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Protein

Geranylgeranyl transferase type-1 subunit beta

Gene

Pggt1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity).By similarity

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi269 – 2691Zinc; catalyticBy similarity
Metal bindingi271 – 2711Zinc; catalyticBy similarity
Metal bindingi321 – 3211Zinc; via tele nitrogen; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-1 subunit beta (EC:2.5.1.59)
Alternative name(s):
Geranylgeranyl transferase type I subunit beta
Short name:
GGTase-I-beta
Type I protein geranyl-geranyltransferase subunit beta
Gene namesi
Name:Pggt1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1917514. Pggt1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3301421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Geranylgeranyl transferase type-1 subunit betaPRO_0000119770Add
BLAST

Proteomic databases

EPDiQ8BUY9.
MaxQBiQ8BUY9.
PaxDbiQ8BUY9.
PRIDEiQ8BUY9.

PTM databases

iPTMnetiQ8BUY9.
PhosphoSiteiQ8BUY9.

Expressioni

Gene expression databases

BgeeiQ8BUY9.
GenevisibleiQ8BUY9. MM.

Interactioni

Subunit structurei

Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025354.

Structurei

3D structure databases

ProteinModelPortaliQ8BUY9.
SMRiQ8BUY9. Positions 18-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati144 – 18643PFTB 1Add
BLAST
Repeati193 – 23442PFTB 2Add
BLAST
Repeati245 – 28440PFTB 3Add
BLAST
Repeati291 – 33343PFTB 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2213Geranylgeranyl diphosphate bindingBy similarity
Regioni263 – 2664Geranylgeranyl diphosphate bindingBy similarity
Regioni272 – 2754Geranylgeranyl diphosphate bindingBy similarity

Sequence similaritiesi

Contains 4 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0367. Eukaryota.
COG5029. LUCA.
GeneTreeiENSGT00530000063392.
HOGENOMiHOG000180333.
HOVERGENiHBG008181.
InParanoidiQ8BUY9.
KOiK11713.
OMAiQMDGFQG.
OrthoDBiEOG7KDF9Z.
PhylomeDBiQ8BUY9.
TreeFamiTF105968.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 4 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BUY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTEDDRLA GSGEGERLDF LRDRHVRFFQ RCLQVLPERY SSLETSRLTI
60 70 80 90 100
AFFALSGLDM LDSLDVVNKD DIIEWIYSLQ VLPTEDRSNL SRCGFRGSSY
110 120 130 140 150
LGIPFNPSKN PGAAHPYDSG HIAMTYTGLS CLIILGDDLG RVDKEACLAG
160 170 180 190 200
LRALQLEDGS FCAVPEGSEN DMRFVYCASC ICYMLNNWSG MDMKKAISYI
210 220 230 240 250
RRSMSYDNGL AQGAGLESHG GSTFCGIASL CLMGKLEEVF SEKELNRIKR
260 270 280 290 300
WCIMRQQNGY HGRPNKPVDT CYSFWVGATL KLLKIFQYTN FEKNRNYILS
310 320 330 340 350
TQDRLVGGFA KWPDSHPDAL HAYFGICGLS LMEESGICKV HPALNVSTRT
360 370
SERLRDLHQS WKTKDSKQCS DNVHIAT
Length:377
Mass (Da):42,354
Last modified:March 1, 2003 - v1
Checksum:i7046611ECFCFDAAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081731 mRNA. Translation: BAC38314.1.
CCDSiCCDS29230.1.
RefSeqiNP_766215.1. NM_172627.3.
UniGeneiMm.262096.
Mm.393044.

Genome annotation databases

EnsembliENSMUST00000025354; ENSMUSP00000025354; ENSMUSG00000024477.
GeneIDi225467.
KEGGimmu:225467.
UCSCiuc008evk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081731 mRNA. Translation: BAC38314.1.
CCDSiCCDS29230.1.
RefSeqiNP_766215.1. NM_172627.3.
UniGeneiMm.262096.
Mm.393044.

3D structure databases

ProteinModelPortaliQ8BUY9.
SMRiQ8BUY9. Positions 18-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025354.

Chemistry

ChEMBLiCHEMBL3301421.

PTM databases

iPTMnetiQ8BUY9.
PhosphoSiteiQ8BUY9.

Proteomic databases

EPDiQ8BUY9.
MaxQBiQ8BUY9.
PaxDbiQ8BUY9.
PRIDEiQ8BUY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025354; ENSMUSP00000025354; ENSMUSG00000024477.
GeneIDi225467.
KEGGimmu:225467.
UCSCiuc008evk.1. mouse.

Organism-specific databases

CTDi5229.
MGIiMGI:1917514. Pggt1b.

Phylogenomic databases

eggNOGiKOG0367. Eukaryota.
COG5029. LUCA.
GeneTreeiENSGT00530000063392.
HOGENOMiHOG000180333.
HOVERGENiHBG008181.
InParanoidiQ8BUY9.
KOiK11713.
OMAiQMDGFQG.
OrthoDBiEOG7KDF9Z.
PhylomeDBiQ8BUY9.
TreeFamiTF105968.

Miscellaneous databases

PROiQ8BUY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BUY9.
GenevisibleiQ8BUY9. MM.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 4 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Testis.

Entry informationi

Entry nameiPGTB1_MOUSE
AccessioniPrimary (citable) accession number: Q8BUY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.