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Q8BUM3

- PTN7_MOUSE

UniProt

Q8BUM3 - PTN7_MOUSE

Protein

Tyrosine-protein phosphatase non-receptor type 7

Gene

Ptpn7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of T and B-lymphocyte development and signal transduction.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Enzyme regulationi

    Inhibited upon FCER1A triggering.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei257 – 2571SubstrateBy similarity
    Active sitei290 – 2901Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei334 – 3341SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: MGI

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: GOC
    2. protein dephosphorylation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 7 (EC:3.1.3.48)
    Alternative name(s):
    Hematopoietic protein-tyrosine phosphatase
    Short name:
    HEPTP
    Gene namesi
    Name:Ptpn7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2156893. Ptpn7.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication
    Note: Oxidized form is preferentially associated with actin cytoskeleton.

    GO - Cellular componenti

    1. cytoplasmic side of plasma membrane Source: Ensembl
    2. cytoskeleton Source: UniProtKB-SubCell
    3. cytosol Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Tyrosine-protein phosphatase non-receptor type 7PRO_0000094762Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei44 – 441PhosphoserineBy similarity
    Modified residuei66 – 661PhosphothreonineBy similarity
    Modified residuei93 – 931PhosphoserineBy similarity
    Modified residuei143 – 1431PhosphoserineBy similarity
    Modified residuei290 – 2901Cysteine sulfenic acid (-SOH)1 Publication

    Post-translational modificationi

    Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H2O2) or with antigen enhanced oxidation of active site cysteine.1 Publication

    Keywords - PTMi

    Oxidation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8BUM3.
    PaxDbiQ8BUM3.
    PRIDEiQ8BUM3.

    PTM databases

    PhosphoSiteiQ8BUM3.

    Expressioni

    Tissue specificityi

    Expressed in bone marrow-derived mast cells.1 Publication

    Gene expression databases

    ArrayExpressiQ8BUM3.
    BgeeiQ8BUM3.
    CleanExiMM_PTPN7.
    GenevestigatoriQ8BUM3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000045803.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BUM3.
    SMRiQ8BUM3. Positions 65-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini97 – 349253Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni38 – 5114Interaction with MAP kinasesBy similarityAdd
    BLAST
    Regioni290 – 2967Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117606.
    HOGENOMiHOG000294188.
    HOVERGENiHBG001594.
    InParanoidiQ8BUM3.
    KOiK18019.
    OMAiGTVEPIC.
    OrthoDBiEOG7288QX.
    PhylomeDBiQ8BUM3.
    TreeFamiTF331016.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BUM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQACEGRSR AQLPTLSLGA DMTQPPPTKA PAKKHVRLQE RRGSSVALML    50
    DVQSLGTVEP ICSVNTPREV TLHFLRTAGH PLTRWTLQHQ PPSPKQLEEE 100
    FLKIPSNFVN PEDLDIPGHA SKDRYKTILP NPQSRVCLGR AQSQEDSDYI 150
    NANYIRGYDG KEKVYIATQG PMPNTVADFW EMVWQEDVSL IVMLTQLREG 200
    KEKCVHYWPT EEEAYGPFQI RIQDMKEHPE YTVRQLTIQH QQECRSVKHI 250
    LFSAWPDHQT PESAGPLLRL VAEVETPETA ANSGPIVVHC SAGIGRTGCF 300
    IATRIGCQQL KARGEVDILG IVCQLRLDRG GMIQTAEQYQ FLHHTLALYA 350
    AQLPPEPNP 359
    Length:359
    Mass (Da):40,351
    Last modified:March 1, 2003 - v1
    Checksum:iE5C62B36E5A77DFD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK083305 mRNA. Translation: BAC38856.1.
    BC098475 mRNA. Translation: AAH98475.1.
    CCDSiCCDS15315.1.
    RefSeqiNP_796055.1. NM_177081.3.
    XP_006529759.1. XM_006529696.1.
    XP_006529760.1. XM_006529697.1.
    XP_006529761.1. XM_006529698.1.
    UniGeneiMm.258388.

    Genome annotation databases

    EnsembliENSMUST00000049449; ENSMUSP00000045803; ENSMUSG00000031506.
    ENSMUST00000167080; ENSMUSP00000129474; ENSMUSG00000031506.
    GeneIDi320139.
    KEGGimmu:320139.
    UCSCiuc007css.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK083305 mRNA. Translation: BAC38856.1 .
    BC098475 mRNA. Translation: AAH98475.1 .
    CCDSi CCDS15315.1.
    RefSeqi NP_796055.1. NM_177081.3.
    XP_006529759.1. XM_006529696.1.
    XP_006529760.1. XM_006529697.1.
    XP_006529761.1. XM_006529698.1.
    UniGenei Mm.258388.

    3D structure databases

    ProteinModelPortali Q8BUM3.
    SMRi Q8BUM3. Positions 65-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000045803.

    PTM databases

    PhosphoSitei Q8BUM3.

    Proteomic databases

    MaxQBi Q8BUM3.
    PaxDbi Q8BUM3.
    PRIDEi Q8BUM3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049449 ; ENSMUSP00000045803 ; ENSMUSG00000031506 .
    ENSMUST00000167080 ; ENSMUSP00000129474 ; ENSMUSG00000031506 .
    GeneIDi 320139.
    KEGGi mmu:320139.
    UCSCi uc007css.1. mouse.

    Organism-specific databases

    CTDi 5778.
    MGIi MGI:2156893. Ptpn7.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117606.
    HOGENOMi HOG000294188.
    HOVERGENi HBG001594.
    InParanoidi Q8BUM3.
    KOi K18019.
    OMAi GTVEPIC.
    OrthoDBi EOG7288QX.
    PhylomeDBi Q8BUM3.
    TreeFami TF331016.

    Miscellaneous databases

    NextBioi 396113.
    PROi Q8BUM3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BUM3.
    Bgeei Q8BUM3.
    CleanExi MM_PTPN7.
    Genevestigatori Q8BUM3.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6NCr.
      Tissue: Hematopoietic stem cell.
    3. "Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts."
      Heneberg P., Draberova L., Bambouskova M., Pompach P., Draber P.
      J. Biol. Chem. 285:12787-12802(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, OXIDATION AT CYS-290, ENZYME REGULATION, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPTN7_MOUSE
    AccessioniPrimary (citable) accession number: Q8BUM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3