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Protein
Submitted name:

Potassium channel, subfamily K, member 10

Gene

Kcnk10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1299503. TWIK related potassium channel (TREK).

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel, subfamily K, member 10Imported
Submitted name:
Protein Kcnk10Imported
Submitted name:
RIKEN cDNA 1700024D23, isoform CRA_aImported
Gene namesi
Name:Kcnk10Imported
Synonyms:1700024D23RikImported
ORF Names:mCG_22435Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1919508. Kcnk10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei69 – 9022HelicalSequence analysisAdd
BLAST
Transmembranei151 – 17020HelicalSequence analysisAdd
BLAST
Transmembranei182 – 20726HelicalSequence analysisAdd
BLAST
Transmembranei228 – 25225HelicalSequence analysisAdd
BLAST
Transmembranei264 – 28522HelicalSequence analysisAdd
BLAST
Transmembranei297 – 31923HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 535519Sequence analysisPRO_5007927347Add
BLAST

Expressioni

Gene expression databases

BgeeiENSMUSG00000033854.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105740.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 20258Ion_trans_2InterPro annotationAdd
BLAST
Domaini241 – 32080Ion_trans_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
OMAiKQVNWDP.
OrthoDBiEOG091G0E3R.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q8BUW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFSYIGYFF LPPLVAVPAA APPVCQPKSA TNGHHPVPRL SISSRATVVA
60 70 80 90 100
RMEGASQGGL QTVMKWKTVV AIFVVVVVYL VTGGLVFRAL EQPFESSQKN
110 120 130 140 150
TIALEKAEFL RDHICVSPQE LETLIQHALD ADNAGVSPVG NSSNSSSHWD
160 170 180 190 200
LGSAFFFAGT VITTIGYGNI APSTEGGKIF CILYAIFGIP LFGFLLAGIG
210 220 230 240 250
DQLGTIFGKS IARVEKVFRK KQVSQTKIRV ISTILFILAG CIVFVTIPAV
260 270 280 290 300
IFKYIEGWTA LESIYFVVVT LTTVGFGDFV AGGNAGINYR EWYKPLVWFW
310 320 330 340 350
ILVGLAYFAA VLSMIGDWLR VLSKKTKEEV GEIKAHAAEW KANVTAEFRE
360 370 380 390 400
TRRRLSVEIH DKLQRAATIR SMERRRLGLD QRAHSLDMLS PEKRSVFAAL
410 420 430 440 450
DTGRFKASSQ ESINNRPNNL RLKGPEQLTK HGQGASEDNI INKFGSTSKL
460 470 480 490 500
TKRKNKDLKK TLPEDVQKIY KTFRNYSLDE EKKEDETEKM CNSDNSSTAM
510 520 530
LTECIQQQAE MENGMVPTDT KDQGLENNSL LEDRN
Length:535
Mass (Da):59,401
Last modified:March 1, 2003 - v1
Checksum:i3E98E89F875C26BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124516 Genomic DNA. No translation available.
AC134249 Genomic DNA. No translation available.
BC132487 mRNA. Translation: AAI32488.1.
BC137869 mRNA. Translation: AAI37870.1.
AK082153 mRNA. Translation: BAC38424.1.
CH466549 Genomic DNA. Translation: EDL18932.1.
RefSeqiNP_084187.2. NM_029911.5.
UniGeneiMm.196158.
Mm.400628.

Genome annotation databases

EnsembliENSMUST00000110113; ENSMUSP00000105740; ENSMUSG00000033854.
GeneIDi72258.
UCSCiuc007oqh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124516 Genomic DNA. No translation available.
AC134249 Genomic DNA. No translation available.
BC132487 mRNA. Translation: AAI32488.1.
BC137869 mRNA. Translation: AAI37870.1.
AK082153 mRNA. Translation: BAC38424.1.
CH466549 Genomic DNA. Translation: EDL18932.1.
RefSeqiNP_084187.2. NM_029911.5.
UniGeneiMm.196158.
Mm.400628.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105740.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110113; ENSMUSP00000105740; ENSMUSG00000033854.
GeneIDi72258.
UCSCiuc007oqh.1. mouse.

Organism-specific databases

CTDi54207.
MGIiMGI:1919508. Kcnk10.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
OMAiKQVNWDP.
OrthoDBiEOG091G0E3R.
TreeFamiTF313947.

Enzyme and pathway databases

ReactomeiR-MMU-1299503. TWIK related potassium channel (TREK).

Miscellaneous databases

ChiTaRSiKcnk10. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033854.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8BUW1_MOUSE
AccessioniPrimary (citable) accession number: Q8BUW1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.