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Protein

Protein GPR107

Gene

Gpr107

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in Golgi-to-ER retrograde transport.By similarity

GO - Molecular functioni

  • clathrin heavy chain binding Source: MGI

GO - Biological processi

  • clathrin-mediated endocytosis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GPR107
Gene namesi
Name:Gpr107
Synonyms:Kiaa1624
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139054. Gpr107.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini40 – 262223LumenalSequence analysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini284 – 2929CytoplasmicSequence analysis
Transmembranei293 – 31321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini314 – 33623LumenalSequence analysisAdd
BLAST
Transmembranei337 – 35721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini358 – 36710CytoplasmicSequence analysis
Transmembranei368 – 38821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini389 – 40113LumenalSequence analysisAdd
BLAST
Transmembranei402 – 42221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini423 – 44927CytoplasmicSequence analysisAdd
BLAST
Transmembranei450 – 47021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini471 – 4755LumenalSequence analysis
Transmembranei476 – 49520Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini496 – 55156CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • clathrin-coated vesicle Source: MGI
  • early endosome Source: MGI
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 551518Protein GPR107PRO_0000021341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Disulfide bondi106 ↔ 226By similarity
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis
Modified residuei537 – 5371PhosphoserineCombined sources

Post-translational modificationi

Cleaved by a furin endopeptidase to yield two fragments that remain associated via a disulfide bond.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8BUV8.
MaxQBiQ8BUV8.
PaxDbiQ8BUV8.
PRIDEiQ8BUV8.

PTM databases

iPTMnetiQ8BUV8.
PhosphoSiteiQ8BUV8.

Expressioni

Gene expression databases

BgeeiQ8BUV8.
CleanExiMM_GPR107.
ExpressionAtlasiQ8BUV8. baseline and differential.
GenevisibleiQ8BUV8. MM.

Interactioni

GO - Molecular functioni

  • clathrin heavy chain binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056739.

Family & Domainsi

Sequence similaritiesi

Belongs to the LU7TM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2569. Eukaryota.
ENOG410XQAQ. LUCA.
GeneTreeiENSGT00390000008649.
HOGENOMiHOG000238447.
HOVERGENiHBG056147.
InParanoidiQ8BUV8.
OMAiFTRIIAF.
OrthoDBiEOG7D85WF.
PhylomeDBiQ8BUV8.
TreeFamiTF314804.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BUV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPVPLGRF GSFCLRLLRL LALLELLVHP VLGRVHHLAL KDDVRHKVHL
60 70 80 90 100
NTFGFFKDGY MVVNVSSLSV NEPEGATDKD AEIGFSLDRT KNDGFSSYLD
110 120 130 140 150
EDVNYCILKK KSMSSVTLVI LDISGSIVKV RSPPEAGKQL PEIVFSKDEK
160 170 180 190 200
ILSQSQEPAV SSNPKDSEAR RTLDGFKAGR STVDSKAITE RSFSIHKNDG
210 220 230 240 250
VVSFQFFFNI STDDQEGLYS LYFHKCSGNN VKPGEQASFS LNIAITEKNP
260 270 280 290 300
NSYLSAGEIP LPKLYVSMAL FFFLSGTIWI HILRKRRNDV FKIHWLMAAL
310 320 330 340 350
PFTKSLSLVF HAIDYHYISS QGFPIEGWAV VYYITHLLKG ALLFITIALI
360 370 380 390 400
GTGWAFIKHI LSDKDKKIFM IVIPLQVLAN VAYIIIESTE EGTTEYGLWK
410 420 430 440 450
DSLFLVDLLC CGAILFPVVW SIRHLQEASA TDGKAAINLA KLRLFRHYYV
460 470 480 490 500
LIVCYIYFTR IIAFLLKFAV PFQWKWLYQL LDETATLVFF VLTGYKFRPA
510 520 530 540 550
SDNPYLQLSQ EDDDLEMESV VTTSGVMENM KKVKKVSNGA VEPQGSWEGT

A
Length:551
Mass (Da):62,056
Last modified:July 19, 2005 - v2
Checksum:iB79DBE97D56BD2B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271I → L in BAC38445 (PubMed:16141072).Curated
Sequence conflicti154 – 1541Q → R in BAC40414 (PubMed:16141072).Curated
Sequence conflicti154 – 1541Q → R in BAC98217 (PubMed:14621295).Curated
Sequence conflicti532 – 5321K → R in BAC28840 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030433 mRNA. Translation: BAC26961.1.
AK034815 mRNA. Translation: BAC28840.1.
AK082237 mRNA. Translation: BAC38445.1.
AK088544 mRNA. Translation: BAC40414.1.
BC092231 mRNA. Translation: AAH92231.1.
AK129407 mRNA. Translation: BAC98217.1.
CCDSiCCDS15895.1.
RefSeqiNP_848875.2. NM_178760.4.
UniGeneiMm.236074.
Mm.474294.

Genome annotation databases

EnsembliENSMUST00000056433; ENSMUSP00000056739; ENSMUSG00000000194.
GeneIDi277463.
KEGGimmu:277463.
UCSCiuc008jdp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030433 mRNA. Translation: BAC26961.1.
AK034815 mRNA. Translation: BAC28840.1.
AK082237 mRNA. Translation: BAC38445.1.
AK088544 mRNA. Translation: BAC40414.1.
BC092231 mRNA. Translation: AAH92231.1.
AK129407 mRNA. Translation: BAC98217.1.
CCDSiCCDS15895.1.
RefSeqiNP_848875.2. NM_178760.4.
UniGeneiMm.236074.
Mm.474294.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056739.

PTM databases

iPTMnetiQ8BUV8.
PhosphoSiteiQ8BUV8.

Proteomic databases

EPDiQ8BUV8.
MaxQBiQ8BUV8.
PaxDbiQ8BUV8.
PRIDEiQ8BUV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056433; ENSMUSP00000056739; ENSMUSG00000000194.
GeneIDi277463.
KEGGimmu:277463.
UCSCiuc008jdp.2. mouse.

Organism-specific databases

CTDi57720.
MGIiMGI:2139054. Gpr107.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2569. Eukaryota.
ENOG410XQAQ. LUCA.
GeneTreeiENSGT00390000008649.
HOGENOMiHOG000238447.
HOVERGENiHBG056147.
InParanoidiQ8BUV8.
OMAiFTRIIAF.
OrthoDBiEOG7D85WF.
PhylomeDBiQ8BUV8.
TreeFamiTF314804.

Miscellaneous databases

PROiQ8BUV8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BUV8.
CleanExiMM_GPR107.
ExpressionAtlasiQ8BUV8. baseline and differential.
GenevisibleiQ8BUV8. MM.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Embryoid bodies, Pituitary and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-551.
    Tissue: Embryonic tail.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiGP107_MOUSE
AccessioniPrimary (citable) accession number: Q8BUV8
Secondary accession number(s): Q6ZPL4
, Q8BM58, Q8BMN6, Q8BTW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.