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Protein

Tyrosine-protein phosphatase non-receptor type 7

Gene

Ptpn7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of T and B-lymphocyte development and signal transduction.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited upon FCER1A triggering.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei257SubstrateBy similarity1
Active sitei290Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei334SubstrateBy similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: MGI

GO - Biological processi

  • protein dephosphorylation Source: MGI

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 7 (EC:3.1.3.48)
Alternative name(s):
Hematopoietic protein-tyrosine phosphatase
Short name:
HEPTP
Gene namesi
Name:Ptpn7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2156893. Ptpn7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947621 – 359Tyrosine-protein phosphatase non-receptor type 7Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1
Modified residuei66PhosphothreonineBy similarity1
Modified residuei93PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei290Cysteine sulfenic acid (-SOH)1 Publication1

Post-translational modificationi

Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H2O2) or with antigen enhanced oxidation of active site cysteine.1 Publication

Keywords - PTMi

Oxidation, Phosphoprotein

Proteomic databases

EPDiQ8BUM3.
MaxQBiQ8BUM3.
PaxDbiQ8BUM3.
PRIDEiQ8BUM3.

PTM databases

iPTMnetiQ8BUM3.
PhosphoSitePlusiQ8BUM3.

Expressioni

Tissue specificityi

Expressed in bone marrow-derived mast cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000031506.
CleanExiMM_PTPN7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045803.

Structurei

3D structure databases

ProteinModelPortaliQ8BUM3.
SMRiQ8BUM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 349Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 51Interaction with MAP kinasesBy similarityAdd BLAST14
Regioni290 – 296Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00890000139412.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiQ8BUM3.
KOiK18019.
OMAiSEQYQFL.
OrthoDBiEOG091G0HLB.
PhylomeDBiQ8BUM3.
TreeFamiTF331016.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR008356. Tyr_Pase_KIM-con.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BUM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQACEGRSR AQLPTLSLGA DMTQPPPTKA PAKKHVRLQE RRGSSVALML
60 70 80 90 100
DVQSLGTVEP ICSVNTPREV TLHFLRTAGH PLTRWTLQHQ PPSPKQLEEE
110 120 130 140 150
FLKIPSNFVN PEDLDIPGHA SKDRYKTILP NPQSRVCLGR AQSQEDSDYI
160 170 180 190 200
NANYIRGYDG KEKVYIATQG PMPNTVADFW EMVWQEDVSL IVMLTQLREG
210 220 230 240 250
KEKCVHYWPT EEEAYGPFQI RIQDMKEHPE YTVRQLTIQH QQECRSVKHI
260 270 280 290 300
LFSAWPDHQT PESAGPLLRL VAEVETPETA ANSGPIVVHC SAGIGRTGCF
310 320 330 340 350
IATRIGCQQL KARGEVDILG IVCQLRLDRG GMIQTAEQYQ FLHHTLALYA

AQLPPEPNP
Length:359
Mass (Da):40,351
Last modified:March 1, 2003 - v1
Checksum:iE5C62B36E5A77DFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083305 mRNA. Translation: BAC38856.1.
BC098475 mRNA. Translation: AAH98475.1.
CCDSiCCDS15315.1.
RefSeqiNP_796055.1. NM_177081.3.
XP_006529759.1. XM_006529696.3.
XP_006529760.1. XM_006529697.3.
XP_006529761.1. XM_006529698.3.
UniGeneiMm.258388.

Genome annotation databases

EnsembliENSMUST00000049449; ENSMUSP00000045803; ENSMUSG00000031506.
ENSMUST00000167080; ENSMUSP00000129474; ENSMUSG00000031506.
ENSMUST00000187985; ENSMUSP00000141133; ENSMUSG00000031506.
GeneIDi320139.
KEGGimmu:320139.
UCSCiuc007css.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPTN7_MOUSE
AccessioniPrimary (citable) accession number: Q8BUM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families