Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8BUY8 (GASP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor-associated sorting protein 2

Short name=GASP-2
Gene names
Name:Gprasp2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length826 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in regulation of a variety of G-protein coupled receptors By similarity.

Subunit structure

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR By similarity.

Sequence similarities

Belongs to the GPRASP family.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionbeta-amyloid binding

Inferred from direct assay PubMed 9173930. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 826826G-protein coupled receptor-associated sorting protein 2
PRO_0000239054

Sequences

Sequence LengthMass (Da)Tools
Q8BUY8 [UniParc].

Last modified May 30, 2006. Version 2.
Checksum: 01E28D8B629F36A6

FASTA82692,802
        10         20         30         40         50         60 
MTGAEVETGS QAKPDKKPQE EVAGGAERES EAPLVVRPKV RPQAPATSGA RPKTETKSSS 

        70         80         90        100        110        120 
RARPKTETQS VSGTRHRMSG ARPRSEAQLM SGARPKTDAR AVGGARPKTE AKPIPGARPK 

       130        140        150        160        170        180 
GDAQAWAHSE FGAEAMPRAE RAHLSNSVTW PPVNVGSATV TKSKSLSMNT ELASMGSEIF 

       190        200        210        220        230        240 
SGTQGQPGIE PWFGPREEAN MGSWCYPRPR AREETSNESA DENSTMSSFW TREETSIRSW 

       250        260        270        280        290        300 
PREEVNTRSR HRAKHQTNAR SKPRSKQDPY IDSLSGSEDE ASNPFCFWAG ENTNDMFRAR 

       310        320        330        340        350        360 
GRDEANARPK IRTKREDYFE DEDEIYKESW LLPGEEGNRF RRRDKEEPNK TLKNENEKDV 

       370        380        390        400        410        420 
KNDETVEQES RLEEEVIIGS WFWAEQETNV EAGASAICDA EPGAEEGAIG GSLFWTEEKP 

       430        440        450        460        470        480 
SLGAVARDEV RPESEEEALF GSWFWDRDEA CFDPNPTPVY TAKSRYRDPE EDLNLASRPK 

       490        500        510        520        530        540 
TWDEVTIEFK PPCHGLGFPS PRPFIIPEGA SGNSEEKAKN AELGAEGEEQ DSVAQRDLPE 

       550        560        570        580        590        600 
PEFPFQYDPS YRSVQEIREH LKARESAQPE NWSCTCIQCE LRISSAEFEE LLLLMDRIRD 

       610        620        630        640        650        660 
PFIHEIAKIA MGMRTASQFT RDFIRDSGVV SLIEALMNYP SSRVRTNFLE NMVHMAPPYP 

       670        680        690        700        710        720 
NLNMIETFIC QVCEETLSHS VNSPEQLTGM RMLRHLTITT DYHVLIANYV SGFLALLTTG 

       730        740        750        760        770        780 
DARTKFHVLK MLLNLSDNPM VAKKLFSAKA LSIFVGLFNI EETNDNIQIV IKMFQNISNI 

       790        800        810        820 
VKSGAMSLLD DDFSLEPLVS AFHEFEELAK QLQIQIDNQN DPEEGQ 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-352.
Strain: C57BL/6J.
Tissue: Head.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL683822 Genomic DNA. Translation: CAM27376.1.
BC117923 mRNA. Translation: AAI17924.1.
BC117924 mRNA. Translation: AAI17925.1.
AK081764 mRNA. Translation: BAC38324.1.
CCDSCCDS53191.1.
RefSeqNP_001156487.1. NM_001163015.1.
NP_001156488.1. NM_001163016.1.
NP_001156489.1. NM_001163017.1.
XP_006528589.1. XM_006528526.1.
XP_006528590.1. XM_006528527.1.
XP_006528591.1. XM_006528528.1.
XP_006528592.1. XM_006528529.1.
UniGeneMm.489763.

3D structure databases

ProteinModelPortalQ8BUY8.
SMRQ8BUY8. Positions 591-645, 710-758.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BUY8.

Proteomic databases

MaxQBQ8BUY8.
PaxDbQ8BUY8.
PRIDEQ8BUY8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000113136; ENSMUSP00000108761; ENSMUSG00000072966.
ENSMUST00000173804; ENSMUSP00000134666; ENSMUSG00000072966.
GeneID245607.
KEGGmmu:245607.
UCSCuc009uhs.2. mouse.

Organism-specific databases

CTD114928.
MGIMGI:2442071. Gprasp2.

Phylogenomic databases

eggNOGNOG41843.
GeneTreeENSGT00550000074488.
HOGENOMHOG000231409.
HOVERGENHBG057167.
InParanoidQ8BUY8.
OMAWFWDRDE.
OrthoDBEOG70PBZ0.
PhylomeDBQ8BUY8.
TreeFamTF335652.

Gene expression databases

BgeeQ8BUY8.
GenevestigatorQ8BUY8.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Other

NextBio386846.
PROQ8BUY8.
SOURCESearch...

Entry information

Entry nameGASP2_MOUSE
AccessionPrimary (citable) accession number: Q8BUY8
Secondary accession number(s): Q148X7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot