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Protein

Kelch-like protein 7

Gene

Klhl7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 7
Gene namesi
Name:Klhl7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1196453. Klhl7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289891 – 586Kelch-like protein 7Add BLAST586

Proteomic databases

MaxQBiQ8BUL5.
PaxDbiQ8BUL5.
PeptideAtlasiQ8BUL5.
PRIDEiQ8BUL5.

PTM databases

iPTMnetiQ8BUL5.
PhosphoSitePlusiQ8BUL5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028986.
CleanExiMM_KLHL7.
ExpressionAtlasiQ8BUL5. baseline and differential.
GenevisibleiQ8BUL5. MM.

Interactioni

Subunit structurei

Homodimer. Component of the BCR(KLHL7) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL7 and RBX1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030841.

Structurei

3D structure databases

ProteinModelPortaliQ8BUL5.
SMRiQ8BUL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 111BTBPROSITE-ProRule annotationAdd BLAST68
Domaini146 – 248BACKAdd BLAST103
Repeati294 – 336Kelch 1Add BLAST43
Repeati337 – 382Kelch 2Add BLAST46
Repeati383 – 430Kelch 3Add BLAST48
Repeati431 – 481Kelch 4Add BLAST51
Repeati483 – 528Kelch 5Add BLAST46
Repeati530 – 575Kelch 6Add BLAST46

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000119153.
HOGENOMiHOG000230816.
HOVERGENiHBG106113.
InParanoidiQ8BUL5.
KOiK10445.
OMAiNNCEVYD.
OrthoDBiEOG091G03G7.
PhylomeDBiQ8BUL5.
TreeFamiTF351653.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030599. KLHL7.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF216. PTHR24412:SF216. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BUL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSGVEKSS KKKTEKKLAA REEAKLLAGF MGVMNNMRKQ RTLCDVILTV
60 70 80 90 100
QERKIPAHRV VLAAASHFFN LMFTTNMLES KSFEVELKDA EPDIIEQLVE
110 120 130 140 150
FAYTARISVN SNNVQSLLDA ANQYQIEPVK KMCVDFLKEQ VDASNCLGIS
160 170 180 190 200
VLAECLDCPE LKATADDFIH QHFTEVYKTD EFLQLDVKRV THLLSQDTLT
210 220 230 240 250
VRAEDQVYDA AVRWLKYDEP NRQPFMVDIL AKVRFPLISK NFLSKTVQAE
260 270 280 290 300
PLIQDNPECL KMVISGMRYH LLSPEDREEL AGGTRPRRKK HDYRIALFGG
310 320 330 340 350
SQPQSCRYFN PKDYSWTDIR CPFEKRRDAA CVFWDNVVYI LGGSQLFPIK
360 370 380 390 400
RMDCYNVVKD SWYSKLGPPT PRDSLAACAA EGKIYTSGGS EVGNSALYLF
410 420 430 440 450
ECYDTRTESW HTKPSMLTQR CSHGMVEANG LIYVCGGSLG NNVSGRVLSS
460 470 480 490 500
CEVYDPATET WTELCSMIEP RKNHGLVFVK DKIFAVGGQN GLGGLDNVEY
510 520 530 540 550
YDIKLNEWKM VSPMPWRGVT VKCAAVGSVI YVLAGFQGVG RLGHILEYNT
560 570 580
ETDKWIANSK VRAFPVTSCL ICVVDTCGAN EETLET
Length:586
Mass (Da):65,938
Last modified:March 1, 2003 - v1
Checksum:i1E676E01FA143653
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti529V → D in BAB28163 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012326 mRNA. Translation: BAB28163.1.
AK083358 mRNA. Translation: BAC38883.1.
CCDSiCCDS19114.1.
RefSeqiNP_080724.2. NM_026448.3.
UniGeneiMm.273768.

Genome annotation databases

EnsembliENSMUST00000030841; ENSMUSP00000030841; ENSMUSG00000028986.
GeneIDi52323.
KEGGimmu:52323.
UCSCiuc008wqy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012326 mRNA. Translation: BAB28163.1.
AK083358 mRNA. Translation: BAC38883.1.
CCDSiCCDS19114.1.
RefSeqiNP_080724.2. NM_026448.3.
UniGeneiMm.273768.

3D structure databases

ProteinModelPortaliQ8BUL5.
SMRiQ8BUL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030841.

PTM databases

iPTMnetiQ8BUL5.
PhosphoSitePlusiQ8BUL5.

Proteomic databases

MaxQBiQ8BUL5.
PaxDbiQ8BUL5.
PeptideAtlasiQ8BUL5.
PRIDEiQ8BUL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030841; ENSMUSP00000030841; ENSMUSG00000028986.
GeneIDi52323.
KEGGimmu:52323.
UCSCiuc008wqy.2. mouse.

Organism-specific databases

CTDi55975.
MGIiMGI:1196453. Klhl7.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000119153.
HOGENOMiHOG000230816.
HOVERGENiHBG106113.
InParanoidiQ8BUL5.
KOiK10445.
OMAiNNCEVYD.
OrthoDBiEOG091G03G7.
PhylomeDBiQ8BUL5.
TreeFamiTF351653.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8BUL5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028986.
CleanExiMM_KLHL7.
ExpressionAtlasiQ8BUL5. baseline and differential.
GenevisibleiQ8BUL5. MM.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030599. KLHL7.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF216. PTHR24412:SF216. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLHL7_MOUSE
AccessioniPrimary (citable) accession number: Q8BUL5
Secondary accession number(s): Q9CZP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.