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Protein

G-protein coupled receptor-associated sorting protein 2

Gene

Gprasp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in regulation of a variety of G-protein coupled receptors.By similarity

GO - Molecular functioni

  • beta-amyloid binding Source: MGI
  • G-protein coupled receptor binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor-associated sorting protein 2
Short name:
GASP-2
Gene namesi
Name:Gprasp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2442071. Gprasp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 826826G-protein coupled receptor-associated sorting protein 2PRO_0000239054Add
BLAST

Proteomic databases

MaxQBiQ8BUY8.
PaxDbiQ8BUY8.
PRIDEiQ8BUY8.

PTM databases

PhosphoSiteiQ8BUY8.

Expressioni

Gene expression databases

BgeeiQ8BUY8.
GenevestigatoriQ8BUY8.

Interactioni

Subunit structurei

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BUY8.
SMRiQ8BUY8. Positions 621-656, 711-736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPRASP family.Curated

Phylogenomic databases

eggNOGiNOG41843.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231409.
HOVERGENiHBG057167.
InParanoidiQ8BUY8.
OMAiWFWDRDE.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ8BUY8.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BUY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGAEVETGS QAKPDKKPQE EVAGGAERES EAPLVVRPKV RPQAPATSGA
60 70 80 90 100
RPKTETKSSS RARPKTETQS VSGTRHRMSG ARPRSEAQLM SGARPKTDAR
110 120 130 140 150
AVGGARPKTE AKPIPGARPK GDAQAWAHSE FGAEAMPRAE RAHLSNSVTW
160 170 180 190 200
PPVNVGSATV TKSKSLSMNT ELASMGSEIF SGTQGQPGIE PWFGPREEAN
210 220 230 240 250
MGSWCYPRPR AREETSNESA DENSTMSSFW TREETSIRSW PREEVNTRSR
260 270 280 290 300
HRAKHQTNAR SKPRSKQDPY IDSLSGSEDE ASNPFCFWAG ENTNDMFRAR
310 320 330 340 350
GRDEANARPK IRTKREDYFE DEDEIYKESW LLPGEEGNRF RRRDKEEPNK
360 370 380 390 400
TLKNENEKDV KNDETVEQES RLEEEVIIGS WFWAEQETNV EAGASAICDA
410 420 430 440 450
EPGAEEGAIG GSLFWTEEKP SLGAVARDEV RPESEEEALF GSWFWDRDEA
460 470 480 490 500
CFDPNPTPVY TAKSRYRDPE EDLNLASRPK TWDEVTIEFK PPCHGLGFPS
510 520 530 540 550
PRPFIIPEGA SGNSEEKAKN AELGAEGEEQ DSVAQRDLPE PEFPFQYDPS
560 570 580 590 600
YRSVQEIREH LKARESAQPE NWSCTCIQCE LRISSAEFEE LLLLMDRIRD
610 620 630 640 650
PFIHEIAKIA MGMRTASQFT RDFIRDSGVV SLIEALMNYP SSRVRTNFLE
660 670 680 690 700
NMVHMAPPYP NLNMIETFIC QVCEETLSHS VNSPEQLTGM RMLRHLTITT
710 720 730 740 750
DYHVLIANYV SGFLALLTTG DARTKFHVLK MLLNLSDNPM VAKKLFSAKA
760 770 780 790 800
LSIFVGLFNI EETNDNIQIV IKMFQNISNI VKSGAMSLLD DDFSLEPLVS
810 820
AFHEFEELAK QLQIQIDNQN DPEEGQ
Length:826
Mass (Da):92,802
Last modified:May 30, 2006 - v2
Checksum:i01E28D8B629F36A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683822 Genomic DNA. Translation: CAM27376.1.
BC117923 mRNA. Translation: AAI17924.1.
BC117924 mRNA. Translation: AAI17925.1.
AK081764 mRNA. Translation: BAC38324.1.
CCDSiCCDS53191.1.
RefSeqiNP_001156487.1. NM_001163015.1.
NP_001156488.1. NM_001163016.1.
NP_001156489.1. NM_001163017.1.
UniGeneiMm.489763.

Genome annotation databases

EnsembliENSMUST00000113136; ENSMUSP00000108761; ENSMUSG00000072966.
ENSMUST00000173804; ENSMUSP00000134666; ENSMUSG00000072966.
GeneIDi245607.
KEGGimmu:245607.
UCSCiuc009uhs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683822 Genomic DNA. Translation: CAM27376.1.
BC117923 mRNA. Translation: AAI17924.1.
BC117924 mRNA. Translation: AAI17925.1.
AK081764 mRNA. Translation: BAC38324.1.
CCDSiCCDS53191.1.
RefSeqiNP_001156487.1. NM_001163015.1.
NP_001156488.1. NM_001163016.1.
NP_001156489.1. NM_001163017.1.
UniGeneiMm.489763.

3D structure databases

ProteinModelPortaliQ8BUY8.
SMRiQ8BUY8. Positions 621-656, 711-736.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8BUY8.

Proteomic databases

MaxQBiQ8BUY8.
PaxDbiQ8BUY8.
PRIDEiQ8BUY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113136; ENSMUSP00000108761; ENSMUSG00000072966.
ENSMUST00000173804; ENSMUSP00000134666; ENSMUSG00000072966.
GeneIDi245607.
KEGGimmu:245607.
UCSCiuc009uhs.2. mouse.

Organism-specific databases

CTDi114928.
MGIiMGI:2442071. Gprasp2.

Phylogenomic databases

eggNOGiNOG41843.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231409.
HOVERGENiHBG057167.
InParanoidiQ8BUY8.
OMAiWFWDRDE.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ8BUY8.
TreeFamiTF335652.

Miscellaneous databases

ChiTaRSiGprasp2. mouse.
NextBioi386846.
PROiQ8BUY8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BUY8.
GenevestigatoriQ8BUY8.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-352.
    Strain: C57BL/6J.
    Tissue: Head.

Entry informationi

Entry nameiGASP2_MOUSE
AccessioniPrimary (citable) accession number: Q8BUY8
Secondary accession number(s): Q148X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: May 27, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.