Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8BUX5

- RHBG_MOUSE

UniProt

Q8BUX5 - RHBG_MOUSE

Protein

Ammonium transporter Rh type B

Gene

Rhbg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Functions as a specific ammonium transporter.2 Publications

    GO - Molecular functioni

    1. ammonium transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. ammonium transport Source: UniProtKB
    2. transepithelial ammonium transport Source: Ensembl

    Keywords - Biological processi

    Ammonia transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198711. Rhesus glycoproteins mediate ammonium transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ammonium transporter Rh type B
    Alternative name(s):
    Rhesus blood group family type B glycoprotein
    Short name:
    Rh family type B glycoprotein
    Short name:
    Rh type B glycoprotein
    Gene namesi
    Name:Rhbg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1927379. Rhbg.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: UniProtKB
    3. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    4. integral component of plasma membrane Source: UniProtKB
    5. membrane Source: UniProtKB
    6. spectrin-associated cytoskeleton Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Ammonium transporter Rh type BPRO_0000283599Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8BUX5.
    PRIDEiQ8BUX5.

    Expressioni

    Tissue specificityi

    Expressed in kidney by connecting segments and collecting tubules. Also expressed in liver by perivenous hepatocytes. Expressed in the forestomach and the fundus of the stomach. Expressed in duodenum, jejunum, ileum and colon at the level of villous (at protein level). Specifically expressed in kidney where it is restricted to the epithelial linings of the convoluted tubules and the loop of Henle. Also detected in ovary. Expressed by hepatocytes and dermal hair follicles and papillae.4 Publications

    Developmental stagei

    Detected in embryos at E15 and E17. Expressed in kidney, skin and liver of E16.5 embryos.1 Publication

    Gene expression databases

    ArrayExpressiQ8BUX5.
    BgeeiQ8BUX5.
    CleanExiMM_RHBG.
    GenevestigatoriQ8BUX5.

    Interactioni

    Subunit structurei

    Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000001453.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BUX5.
    SMRiQ8BUX5. Positions 9-435.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 5827ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini80 – 834CytoplasmicSequence Analysis
    Topological domaini105 – 12117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini143 – 1464CytoplasmicSequence Analysis
    Topological domaini168 – 1758ExtracellularSequence Analysis
    Topological domaini199 – 21618CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini238 – 24811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini270 – 27910CytoplasmicSequence Analysis
    Topological domaini301 – 3011ExtracellularSequence Analysis
    Topological domaini323 – 34321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini365 – 39026ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini412 – 45544CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei280 – 30021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei391 – 41121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni413 – 4219Interaction with ANK3By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG276393.
    GeneTreeiENSGT00390000005787.
    HOGENOMiHOG000007656.
    HOVERGENiHBG004374.
    InParanoidiQ8BUX5.
    KOiK06580.
    OMAiDSQCYED.
    OrthoDBiEOG73NG3C.
    PhylomeDBiQ8BUX5.
    TreeFamiTF314450.

    Family and domain databases

    Gene3Di1.10.3430.10. 1 hit.
    InterProiIPR029020. Ammonium/urea_transptr.
    IPR024041. NH4_transpt_AmtB-like_dom.
    IPR002229. RhesusRHD.
    [Graphical view]
    PfamiPF00909. Ammonium_transp. 1 hit.
    [Graphical view]
    PRINTSiPR00342. RHESUSRHD.
    SUPFAMiSSF111352. SSF111352. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8BUX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARVPRHRRL VLPLLCLLFQ GATALLFAIF VRYNHETDAA LWHWGNHSNV    50
    DNEFYFRYPS FQDVHVMVFV GFGFLMVFLQ RYGFSSVGFT FLVASLTLQW 100
    ATLLQGFLHS FHGGHIHVGV ESLINADFCA GAVLISFGAV LGKTGPAQLL 150
    LMALLEAVLF SVNEFILLSL LGVRDAGGSM TIHTFGAYFG LFLSWVLYRS 200
    QLEKSRHRQS SVYNSDLFAM IGTIFLWVFW PSFNSAPTAL GDGQHRTVVN 250
    TYYSLTASTL STFALSALVS GDGRLDMVHV QNAALAGGVV VGTSSEMMLT 300
    PFGALAAGFL AGTVSTLGYK FFTPILESRF KLQDTCGVHN LHGMPGVLGA 350
    ILGVVVAALA THEAYGDGLQ SVFPLIAKGQ RSATSQAVYQ LFGMFVTLVF 400
    ASVGGSLGGL LLRLPFLDSP PDSQCFEDQV YWEVPGEQET ETQRPLRGGE 450
    SDTRA 455
    Length:455
    Mass (Da):49,543
    Last modified:March 1, 2003 - v1
    Checksum:iC8D57B88A37089D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti195 – 1951W → R in AAF19371. (PubMed:11024028)Curated
    Sequence conflicti195 – 1951W → R in AAH29236. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193808 mRNA. Translation: AAF19371.1.
    AY254685 mRNA. Translation: AAP81167.1.
    AK081882 mRNA. Translation: BAC38359.1.
    BC029236 mRNA. Translation: AAH29236.1.
    CCDSiCCDS17466.1.
    RefSeqiNP_067350.2. NM_021375.3.
    UniGeneiMm.103777.

