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Protein

Geranylgeranyl transferase type-1 subunit beta

Gene

Pggt1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity).By similarity

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi269Zinc; catalyticBy similarity1
Metal bindingi271Zinc; catalyticBy similarity1
Metal bindingi321Zinc; via tele nitrogen; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-1 subunit beta (EC:2.5.1.59)
Alternative name(s):
Geranylgeranyl transferase type I subunit beta
Short name:
GGTase-I-beta
Type I protein geranyl-geranyltransferase subunit beta
Gene namesi
Name:Pggt1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1917514. Pggt1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3301421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197701 – 377Geranylgeranyl transferase type-1 subunit betaAdd BLAST377

Proteomic databases

MaxQBiQ8BUY9.
PaxDbiQ8BUY9.
PRIDEiQ8BUY9.

PTM databases

iPTMnetiQ8BUY9.
PhosphoSitePlusiQ8BUY9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024477.
GenevisibleiQ8BUY9. MM.

Interactioni

Subunit structurei

Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025354.

Structurei

3D structure databases

ProteinModelPortaliQ8BUY9.
SMRiQ8BUY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati144 – 186PFTB 1Add BLAST43
Repeati193 – 234PFTB 2Add BLAST42
Repeati245 – 284PFTB 3Add BLAST40
Repeati291 – 333PFTB 4Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 221Geranylgeranyl diphosphate bindingBy similarity3
Regioni263 – 266Geranylgeranyl diphosphate bindingBy similarity4
Regioni272 – 275Geranylgeranyl diphosphate bindingBy similarity4

Sequence similaritiesi

Contains 4 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0367. Eukaryota.
COG5029. LUCA.
GeneTreeiENSGT00530000063392.
HOGENOMiHOG000180333.
HOVERGENiHBG008181.
InParanoidiQ8BUY9.
KOiK11713.
OMAiQMDGFQG.
OrthoDBiEOG091G01YZ.
PhylomeDBiQ8BUY9.
TreeFamiTF105968.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 4 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BUY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTEDDRLA GSGEGERLDF LRDRHVRFFQ RCLQVLPERY SSLETSRLTI
60 70 80 90 100
AFFALSGLDM LDSLDVVNKD DIIEWIYSLQ VLPTEDRSNL SRCGFRGSSY
110 120 130 140 150
LGIPFNPSKN PGAAHPYDSG HIAMTYTGLS CLIILGDDLG RVDKEACLAG
160 170 180 190 200
LRALQLEDGS FCAVPEGSEN DMRFVYCASC ICYMLNNWSG MDMKKAISYI
210 220 230 240 250
RRSMSYDNGL AQGAGLESHG GSTFCGIASL CLMGKLEEVF SEKELNRIKR
260 270 280 290 300
WCIMRQQNGY HGRPNKPVDT CYSFWVGATL KLLKIFQYTN FEKNRNYILS
310 320 330 340 350
TQDRLVGGFA KWPDSHPDAL HAYFGICGLS LMEESGICKV HPALNVSTRT
360 370
SERLRDLHQS WKTKDSKQCS DNVHIAT
Length:377
Mass (Da):42,354
Last modified:March 1, 2003 - v1
Checksum:i7046611ECFCFDAAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081731 mRNA. Translation: BAC38314.1.
CCDSiCCDS29230.1.
RefSeqiNP_766215.1. NM_172627.3.
UniGeneiMm.262096.
Mm.393044.

Genome annotation databases

EnsembliENSMUST00000025354; ENSMUSP00000025354; ENSMUSG00000024477.
GeneIDi225467.
KEGGimmu:225467.
UCSCiuc008evk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081731 mRNA. Translation: BAC38314.1.
CCDSiCCDS29230.1.
RefSeqiNP_766215.1. NM_172627.3.
UniGeneiMm.262096.
Mm.393044.

3D structure databases

ProteinModelPortaliQ8BUY9.
SMRiQ8BUY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025354.

Chemistry databases

ChEMBLiCHEMBL3301421.

PTM databases

iPTMnetiQ8BUY9.
PhosphoSitePlusiQ8BUY9.

Proteomic databases

MaxQBiQ8BUY9.
PaxDbiQ8BUY9.
PRIDEiQ8BUY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025354; ENSMUSP00000025354; ENSMUSG00000024477.
GeneIDi225467.
KEGGimmu:225467.
UCSCiuc008evk.1. mouse.

Organism-specific databases

CTDi5229.
MGIiMGI:1917514. Pggt1b.

Phylogenomic databases

eggNOGiKOG0367. Eukaryota.
COG5029. LUCA.
GeneTreeiENSGT00530000063392.
HOGENOMiHOG000180333.
HOVERGENiHBG008181.
InParanoidiQ8BUY9.
KOiK11713.
OMAiQMDGFQG.
OrthoDBiEOG091G01YZ.
PhylomeDBiQ8BUY9.
TreeFamiTF105968.

Miscellaneous databases

PROiQ8BUY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024477.
GenevisibleiQ8BUY9. MM.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 4 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGTB1_MOUSE
AccessioniPrimary (citable) accession number: Q8BUY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.