Dedicator of cytokinesis protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• GTPase activator activity Source: InterPro
• guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
• SH3 domain binding Source: UniProtKB-KW

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• apoptotic process Source: UniProtKB-KW
• cell migration Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15728191
• cytoskeleton organization Source: InterPro
• hematopoietic progenitor cell differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 24029230
• phagocytosis Source: UniProtKB-KW
• positive regulation of epithelial cell migration Source: UniProtKB
• positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
• small GTPase mediated signal transduction Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• cytoplasm Source: MGI
• guanyl-nucleotide exchange factor complex Source: MGI
• membrane Source: UniProtKB-SubCell

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the ‘Interaction’ section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• SH3 domain binding Source: UniProtKB-KW

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT 
        60         70         80         90        100
LRKKSKKGIF PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS 
       110        120        130        140        150
TIWRQLYVQD NREMFRSVRH MIYDLIEWRS QILSGTLPQD ELKELKKKVT 
       160        170        180        190        200
AKIDYGNRIL DLDLVVRDED GNILDPELTS TISLFRAHEV ASKQVEERLQ 
       210        220        230        240        250
EEKSQKQNMD INRQAKFAAT PSLALFVNLK NVVCKIGEDA EVLMSLYDPM 
       260        270        280        290        300
ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ 
       310        320        330        340        350
IVRVGRMELR DSNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP 
       360        370        380        390        400
FQAVAGENDF LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP 
       410        420        430        440        450
HLVDRTTAVA RKTGFPEIIM PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV 
       460        470        480        490        500
TVSVYDEDGK RLEHVIFPGA GDEAISEYKS VIYYQVKQPR WFETLKVAIP 
       510        520        530        540        550
IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA LAFVKLMRYD GTTLRDGEHD 
       560        570        580        590        600
LIVYKAEAKK LEDAATYLSL PSTKGELEEK GHSATGKGMQ SLGSCTISKD 
       610        620        630        640        650
SFQISTLVCS TKLTQNVDLL GLLKWRSNTN LLQQNLRQLM KVDGGEVVKF 
       660        670        680        690        700
LQDTLDALFN IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET 
       710        720        730        740        750
YIKKHFSATL AYTKLTKVLR TYVASAEKPG VNEQLYKAIK ALEYIFKFIV 
       760        770        780        790        800
RSRVLFNQLY ENKGEADFVE SLLQLFRSIN DMMSSLSELT VRVKGAALKY 
       810        820        830        840        850
LPTIVNDVKL VFDPKELSKM FTEFILNVPA GLLTVQKLSC LIEIVHSDLF 
       860        870        880        890        900
TQHDCREILL PMMTDQLKYH LERQEELEAC CQLLSNILEV LYRKDVGPTQ 
       910        920        930        940        950
RHVQIIMETL LRTVNRTVIS MGRDSELIGN FVACMTAILR QMEDYHYAHL 
       960        970        980        990       1000
IKTFGKMRTD VVDFLMETFI MFKNLIGKNV YPFDWVIMNT MQNKVFLRAI 
      1010       1020       1030       1040       1050
NQYADMLNKR FLDQANFELQ LWNNYFHLAV AFLTQESLQL ENFSSAKRAK 
      1060       1070       1080       1090       1100
ILNKYGDMRR QIGFEIRDMW YNLGQHKIKF IPEMVGPILE MTLIPETELR 
      1110       1120       1130       1140       1150
KATLPIFFDM MQCEFHSTRS FQMFENEIIT KLDHEVEGGR GDEQYKVLFD 
      1160       1170       1180       1190       1200
KILLEHCRKH KYLAKTGETF VKLVVRLMER LLDYRTIMHD ENKDNRMSCT 
      1210       1220       1230       1240       1250
VNVLNFYKEI EREEMYIRYL YKLCDLHKEC DNYTEAAYTL LLHAKLLKWS 
      1260       1270       1280       1290       1300
EDVCAAHLTQ RDGFQATTQG QLKEQLYQEI IHYFDKGKMW EEAIALGKEL 
      1310       1320       1330       1340       1350
AEQYETEMFD YEQLSELLKK QAQFYENIVK VIRPKPDYFA VGYYGQGFPS 
      1360       1370       1380       1390       1400
FLRGKVFIYR GKEYERREDF EARLLTQFPN AEKMKTTSPP GDDIKTSPGQ 
      1410       1420       1430       1440       1450
YIQCFTVKPK LDLPPRFHRP VSEQIVSFYR VNEVQRFEYS RPIRKGEKNP 
      1460       1470       1480       1490       1500
DNEFANMWIE RTIYTTAYKL PGILRWFEVK SVFMVEISPL ENAIETMQLT 
      1510       1520       1530       1540       1550
NDKISSMVQQ HLDDPGLPIN PLSMLLNGIV DPAVMGGFAN YEKAFFTDRY 
      1560       1570       1580       1590       1600
LQEHPEAHGQ IEKLKDLIAW QIPFLAEGIR IHGDKVTEAL RPFHERMEAC 
      1610       1620       1630       1640       1650
FKQLKEKVEK QYGVRTMPSG LDDRRGSRPR SMVRSFTMPS SSRPLSVASV 
      1660       1670       1680       1690       1700
SSFSSDSTPS RPGSDGFALE PLLPKKMHSR SQDKLDKDDP DKEKKDKKKE 
      1710       1720       1730       1740       1750
KRNSKHQEIF DKEFKPADSS LQQSEAVILS ETISPLRPQR PKSQVINVIG 
      1760       1770       1780       1790       1800
NERRFSVSPA SPSSQQTPPP VTPRAKLSFS IQPSLELNGM MGMDVADVPP 
      1810       1820       1830       1840       1850
PLPLKGNMAD YGNLMENQDM MVSPTSPPPP PPQRQQPPPL PSKTPPPPPP 
      1860 
KTTRKQTSVD SGIVQ                                  

