ID   FA43A_MOUSE             Reviewed;         424 AA.
AC   Q8BUP8; A4FTY9; Q8R231;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 122.
DE   RecName: Full=Protein FAM43A;
GN   Name=Fam43a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Spinal cord;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CD-1, and FVB/N;
RC   TISSUE=Brain, Neural stem cell, and Salivary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the FAM43 family. {ECO:0000305}.
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DR   EMBL; AK083036; BAC38739.1; -; mRNA.
DR   EMBL; BC022623; AAH22623.1; -; mRNA.
DR   EMBL; BC099947; AAH99947.1; -; mRNA.
DR   EMBL; BC138882; AAI38883.1; -; mRNA.
DR   EMBL; BC138884; AAI38885.1; -; mRNA.
DR   CCDS; CCDS28103.1; -.
DR   RefSeq; NP_808300.1; NM_177632.3.
DR   AlphaFoldDB; Q8BUP8; -.
DR   SMR; Q8BUP8; -.
DR   STRING; 10090.ENSMUSP00000056555; -.
DR   PhosphoSitePlus; Q8BUP8; -.
DR   MaxQB; Q8BUP8; -.
DR   PaxDb; 10090-ENSMUSP00000056555; -.
DR   ProteomicsDB; 266822; -.
DR   Antibodypedia; 68591; 39 antibodies from 11 providers.
DR   DNASU; 224093; -.
DR   Ensembl; ENSMUST00000059078.4; ENSMUSP00000056555.4; ENSMUSG00000046546.4.
DR   GeneID; 224093; -.
DR   KEGG; mmu:224093; -.
DR   UCSC; uc007ywy.2; mouse.
DR   AGR; MGI:2676309; -.
DR   CTD; 131583; -.
DR   MGI; MGI:2676309; Fam43a.
DR   VEuPathDB; HostDB:ENSMUSG00000046546; -.
DR   eggNOG; KOG4448; Eukaryota.
DR   GeneTree; ENSGT00940000161593; -.
DR   HOGENOM; CLU_056673_2_0_1; -.
DR   InParanoid; Q8BUP8; -.
DR   OMA; AMHLECG; -.
DR   OrthoDB; 4030020at2759; -.
DR   PhylomeDB; Q8BUP8; -.
DR   TreeFam; TF314159; -.
DR   BioGRID-ORCS; 224093; 1 hit in 77 CRISPR screens.
DR   ChiTaRS; Fam43a; mouse.
DR   PRO; PR:Q8BUP8; -.
DR   Proteomes; UP000000589; Chromosome 16.
DR   RNAct; Q8BUP8; Protein.
DR   Bgee; ENSMUSG00000046546; Expressed in vestibular membrane of cochlear duct and 203 other cell types or tissues.
DR   CDD; cd01214; PTB_FAM43A; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR033930; FAM43A/B_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   PANTHER; PTHR11232; PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER; 1.
DR   PANTHER; PTHR11232:SF36; PROTEIN FAM43A; 1.
DR   Pfam; PF14719; PID_2; 1.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   Genevisible; Q8BUP8; MM.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..424
FT                   /note="Protein FAM43A"
FT                   /id="PRO_0000187025"
FT   REGION          261..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..293
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..424
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   424 AA;  46206 MW;  AC7C4F9B751365C0 CRC64;
     MLPWKKHKFE LLAEAPPRQA SKPKGYAVSL HYSALSSLAR ACPEGALSRV GSMFRSKRKK
     LHITSEDPTY TVLYLGNATT IQARGDGCTD LAVGKIWSKS EAGRQGTKMK LTVSAQGIRM
     VHAEERALRR PGHLYLLHRV TYCVADARLP KVFAWVYRHE LKHKAVMLRC HAVLVSKPEK
     AQAMALLLYQ TSANALAEFK RLKRRDDARH QQQELVGAHT IPLVPLRKLL LHGPCCYKPP
     VERSRSAPKL GSITEDLLGE QQEEELQEEE EEHLEDCLEE EEEEDGVGDG DPAEEEAEAQ
     RALVVAMQLE CEDLLDPLEN GHEEALGDGG VSLGPSSGTS LPLSVCASDM KAQLSQLISD
     LGDLSFGNDV STLETDLRVT RLLSGESTGS ESSIEGGGLD ATPVSPGNPS GPADSTSLDE
     PYSG
//