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Q8BUX5

- RHBG_MOUSE

UniProt

Q8BUX5 - RHBG_MOUSE

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Protein
Ammonium transporter Rh type B
Gene
Rhbg
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as a specific ammonium transporter.2 Publications

GO - Molecular functioni

  1. ammonium transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. ammonium transport Source: UniProtKB
  2. transepithelial ammonium transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ammonia transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198711. Rhesus glycoproteins mediate ammonium transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type B
Alternative name(s):
Rhesus blood group family type B glycoprotein
Short name:
Rh family type B glycoprotein
Short name:
Rh type B glycoprotein
Gene namesi
Name:Rhbg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1927379. Rhbg.

Subcellular locationi

Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein By similarity 3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Cytoplasmic Reviewed prediction
Transmembranei11 – 3121Helical; Reviewed prediction
Add
BLAST
Topological domaini32 – 5827Extracellular Reviewed prediction
Add
BLAST
Transmembranei59 – 7921Helical; Reviewed prediction
Add
BLAST
Topological domaini80 – 834Cytoplasmic Reviewed prediction
Transmembranei84 – 10421Helical; Reviewed prediction
Add
BLAST
Topological domaini105 – 12117Extracellular Reviewed prediction
Add
BLAST
Transmembranei122 – 14221Helical; Reviewed prediction
Add
BLAST
Topological domaini143 – 1464Cytoplasmic Reviewed prediction
Transmembranei147 – 16721Helical; Reviewed prediction
Add
BLAST
Topological domaini168 – 1758Extracellular Reviewed prediction
Transmembranei176 – 19823Helical; Reviewed prediction
Add
BLAST
Topological domaini199 – 21618Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Reviewed prediction
Add
BLAST
Topological domaini238 – 24811Extracellular Reviewed prediction
Add
BLAST
Transmembranei249 – 26921Helical; Reviewed prediction
Add
BLAST
Topological domaini270 – 27910Cytoplasmic Reviewed prediction
Transmembranei280 – 30021Helical; Reviewed prediction
Add
BLAST
Topological domaini301 – 3011Extracellular Reviewed prediction
Transmembranei302 – 32221Helical; Reviewed prediction
Add
BLAST
Topological domaini323 – 34321Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei344 – 36421Helical; Reviewed prediction
Add
BLAST
Topological domaini365 – 39026Extracellular Reviewed prediction
Add
BLAST
Transmembranei391 – 41121Helical; Reviewed prediction
Add
BLAST
Topological domaini412 – 45544Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. anchored component of plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: UniProtKB
  3. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  4. integral component of plasma membrane Source: UniProtKB
  5. membrane Source: UniProtKB
  6. spectrin-associated cytoskeleton Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Ammonium transporter Rh type B
PRO_0000283599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BUX5.
PRIDEiQ8BUX5.

Expressioni

Tissue specificityi

Expressed in kidney by connecting segments and collecting tubules. Also expressed in liver by perivenous hepatocytes. Expressed in the forestomach and the fundus of the stomach. Expressed in duodenum, jejunum, ileum and colon at the level of villous (at protein level). Specifically expressed in kidney where it is restricted to the epithelial linings of the convoluted tubules and the loop of Henle. Also detected in ovary. Expressed by hepatocytes and dermal hair follicles and papillae.4 Publications

Developmental stagei

Detected in embryos at E15 and E17. Expressed in kidney, skin and liver of E16.5 embryos.1 Publication

Gene expression databases

ArrayExpressiQ8BUX5.
BgeeiQ8BUX5.
CleanExiMM_RHBG.
GenevestigatoriQ8BUX5.

Interactioni

Subunit structurei

Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001453.

Structurei

3D structure databases

ProteinModelPortaliQ8BUX5.
SMRiQ8BUX5. Positions 9-435.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni413 – 4219Interaction with ANK3 By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276393.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ8BUX5.
KOiK06580.
OMAiDSQCYED.
OrthoDBiEOG73NG3C.
PhylomeDBiQ8BUX5.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BUX5-1 [UniParc]FASTAAdd to Basket