        10         20         30         40         50
MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT 
        60         70         80         90        100
LRKKSKKGIF PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS 
       110        120        130        140        150
TIWRQLYVQD NREMFRSVRH MIYDLIEWRS QILSGTLPQD ELKELKKKVT 
       160        170        180        190        200
AKIDYGNRIL DLDLVVRDED GNILDPELTS TISLFRAHEV ASKQVEERLQ 
       210        220        230        240        250
EEKSQKQNMD INRQAKFAAT PSLALFVNLK NVVCKIGEDA EVLMSLYDPM 
       260        270        280        290        300
ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ 
       310        320        330        340        350
IVRVGRMELR DSNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP 
       360        370        380        390        400
FQAVAGENDF LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP 
       410        420        430        440        450
HLVDRTTAVA RKTGFPEIIM PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV 
       460        470        480        490        500
TVSVYDEDGK RLEHVIFPGA GDEAISEYKS VIYYQVKQPR WFETLKVAIP 
       510        520        530        540        550
IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA LAFVKLMRYD GTTLRDGEHD 
       560        570        580        590        600
LIVYKAEAKK LEDAATYLSL PSTKGELEEK GHSATGKGMQ SLGSCTISKD 
       610        620        630        640        650
SFQISTLVCS TKLTQNVDLL GLLKWRSNTN LLQQNLRQLM KVDGGEVVKF 
       660        670        680        690        700
LQDTLDALFN IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET 
       710        720        730        740        750
YIKKHFSATL AYTKLTKVLR TYVASAEKPG VNEQLYKAIK ALEYIFKFIV 
       760        770        780        790        800
RSRVLFNQLY ENKGEADFVE SLLQLFRSIN DMMSSLSELT VRVKGAALKY 
       810        820        830        840        850
LPTIVNDVKL VFDPKELSKM FTEFILNVPA GLLTVQKLSC LIEIVHSDLF 
       860        870        880        890        900
TQHDCREILL PMMTDQLKYH LERQEELEAC CQLLSNILEV LYRKDVGPTQ 
       910        920        930        940        950
RHVQIIMETL LRTVNRTVIS MGRDSELIGN FVACMTAILR QMEDYHYAHL 
       960        970        980        990       1000
IKTFGKMRTD VVDFLMETFI MFKNLIGKNV YPFDWVIMNT MQNKVFLRAI 
      1010       1020       1030       1040       1050
NQYADMLNKR FLDQANFELQ LWNNYFHLAV AFLTQESLQL ENFSSAKRAK 
      1060       1070       1080       1090       1100
ILNKYGDMRR QIGFEIRDMW YNLGQHKIKF IPEMVGPILE MTLIPETELR 
      1110       1120       1130       1140       1150
KATLPIFFDM MQCEFHSTRS FQMFENEIIT KLDHEVEGGR GDEQYKVLFD 
      1160       1170       1180       1190       1200
KILLEHCRKH KYLAKTGETF VKLVVRLMER LLDYRTIMHD ENKDNRMSCT 
      1210       1220       1230       1240       1250
VNVLNFYKEI EREEMYIRYL YKLCDLHKEC DNYTEAAYTL LLHAKLLKWS 
      1260       1270       1280       1290       1300
EDVCAAHLTQ RDGFQATTQG QLKEQLYQEI IHYFDKGKMW EEAIALGKEL 
      1310       1320       1330       1340       1350
AEQYETEMFD YEQLSELLKK QAQFYENIVK VIRPKPDYFA VGYYGQGFPS 
      1360       1370       1380       1390       1400
FLRGKVFIYR GKEYERREDF EARLLTQFPN AEKMKTTSPP GDDIKTSPGQ 
      1410       1420       1430       1440       1450
YIQCFTVKPK LDLPPRFHRP VSEQIVSFYR VNEVQRFEYS RPIRKGEKNP 
      1460       1470       1480       1490       1500
DNEFANMWIE RTIYTTAYKL PGILRWFEVK SVFMVEISPL ENAIETMQLT 
      1510       1520       1530       1540       1550
NDKISSMVQQ HLDDPGLPIN PLSMLLNGIV DPAVMGGFAN YEKAFFTDRY 
      1560       1570 
LQEHPEAHGQ IEKLKDLIAW QV                       

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to the UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families