3D structure databases

ProteinModelPortaliQ8BV66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFI44 family.Curated

Phylogenomic databases

eggNOGiENOG410IDX3. Eukaryota.
ENOG410XP4J. LUCA.
GeneTreeiENSGT00390000017981.
HOGENOMiHOG000035123.
HOVERGENiHBG052085.
InParanoidiQ8BV66.
OrthoDBiEOG7TQV0X.
PhylomeDBiQ8BV66.
TreeFamiTF328728.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR024644. IFI44_fam.
IPR027417. P-loop_NTPase.
IPR006571. TLDc_dom.
[Graphical view]
PANTHERiPTHR14241:SF3. PTHR14241:SF3. 1 hit.
PfamiPF07534. TLD. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BV66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRTRLTWQ QEKCLQNYFG GKRFCLLYKA SVQKFSHQNL LCTCENQGPT
60 70 80 90 100
MIVVYSEKCV IGMYLKEGFQ GKDVSITIFA LQETGFSLCA KGPDSPYLLF
110 120 130 140 150
HKRKTNDFSI LLDEKAVIVS SAICKMLQLT ARNNVIPIQE CEAFRCEELL
160 170 180 190 200
DERKTRGIAV LHSNLLQALR DYKPYGDLVQ QTRVLLLGPI GAGKSSFVNS
210 220 230 240 250
VKSVFKGSIT HQILVGCDED GISDKYRTYS IKAKDDSDPL PFILCDSLGL
260 270 280 290 300
GENAGLHTDD VWHILKGHTP DRYQFDSMKP ITSNHPNYTH DPLLKDRIHC
310 320 330 340 350
VVFVFDINSF EMHSSELVAK IKKIRRDLIK HGILHLALLT HVDSLDLITK
360 370 380 390 400
EDMTDIYNYS PVKSKLEAFH GVFGFALSDI LVVSNYVSEW QLDPVKDMLI
410 420
LSALKEILYT ANEFLEDLPL NK
Length:422
Mass (Da):47,852
Last modified:March 1, 2003 - v1
Checksum:iFBE1070ABF1D4F5E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti233 – 2331A → V in CAC13979 (Ref. 1) Curated
Sequence conflicti233 – 2331A → V in AAI11883 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ299405 mRNA. Translation: CAC13979.1.
AK079749 mRNA. Translation: BAC37740.1.
AK136553 mRNA. Translation: BAE23041.1.
AK171676 mRNA. Translation: BAE42605.1.
BC111882 mRNA. Translation: AAI11883.1.
CCDSiCCDS17911.1.
RefSeqiNP_598632.2. NM_133871.2.
UniGeneiMm.30756.

Genome annotation databases

EnsembliENSMUST00000029671; ENSMUSP00000029671; ENSMUSG00000028037.
GeneIDi99899.
KEGGimmu:99899.
UCSCiuc008rsk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ299405 mRNA. Translation: CAC13979.1.
AK079749 mRNA. Translation: BAC37740.1.
AK136553 mRNA. Translation: BAE23041.1.
AK171676 mRNA. Translation: BAE42605.1.
BC111882 mRNA. Translation: AAI11883.1.
CCDSiCCDS17911.1.
RefSeqiNP_598632.2. NM_133871.2.
UniGeneiMm.30756.

3D structure databases

ProteinModelPortaliQ8BV66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029671.

PTM databases

PhosphoSiteiQ8BV66.

Proteomic databases

MaxQBiQ8BV66.
PaxDbiQ8BV66.
PRIDEiQ8BV66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029671; ENSMUSP00000029671; ENSMUSG00000028037.
GeneIDi99899.
KEGGimmu:99899.
UCSCiuc008rsk.2. mouse.

Organism-specific databases

CTDi10561.
MGIiMGI:2443016. Ifi44.

Phylogenomic databases

eggNOGiENOG410IDX3. Eukaryota.
ENOG410XP4J. LUCA.
GeneTreeiENSGT00390000017981.
HOGENOMiHOG000035123.
HOVERGENiHBG052085.
InParanoidiQ8BV66.
OrthoDBiEOG7TQV0X.
PhylomeDBiQ8BV66.
TreeFamiTF328728.

Miscellaneous databases

ChiTaRSiIfi44. mouse.
NextBioi354161.
PROiQ8BV66.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BV66.
GenevisibleiQ8BV66. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR024644. IFI44_fam.
IPR027417. P-loop_NTPase.
IPR006571. TLDc_dom.
[Graphical view]
PANTHERiPTHR14241:SF3. PTHR14241:SF3. 1 hit.
PfamiPF07534. TLD. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of novel interferon responsive genes."
    Dron M., Meritet J.F., Tovey M.G.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Cecum, Spleen and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiIFI44_MOUSE
AccessioniPrimary (citable) accession number: Q8BV66
Secondary accession number(s): Q9ER37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.