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Q8BUY8

- GASP2_MOUSE

UniProt

Q8BUY8 - GASP2_MOUSE

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Protein

G-protein coupled receptor-associated sorting protein 2

Gene

Gprasp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in regulation of a variety of G-protein coupled receptors.By similarity

GO - Molecular functioni

  1. beta-amyloid binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor-associated sorting protein 2
Short name:
GASP-2
Gene namesi
Name:Gprasp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2442071. Gprasp2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 826826G-protein coupled receptor-associated sorting protein 2PRO_0000239054Add
BLAST

Proteomic databases

MaxQBiQ8BUY8.
PaxDbiQ8BUY8.
PRIDEiQ8BUY8.

PTM databases

PhosphoSiteiQ8BUY8.

Expressioni

Gene expression databases

BgeeiQ8BUY8.
GenevestigatoriQ8BUY8.

Interactioni

Subunit structurei

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BUY8.
SMRiQ8BUY8. Positions 591-645, 710-758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPRASP family.Curated

Phylogenomic databases

eggNOGiNOG41843.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231409.
HOVERGENiHBG057167.
InParanoidiQ8BUY8.
OMAiWFWDRDE.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ8BUY8.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BUY8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGAEVETGS QAKPDKKPQE EVAGGAERES EAPLVVRPKV RPQAPATSGA
60 70 80 90 100
RPKTETKSSS RARPKTETQS VSGTRHRMSG ARPRSEAQLM SGARPKTDAR
110 120 130 140 150
AVGGARPKTE AKPIPGARPK GDAQAWAHSE FGAEAMPRAE RAHLSNSVTW
160 170 180 190 200
PPVNVGSATV TKSKSLSMNT ELASMGSEIF SGTQGQPGIE PWFGPREEAN
210 220 230 240 250
MGSWCYPRPR AREETSNESA DENSTMSSFW TREETSIRSW PREEVNTRSR
260 270 280 290 300
HRAKHQTNAR SKPRSKQDPY IDSLSGSEDE ASNPFCFWAG ENTNDMFRAR
310 320 330 340 350
GRDEANARPK IRTKREDYFE DEDEIYKESW LLPGEEGNRF RRRDKEEPNK
360 370 380 390 400
TLKNENEKDV KNDETVEQES RLEEEVIIGS WFWAEQETNV EAGASAICDA
410 420 430 440 450
EPGAEEGAIG GSLFWTEEKP SLGAVARDEV RPESEEEALF GSWFWDRDEA
460 470 480 490 500
CFDPNPTPVY TAKSRYRDPE EDLNLASRPK TWDEVTIEFK PPCHGLGFPS
510 520 530 540 550
PRPFIIPEGA SGNSEEKAKN AELGAEGEEQ DSVAQRDLPE PEFPFQYDPS
560 570 580 590 600
YRSVQEIREH LKARESAQPE NWSCTCIQCE LRISSAEFEE LLLLMDRIRD
610 620 630 640 650
PFIHEIAKIA MGMRTASQFT RDFIRDSGVV SLIEALMNYP SSRVRTNFLE
660 670 680 690 700
NMVHMAPPYP NLNMIETFIC QVCEETLSHS VNSPEQLTGM RMLRHLTITT
710 720 730 740 750
DYHVLIANYV SGFLALLTTG DARTKFHVLK MLLNLSDNPM VAKKLFSAKA
760 770 780 790 800
LSIFVGLFNI EETNDNIQIV IKMFQNISNI VKSGAMSLLD DDFSLEPLVS
810 820
AFHEFEELAK QLQIQIDNQN DPEEGQ
Length:826
Mass (Da):92,802
Last modified:May 30, 2006 - v2
Checksum:i01E28D8B629F36A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL683822 Genomic DNA. Translation: CAM27376.1.
BC117923 mRNA. Translation: AAI17924.1.
BC117924 mRNA. Translation: AAI17925.1.
AK081764 mRNA. Translation: BAC38324.1.
CCDSiCCDS53191.1.
RefSeqiNP_001156487.1. NM_001163015.1.
NP_001156488.1. NM_001163016.1.
NP_001156489.1. NM_001163017.1.
XP_006528589.1. XM_006528526.1.
XP_006528590.1. XM_006528527.1.
XP_006528591.1. XM_006528528.1.
XP_006528592.1. XM_006528529.1.
UniGeneiMm.489763.

Genome annotation databases

EnsembliENSMUST00000113136; ENSMUSP00000108761; ENSMUSG00000072966.
ENSMUST00000173804; ENSMUSP00000134666; ENSMUSG00000072966.
GeneIDi245607.
KEGGimmu:245607.
UCSCiuc009uhs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL683822 Genomic DNA. Translation: CAM27376.1 .
BC117923 mRNA. Translation: AAI17924.1 .
BC117924 mRNA. Translation: AAI17925.1 .
AK081764 mRNA. Translation: BAC38324.1 .
CCDSi CCDS53191.1.
RefSeqi NP_001156487.1. NM_001163015.1.
NP_001156488.1. NM_001163016.1.
NP_001156489.1. NM_001163017.1.
XP_006528589.1. XM_006528526.1.
XP_006528590.1. XM_006528527.1.
XP_006528591.1. XM_006528528.1.
XP_006528592.1. XM_006528529.1.
UniGenei Mm.489763.

3D structure databases

ProteinModelPortali Q8BUY8.
SMRi Q8BUY8. Positions 591-645, 710-758.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BUY8.

Proteomic databases

MaxQBi Q8BUY8.
PaxDbi Q8BUY8.
PRIDEi Q8BUY8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113136 ; ENSMUSP00000108761 ; ENSMUSG00000072966 .
ENSMUST00000173804 ; ENSMUSP00000134666 ; ENSMUSG00000072966 .
GeneIDi 245607.
KEGGi mmu:245607.
UCSCi uc009uhs.2. mouse.

Organism-specific databases

CTDi 114928.
MGIi MGI:2442071. Gprasp2.

Phylogenomic databases

eggNOGi NOG41843.
GeneTreei ENSGT00550000074488.
HOGENOMi HOG000231409.
HOVERGENi HBG057167.
InParanoidi Q8BUY8.
OMAi WFWDRDE.
OrthoDBi EOG70PBZ0.
PhylomeDBi Q8BUY8.
TreeFami TF335652.

Miscellaneous databases

NextBioi 386846.
PROi Q8BUY8.
SOURCEi Search...

Gene expression databases

Bgeei Q8BUY8.
Genevestigatori Q8BUY8.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view ]
Pfami PF04826. Arm_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-352.
    Strain: C57BL/6J.
    Tissue: Head.

Entry informationi

Entry nameiGASP2_MOUSE
AccessioniPrimary (citable) accession number: Q8BUY8
Secondary accession number(s): Q148X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: October 1, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3