    Genome annotation databases

    EnsembliENSMUST00000171887; ENSMUSP00000130767; ENSMUSG00000001417.
    GeneIDi58176.
    KEGGimmu:58176.
    UCSCiuc008pui.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193808 mRNA. Translation: AAF19371.1 .
    AY254685 mRNA. Translation: AAP81167.1 .
    AK081882 mRNA. Translation: BAC38359.1 .
    BC029236 mRNA. Translation: AAH29236.1 .
    CCDSi CCDS17466.1.
    RefSeqi NP_067350.2. NM_021375.3.
    UniGenei Mm.103777.

    3D structure databases

    ProteinModelPortali Q8BUX5.
    SMRi Q8BUX5. Positions 9-435.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000001453.

    Proteomic databases

    PaxDbi Q8BUX5.
    PRIDEi Q8BUX5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000171887 ; ENSMUSP00000130767 ; ENSMUSG00000001417 .
    GeneIDi 58176.
    KEGGi mmu:58176.
    UCSCi uc008pui.1. mouse.

    Organism-specific databases

    CTDi 57127.
    MGIi MGI:1927379. Rhbg.

    Phylogenomic databases

    eggNOGi NOG276393.
    GeneTreei ENSGT00390000005787.
    HOGENOMi HOG000007656.
    HOVERGENi HBG004374.
    InParanoidi Q8BUX5.
    KOi K06580.
    OMAi DSQCYED.
    OrthoDBi EOG73NG3C.
    PhylomeDBi Q8BUX5.
    TreeFami TF314450.

    Enzyme and pathway databases

    Reactomei REACT_198711. Rhesus glycoproteins mediate ammonium transport.

    Miscellaneous databases

    ChiTaRSi RHBG. mouse.
    NextBioi 314119.
    PROi Q8BUX5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BUX5.
    Bgeei Q8BUX5.
    CleanExi MM_RHBG.
    Genevestigatori Q8BUX5.

    Family and domain databases

    Gene3Di 1.10.3430.10. 1 hit.
    InterProi IPR029020. Ammonium/urea_transptr.
    IPR024041. NH4_transpt_AmtB-like_dom.
    IPR002229. RhesusRHD.
    [Graphical view ]
    Pfami PF00909. Ammonium_transp. 1 hit.
    [Graphical view ]
    PRINTSi PR00342. RHESUSRHD.
    SUPFAMi SSF111352. SSF111352. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals."
      Liu Z., Peng J., Mo R., Hui C.-C., Huang C.-H.
      J. Biol. Chem. 276:1424-1433(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, GLYCOSYLATION.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: C3H.
      Tissue: Kidney cortex.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    5. "Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney."
      Verlander J.W., Miller R.T., Frank A.E., Royaux I.E., Kim Y.-H., Weiner I.D.
      Am. J. Physiol. 284:F323-F337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. "Localization of the ammonium transporters, Rh B glycoprotein and Rh C glycoprotein, in the mouse liver."
      Weiner I.D., Miller R.T., Verlander J.W.
      Gastroenterology 124:1432-1440(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. "Expression of the ammonia transporter proteins Rh B glycoprotein and Rh C glycoprotein in the intestinal tract."
      Handlogten M.E., Hong S.-P., Zhang L., Vander A.W., Steinbaum M.L., Campbell-Thompson M., Weiner I.D.
      Am. J. Physiol. 288:G1036-G1047(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    8. "Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG."
      Mak D.-O., Dang B., Weiner I.D., Foskett J.K., Westhoff C.M.
      Am. J. Physiol. 290:F297-F305(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiRHBG_MOUSE
    AccessioniPrimary (citable) accession number: Q8BUX5
    Secondary accession number(s): Q9QXP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3