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Protein

Protein GPR107

Gene

Gpr107

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in Golgi-to-ER retrograde transport.By similarity

GO - Molecular functioni

  • clathrin heavy chain binding Source: MGI

GO - Biological processi

  • clathrin-dependent endocytosis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GPR107
Gene namesi
Name:Gpr107
Synonyms:Kiaa1624
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139054. Gpr107.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini40 – 262LumenalSequence analysisAdd BLAST223
Transmembranei263 – 283Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini284 – 292CytoplasmicSequence analysis9
Transmembranei293 – 313Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini314 – 336LumenalSequence analysisAdd BLAST23
Transmembranei337 – 357Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini358 – 367CytoplasmicSequence analysis10
Transmembranei368 – 388Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini389 – 401LumenalSequence analysisAdd BLAST13
Transmembranei402 – 422Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini423 – 449CytoplasmicSequence analysisAdd BLAST27
Transmembranei450 – 470Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini471 – 475LumenalSequence analysis5
Transmembranei476 – 495Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini496 – 551CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

  • clathrin-coated vesicle Source: MGI
  • early endosome Source: MGI
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000002134134 – 551Protein GPR107Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 226By similarity
Glycosylationi209N-linked (GlcNAc...)Sequence analysis1
Modified residuei537PhosphoserineCombined sources1

Post-translational modificationi

Cleaved by a furin endopeptidase to yield two fragments that remain associated via a disulfide bond.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8BUV8.
MaxQBiQ8BUV8.
PaxDbiQ8BUV8.
PRIDEiQ8BUV8.

PTM databases

iPTMnetiQ8BUV8.
PhosphoSitePlusiQ8BUV8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000194.
CleanExiMM_GPR107.
ExpressionAtlasiQ8BUV8. baseline and differential.
GenevisibleiQ8BUV8. MM.

Interactioni

GO - Molecular functioni

  • clathrin heavy chain binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056739.

Structurei

3D structure databases

ProteinModelPortaliQ8BUV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LU7TM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2569. Eukaryota.
ENOG410XQAQ. LUCA.
GeneTreeiENSGT00390000008649.
HOGENOMiHOG000238447.
HOVERGENiHBG056147.
InParanoidiQ8BUV8.
OMAiFTRIIAF.
OrthoDBiEOG091G05OJ.
PhylomeDBiQ8BUV8.
TreeFamiTF314804.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BUV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPVPLGRF GSFCLRLLRL LALLELLVHP VLGRVHHLAL KDDVRHKVHL
60 70 80 90 100
NTFGFFKDGY MVVNVSSLSV NEPEGATDKD AEIGFSLDRT KNDGFSSYLD
110 120 130 140 150
EDVNYCILKK KSMSSVTLVI LDISGSIVKV RSPPEAGKQL PEIVFSKDEK
160 170 180 190 200
ILSQSQEPAV SSNPKDSEAR RTLDGFKAGR STVDSKAITE RSFSIHKNDG
210 220 230 240 250
VVSFQFFFNI STDDQEGLYS LYFHKCSGNN VKPGEQASFS LNIAITEKNP
260 270 280 290 300
NSYLSAGEIP LPKLYVSMAL FFFLSGTIWI HILRKRRNDV FKIHWLMAAL
310 320 330 340 350
PFTKSLSLVF HAIDYHYISS QGFPIEGWAV VYYITHLLKG ALLFITIALI
360 370 380 390 400
GTGWAFIKHI LSDKDKKIFM IVIPLQVLAN VAYIIIESTE EGTTEYGLWK
410 420 430 440 450
DSLFLVDLLC CGAILFPVVW SIRHLQEASA TDGKAAINLA KLRLFRHYYV
460 470 480 490 500
LIVCYIYFTR IIAFLLKFAV PFQWKWLYQL LDETATLVFF VLTGYKFRPA
510 520 530 540 550
SDNPYLQLSQ EDDDLEMESV VTTSGVMENM KKVKKVSNGA VEPQGSWEGT

A
Length:551
Mass (Da):62,056
Last modified:July 19, 2005 - v2
Checksum:iB79DBE97D56BD2B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127I → L in BAC38445 (PubMed:16141072).Curated1
Sequence conflicti154Q → R in BAC40414 (PubMed:16141072).Curated1
Sequence conflicti154Q → R in BAC98217 (PubMed:14621295).Curated1
Sequence conflicti532K → R in BAC28840 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030433 mRNA. Translation: BAC26961.1.
AK034815 mRNA. Translation: BAC28840.1.
AK082237 mRNA. Translation: BAC38445.1.
AK088544 mRNA. Translation: BAC40414.1.
BC092231 mRNA. Translation: AAH92231.1.
AK129407 mRNA. Translation: BAC98217.1.
CCDSiCCDS15895.1.
RefSeqiNP_848875.2. NM_178760.4.
UniGeneiMm.236074.
Mm.474294.

Genome annotation databases

EnsembliENSMUST00000056433; ENSMUSP00000056739; ENSMUSG00000000194.
GeneIDi277463.
KEGGimmu:277463.
UCSCiuc008jdp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030433 mRNA. Translation: BAC26961.1.
AK034815 mRNA. Translation: BAC28840.1.
AK082237 mRNA. Translation: BAC38445.1.
AK088544 mRNA. Translation: BAC40414.1.
BC092231 mRNA. Translation: AAH92231.1.
AK129407 mRNA. Translation: BAC98217.1.
CCDSiCCDS15895.1.
RefSeqiNP_848875.2. NM_178760.4.
UniGeneiMm.236074.
Mm.474294.

3D structure databases

ProteinModelPortaliQ8BUV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056739.

PTM databases

iPTMnetiQ8BUV8.
PhosphoSitePlusiQ8BUV8.

Proteomic databases

EPDiQ8BUV8.
MaxQBiQ8BUV8.
PaxDbiQ8BUV8.
PRIDEiQ8BUV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056433; ENSMUSP00000056739; ENSMUSG00000000194.
GeneIDi277463.
KEGGimmu:277463.
UCSCiuc008jdp.2. mouse.

Organism-specific databases

CTDi57720.
MGIiMGI:2139054. Gpr107.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2569. Eukaryota.
ENOG410XQAQ. LUCA.
GeneTreeiENSGT00390000008649.
HOGENOMiHOG000238447.
HOVERGENiHBG056147.
InParanoidiQ8BUV8.
OMAiFTRIIAF.
OrthoDBiEOG091G05OJ.
PhylomeDBiQ8BUV8.
TreeFamiTF314804.

Miscellaneous databases

PROiQ8BUV8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000194.
CleanExiMM_GPR107.
ExpressionAtlasiQ8BUV8. baseline and differential.
GenevisibleiQ8BUV8. MM.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP107_MOUSE
AccessioniPrimary (citable) accession number: Q8BUV8
Secondary accession number(s): Q6ZPL4
, Q8BM58, Q8BMN6, Q8BTW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.