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Protein

Pyrin and HIN domain-containing protein 1

Gene

Pyhin1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to interferon-beta Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrin and HIN domain-containing protein 1
Alternative name(s):
Interferon-inducible protein 209
Short name:
Ifi-209
Interferon-inducible protein X
Interferon-inducible protein p209
Gene namesi
Name:Pyhin1
Synonyms:Ifi209, Ifix
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138243. Pyhin1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Pyrin and HIN domain-containing protein 1PRO_0000334525Add
BLAST

Proteomic databases

EPDiQ8BV49.
MaxQBiQ8BV49.
PaxDbiQ8BV49.
PeptideAtlasiQ8BV49.
PRIDEiQ8BV49.

PTM databases

iPTMnetiQ8BV49.
PhosphoSiteiQ8BV49.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043263.
ExpressionAtlasiQ8BV49. baseline and differential.
GenevisibleiQ8BV49. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BV49. 1 interaction.
MINTiMINT-4112754.
STRINGi10090.ENSMUSP00000061900.

Structurei

3D structure databases

ProteinModelPortaliQ8BV49.
SMRiQ8BV49. Positions 1-87, 235-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8787PyrinPROSITE-ProRule annotationAdd
BLAST
Domaini219 – 416198HIN-200PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi157 – 20044Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the HIN-200 family.Curated
Contains 1 HIN-200 domain.PROSITE-ProRule annotation
Contains 1 pyrin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J5NP. Eukaryota.
ENOG410Y78B. LUCA.
GeneTreeiENSGT00390000013296.
HOGENOMiHOG000033871.
HOVERGENiHBG006122.
InParanoidiQ8BV49.
OMAiTQSTCSY.
OrthoDBiEOG091G0E9X.
PhylomeDBiQ8BV49.
TreeFamiTF337385.

Family and domain databases

Gene3Di2.40.50.140. 2 hits.
InterProiIPR004020. DAPIN.
IPR004021. HIN200/IF120x.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF02760. HIN. 1 hit.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
PROSITEiPS50824. DAPIN. 1 hit.
PS50834. HIN_200. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BV49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNEYKRIVL LTGLMGINDH DFRMVKSLLS KELKLNRMQD QYDRVKIADL
60 70 80 90 100
MEDKFPKDAG VDQLIKLYKQ IPGLGDIANK LKNEKAKAKR TRTGKRKTAA
110 120 130 140 150
KRQRQEEPST SQPMSTTNED AEPESGRSTP DTQVAQLSLP TASRRNQAIQ
160 170 180 190 200
ISPTIASSSG QTSSRSSETL QSIIQSPKTP KRPSSSILDP PVSSGTASSS
210 220 230 240 250
AQALGVPLAT IAKRQRLKNV PKEPSEENGH QQGSKKVMVL KVTEPFSYDV
260 270 280 290 300
TEEKMFHATV ATETEFFRVK VFDIVLKEKF IPNKVLTISN YVGCNGFINI
310 320 330 340 350
YSASSVSEVN DGEPMNIPLS LRKSANRTPK INYLCSKKRG IFVNGVFTVC
360 370 380 390 400
KKEEKWNYIC YEIGDDTGMM EVEVYGRLTN IACNPGDKLR LICFKLIPDE
410 420
EKAQLRSTTH SNMQVIKAKN
Length:420
Mass (Da):46,887
Last modified:March 1, 2003 - v1
Checksum:iA1983C4F11956A8D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851K → M in AAI07379 (PubMed:15489334).Curated
Sequence conflicti85 – 851K → M in AAI07380 (PubMed:15489334).Curated
Sequence conflicti227 – 2271E → V in AAI07380 (PubMed:15489334).Curated
Sequence conflicti248 – 2481Y → H in BAC30731 (PubMed:16141072).Curated
Sequence conflicti291 – 2911Y → C in BAC30731 (PubMed:16141072).Curated
Sequence conflicti313 – 3131E → D in AAI07380 (PubMed:15489334).Curated
Sequence conflicti338 – 3381K → R in AAI07380 (PubMed:15489334).Curated
Sequence conflicti418 – 4181A → T in AAI07380 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040884 mRNA. Translation: BAC30731.1.
AK076726 mRNA. Translation: BAC36457.1.
AK080371 mRNA. Translation: BAC37894.1.
AK150817 mRNA. Translation: BAE29880.1.
BC096384 mRNA. Translation: AAH96384.1.
BC107378 mRNA. Translation: AAI07379.1.
BC107379 mRNA. Translation: AAI07380.1.
CCDSiCCDS35791.1.
RefSeqiNP_778191.1. NM_175026.3.
UniGeneiMm.447.

Genome annotation databases

EnsembliENSMUST00000056071; ENSMUSP00000061900; ENSMUSG00000043263.
GeneIDi236312.
KEGGimmu:236312.
UCSCiuc007drr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040884 mRNA. Translation: BAC30731.1.
AK076726 mRNA. Translation: BAC36457.1.
AK080371 mRNA. Translation: BAC37894.1.
AK150817 mRNA. Translation: BAE29880.1.
BC096384 mRNA. Translation: AAH96384.1.
BC107378 mRNA. Translation: AAI07379.1.
BC107379 mRNA. Translation: AAI07380.1.
CCDSiCCDS35791.1.
RefSeqiNP_778191.1. NM_175026.3.
UniGeneiMm.447.

3D structure databases

ProteinModelPortaliQ8BV49.
SMRiQ8BV49. Positions 1-87, 235-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BV49. 1 interaction.
MINTiMINT-4112754.
STRINGi10090.ENSMUSP00000061900.

PTM databases

iPTMnetiQ8BV49.
PhosphoSiteiQ8BV49.

Proteomic databases

EPDiQ8BV49.
MaxQBiQ8BV49.
PaxDbiQ8BV49.
PeptideAtlasiQ8BV49.
PRIDEiQ8BV49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056071; ENSMUSP00000061900; ENSMUSG00000043263.
GeneIDi236312.
KEGGimmu:236312.
UCSCiuc007drr.2. mouse.

Organism-specific databases

CTDi149628.
MGIiMGI:2138243. Pyhin1.

Phylogenomic databases

eggNOGiENOG410J5NP. Eukaryota.
ENOG410Y78B. LUCA.
GeneTreeiENSGT00390000013296.
HOGENOMiHOG000033871.
HOVERGENiHBG006122.
InParanoidiQ8BV49.
OMAiTQSTCSY.
OrthoDBiEOG091G0E9X.
PhylomeDBiQ8BV49.
TreeFamiTF337385.

Miscellaneous databases

PROiQ8BV49.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043263.
ExpressionAtlasiQ8BV49. baseline and differential.
GenevisibleiQ8BV49. MM.

Family and domain databases

Gene3Di2.40.50.140. 2 hits.
InterProiIPR004020. DAPIN.
IPR004021. HIN200/IF120x.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF02760. HIN. 1 hit.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
PROSITEiPS50824. DAPIN. 1 hit.
PS50834. HIN_200. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFIX_MOUSE
AccessioniPrimary (citable) accession number: Q8BV49
Secondary accession number(s): Q3KNA6
, Q3KNA7, Q8BLY5, Q8BVS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.