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Protein

Ammonium transporter Rh type B

Gene

Rhbg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a specific ammonium transporter.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmmonia transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-444411 Rhesus glycoproteins mediate ammonium transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type B
Alternative name(s):
Rhesus blood group family type B glycoprotein
Short name:
Rh family type B glycoprotein
Short name:
Rh type B glycoprotein
Gene namesi
Name:Rhbg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1927379 Rhbg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 58ExtracellularSequence analysisAdd BLAST27
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 83CytoplasmicSequence analysis4
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 121ExtracellularSequence analysisAdd BLAST17
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 146CytoplasmicSequence analysis4
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 175ExtracellularSequence analysis8
Transmembranei176 – 198HelicalSequence analysisAdd BLAST23
Topological domaini199 – 216CytoplasmicSequence analysisAdd BLAST18
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 248ExtracellularSequence analysisAdd BLAST11
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 279CytoplasmicSequence analysis10
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Topological domaini301ExtracellularSequence analysis1
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 343CytoplasmicSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 390ExtracellularSequence analysisAdd BLAST26
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 455CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002835991 – 455Ammonium transporter Rh type BAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BUX5
PaxDbiQ8BUX5
PRIDEiQ8BUX5

PTM databases

iPTMnetiQ8BUX5
PhosphoSitePlusiQ8BUX5

Expressioni

Tissue specificityi

Expressed in kidney by connecting segments and collecting tubules. Also expressed in liver by perivenous hepatocytes. Expressed in the forestomach and the fundus of the stomach. Expressed in duodenum, jejunum, ileum and colon at the level of villous (at protein level). Specifically expressed in kidney where it is restricted to the epithelial linings of the convoluted tubules and the loop of Henle. Also detected in ovary. Expressed by hepatocytes and dermal hair follicles and papillae.4 Publications

Developmental stagei

Detected in embryos at E15 and E17. Expressed in kidney, skin and liver of E16.5 embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000104445
CleanExiMM_RHBG
GenevisibleiQ8BUX5 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130767

Structurei

3D structure databases

ProteinModelPortaliQ8BUX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni413 – 421Interaction with ANK3By similarity9

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796 Eukaryota
ENOG410XTF8 LUCA
GeneTreeiENSGT00390000005787
HOGENOMiHOG000007656
HOVERGENiHBG004374
InParanoidiQ8BUX5
KOiK06580
OMAiDSQCYED
OrthoDBiEOG091G06KX
PhylomeDBiQ8BUX5
TreeFamiTF314450

Family and domain databases

Gene3Di1.10.3430.101 hit
InterProiView protein in InterPro
IPR029020 Ammonium/urea_transptr
IPR024041 NH4_transpt_AmtB-like_dom
IPR002229 RhesusRHD
PfamiView protein in Pfam
PF00909 Ammonium_transp, 1 hit
PRINTSiPR00342 RHESUSRHD

Sequencei

Sequence statusi: Complete.

Q8BUX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVPRHRRL VLPLLCLLFQ GATALLFAIF VRYNHETDAA LWHWGNHSNV
60 70 80 90 100
DNEFYFRYPS FQDVHVMVFV GFGFLMVFLQ RYGFSSVGFT FLVASLTLQW
110 120 130 140 150
ATLLQGFLHS FHGGHIHVGV ESLINADFCA GAVLISFGAV LGKTGPAQLL
160 170 180 190 200
LMALLEAVLF SVNEFILLSL LGVRDAGGSM TIHTFGAYFG LFLSWVLYRS
210 220 230 240 250
QLEKSRHRQS SVYNSDLFAM IGTIFLWVFW PSFNSAPTAL GDGQHRTVVN
260 270 280 290 300
TYYSLTASTL STFALSALVS GDGRLDMVHV QNAALAGGVV VGTSSEMMLT
310 320 330 340 350
PFGALAAGFL AGTVSTLGYK FFTPILESRF KLQDTCGVHN LHGMPGVLGA
360 370 380 390 400
ILGVVVAALA THEAYGDGLQ SVFPLIAKGQ RSATSQAVYQ LFGMFVTLVF
410 420 430 440 450
ASVGGSLGGL LLRLPFLDSP PDSQCFEDQV YWEVPGEQET ETQRPLRGGE

SDTRA
Length:455
Mass (Da):49,543
Last modified:March 1, 2003 - v1
Checksum:iC8D57B88A37089D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195W → R in AAF19371 (PubMed:11024028).Curated1
Sequence conflicti195W → R in AAH29236 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193808 mRNA Translation: AAF19371.1
AY254685 mRNA Translation: AAP81167.1
AK081882 mRNA Translation: BAC38359.1
BC029236 mRNA Translation: AAH29236.1
CCDSiCCDS17466.1
RefSeqiNP_067350.2, NM_021375.3
UniGeneiMm.103777

Genome annotation databases

EnsembliENSMUST00000171887; ENSMUSP00000130767; ENSMUSG00000104445
GeneIDi58176
KEGGimmu:58176
UCSCiuc008pui.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRHBG_MOUSE
AccessioniPrimary (citable) accession number: Q8BUX5
Secondary accession number(s): Q9QXP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome