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Q8BUM3

- PTN7_MOUSE

UniProt

Q8BUM3 - PTN7_MOUSE

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Protein

Tyrosine-protein phosphatase non-receptor type 7

Gene

Ptpn7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the regulation of T and B-lymphocyte development and signal transduction.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited upon FCER1A triggering.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei257 – 2571SubstrateBy similarity
Active sitei290 – 2901Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei334 – 3341SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: MGI

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: GOC
  2. protein dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 7 (EC:3.1.3.48)
Alternative name(s):
Hematopoietic protein-tyrosine phosphatase
Short name:
HEPTP
Gene namesi
Name:Ptpn7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2156893. Ptpn7.

Subcellular locationi

Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication
Note: Oxidized form is preferentially associated with actin cytoskeleton.

GO - Cellular componenti

  1. cytoplasmic side of plasma membrane Source: Ensembl
  2. cytoskeleton Source: UniProtKB-KW
  3. cytosol Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Tyrosine-protein phosphatase non-receptor type 7PRO_0000094762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441PhosphoserineBy similarity
Modified residuei66 – 661PhosphothreonineBy similarity
Modified residuei93 – 931PhosphoserineBy similarity
Modified residuei143 – 1431PhosphoserineBy similarity
Modified residuei290 – 2901Cysteine sulfenic acid (-SOH)1 Publication

Post-translational modificationi

Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H2O2) or with antigen enhanced oxidation of active site cysteine.1 Publication

Keywords - PTMi

Oxidation, Phosphoprotein

Proteomic databases

MaxQBiQ8BUM3.
PaxDbiQ8BUM3.
PRIDEiQ8BUM3.

PTM databases

PhosphoSiteiQ8BUM3.

Expressioni

Tissue specificityi

Expressed in bone marrow-derived mast cells.1 Publication

Gene expression databases

BgeeiQ8BUM3.
CleanExiMM_PTPN7.
ExpressionAtlasiQ8BUM3. baseline and differential.
GenevestigatoriQ8BUM3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045803.

Structurei

3D structure databases

ProteinModelPortaliQ8BUM3.
SMRiQ8BUM3. Positions 65-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 349253Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni38 – 5114Interaction with MAP kinasesBy similarityAdd
BLAST
Regioni290 – 2967Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiQ8BUM3.
KOiK18019.
OMAiGTVEPIC.
OrthoDBiEOG7288QX.
PhylomeDBiQ8BUM3.
TreeFamiTF331016.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BUM3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQACEGRSR AQLPTLSLGA DMTQPPPTKA PAKKHVRLQE RRGSSVALML
60 70 80 90 100
DVQSLGTVEP ICSVNTPREV TLHFLRTAGH PLTRWTLQHQ PPSPKQLEEE
110 120 130 140 150
FLKIPSNFVN PEDLDIPGHA SKDRYKTILP NPQSRVCLGR AQSQEDSDYI
160 170 180 190 200
NANYIRGYDG KEKVYIATQG PMPNTVADFW EMVWQEDVSL IVMLTQLREG
210 220 230 240 250
KEKCVHYWPT EEEAYGPFQI RIQDMKEHPE YTVRQLTIQH QQECRSVKHI
260 270 280 290 300
LFSAWPDHQT PESAGPLLRL VAEVETPETA ANSGPIVVHC SAGIGRTGCF
310 320 330 340 350
IATRIGCQQL KARGEVDILG IVCQLRLDRG GMIQTAEQYQ FLHHTLALYA

AQLPPEPNP
Length:359
Mass (Da):40,351
Last modified:March 1, 2003 - v1
Checksum:iE5C62B36E5A77DFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083305 mRNA. Translation: BAC38856.1.
BC098475 mRNA. Translation: AAH98475.1.
CCDSiCCDS15315.1.
RefSeqiNP_796055.1. NM_177081.3.
XP_006529759.1. XM_006529696.1.
XP_006529760.1. XM_006529697.1.
XP_006529761.1. XM_006529698.1.
UniGeneiMm.258388.

Genome annotation databases

EnsembliENSMUST00000049449; ENSMUSP00000045803; ENSMUSG00000031506.
ENSMUST00000167080; ENSMUSP00000129474; ENSMUSG00000031506.
ENSMUST00000187985; ENSMUSP00000141133; ENSMUSG00000031506.
GeneIDi320139.
KEGGimmu:320139.
UCSCiuc007css.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083305 mRNA. Translation: BAC38856.1 .
BC098475 mRNA. Translation: AAH98475.1 .
CCDSi CCDS15315.1.
RefSeqi NP_796055.1. NM_177081.3.
XP_006529759.1. XM_006529696.1.
XP_006529760.1. XM_006529697.1.
XP_006529761.1. XM_006529698.1.
UniGenei Mm.258388.

3D structure databases

ProteinModelPortali Q8BUM3.
SMRi Q8BUM3. Positions 65-356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000045803.

PTM databases

PhosphoSitei Q8BUM3.

Proteomic databases

MaxQBi Q8BUM3.
PaxDbi Q8BUM3.
PRIDEi Q8BUM3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049449 ; ENSMUSP00000045803 ; ENSMUSG00000031506 .
ENSMUST00000167080 ; ENSMUSP00000129474 ; ENSMUSG00000031506 .
ENSMUST00000187985 ; ENSMUSP00000141133 ; ENSMUSG00000031506 .
GeneIDi 320139.
KEGGi mmu:320139.
UCSCi uc007css.1. mouse.

Organism-specific databases

CTDi 5778.
MGIi MGI:2156893. Ptpn7.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00770000120452.
HOGENOMi HOG000294188.
HOVERGENi HBG001594.
InParanoidi Q8BUM3.
KOi K18019.
OMAi GTVEPIC.
OrthoDBi EOG7288QX.
PhylomeDBi Q8BUM3.
TreeFami TF331016.

Miscellaneous databases

NextBioi 396113.
PROi Q8BUM3.
SOURCEi Search...

Gene expression databases

Bgeei Q8BUM3.
CleanExi MM_PTPN7.
ExpressionAtlasi Q8BUM3. baseline and differential.
Genevestigatori Q8BUM3.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6NCr.
    Tissue: Hematopoietic stem cell.
  3. "Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts."
    Heneberg P., Draberova L., Bambouskova M., Pompach P., Draber P.
    J. Biol. Chem. 285:12787-12802(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, OXIDATION AT CYS-290, ENZYME REGULATION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPTN7_MOUSE
AccessioniPrimary (citable) accession number: Q8BUM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3