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Protein

COP9 signalosome complex subunit 7b

Gene

Cops7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5696394. DNA Damage Recognition in GG-NER.
R-MMU-6781823. Formation of TC-NER Pre-Incision Complex.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 7b
Short name:
SGN7b
Short name:
Signalosome subunit 7b
Alternative name(s):
JAB1-containing signalosome subunit 7b
Gene namesi
Name:Cops7b
Synonyms:Csn7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1349388. Cops7b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 264263COP9 signalosome complex subunit 7bPRO_0000121000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BV13.
MaxQBiQ8BV13.
PaxDbiQ8BV13.
PeptideAtlasiQ8BV13.
PRIDEiQ8BV13.

PTM databases

iPTMnetiQ8BV13.
PhosphoSiteiQ8BV13.

Expressioni

Gene expression databases

BgeeiQ8BV13.
ExpressionAtlasiQ8BV13. baseline and differential.
GenevisibleiQ8BV13. MM.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8 (By similarity).By similarity

Protein-protein interaction databases

BioGridi205046. 3 interactions.
IntActiQ8BV13. 2 interactions.
MINTiMINT-4092196.
STRINGi10090.ENSMUSP00000027446.

Structurei

3D structure databases

ProteinModelPortaliQ8BV13.
SMRiQ8BV13. Positions 13-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 156105PCIAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili194 – 23744Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated
Contains 1 PCI domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3250. Eukaryota.
ENOG410XP7W. LUCA.
GeneTreeiENSGT00390000013069.
HOGENOMiHOG000006003.
HOVERGENiHBG051138.
InParanoidiQ8BV13.
KOiK12180.
OMAiRECPPHT.
OrthoDBiEOG7N63NJ.
PhylomeDBiQ8BV13.
TreeFamiTF101149.

Family and domain databases

InterProiIPR027530. Csn7b.
IPR000717. PCI_dom.
[Graphical view]
PANTHERiPTHR15350:SF8. PTHR15350:SF8. 1 hit.
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BV13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEQKPSSN LLEQFILLAK GTSGSALTTL ISQVLEAPGV YVFGELLELA
60 70 80 90 100
NVQELAEGAN AAYLQLLNLF AYGTYPDYIA NKESLPELSV AQQNKLKHLT
110 120 130 140 150
IVSLASRMKC IPYSVLLKDL EMRNLRELED LIIEAVYTDI IQGKLDQRNQ
160 170 180 190 200
LLEVDFCIGR DIRKKDINNI VKTLHEWCDG CEAVLLGIEQ QVLRANQYKE
210 220 230 240 250
NHHRTQQQVE AEVSNIKKTL KATASSSAQE MEQQLAEREC PPHTEQRQPT
260
KKMSKVKGLV SSRH
Length:264
Mass (Da):29,689
Last modified:March 1, 2003 - v1
Checksum:iBD6088424F5537EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901V → A in AAH12659 (PubMed:15489334).Curated
Sequence conflicti97 – 971K → N in AAC33904 (PubMed:9707402).Curated
Sequence conflicti102 – 1021V → L in AAC33904 (PubMed:9707402).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071317 mRNA. Translation: AAC33904.1.
AK081309 mRNA. Translation: BAC38192.1.
AK168740 mRNA. Translation: BAE40581.1.
BC012659 mRNA. Translation: AAH12659.1.
CCDSiCCDS15122.1.
RefSeqiNP_766562.1. NM_172974.2.
XP_006529686.1. XM_006529623.2.
XP_006529687.1. XM_006529624.2.
UniGeneiMm.12973.

Genome annotation databases

EnsembliENSMUST00000027446; ENSMUSP00000027446; ENSMUSG00000026240.
ENSMUST00000121534; ENSMUSP00000113587; ENSMUSG00000026240.
GeneIDi26895.
KEGGimmu:26895.
UCSCiuc007bvr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071317 mRNA. Translation: AAC33904.1.
AK081309 mRNA. Translation: BAC38192.1.
AK168740 mRNA. Translation: BAE40581.1.
BC012659 mRNA. Translation: AAH12659.1.
CCDSiCCDS15122.1.
RefSeqiNP_766562.1. NM_172974.2.
XP_006529686.1. XM_006529623.2.
XP_006529687.1. XM_006529624.2.
UniGeneiMm.12973.

3D structure databases

ProteinModelPortaliQ8BV13.
SMRiQ8BV13. Positions 13-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205046. 3 interactions.
IntActiQ8BV13. 2 interactions.
MINTiMINT-4092196.
STRINGi10090.ENSMUSP00000027446.

PTM databases

iPTMnetiQ8BV13.
PhosphoSiteiQ8BV13.

Proteomic databases

EPDiQ8BV13.
MaxQBiQ8BV13.
PaxDbiQ8BV13.
PeptideAtlasiQ8BV13.
PRIDEiQ8BV13.

Protocols and materials databases

DNASUi26895.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027446; ENSMUSP00000027446; ENSMUSG00000026240.
ENSMUST00000121534; ENSMUSP00000113587; ENSMUSG00000026240.
GeneIDi26895.
KEGGimmu:26895.
UCSCiuc007bvr.1. mouse.

Organism-specific databases

CTDi64708.
MGIiMGI:1349388. Cops7b.

Phylogenomic databases

eggNOGiKOG3250. Eukaryota.
ENOG410XP7W. LUCA.
GeneTreeiENSGT00390000013069.
HOGENOMiHOG000006003.
HOVERGENiHBG051138.
InParanoidiQ8BV13.
KOiK12180.
OMAiRECPPHT.
OrthoDBiEOG7N63NJ.
PhylomeDBiQ8BV13.
TreeFamiTF101149.

Enzyme and pathway databases

ReactomeiR-MMU-5696394. DNA Damage Recognition in GG-NER.
R-MMU-6781823. Formation of TC-NER Pre-Incision Complex.

Miscellaneous databases

ChiTaRSiCops7b. mouse.
PROiQ8BV13.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BV13.
ExpressionAtlasiQ8BV13. baseline and differential.
GenevisibleiQ8BV13. MM.

Family and domain databases

InterProiIPR027530. Csn7b.
IPR000717. PCI_dom.
[Graphical view]
PANTHERiPTHR15350:SF8. PTHR15350:SF8. 1 hit.
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex."
    Wei N., Tsuge T., Serino G., Dohmae N., Takio K., Matsui M., Deng X.-W.
    Curr. Biol. 8:919-922(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE CSN COMPLEX.
    Strain: C57BLKS/J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion and Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCSN7B_MOUSE
AccessioniPrimary (citable) accession number: Q8BV13
Secondary accession number(s): O88547, Q3TGG7, Q921G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.