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Q8BUY8

- GASP2_MOUSE

UniProt

Q8BUY8 - GASP2_MOUSE

Protein

G-protein coupled receptor-associated sorting protein 2

Gene

Gprasp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (30 May 2006)
      Previous versions | rss
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    Functioni

    May play a role in regulation of a variety of G-protein coupled receptors.By similarity

    GO - Molecular functioni

    1. beta-amyloid binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor-associated sorting protein 2
    Short name:
    GASP-2
    Gene namesi
    Name:Gprasp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2442071. Gprasp2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 826826G-protein coupled receptor-associated sorting protein 2PRO_0000239054Add
    BLAST

    Proteomic databases

    MaxQBiQ8BUY8.
    PaxDbiQ8BUY8.
    PRIDEiQ8BUY8.

    PTM databases

    PhosphoSiteiQ8BUY8.

    Expressioni

    Gene expression databases

    BgeeiQ8BUY8.
    GenevestigatoriQ8BUY8.

    Interactioni

    Subunit structurei

    Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BUY8.
    SMRiQ8BUY8. Positions 591-645, 710-758.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPRASP family.Curated

    Phylogenomic databases

    eggNOGiNOG41843.
    GeneTreeiENSGT00550000074488.
    HOGENOMiHOG000231409.
    HOVERGENiHBG057167.
    InParanoidiQ8BUY8.
    OMAiWFWDRDE.
    OrthoDBiEOG70PBZ0.
    PhylomeDBiQ8BUY8.
    TreeFamiTF335652.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    [Graphical view]
    PfamiPF04826. Arm_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8BUY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGAEVETGS QAKPDKKPQE EVAGGAERES EAPLVVRPKV RPQAPATSGA    50
    RPKTETKSSS RARPKTETQS VSGTRHRMSG ARPRSEAQLM SGARPKTDAR 100
    AVGGARPKTE AKPIPGARPK GDAQAWAHSE FGAEAMPRAE RAHLSNSVTW 150
    PPVNVGSATV TKSKSLSMNT ELASMGSEIF SGTQGQPGIE PWFGPREEAN 200
    MGSWCYPRPR AREETSNESA DENSTMSSFW TREETSIRSW PREEVNTRSR 250
    HRAKHQTNAR SKPRSKQDPY IDSLSGSEDE ASNPFCFWAG ENTNDMFRAR 300
    GRDEANARPK IRTKREDYFE DEDEIYKESW LLPGEEGNRF RRRDKEEPNK 350
    TLKNENEKDV KNDETVEQES RLEEEVIIGS WFWAEQETNV EAGASAICDA 400
    EPGAEEGAIG GSLFWTEEKP SLGAVARDEV RPESEEEALF GSWFWDRDEA 450
    CFDPNPTPVY TAKSRYRDPE EDLNLASRPK TWDEVTIEFK PPCHGLGFPS 500
    PRPFIIPEGA SGNSEEKAKN AELGAEGEEQ DSVAQRDLPE PEFPFQYDPS 550
    YRSVQEIREH LKARESAQPE NWSCTCIQCE LRISSAEFEE LLLLMDRIRD 600
    PFIHEIAKIA MGMRTASQFT RDFIRDSGVV SLIEALMNYP SSRVRTNFLE 650
    NMVHMAPPYP NLNMIETFIC QVCEETLSHS VNSPEQLTGM RMLRHLTITT 700
    DYHVLIANYV SGFLALLTTG DARTKFHVLK MLLNLSDNPM VAKKLFSAKA 750
    LSIFVGLFNI EETNDNIQIV IKMFQNISNI VKSGAMSLLD DDFSLEPLVS 800
    AFHEFEELAK QLQIQIDNQN DPEEGQ 826
    Length:826
    Mass (Da):92,802
    Last modified:May 30, 2006 - v2
    Checksum:i01E28D8B629F36A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL683822 Genomic DNA. Translation: CAM27376.1.
    BC117923 mRNA. Translation: AAI17924.1.
    BC117924 mRNA. Translation: AAI17925.1.
    AK081764 mRNA. Translation: BAC38324.1.
    CCDSiCCDS53191.1.
    RefSeqiNP_001156487.1. NM_001163015.1.
    NP_001156488.1. NM_001163016.1.
    NP_001156489.1. NM_001163017.1.
    XP_006528589.1. XM_006528526.1.
    XP_006528590.1. XM_006528527.1.
    XP_006528591.1. XM_006528528.1.
    XP_006528592.1. XM_006528529.1.
    UniGeneiMm.489763.

    Genome annotation databases

    EnsembliENSMUST00000113136; ENSMUSP00000108761; ENSMUSG00000072966.
    ENSMUST00000173804; ENSMUSP00000134666; ENSMUSG00000072966.
    GeneIDi245607.
    KEGGimmu:245607.
    UCSCiuc009uhs.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL683822 Genomic DNA. Translation: CAM27376.1 .
    BC117923 mRNA. Translation: AAI17924.1 .
    BC117924 mRNA. Translation: AAI17925.1 .
    AK081764 mRNA. Translation: BAC38324.1 .
    CCDSi CCDS53191.1.
    RefSeqi NP_001156487.1. NM_001163015.1.
    NP_001156488.1. NM_001163016.1.
    NP_001156489.1. NM_001163017.1.
    XP_006528589.1. XM_006528526.1.
    XP_006528590.1. XM_006528527.1.
    XP_006528591.1. XM_006528528.1.
    XP_006528592.1. XM_006528529.1.
    UniGenei Mm.489763.

    3D structure databases

    ProteinModelPortali Q8BUY8.
    SMRi Q8BUY8. Positions 591-645, 710-758.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BUY8.

    Proteomic databases

    MaxQBi Q8BUY8.
    PaxDbi Q8BUY8.
    PRIDEi Q8BUY8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000113136 ; ENSMUSP00000108761 ; ENSMUSG00000072966 .
    ENSMUST00000173804 ; ENSMUSP00000134666 ; ENSMUSG00000072966 .
    GeneIDi 245607.
    KEGGi mmu:245607.
    UCSCi uc009uhs.2. mouse.

    Organism-specific databases

    CTDi 114928.
    MGIi MGI:2442071. Gprasp2.

    Phylogenomic databases

    eggNOGi NOG41843.
    GeneTreei ENSGT00550000074488.
    HOGENOMi HOG000231409.
    HOVERGENi HBG057167.
    InParanoidi Q8BUY8.
    OMAi WFWDRDE.
    OrthoDBi EOG70PBZ0.
    PhylomeDBi Q8BUY8.
    TreeFami TF335652.

    Miscellaneous databases

    NextBioi 386846.
    PROi Q8BUY8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BUY8.
    Genevestigatori Q8BUY8.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    [Graphical view ]
    Pfami PF04826. Arm_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-352.
      Strain: C57BL/6J.
      Tissue: Head.

    Entry informationi

    Entry nameiGASP2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BUY8
    Secondary accession number(s): Q148X7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3