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Q8BUY8

- GASP2_MOUSE

UniProt

Q8BUY8 - GASP2_MOUSE

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Protein
G-protein coupled receptor-associated sorting protein 2
Gene
Gprasp2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in regulation of a variety of G-protein coupled receptors By similarity.

GO - Molecular functioni

  1. beta-amyloid binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor-associated sorting protein 2
Short name:
GASP-2
Gene namesi
Name:Gprasp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2442071. Gprasp2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 826826G-protein coupled receptor-associated sorting protein 2
PRO_0000239054Add
BLAST

Proteomic databases

MaxQBiQ8BUY8.
PaxDbiQ8BUY8.
PRIDEiQ8BUY8.

PTM databases

PhosphoSiteiQ8BUY8.

Expressioni

Gene expression databases

BgeeiQ8BUY8.
GenevestigatoriQ8BUY8.

Interactioni

Subunit structurei

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8BUY8.
SMRiQ8BUY8. Positions 591-645, 710-758.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPRASP family.

Phylogenomic databases

eggNOGiNOG41843.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231409.
HOVERGENiHBG057167.
InParanoidiQ8BUY8.
OMAiWFWDRDE.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ8BUY8.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BUY8-1 [UniParc]FASTAAdd to Basket

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MTGAEVETGS QAKPDKKPQE EVAGGAERES EAPLVVRPKV RPQAPATSGA    50
RPKTETKSSS RARPKTETQS VSGTRHRMSG ARPRSEAQLM SGARPKTDAR 100
AVGGARPKTE AKPIPGARPK GDAQAWAHSE FGAEAMPRAE RAHLSNSVTW 150
PPVNVGSATV TKSKSLSMNT ELASMGSEIF SGTQGQPGIE PWFGPREEAN 200
MGSWCYPRPR AREETSNESA DENSTMSSFW TREETSIRSW PREEVNTRSR 250
HRAKHQTNAR SKPRSKQDPY IDSLSGSEDE ASNPFCFWAG ENTNDMFRAR 300
GRDEANARPK IRTKREDYFE DEDEIYKESW LLPGEEGNRF RRRDKEEPNK 350
TLKNENEKDV KNDETVEQES RLEEEVIIGS WFWAEQETNV EAGASAICDA 400
EPGAEEGAIG GSLFWTEEKP SLGAVARDEV RPESEEEALF GSWFWDRDEA 450
CFDPNPTPVY TAKSRYRDPE EDLNLASRPK TWDEVTIEFK PPCHGLGFPS 500
PRPFIIPEGA SGNSEEKAKN AELGAEGEEQ DSVAQRDLPE PEFPFQYDPS 550
YRSVQEIREH LKARESAQPE NWSCTCIQCE LRISSAEFEE LLLLMDRIRD 600
PFIHEIAKIA MGMRTASQFT RDFIRDSGVV SLIEALMNYP SSRVRTNFLE 650
NMVHMAPPYP NLNMIETFIC QVCEETLSHS VNSPEQLTGM RMLRHLTITT 700
DYHVLIANYV SGFLALLTTG DARTKFHVLK MLLNLSDNPM VAKKLFSAKA 750
LSIFVGLFNI EETNDNIQIV IKMFQNISNI VKSGAMSLLD DDFSLEPLVS 800
AFHEFEELAK QLQIQIDNQN DPEEGQ 826
Length:826
Mass (Da):92,802
Last modified:May 30, 2006 - v2
Checksum:i01E28D8B629F36A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL683822 Genomic DNA. Translation: CAM27376.1.
BC117923 mRNA. Translation: AAI17924.1.
BC117924 mRNA. Translation: AAI17925.1.
AK081764 mRNA. Translation: BAC38324.1.
CCDSiCCDS53191.1.
RefSeqiNP_001156487.1. NM_001163015.1.
NP_001156488.1. NM_001163016.1.
NP_001156489.1. NM_001163017.1.
XP_006528589.1. XM_006528526.1.
XP_006528590.1. XM_006528527.1.
XP_006528591.1. XM_006528528.1.
XP_006528592.1. XM_006528529.1.
UniGeneiMm.489763.

Genome annotation databases

EnsembliENSMUST00000113136; ENSMUSP00000108761; ENSMUSG00000072966.
ENSMUST00000173804; ENSMUSP00000134666; ENSMUSG00000072966.
GeneIDi245607.
KEGGimmu:245607.
UCSCiuc009uhs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL683822 Genomic DNA. Translation: CAM27376.1 .
BC117923 mRNA. Translation: AAI17924.1 .
BC117924 mRNA. Translation: AAI17925.1 .
AK081764 mRNA. Translation: BAC38324.1 .
CCDSi CCDS53191.1.
RefSeqi NP_001156487.1. NM_001163015.1.
NP_001156488.1. NM_001163016.1.
NP_001156489.1. NM_001163017.1.
XP_006528589.1. XM_006528526.1.
XP_006528590.1. XM_006528527.1.
XP_006528591.1. XM_006528528.1.
XP_006528592.1. XM_006528529.1.
UniGenei Mm.489763.

3D structure databases

ProteinModelPortali Q8BUY8.
SMRi Q8BUY8. Positions 591-645, 710-758.
ModBasei Search...

PTM databases

PhosphoSitei Q8BUY8.

Proteomic databases

MaxQBi Q8BUY8.
PaxDbi Q8BUY8.
PRIDEi Q8BUY8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113136 ; ENSMUSP00000108761 ; ENSMUSG00000072966 .
ENSMUST00000173804 ; ENSMUSP00000134666 ; ENSMUSG00000072966 .
GeneIDi 245607.
KEGGi mmu:245607.
UCSCi uc009uhs.2. mouse.

Organism-specific databases

CTDi 114928.
MGIi MGI:2442071. Gprasp2.

Phylogenomic databases

eggNOGi NOG41843.
GeneTreei ENSGT00550000074488.
HOGENOMi HOG000231409.
HOVERGENi HBG057167.
InParanoidi Q8BUY8.
OMAi WFWDRDE.
OrthoDBi EOG70PBZ0.
PhylomeDBi Q8BUY8.
TreeFami TF335652.

Miscellaneous databases

NextBioi 386846.
PROi Q8BUY8.
SOURCEi Search...

Gene expression databases

Bgeei Q8BUY8.
Genevestigatori Q8BUY8.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view ]
Pfami PF04826. Arm_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-352.
    Strain: C57BL/6J.
    Tissue: Head.

Entry informationi

Entry nameiGASP2_MOUSE
AccessioniPrimary (citable) accession number: Q8BUY8
Secondary accession number(s): Q148X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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