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Protein

Kelch-like protein 7

Gene

Klhl7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 7
Gene namesi
Name:Klhl7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1196453 Klhl7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289891 – 586Kelch-like protein 7Add BLAST586

Proteomic databases

MaxQBiQ8BUL5
PaxDbiQ8BUL5
PeptideAtlasiQ8BUL5
PRIDEiQ8BUL5

PTM databases

iPTMnetiQ8BUL5
PhosphoSitePlusiQ8BUL5

Expressioni

Gene expression databases

BgeeiENSMUSG00000028986
CleanExiMM_KLHL7
ExpressionAtlasiQ8BUL5 baseline and differential
GenevisibleiQ8BUL5 MM

Interactioni

Subunit structurei

Homodimer. Component of the BCR(KLHL7) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL7 and RBX1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206516, 1 interactor
IntActiQ8BUL5, 1 interactor
STRINGi10090.ENSMUSP00000030841

Structurei

3D structure databases

ProteinModelPortaliQ8BUL5
SMRiQ8BUL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 111BTBPROSITE-ProRule annotationAdd BLAST68
Domaini146 – 248BACKAdd BLAST103
Repeati294 – 336Kelch 1Add BLAST43
Repeati337 – 382Kelch 2Add BLAST46
Repeati383 – 430Kelch 3Add BLAST48
Repeati431 – 481Kelch 4Add BLAST51
Repeati483 – 528Kelch 5Add BLAST46
Repeati530 – 575Kelch 6Add BLAST46

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118825
HOGENOMiHOG000230816
HOVERGENiHBG106113
InParanoidiQ8BUL5
KOiK10445
OMAiNNCEVYD
OrthoDBiEOG091G03G7
PhylomeDBiQ8BUL5
TreeFamiTF351653

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030599 KLHL7
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF216 PTHR24412:SF216, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 4 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BUL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSGVEKSS KKKTEKKLAA REEAKLLAGF MGVMNNMRKQ RTLCDVILTV
60 70 80 90 100
QERKIPAHRV VLAAASHFFN LMFTTNMLES KSFEVELKDA EPDIIEQLVE
110 120 130 140 150
FAYTARISVN SNNVQSLLDA ANQYQIEPVK KMCVDFLKEQ VDASNCLGIS
160 170 180 190 200
VLAECLDCPE LKATADDFIH QHFTEVYKTD EFLQLDVKRV THLLSQDTLT
210 220 230 240 250
VRAEDQVYDA AVRWLKYDEP NRQPFMVDIL AKVRFPLISK NFLSKTVQAE
260 270 280 290 300
PLIQDNPECL KMVISGMRYH LLSPEDREEL AGGTRPRRKK HDYRIALFGG
310 320 330 340 350
SQPQSCRYFN PKDYSWTDIR CPFEKRRDAA CVFWDNVVYI LGGSQLFPIK
360 370 380 390 400
RMDCYNVVKD SWYSKLGPPT PRDSLAACAA EGKIYTSGGS EVGNSALYLF
410 420 430 440 450
ECYDTRTESW HTKPSMLTQR CSHGMVEANG LIYVCGGSLG NNVSGRVLSS
460 470 480 490 500
CEVYDPATET WTELCSMIEP RKNHGLVFVK DKIFAVGGQN GLGGLDNVEY
510 520 530 540 550
YDIKLNEWKM VSPMPWRGVT VKCAAVGSVI YVLAGFQGVG RLGHILEYNT
560 570 580
ETDKWIANSK VRAFPVTSCL ICVVDTCGAN EETLET
Length:586
Mass (Da):65,938
Last modified:March 1, 2003 - v1
Checksum:i1E676E01FA143653
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti529V → D in BAB28163 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012326 mRNA Translation: BAB28163.1
AK083358 mRNA Translation: BAC38883.1
CCDSiCCDS19114.1
RefSeqiNP_080724.2, NM_026448.3
UniGeneiMm.273768

Genome annotation databases

EnsembliENSMUST00000030841; ENSMUSP00000030841; ENSMUSG00000028986
GeneIDi52323
KEGGimmu:52323
UCSCiuc008wqy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKLHL7_MOUSE
AccessioniPrimary (citable) accession number: Q8BUL5
Secondary accession number(s): Q9CZP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health