« Hide

MARVPRHRRL VLPLLCLLFQ GATALLFAIF VRYNHETDAA LWHWGNHSNV    50
DNEFYFRYPS FQDVHVMVFV GFGFLMVFLQ RYGFSSVGFT FLVASLTLQW 100
ATLLQGFLHS FHGGHIHVGV ESLINADFCA GAVLISFGAV LGKTGPAQLL 150
LMALLEAVLF SVNEFILLSL LGVRDAGGSM TIHTFGAYFG LFLSWVLYRS 200
QLEKSRHRQS SVYNSDLFAM IGTIFLWVFW PSFNSAPTAL GDGQHRTVVN 250
TYYSLTASTL STFALSALVS GDGRLDMVHV QNAALAGGVV VGTSSEMMLT 300
PFGALAAGFL AGTVSTLGYK FFTPILESRF KLQDTCGVHN LHGMPGVLGA 350
ILGVVVAALA THEAYGDGLQ SVFPLIAKGQ RSATSQAVYQ LFGMFVTLVF 400
ASVGGSLGGL LLRLPFLDSP PDSQCFEDQV YWEVPGEQET ETQRPLRGGE 450
SDTRA 455
Length:455
Mass (Da):49,543
Last modified:March 1, 2003 - v1
Checksum:iC8D57B88A37089D2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951W → R in AAF19371. 1 Publication
Sequence conflicti195 – 1951W → R in AAH29236. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193808 mRNA. Translation: AAF19371.1.
AY254685 mRNA. Translation: AAP81167.1.
AK081882 mRNA. Translation: BAC38359.1.
BC029236 mRNA. Translation: AAH29236.1.
CCDSiCCDS17466.1.
RefSeqiNP_067350.2. NM_021375.3.
UniGeneiMm.103777.

Genome annotation databases

EnsembliENSMUST00000171887; ENSMUSP00000130767; ENSMUSG00000001417.
GeneIDi58176.
KEGGimmu:58176.
UCSCiuc008pui.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193808 mRNA. Translation: AAF19371.1 .
AY254685 mRNA. Translation: AAP81167.1 .
AK081882 mRNA. Translation: BAC38359.1 .
BC029236 mRNA. Translation: AAH29236.1 .
CCDSi CCDS17466.1.
RefSeqi NP_067350.2. NM_021375.3.
UniGenei Mm.103777.

3D structure databases

ProteinModelPortali Q8BUX5.
SMRi Q8BUX5. Positions 9-435.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000001453.

Proteomic databases

PaxDbi Q8BUX5.
PRIDEi Q8BUX5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000171887 ; ENSMUSP00000130767 ; ENSMUSG00000001417 .
GeneIDi 58176.
KEGGi mmu:58176.
UCSCi uc008pui.1. mouse.

Organism-specific databases

CTDi 57127.
MGIi MGI:1927379. Rhbg.

Phylogenomic databases

eggNOGi NOG276393.
GeneTreei ENSGT00390000005787.
HOGENOMi HOG000007656.
HOVERGENi HBG004374.
InParanoidi Q8BUX5.
KOi K06580.
OMAi DSQCYED.
OrthoDBi EOG73NG3C.
PhylomeDBi Q8BUX5.
TreeFami TF314450.

Enzyme and pathway databases

Reactomei REACT_198711. Rhesus glycoproteins mediate ammonium transport.

Miscellaneous databases

ChiTaRSi RHBG. mouse.
NextBioi 314119.
PROi Q8BUX5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BUX5.
Bgeei Q8BUX5.
CleanExi MM_RHBG.
Genevestigatori Q8BUX5.

Family and domain databases

Gene3Di 1.10.3430.10. 1 hit.
InterProi IPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view ]
Pfami PF00909. Ammonium_transp. 1 hit.
[Graphical view ]
PRINTSi PR00342. RHESUSRHD.
SUPFAMi SSF111352. SSF111352. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals."
    Liu Z., Peng J., Mo R., Hui C.-C., Huang C.-H.
    J. Biol. Chem. 276:1424-1433(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, GLYCOSYLATION.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: C3H.
    Tissue: Kidney cortex.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  5. "Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney."
    Verlander J.W., Miller R.T., Frank A.E., Royaux I.E., Kim Y.-H., Weiner I.D.
    Am. J. Physiol. 284:F323-F337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "Localization of the ammonium transporters, Rh B glycoprotein and Rh C glycoprotein, in the mouse liver."
    Weiner I.D., Miller R.T., Verlander J.W.
    Gastroenterology 124:1432-1440(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "Expression of the ammonia transporter proteins Rh B glycoprotein and Rh C glycoprotein in the intestinal tract."
    Handlogten M.E., Hong S.-P., Zhang L., Vander A.W., Steinbaum M.L., Campbell-Thompson M., Weiner I.D.
    Am. J. Physiol. 288:G1036-G1047(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG."
    Mak D.-O., Dang B., Weiner I.D., Foskett J.K., Westhoff C.M.
    Am. J. Physiol. 290:F297-F305(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRHBG_MOUSE
AccessioniPrimary (citable) accession number: Q8BUX5
Secondary accession number(s): Q9QXP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi