Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein phosphatase non-receptor type 7

Gene

Ptpn7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of T and B-lymphocyte development and signal transduction.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited upon FCER1A triggering.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei257SubstrateBy similarity1
Active sitei290Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei334SubstrateBy similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: MGI

GO - Biological processi

  • protein dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 7 (EC:3.1.3.48)
Alternative name(s):
Hematopoietic protein-tyrosine phosphatase
Short name:
HEPTP
Gene namesi
Name:Ptpn7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2156893. Ptpn7.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: Oxidized form is preferentially associated with actin cytoskeleton.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947621 – 359Tyrosine-protein phosphatase non-receptor type 7Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1
Modified residuei66PhosphothreonineBy similarity1
Modified residuei93PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei290Cysteine sulfenic acid (-SOH)1 Publication1

Post-translational modificationi

Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H2O2) or with antigen enhanced oxidation of active site cysteine.1 Publication

Keywords - PTMi

Oxidation, Phosphoprotein

Proteomic databases

EPDiQ8BUM3.
MaxQBiQ8BUM3.
PaxDbiQ8BUM3.
PRIDEiQ8BUM3.

PTM databases

iPTMnetiQ8BUM3.
PhosphoSitePlusiQ8BUM3.

Expressioni

Tissue specificityi

Expressed in bone marrow-derived mast cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000031506.
CleanExiMM_PTPN7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045803.

Structurei

3D structure databases

ProteinModelPortaliQ8BUM3.
SMRiQ8BUM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 349Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 51Interaction with MAP kinasesBy similarityAdd BLAST14
Regioni290 – 296Substrate bindingBy similarity7

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiQ8BUM3.
KOiK18019.
OMAiSEQYQFL.
OrthoDBiEOG091G0HLB.
PhylomeDBiQ8BUM3.
TreeFamiTF331016.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR008356. Tyr_Pase_KIM-con.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BUM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQACEGRSR AQLPTLSLGA DMTQPPPTKA PAKKHVRLQE RRGSSVALML
60 70 80 90 100
DVQSLGTVEP ICSVNTPREV TLHFLRTAGH PLTRWTLQHQ PPSPKQLEEE
110 120 130 140 150
FLKIPSNFVN PEDLDIPGHA SKDRYKTILP NPQSRVCLGR AQSQEDSDYI
160 170 180 190 200
NANYIRGYDG KEKVYIATQG PMPNTVADFW EMVWQEDVSL IVMLTQLREG
210 220 230 240 250
KEKCVHYWPT EEEAYGPFQI RIQDMKEHPE YTVRQLTIQH QQECRSVKHI
260 270 280 290 300
LFSAWPDHQT PESAGPLLRL VAEVETPETA ANSGPIVVHC SAGIGRTGCF
310 320 330 340 350
IATRIGCQQL KARGEVDILG IVCQLRLDRG GMIQTAEQYQ FLHHTLALYA

AQLPPEPNP
Length:359
Mass (Da):40,351
Last modified:March 1, 2003 - v1
Checksum:iE5C62B36E5A77DFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083305 mRNA. Translation: BAC38856.1.
BC098475 mRNA. Translation: AAH98475.1.
CCDSiCCDS15315.1.
RefSeqiNP_796055.1. NM_177081.3.
XP_006529759.1. XM_006529696.3.
XP_006529760.1. XM_006529697.3.
XP_006529761.1. XM_006529698.3.
UniGeneiMm.258388.

Genome annotation databases

EnsembliENSMUST00000049449; ENSMUSP00000045803; ENSMUSG00000031506.
ENSMUST00000167080; ENSMUSP00000129474; ENSMUSG00000031506.
ENSMUST00000187985; ENSMUSP00000141133; ENSMUSG00000031506.
GeneIDi320139.
KEGGimmu:320139.
UCSCiuc007css.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083305 mRNA. Translation: BAC38856.1.
BC098475 mRNA. Translation: AAH98475.1.
CCDSiCCDS15315.1.
RefSeqiNP_796055.1. NM_177081.3.
XP_006529759.1. XM_006529696.3.
XP_006529760.1. XM_006529697.3.
XP_006529761.1. XM_006529698.3.
UniGeneiMm.258388.

3D structure databases

ProteinModelPortaliQ8BUM3.
SMRiQ8BUM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045803.

PTM databases

iPTMnetiQ8BUM3.
PhosphoSitePlusiQ8BUM3.

Proteomic databases

EPDiQ8BUM3.
MaxQBiQ8BUM3.
PaxDbiQ8BUM3.
PRIDEiQ8BUM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049449; ENSMUSP00000045803; ENSMUSG00000031506.
ENSMUST00000167080; ENSMUSP00000129474; ENSMUSG00000031506.
ENSMUST00000187985; ENSMUSP00000141133; ENSMUSG00000031506.
GeneIDi320139.
KEGGimmu:320139.
UCSCiuc007css.1. mouse.

Organism-specific databases

CTDi5778.
MGIiMGI:2156893. Ptpn7.

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiQ8BUM3.
KOiK18019.
OMAiSEQYQFL.
OrthoDBiEOG091G0HLB.
PhylomeDBiQ8BUM3.
TreeFamiTF331016.

Miscellaneous databases

PROiQ8BUM3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031506.
CleanExiMM_PTPN7.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR008356. Tyr_Pase_KIM-con.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTN7_MOUSE
AccessioniPrimary (citable) accession number: Q8BUM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.