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Q8BUM3 (PTN7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 7

EC=3.1.3.48
Alternative name(s):
Hematopoietic protein-tyrosine phosphatase
Short name=HEPTP
Gene names
Name:Ptpn7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the regulation of T and B-lymphocyte development and signal transduction By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulation

Inhibited upon FCER1A triggering. Ref.3

Subcellular location

Cytoplasm. Cytoplasmcytoskeleton. Note: Oxidized form is preferentially associated with actin cytoskeleton. Ref.3

Tissue specificity

Expressed in bone marrow-derived mast cells. Ref.3

Post-translational modification

Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H2O2) or with antigen enhanced oxidation of active site cysteine.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Tyrosine-protein phosphatase non-receptor type 7
PRO_0000094762

Regions

Domain97 – 349253Tyrosine-protein phosphatase
Region38 – 5114Interaction with MAP kinases By similarity
Region290 – 2967Substrate binding By similarity

Sites

Active site2901Phosphocysteine intermediate By similarity
Binding site2571Substrate By similarity
Binding site3341Substrate By similarity

Amino acid modifications

Modified residue441Phosphoserine By similarity
Modified residue661Phosphothreonine By similarity
Modified residue931Phosphoserine By similarity
Modified residue1431Phosphoserine By similarity
Modified residue2901Cysteine sulfenic acid (-SOH)

Sequences

Sequence LengthMass (Da)Tools
Q8BUM3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: E5C62B36E5A77DFD

FASTA35940,351
        10         20         30         40         50         60 
MVQACEGRSR AQLPTLSLGA DMTQPPPTKA PAKKHVRLQE RRGSSVALML DVQSLGTVEP 

        70         80         90        100        110        120 
ICSVNTPREV TLHFLRTAGH PLTRWTLQHQ PPSPKQLEEE FLKIPSNFVN PEDLDIPGHA 

       130        140        150        160        170        180 
SKDRYKTILP NPQSRVCLGR AQSQEDSDYI NANYIRGYDG KEKVYIATQG PMPNTVADFW 

       190        200        210        220        230        240 
EMVWQEDVSL IVMLTQLREG KEKCVHYWPT EEEAYGPFQI RIQDMKEHPE YTVRQLTIQH 

       250        260        270        280        290        300 
QQECRSVKHI LFSAWPDHQT PESAGPLLRL VAEVETPETA ANSGPIVVHC SAGIGRTGCF 

       310        320        330        340        350 
IATRIGCQQL KARGEVDILG IVCQLRLDRG GMIQTAEQYQ FLHHTLALYA AQLPPEPNP 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6NCr.
Tissue: Hematopoietic stem cell.
[3]"Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts."
Heneberg P., Draberova L., Bambouskova M., Pompach P., Draber P.
J. Biol. Chem. 285:12787-12802(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, OXIDATION AT CYS-290, ENZYME REGULATION, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK083305 mRNA. Translation: BAC38856.1.
BC098475 mRNA. Translation: AAH98475.1.
CCDSCCDS15315.1.
RefSeqNP_796055.1. NM_177081.3.
XP_006529759.1. XM_006529696.1.
XP_006529760.1. XM_006529697.1.
XP_006529761.1. XM_006529698.1.
UniGeneMm.258388.

3D structure databases

ProteinModelPortalQ8BUM3.
SMRQ8BUM3. Positions 65-356.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000045803.

PTM databases

PhosphoSiteQ8BUM3.

Proteomic databases

MaxQBQ8BUM3.
PaxDbQ8BUM3.
PRIDEQ8BUM3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049449; ENSMUSP00000045803; ENSMUSG00000031506.
ENSMUST00000167080; ENSMUSP00000129474; ENSMUSG00000031506.
GeneID320139.
KEGGmmu:320139.
UCSCuc007css.1. mouse.

Organism-specific databases

CTD5778.
MGIMGI:2156893. Ptpn7.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00750000117606.
HOGENOMHOG000294188.
HOVERGENHBG001594.
InParanoidQ8BUM3.
KOK18019.
OMAGTVEPIC.
OrthoDBEOG7288QX.
PhylomeDBQ8BUM3.
TreeFamTF331016.

Gene expression databases

ArrayExpressQ8BUM3.
BgeeQ8BUM3.
CleanExMM_PTPN7.
GenevestigatorQ8BUM3.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio396113.
PROQ8BUM3.
SOURCESearch...

Entry information

Entry namePTN7_MOUSE
AccessionPrimary (citable) accession number: Q8BUM3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot