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Protein

COP9 signalosome complex subunit 7b

Gene

Cops7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5696394. DNA Damage Recognition in GG-NER.
R-MMU-6781823. Formation of TC-NER Pre-Incision Complex.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 7b
Short name:
SGN7b
Short name:
Signalosome subunit 7b
Alternative name(s):
JAB1-containing signalosome subunit 7b
Gene namesi
Name:Cops7b
Synonyms:Csn7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1349388. Cops7b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210002 – 264COP9 signalosome complex subunit 7bAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BV13.
MaxQBiQ8BV13.
PaxDbiQ8BV13.
PeptideAtlasiQ8BV13.
PRIDEiQ8BV13.

PTM databases

iPTMnetiQ8BV13.
PhosphoSitePlusiQ8BV13.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026240.
ExpressionAtlasiQ8BV13. baseline and differential.
GenevisibleiQ8BV13. MM.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with EIF3S6 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi205046. 3 interactors.
IntActiQ8BV13. 2 interactors.
MINTiMINT-4092196.
STRINGi10090.ENSMUSP00000027446.

Structurei

3D structure databases

ProteinModelPortaliQ8BV13.
SMRiQ8BV13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 156PCIAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili194 – 237Sequence analysisAdd BLAST44

Sequence similaritiesi

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated
Contains 1 PCI domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3250. Eukaryota.
ENOG410XP7W. LUCA.
GeneTreeiENSGT00390000013069.
HOGENOMiHOG000006003.
HOVERGENiHBG051138.
InParanoidiQ8BV13.
KOiK12180.
OMAiKENHHRT.
OrthoDBiEOG091G0I8H.
PhylomeDBiQ8BV13.
TreeFamiTF101149.

Family and domain databases

InterProiIPR027530. Csn7b.
IPR000717. PCI_dom.
[Graphical view]
PANTHERiPTHR15350:SF8. PTHR15350:SF8. 1 hit.
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BV13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEQKPSSN LLEQFILLAK GTSGSALTTL ISQVLEAPGV YVFGELLELA
60 70 80 90 100
NVQELAEGAN AAYLQLLNLF AYGTYPDYIA NKESLPELSV AQQNKLKHLT
110 120 130 140 150
IVSLASRMKC IPYSVLLKDL EMRNLRELED LIIEAVYTDI IQGKLDQRNQ
160 170 180 190 200
LLEVDFCIGR DIRKKDINNI VKTLHEWCDG CEAVLLGIEQ QVLRANQYKE
210 220 230 240 250
NHHRTQQQVE AEVSNIKKTL KATASSSAQE MEQQLAEREC PPHTEQRQPT
260
KKMSKVKGLV SSRH
Length:264
Mass (Da):29,689
Last modified:March 1, 2003 - v1
Checksum:iBD6088424F5537EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90V → A in AAH12659 (PubMed:15489334).Curated1
Sequence conflicti97K → N in AAC33904 (PubMed:9707402).Curated1
Sequence conflicti102V → L in AAC33904 (PubMed:9707402).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071317 mRNA. Translation: AAC33904.1.
AK081309 mRNA. Translation: BAC38192.1.
AK168740 mRNA. Translation: BAE40581.1.
BC012659 mRNA. Translation: AAH12659.1.
CCDSiCCDS15122.1.
RefSeqiNP_766562.1. NM_172974.2.
XP_006529686.1. XM_006529623.3.
XP_006529687.1. XM_006529624.3.
UniGeneiMm.12973.

Genome annotation databases

EnsembliENSMUST00000027446; ENSMUSP00000027446; ENSMUSG00000026240.
ENSMUST00000121534; ENSMUSP00000113587; ENSMUSG00000026240.
GeneIDi26895.
KEGGimmu:26895.
UCSCiuc007bvr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071317 mRNA. Translation: AAC33904.1.
AK081309 mRNA. Translation: BAC38192.1.
AK168740 mRNA. Translation: BAE40581.1.
BC012659 mRNA. Translation: AAH12659.1.
CCDSiCCDS15122.1.
RefSeqiNP_766562.1. NM_172974.2.
XP_006529686.1. XM_006529623.3.
XP_006529687.1. XM_006529624.3.
UniGeneiMm.12973.

3D structure databases

ProteinModelPortaliQ8BV13.
SMRiQ8BV13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205046. 3 interactors.
IntActiQ8BV13. 2 interactors.
MINTiMINT-4092196.
STRINGi10090.ENSMUSP00000027446.

PTM databases

iPTMnetiQ8BV13.
PhosphoSitePlusiQ8BV13.

Proteomic databases

EPDiQ8BV13.
MaxQBiQ8BV13.
PaxDbiQ8BV13.
PeptideAtlasiQ8BV13.
PRIDEiQ8BV13.

Protocols and materials databases

DNASUi26895.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027446; ENSMUSP00000027446; ENSMUSG00000026240.
ENSMUST00000121534; ENSMUSP00000113587; ENSMUSG00000026240.
GeneIDi26895.
KEGGimmu:26895.
UCSCiuc007bvr.1. mouse.

Organism-specific databases

CTDi64708.
MGIiMGI:1349388. Cops7b.

Phylogenomic databases

eggNOGiKOG3250. Eukaryota.
ENOG410XP7W. LUCA.
GeneTreeiENSGT00390000013069.
HOGENOMiHOG000006003.
HOVERGENiHBG051138.
InParanoidiQ8BV13.
KOiK12180.
OMAiKENHHRT.
OrthoDBiEOG091G0I8H.
PhylomeDBiQ8BV13.
TreeFamiTF101149.

Enzyme and pathway databases

ReactomeiR-MMU-5696394. DNA Damage Recognition in GG-NER.
R-MMU-6781823. Formation of TC-NER Pre-Incision Complex.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.

Miscellaneous databases

ChiTaRSiCops7b. mouse.
PROiQ8BV13.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026240.
ExpressionAtlasiQ8BV13. baseline and differential.
GenevisibleiQ8BV13. MM.

Family and domain databases

InterProiIPR027530. Csn7b.
IPR000717. PCI_dom.
[Graphical view]
PANTHERiPTHR15350:SF8. PTHR15350:SF8. 1 hit.
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSN7B_MOUSE
AccessioniPrimary (citable) accession number: Q8BV13
Secondary accession number(s): O88547, Q3TGG7, Q921G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.