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Q8BUM9

- UBP43_MOUSE

UniProt

Q8BUM9 - UBP43_MOUSE

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Protein
Ubiquitin carboxyl-terminal hydrolase 43
Gene
Usp43
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei110 – 1101Nucleophile By similarity
Active sitei668 – 6681Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.979.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 43 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 43
Ubiquitin thioesterase 43
Ubiquitin-specific-processing protease 43
Gene namesi
Name:Usp43
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2444541. Usp43.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11321132Ubiquitin carboxyl-terminal hydrolase 43
PRO_0000249522Add
BLAST

Proteomic databases

PRIDEiQ8BUM9.

PTM databases

PhosphoSiteiQ8BUM9.

Expressioni

Gene expression databases

ArrayExpressiQ8BUM9.
BgeeiQ8BUM9.
CleanExiMM_USP43.
GenevestigatoriQ8BUM9.

Structurei

3D structure databases

ProteinModelPortaliQ8BUM9.
SMRiQ8BUM9. Positions 99-273, 539-711.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 710610USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00750000117419.
HOGENOMiHOG000293426.
HOVERGENiHBG094126.
InParanoidiQ8BUM9.
KOiK11856.
OMAiWQQQQAH.
OrthoDBiEOG7VMP4B.
PhylomeDBiQ8BUM9.
TreeFamiTF106278.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BUM9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDPGVGNALG EGPPAPRPRR RRSLRRLLNR FLLALGSRSR SGDSPPRPPA     50
QPSPYDGDGE GGFACAPGPA PASAGSPGPD RPPGSQPQIS SGDGARPPGA 100
QGLKNHGNTC FMNAVVQCLS NTDLLAEFLA LGRYRAAPGR AEVTEQLAAL 150
VRALWTREYT PQLSAEFKNA VSKYGSQFQG NSQHDALEFL LWLLDRVHED 200
LEGSAHGLVS EQLPPEVSKI SEDLRPSAAP TSLGPSFVQS HFQAQYRSSL 250
TCPHCLKQSN TFDPFLCVSL PIPLRQTRFL SVTLVFPSKS QRFLRVGLAV 300
PILSTVAALR KMVAEEGGVP AEEVILVELY PNGFQRSFFD EEDLNTIAEG 350
DNVYAFQVPP SPGLGTLSAH PSGLSVSPRL PVRDSQRFSG PLHSENRVVF 400
LFCNLVGSGQ QASRFGPPFL IREDRTISWA QLQQCILSKV RCLMRSEVSA 450
QDLGTLFSIR VVGLSLACSY LSPKDNRPLC HWAVDRALHL RRPGGPPHVK 500
LAVEWDSSVT ERLFGSLQEE RVQDADSVWR QQQAHQQPSC TLDECFQSYT 550
KEEQLAQDDA WKCPHCQVLQ QGVVKLSLWT LPDILIIHLK RFCQVGERRN 600
KLSTLVKFPL SGLNMAPHVA RRSTNSKAGP GPWSSWKQPI CLPTTYPLDF 650
LYDLYAVCNH HGSLQGGHYT AYCRNSLDGQ WYSYDDSTVE ALREDEVNTR 700
GAYILFYQKR NSIPPWSASS SMRGSTSSSL SDHWLMRLGS LNNSTRGSLL 750
SWSSAPCPSM ARVPDSPVFT NGVCHQDKGG VETRPLVRGV GGRSISMKAS 800
PASRSRHGPF KTMPLRWSFG HREKRPGASV ELVEYLESRR RPRSTSQSIV 850
PLLTRAAGGE ETSASPRSDG TLPAKSEDSG RAIGQGTTGV PLSSCHLNHH 900
PALGSLDDSL HTARTRTGNV SQDIRLPKKF DLPLTVMPSV GDEKPARPEG 950
QKMTPWKGSS QVGSQSSPPS PSTGLLRNFK DSGPGTLPKM KSKAAMEERA 1000
PDKDRGQGTF TLLKSVFWKK EHKRTVRTES SPPAPPISLG SDRLSPAAMN 1050
EQALRIRESP AKGLGNHMER DIRSAPSSLH LPRKASRPPR ASTAGTSQRT 1100
IPGEQISYGT LQRVKYHTLS LGRKKSLPES SF 1132
Length:1,132
Mass (Da):123,874
Last modified:September 19, 2006 - v2
Checksum:i3E9E9E46B75E67FA
GO
Isoform 2 (identifier: Q8BUM9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1047-1047: Missing.
     1052-1052: Q → QARGSSP

Note: No experimental confirmation available.

Show »
Length:1,137
Mass (Da):124,359
Checksum:i8EBE4A6ED6AD5AFB
GO

Sequence cautioni

The sequence AAH21474.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC38837.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1047 – 10471Missing in isoform 2.
VSP_020469
Alternative sequencei1052 – 10521Q → QARGSSP in isoform 2.
VSP_020470

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti760 – 7601M → V in AAH21474. 1 Publication
Sequence conflicti982 – 9821S → N in AAH21474. 1 Publication
Sequence conflicti1002 – 10021D → G in AAH21474. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL732570 Genomic DNA. Translation: CAI52000.2.
AK083271 mRNA. Translation: BAC38837.1. Different initiation.
BC021474 mRNA. Translation: AAH21474.1. Different initiation.
CCDSiCCDS24861.2. [Q8BUM9-1]
RefSeqiNP_001277978.1. NM_001291049.1.
NP_776115.2. NM_173754.4. [Q8BUM9-1]
UniGeneiMm.158885.

Genome annotation databases

EnsembliENSMUST00000021288; ENSMUSP00000021288; ENSMUSG00000020905. [Q8BUM9-1]
GeneIDi216835.
KEGGimmu:216835.
UCSCiuc007jne.1. mouse. [Q8BUM9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL732570 Genomic DNA. Translation: CAI52000.2 .
AK083271 mRNA. Translation: BAC38837.1 . Different initiation.
BC021474 mRNA. Translation: AAH21474.1 . Different initiation.
CCDSi CCDS24861.2. [Q8BUM9-1 ]
RefSeqi NP_001277978.1. NM_001291049.1.
NP_776115.2. NM_173754.4. [Q8BUM9-1 ]
UniGenei Mm.158885.

3D structure databases

ProteinModelPortali Q8BUM9.
SMRi Q8BUM9. Positions 99-273, 539-711.
ModBasei Search...

Protein family/group databases

MEROPSi C19.979.

PTM databases

PhosphoSitei Q8BUM9.

Proteomic databases

PRIDEi Q8BUM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021288 ; ENSMUSP00000021288 ; ENSMUSG00000020905 . [Q8BUM9-1 ]
GeneIDi 216835.
KEGGi mmu:216835.
UCSCi uc007jne.1. mouse. [Q8BUM9-1 ]

Organism-specific databases

CTDi 124739.
MGIi MGI:2444541. Usp43.

Phylogenomic databases

eggNOGi COG5560.
GeneTreei ENSGT00750000117419.
HOGENOMi HOG000293426.
HOVERGENi HBG094126.
InParanoidi Q8BUM9.
KOi K11856.
OMAi WQQQQAH.
OrthoDBi EOG7VMP4B.
PhylomeDBi Q8BUM9.
TreeFami TF106278.

Miscellaneous databases

NextBioi 375380.
PROi Q8BUM9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BUM9.
Bgeei Q8BUM9.
CleanExi MM_USP43.
Genevestigatori Q8BUM9.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-1132 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 207-1132 (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiUBP43_MOUSE
AccessioniPrimary (citable) accession number: Q8BUM9
Secondary accession number(s): Q8VDP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: September 3, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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